Identification |
HMDB Protein ID
| CDBP02634 |
Secondary Accession Numbers
| Not Available |
Name
| Indoleamine 2,3-dioxygenase 2 |
Description
| Not Available |
Synonyms
|
- IDO-2
- Indoleamine 2,3-dioxygenase-like protein 1
- Indoleamine-pyrrole 2,3-dioxygenase-like protein 1
|
Gene Name
| IDO2 |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in heme binding |
Specific Function
| Catalyzes the first and rate-limiting step in the kynurenine pathway of tryptophan catabolism.
|
GO Classification
|
Biological Process |
tryptophan catabolic process to kynurenine |
Cellular Component |
cytosol |
Function |
ion binding |
cation binding |
metal ion binding |
binding |
transition metal ion binding |
iron ion binding |
heme binding |
Molecular Function |
metal ion binding |
indoleamine 2,3-dioxygenase activity |
tryptophan 2,3-dioxygenase activity |
heme binding |
|
Cellular Location
|
Not Available
|
Pathways
|
Name | SMPDB/Pathwhiz | KEGG | L-tryptophan degradation via kynurenine pathway | Not Available | Not Available | African trypanosomiasis | Not Available | |
|
Gene Properties |
Chromosome Location
| 8 |
Locus
| 8p11.21 |
SNPs
| IDO2 |
Gene Sequence
|
>1224 bp
ATGGAGCCCCACAGACCGAATGTGAAGACAGCAGTGCCATTGTCTTTGGAAAGCTATCAC
ATATCTGAAGAGTATGGCTTTCTTCTTCCAGATTCTCTGAAAGAACTTCCAGATCATTAT
AGGCCTTGGATGGAAATTGCCAACAAACTTCCTCAATTGATTGATGCTCACCAGCTTCAA
GCTCATGTGGACAAGATGCCCCTGCTGAGCTGCCAGTTCCTGAAGGGTCACCGGGAGCAG
CGCCTGGCCCACCTGGTCCTGAGCTTCCTCACCATGGGTTATGTCTGGCAGGAAGGAGAG
GCGCAGCCTGCAGAGGTCCTGCCAAGGAATCTTGCCCTTCCATTTGTCGAAGTCTCCAGG
AACTTGGGGCTCCCTCCTATCCTGGTCCACTCAGACTTGGTGCTGACGAACTGGACCAAA
AAAGATCCAGACGGATTCCTGGAAATTGGGAACCTGGAGACCATCATCTCATTTCCTGGG
GGAGAGAGCCTGCATGGTTTTATACTGGTGACTGCTTTGGTAGAGAAAGAAGCAGTGCCT
GGGATAAAGGCTCTTGTTCAGGCCACGAATGCTATCTTGCAGCCCAACCAGGAGGCCCTG
CTCCAAGCCCTGCAGCGACTGAGACTGTCTATTCAGGACATCACCAAAACCTTAGGACAG
ATGCATGATTATGTAGATCCAGACATATTTTATGCAGGCATCCGGATCTTTCTCTCTGGA
TGGAAAGACAACCCAGCAATGCCTGCAGGGCTGATGTATGAAGGAGTTTCCCAAGAGCCC
CTGAAATACTCCGGCGGGAGTGCAGCTCAGAGCACAGTGCTTCATGCCTTTGATGAGTTC
TTAGGCATTCGTCATAGCAAGGAAAGTGGTGACTTTCTGTACAGAATGAGGGATTACATG
CCTCCTTCCCATAAGGCCTTCATAGAAGACATCCACTCAGCACCTTCCCTGAGGGACTAC
ATCCTGTCCTCTGGACAGGACCACTTGCTGACAGCTTATAACCAGTGTGTGCAGGCCCTG
GCAGAGCTGCGGAGCTATCACATCACCATGGTCACCAAATACCTCATCACAGCTGCAGCC
AAGGCAAAGCATGGGAAGCCAAACCATCTCCCAGGGCCTCCTCAGGCTTTAAAAGACAGG
GGCACAGGTGGAACCGCAGTTATGAGCTTTCTTAAGAGTGTCAGGGATAAGACCTTGGAG
TCAATCCTTCACCCACGTGGTTAG
|
Protein Properties |
Number of Residues
| 407 |
Molecular Weight
| 47074.745 |
Theoretical pI
| 6.897 |
Pfam Domain Function
|
|
Signals
|
Not Available
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
>Indoleamine 2,3-dioxygenase 2
MEPHRPNVKTAVPLSLESYHISEEYGFLLPDSLKELPDHYRPWMEIANKLPQLIDAHQLQ
AHVDKMPLLSCQFLKGHREQRLAHLVLSFLTMGYVWQEGEAQPAEVLPRNLALPFVEVSR
NLGLPPILVHSDLVLTNWTKKDPDGFLEIGNLETIISFPGGESLHGFILVTALVEKEAVP
GIKALVQATNAILQPNQEALLQALQRLRLSIQDITKTLGQMHDYVDPDIFYAGIRIFLSG
WKDNPAMPAGLMYEGVSQEPLKYSGGSAAQSTVLHAFDEFLGIRHSKESGDFLYRMRDYM
PPSHKAFIEDIHSAPSLRDYILSSGQDHLLTAYNQCVQALAELRSYHITMVTKYLITAAA
KAKHGKPNHLPGPPQALKDRGTGGTAVMSFLKSVRDKTLESILHPRG
|
External Links |
GenBank ID Protein
| 145204985 |
UniProtKB/Swiss-Prot ID
| Q6ZQW0 |
UniProtKB/Swiss-Prot Entry Name
| I23O2_HUMAN |
PDB IDs
|
Not Available |
GenBank Gene ID
| EF052681 |
GeneCard ID
| IDO2 |
GenAtlas ID
| IDO2 |
HGNC ID
| HGNC:27269 |
References |
General References
| Not Available |