Identification |
HMDB Protein ID
| CDBP01437 |
Secondary Accession Numbers
| Not Available |
Name
| Cytochrome P450 2C18 |
Description
| Not Available |
Synonyms
|
- CYPIIC18
- Cytochrome P450-6b/29c
|
Gene Name
| CYP2C18 |
Protein Type
| Metal Binding |
Biological Properties |
General Function
| Involved in monooxygenase activity |
Specific Function
| Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
|
GO Classification
|
Biological Process |
small molecule metabolic process |
xenobiotic metabolic process |
Cellular Component |
endoplasmic reticulum membrane |
Function |
ion binding |
cation binding |
metal ion binding |
binding |
catalytic activity |
transition metal ion binding |
electron carrier activity |
iron ion binding |
monooxygenase activity |
heme binding |
oxidoreductase activity |
Molecular Function |
electron carrier activity |
oxygen binding |
monooxygenase activity |
aromatase activity |
iron ion binding |
heme binding |
testosterone 16-alpha-hydroxylase activity |
Process |
metabolic process |
oxidation reduction |
|
Cellular Location
|
- Peripheral membrane protein
- Peripheral membrane protein
- Endoplasmic reticulum membrane
- Microsome membrane
|
Pathways
|
Name | SMPDB/Pathwhiz | KEGG | Linoleic acid metabolism | Not Available | | Metabolism of xenobiotics by cytochrome P450 | Not Available | | Drug metabolism - cytochrome P450 | Not Available | | Serotonergic synapse | Not Available | | Chemical carcinogenesis | Not Available | |
|
Gene Properties |
Chromosome Location
| 10 |
Locus
| 10q24 |
SNPs
| CYP2C18 |
Gene Sequence
|
>1473 bp
ATGGATCCAGCTGTGGCTCTGGTGCTCTGTCTCTCCTGTTTGTTTCTCCTTTCACTCTGG
AGGCAGAGCTCTGGAAGAGGGAGGCTCCCGTCTGGCCCCACTCCTCTCCCGATTATTGGA
AATATCCTGCAGTTAGATGTTAAGGACATGAGCAAATCCTTAACCAATTTCTCAAAAGTC
TATGGCCCTGTGTTCACTGTGTATTTTGGCCTGAAGCCCATTGTGGTGTTGCATGGATAT
GAAGCAGTGAAGGAGGCCCTGATTGATCATGGAGAGGAGTTTTCTGGAAGAGGAAGTTTT
CCAGTGGCTGAAAAAGTTAACAAAGGACTTGGAATCCTTTTCAGCAATGGAAAGAGATGG
AAGGAGATCCGGCGTTTCTGCCTCATGACTCTGCGGAATTTTGGGATGGGGAAGAGGAGC
ATCGAGGACCGTGTTCAAGAGGAAGCCCGCTGCCTTGTGGAGGAGTTGAGAAAAACCAAT
GCCTCACCCTGTGATCCCACTTTCATCCTGGGCTGTGCTCCCTGCAATGTGATCTGCTCT
GTTATTTTCCATGATCGATTTGATTATAAAGATCAGAGGTTTCTTAACTTGATGGAAAAA
TTCAATGAAAACCTCAGGATTCTGAGCTCTCCATGGATCCAGGTCTGCAATAATTTCCCT
GCTCTCATCGATTATCTCCCAGGAAGTCATAATAAAATAGCTGAAAATTTTGCTTACATT
AAAAGTTATGTATTGGAGAGAATAAAAGAACATCAAGAATCCCTGGACATGAACAGTGCT
CGGGACTTTATTGATTGTTTCCTGATCAAAATGGAACAGGAAAAGCACAATCAACAGTCT
GAATTTACTGTTGAAAGCTTGATAGCCACTGTAACTGATATGTTTGGGGCTGGAACAGAG
ACAACGAGCACCACTCTGAGATATGGACTCCTGCTCCTGCTGAAGTACCCAGAGGTCACA
GCTAAAGTCCAGGAAGAGATTGAATGTGTAGTTGGCAGAAACCGGAGCCCCTGTATGCAG
GACAGGAGTCACATGCCCTACACAGATGCTGTGGTGCACGAGATCCAGAGATACATTGAC
CTCCTCCCCACCAACCTGCCCCATGCAGTGACCTGTGATGTTAAATTCAAAAACTACCTC
ATCCCCAAGGGCACGACCATAATAACATCCCTGACTTCTGTGCTGCACAATGACAAAGAA
TTCCCCAACCCAGAGATGTTTGACCCTGGCCACTTTCTGGATAAGAGTGGCAACTTTAAG
AAAAGTGACTACTTCATGCCTTTCTCAGCAGGAAAACGGATGTGTATGGGAGAGGGCCTG
GCCCGCATGGAGCTGTTTTTATTCCTGACCACCATTTTGCAGAACTTTAACCTGAAATCT
CAGGTTGACCCAAAGGATATTGACATCACCCCCATTGCCAATGCATTTGGTCGTGTGCCA
CCCTTGTACCAGCTCTGCTTCATTCCTGTCTGA
|
Protein Properties |
Number of Residues
| 490 |
Molecular Weight
| 55710.075 |
Theoretical pI
| 7.199 |
Pfam Domain Function
|
|
Signals
|
Not Available
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
>Cytochrome P450 2C18
MDPAVALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSKV
YGPVFTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRW
KEIRRFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICS
VIFHDRFDYKDQRFLNLMEKFNENLRILSSPWIQVCNNFPALIDYLPGSHNKIAENFAYI
KSYVLERIKEHQESLDMNSARDFIDCFLIKMEQEKHNQQSEFTVESLIATVTDMFGAGTE
TTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYID
LLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFK
KSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLKSQVDPKDIDITPIANAFGRVP
PLYQLCFIPV
|
External Links |
GenBank ID Protein
| 189066652 |
UniProtKB/Swiss-Prot ID
| P33260 |
UniProtKB/Swiss-Prot Entry Name
| CP2CI_HUMAN |
PDB IDs
|
|
GenBank Gene ID
| AK313403 |
GeneCard ID
| CYP2C18 |
GenAtlas ID
| CYP2C18 |
HGNC ID
| HGNC:2620 |
References |
General References
| Not Available |