Cannabis Compound Database: Showing Protein Dihydroorotate dehydrogenase (quinone), mitochondrial (CDBP00179)

Identification Biological properties Gene properties Protein properties External links References XML Show 6 compounds

Identification

HMDB Protein ID

CDBP00179

Secondary Accession Numbers

Not Available

Name

Dihydroorotate dehydrogenase (quinone), mitochondrial

Description

Not Available

Synonyms

DHOdehase
Dihydroorotate oxidase

Gene Name

DHODH

Protein Type

Enzyme

Biological Properties

General Function

Involved in catalytic activity

Specific Function

Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.

GO Classification

Biological Process
positive regulation of apoptotic process
pyrimidine nucleoside biosynthetic process
'de novo' pyrimidine nucleobase biosynthetic process
'de novo' UMP biosynthetic process
regulation of mitochondrial fission
Cellular Component
integral to membrane
mitochondrial inner membrane
Component
membrane
cell part
Function
dihydroorotate oxidase activity
oxidoreductase activity, acting on the ch-ch group of donors, quinone or related compound as acceptor
dihydroorotate dehydrogenase activity
oxidoreductase activity
oxidoreductase activity, acting on the ch-ch group of donors
catalytic activity
Molecular Function
dihydroorotate oxidase activity
dihydroorotate dehydrogenase activity
Process
pyrimidine base metabolic process
pyrimidine base biosynthetic process
'de novo' pyrimidine base biosynthetic process
pyrimidine nucleoside monophosphate biosynthetic process
pyrimidine ribonucleoside monophosphate biosynthetic process
ump biosynthetic process
metabolic process
oxidation reduction
nitrogen compound metabolic process
pyrimidine nucleotide metabolic process
cellular nitrogen compound metabolic process
pyrimidine nucleotide biosynthetic process
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
nucleobase, nucleoside and nucleotide metabolic process
nucleoside phosphate metabolic process
nucleotide metabolic process
cellular aromatic compound metabolic process
cellular metabolic process
nucleobase metabolic process

Cellular Location

Mitochondrion inner membrane
Single-pass membrane protein (Potential)

Pathways

Name	SMPDB/Pathwhiz	KEGG
Pyrimidine Metabolism
UMP biosynthesis via de novo pathway	Not Available	Not Available
Beta Ureidopropionase Deficiency		Not Available
UMP Synthase Deficiency (Orotic Aciduria)		Not Available
Dihydropyrimidinase Deficiency		Not Available

Gene Properties

Chromosome Location

Locus

16q22

SNPs

DHODH

Gene Sequence

>1188 bp
ATGGCGTGGAGACACCTGCAAAAGCGGGCCCAGGATGCTGTGATCATCCTGGGGGGAGGA
GGACTTCTCTTCGCCTCCTACCTGATGGCCACGGGAGATGAGCGTTTCTATGCTGAACAC
CTGATGCCGACTCTGCAGGGGCTGCTGGACCCGGAGTCAGCCCACAGACTGGCTGTTCGC
TTCACCTCCCTGGGGCTCCTTCCACGGGCCAGATTTCAAGACTCTGACATGCTGGAAGTG
AGAGTTCTGGGCCATAAATTCCGAAATCCAGTAGGAATTGCTGCAGGATTTGACAAGCAT
GGGGAAGCCGTGGACGGACTTTATAAGATGGGCTTTGGTTTTGTTGAGATAGGAAGTGTG
ACTCCAAAACCTCAGGAAGGAAACCCTAGACCCAGAGTCTTCCGCCTCCCTGAGGACCAA
GCTGTCATTAACAGGTATGGATTTAACAGTCACGGGCTTTCAGTGGTGGAACACAGGTTA
CGGGCCAGACAGCAGAAGCAGGCCAAGCTCACAGAAGATGGACTGCCTCTGGGGGTCAAC
TTGGGGAAGAACAAGACCTCAGTGGACGCCGCGGAGGACTACGCAGAAGGGGTGCGCGTA
CTGGGCCCCCTGGCCGACTACCTGGTGGTGAATGTGTCCAGCCCCAACACTGCCGGGCTG
CGGAGCCTTCAGGGAAAGGCCGAGCTGCGCCGCCTGCTGACCAAGGTGCTGCAGGAGAGG
GATGGCTTGCGGAGAGTGCACAGGCCGGCAGTCCTGGTGAAGATCGCTCCTGACCTCACC
AGCCAGGATAAGGAGGACATTGCCAGTGTGGTCAAAGAGTTGGGCATCGATGGGCTGATT
GTTACGAACACCACCGTGAGTCGCCCTGCGGGCCTCCAGGGTGCCCTGCGCTCTGAAACA
GGAGGGCTGAGTGGGAAGCCCCTCCGGGATTTATCAACTCAAACCATTCGGGAGATGTAT
GCACTCACCCAAGGCCGAGTTCCCATAATTGGGGTTGGTGGTGTGAGCAGCGGGCAGGAC
GCGCTGGAGAAGATCCGGGCAGGGGCCTCCCTGGTGCAGCTGTACACGGCCCTCACCTTC
TGGGGGCCACCCGTTGTGGGCAAAGTCAAGCGGGAACTGGAGGCCCTTCTGAAAGAGCAG
GGCTTTGGCGGAGTCACAGATGCCATTGGAGCAGATCATCGGAGGTGA

Protein Properties

Number of Residues

395

Molecular Weight

42866.93

Theoretical pI

9.667

Pfam Domain Function

DHO_dh (PF01180 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Dihydroorotate dehydrogenase, mitochondrial
MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVR
FTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSV
TPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVN
LGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQER
DGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSET
GGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTF
WGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR

External Links

GenBank ID Protein

158258018

UniProtKB/Swiss-Prot ID

Q02127

UniProtKB/Swiss-Prot Entry Name

PYRD_HUMAN

PDB IDs