| Identification |
|---|
| HMDB Protein ID
| CDBP00980 |
| Secondary Accession Numbers
| Not Available |
| Name
| Steroid 17-alpha-hydroxylase/17,20 lyase |
| Description
| Not Available |
| Synonyms
|
- CYPXVII
- Cytochrome P450 17A1
- Cytochrome P450-C17
- Cytochrome P450c17
- Steroid 17-alpha-monooxygenase
|
| Gene Name
| CYP17A1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in monooxygenase activity |
| Specific Function
| Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty.
|
| GO Classification
|
| Biological Process |
| ovulation |
| positive regulation of steroid hormone biosynthetic process |
| response to acetate |
| response to ionizing radiation |
| small molecule metabolic process |
| sex differentiation |
| response to retinoic acid |
| response to drug |
| biphenyl metabolic process |
| cellular response to lipopolysaccharide |
| cellular response to antibiotic |
| xenobiotic metabolic process |
| dibenzo-p-dioxin metabolic process |
| hippocampus development |
| response to nutrient levels |
| Leydig cell differentiation |
| response to steroid hormone stimulus |
| phenol-containing compound metabolic process |
| response to cytokine stimulus |
| phthalate metabolic process |
| response to herbicide |
| response to fungicide |
| response to methylmercury |
| response to insecticide |
| response to cAMP |
| adrenal gland development |
| androgen biosynthetic process |
| cellular response to gonadotropin stimulus |
| glucocorticoid biosynthetic process |
| Cellular Component |
| endoplasmic reticulum membrane |
| mitochondrion |
| neuronal cell body |
| axon |
| Function |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| catalytic activity |
| transition metal ion binding |
| electron carrier activity |
| iron ion binding |
| monooxygenase activity |
| heme binding |
| oxidoreductase activity |
| Molecular Function |
| oxygen binding |
| steroid 17-alpha-monooxygenase activity |
| iron ion binding |
| heme binding |
| electron carrier activity |
| Process |
| metabolic process |
| oxidation reduction |
|
| Cellular Location
|
- Membrane (Potential)
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Steroid hormone biosynthesis | Not Available |  | | Androgen and Estrogen Metabolism |    |  | | 17-Beta Hydroxysteroid Dehydrogenase III Deficiency |    | Not Available | | Aromatase deficiency |    | Not Available | | Steroidogenesis |    | |
|
| Gene Properties |
|---|
| Chromosome Location
| 10 |
| Locus
| 10q24.3 |
| SNPs
| CYP17A1 |
| Gene Sequence
|
>1527 bp
ATGTGGGAGCTCGTGGCTCTCTTGCTGCTTACCCTAGCTTATTTGTTTTGGCCCAAGAGA
AGGTGCCCTGGTGCCAAGTACCCCAAGAGCCTCCTGTCCCTGCCCCTGGTGGGCAGCCTG
CCATTCCTCCCCAGACATGGCCATATGCATAACAACTTCTTCAAGCTGCAGAAAAAATAT
GGCCCCATCTATTCTGTTCGTATGGGCACCAAGACTACAGTGATTGTCGGCCACCACCAG
CTGGCCAAGGAGGTGCTTATTAAGAAGGGCAAGGACTTCTCTGGGCGGCCTCAAATGGCA
ACTCTAGACATCGCGTCCAACAACCGTAAGGGTATCGCCTTCGCTGACTCTGGCGCACAC
TGGCAGCTGCATCGAAGGCTGGCGATGGCCACCTTTGCCCTGTTCAAGGATGGCGATCAG
AAGCTGGAGAAGATCATTTGTCAGGAAATCAGTACATTGTGTGATATGCTGGCCACCCAC
AACGGACAGTCCATAGACATCTCCTTTCCTGTCTTCGTGGCGGTAACCAATGTCATCTCC
TTGATCTGCTTCAATACCTCCTACAAGAATGGGGACCCTGAGTTGAATGTCATACAGAAT
TACAATGAAGGCATCATAGACAACCTGAGCAAAGACAGCCTGGTGGACCTAGTCCCCTGG
TTGAAGATTTTCCCCAACAAAACCCTGGAAAAATTAAAGAGCCATGTTAAAATACGAAAT
GATCTGCTGAATAAAATACTTGAAAATTACAAGGAGAAATTCCGGAGTGACTCTATCACC
AACATGCTGGACACACTGATGCAAGCCAAGATGAACTCAGATAATGGCAATGCTGGCCCA
GATCAAGATTCAGAGCTGCTTTCAGATAACCACATTCTCACCACCATAGGGGACATCTTT
GGGGCTGGCGTGGAGACCACCACCTCTGTGGTTAAATGGACCCTGGCCTTCCTGCTGCAC
AATCCTCAGGTGAAGAAGAAGCTCTACGAGGAGATTGACCAGAATGTGGGTTTCAGCCGC
ACACCAACTATCAGTGACCGTAACCGTCTCCTCCTGCTGGAGGCCACCATCCGAGAGGTG
CTTCGCCTCAGGCCCGTGGCCCCTATGCTCATCCCCCACAAGGCCAACGTTGACTCCAGC
ATCGGTGAGTTTGCTGTGGACAAGGGCACAGAAGTTATCATCAATCTGTGGGCGCTGCAT
CACAATGAGAAGGAGTGGCACCAGCCGGATCAGTTCATGCCTGAGCGTTTCTTGAATCCA
GCGGGGACCCAGCTCATCTCACCGTCAGTAAGCTATTTGCCCTTCGGAGCAGGACCTCGC
TCCTGTATAGGTGAGATCCTGGCCCGCCAGGAGCTCTTCCTCATCATGGCCTGGCTGCTG
CAGAGGTTCGACCTGGAGGTGCCAGATGATGGGCAGCTGCCCTCCCTGGAAGGCATCCCC
AAGGTGGTCTTTCTGATCGACTCTTTCAAAGTGAAGATCAAGGTGCGCCAGGCCTGGAGG
GAAGCCCAGGCTGAGGGTAGCACCTAA
|
| Protein Properties |
|---|
| Number of Residues
| 508 |
| Molecular Weight
| 57369.995 |
| Theoretical pI
| 8.568 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Steroid 17-alpha-hydroxylase/17,20 lyase
MWELVALLLLTLAYLFWPKRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKY
GPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAH
WQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVIS
LICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRN
DLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIF
GAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREV
LRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNP
AGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIP
KVVFLIDSFKVKIKVRQAWREAQAEGST
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P05093 |
| UniProtKB/Swiss-Prot Entry Name
| CP17A_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| M14564 |
| GeneCard ID
| CYP17A1 |
| GenAtlas ID
| CYP17A1 |
| HGNC ID
| HGNC:2593 |
| References |
|---|
| General References
| Not Available |