| Identification |
|---|
| HMDB Protein ID
| CDBP03502 |
| Secondary Accession Numbers
| Not Available |
| Name
| Sulfhydryl oxidase 2 |
| Description
| Not Available |
| Synonyms
|
- Neuroblastoma-derived sulfhydryl oxidase
- Quiescin Q6-like protein 1
|
| Gene Name
| QSOX2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in thiol oxidase activity |
| Specific Function
| Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins. Also seems to play a role in regulating the sensitization of neuroblastoma cells for interferon-gamma-induced apoptosis.
|
| GO Classification
|
| Biological Process |
| cell redox homeostasis |
| Cellular Component |
| plasma membrane |
| extracellular region |
| nuclear membrane |
| integral to membrane |
| Function |
| catalytic activity |
| oxidoreductase activity, acting on a sulfur group of donors |
| oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor |
| thiol oxidase activity |
| oxidoreductase activity |
| Molecular Function |
| thiol oxidase activity |
| Process |
| cellular process |
| oxidation reduction |
| cellular homeostasis |
| cell redox homeostasis |
| metabolic process |
|
| Cellular Location
|
- Cell membrane
- Secreted
- Membrane
- Single-pass membrane protein
- Single-pass membrane protein (Potential)
- Single-pass membrane protein (Potential)
- Nucleus membrane
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 9 |
| Locus
| 9q34.3 |
| SNPs
| QSOX2 |
| Gene Sequence
|
>2097 bp
ATGGCGGCGGCCGGGGCGGCGGTAGCGCGCAGCCCGGGAATCGGAGCGGGACCTGCGCTG
AGAGCCCGGCGCTCGCCCCCGCCGCGGGCCGCACGGCTGCCGCGGCTGCTAGTGCTGCTA
GCGGCGGCGGCGGTGGGGCCGGGCGCGGGCGGTGCGGCGCGGCTGTACCGCGCGGGCGAG
GACGCCGTGTGGGTGCTGGACAGCGGCAGCGTGCGCGGGGCCACCGCCAACAGCTCGGCC
GCGTGGCTCGTGCAGTTCTACTCGTCGTGGTGTGGCCACTGCATCGCGTACGCGCCCACT
TGGCGGGCCCTGGCTGGGGATGTGCGAGACTGGGCCAGTGCCATTCGCGTCGCAGCTCTG
GACTGCATGGAAGAGAAGAACCAGGCCGTGTGCCATGACTACGACATCCACTTCTACCCC
ACCTTCCGGTATTTTAAAGCATTTACAAAGGAGTTTACAACTGGAGAAAATTTTAAAGGA
CCTGACCGAGAGCTGCGAACAGTCAGACAGACGATGATTGACTTCCTGCAGAACCACACG
GAAGGAAGCCGGCCCCCTGCCTGCCCGCGCCTAGACCCCATTCAGCCCAGTGATGTTCTT
TCCCTTCTTGACAACCGTGGCAGCCATTACGTGGCTATCGTCTTTGAAAGCAACAGCTCC
TACCTTGGATGGGAGGTGATCTTAGACCTGATCCCGTATGAAAGCATCGTGGTGACCCGA
GCACTGGACGGGGACAAAGCATTTCTGGAGAAACTTGGTGTTTCTTCAGTCCCTTCGTGT
TACCTGATCTACCCAAATGGGTCGCATGGATTGATTAACGTCGTGAAGCCTCTGCGGGCC
TTCTTTTCGTCTTATTTGAAGTCATTGCCGGATGTGAGGAAAAAATCGCTTCCCTTGCCT
GAAAAGCCACACAAAGAAGAAAATTCAGAAATCGTGGTTTGGAGAGAATTTGACAAGTCG
AAGCTGTACACGGTGGACCTGGAGTCAGGGCTACACTACCTCCTGCGGGTGGAGCTGGCA
GCCCACAAGTCCCTGGCCGGAGCAGAGCTGAAGACGCTNCAAGGACTTTGTGACTGTCTT
GGCCAAGCTGTTCCCTGGACGGCCGCCGTCAAGAAGCTGTTGGAGATGCTGCAGGAGTGG
CTGGCCAGCCTTCCCCTGGACAGGATCCCCTACAACGCCGTGCTTGACCTGGTCAACAAC
AAGATGCGGATTTCTGGAATATTCCTTACTAATCACATAAAGTGGGTTGGATGTCAAGGA
AGCCGATCTGAGTTGAGGGGTTACCCGTGTTCTCTCTGGAAACTGTTCCACACTTTGACT
GTTGAAGCCTCGACCCACCCAGATGCACTGGTTGGCACAGGCTTTGAAGACGACCCCCAG
GCTGTGCTGCAGACAATGAGGAGGTACGTTCACACCTTCTTTGGGTGTAAGGAATGTGGT
GAGCACTTTGAGGAAATGGCTAAAGAATCCATGGACTCGGTGAAAACCCCAGACCAAGCC
ATCCTCTGGCTGTGGAAGAAGCATAATATGGTGAACGGCCGCCTGGCAGGCCATCTGAGT
GAGGATCCCCGGTTTCCAAAGCTTCAGTGGCCCACTCCGGACCTCTGCCCAGCCTGCCAT
GAGGAAATTAAGGGCCTGGCCAGCTGGGATGAAGGCCACGTGCTCACATTCTTGAAGCAG
CACTATGGCCGCGACAACCTCTTAGACACGTATTCCGCAGACCAGGGGGATTCCAGTGAA
GGAGGAACCCTGGCCAGGGGTGAGGAAGAGGAGAAAAGACTCACTCCCCCAGAGGTGTCC
CATGGAGACCGAGACACCCAGAGCGTCCGTCCACCTGGTGCACTGGCCCCAGGGCCTGCC
CTTCCAGAGAGCTTGCATCACAGCTTGGACGGGAAACTCCAGAGTCTGGATGGGCCCGGG
GCCCACAAGGAGGTGGGCGGGGCCGCACCCTTCCTCGGGGTTGACTTCTCCAGCCTGGAC
ATGAGTCTCTGTGTCGTGCTGTACGTGGCTTCATCCCTGTTCCTCATGGTGATGTACTTC
TTCTTCCGGGTGAGGTCCAGGCGGTGGAAGGTCAAGCACCACCACCCGGCCGTGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 698 |
| Molecular Weight
| 77527.975 |
| Theoretical pI
| 7.723 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Sulfhydryl oxidase 2
MAAAGAAVARSPGIGAGPALRARRSPPPRAARLPRLLVLLAAAAVGPGAGGAARLYRAGE
DAVWVLDSGSVRGATANSSAAWLVQFYSSWCGHCIGYAPTWRALAGDVRDWASAIRVAAL
DCMEEKNQAVCHDYDIHFYPTFRYFKAFTKEFTTGENFKGPDRELRTVRQTMIDFLQNHT
EGSRPPACPRLDPIQPSDVLSLLDNRGSHYVAIVFESNSSYLGREVILDLIPYESIVVTR
ALDGDKAFLEKLGVSSVPSCYLIYPNGSHGLINVVKPLRAFFSSYLKSLPDVRKKSLPLP
EKPHKEENSEIVVWREFDKSKLYTVDLESGLHYLLRVELAAHKSLAGAELKTLKDFVTVL
AKLFPGRPPVKKLLEMLQEWLASLPLDRIPYNAVLDLVNNKMRISGIFLTNHIKWVGCQG
SRSELRGYPCSLWKLFHTLTVEASTHPDALVGTGFEDDPQAVLQTMRRYVHTFFGCKECG
EHFEEMAKESMDSVKTPDQAILWLWKKHNMVNGRLAGHLSEDPRFPKLQWPTPDLCPACH
EEIKGLASWDEGHVLTFLKQHYGRDNLLDTYSADQGDSSEGGTLARGEEEEKRLTPPEVS
HGDRDTQSVRPPGALGPRPALPESLHHSLDGKLQSLDGPGAHKEVGGAAPFLGVDFSSLD
MSLCVVLYVASSLFLMVMYFFFRVRSRRWKVKHHHPAV
|
| External Links |
|---|
| GenBank ID Protein
| 30842594 |
| UniProtKB/Swiss-Prot ID
| Q6ZRP7 |
| UniProtKB/Swiss-Prot Entry Name
| QSOX2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AJ318051 |
| GeneCard ID
| QSOX2 |
| GenAtlas ID
| QSOX2 |
| HGNC ID
| HGNC:30249 |
| References |
|---|
| General References
| Not Available |