| Identification |
|---|
| HMDB Protein ID
| CDBP02634 |
| Secondary Accession Numbers
| Not Available |
| Name
| Indoleamine 2,3-dioxygenase 2 |
| Description
| Not Available |
| Synonyms
|
- IDO-2
- Indoleamine 2,3-dioxygenase-like protein 1
- Indoleamine-pyrrole 2,3-dioxygenase-like protein 1
|
| Gene Name
| IDO2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in heme binding |
| Specific Function
| Catalyzes the first and rate-limiting step in the kynurenine pathway of tryptophan catabolism.
|
| GO Classification
|
| Biological Process |
| tryptophan catabolic process to kynurenine |
| Cellular Component |
| cytosol |
| Function |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| transition metal ion binding |
| iron ion binding |
| heme binding |
| Molecular Function |
| tryptophan 2,3-dioxygenase activity |
| heme binding |
| metal ion binding |
| indoleamine 2,3-dioxygenase activity |
|
| Cellular Location
|
Not Available
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | L-tryptophan degradation via kynurenine pathway | Not Available | Not Available | | African trypanosomiasis | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 8 |
| Locus
| 8p11.21 |
| SNPs
| IDO2 |
| Gene Sequence
|
>1224 bp
ATGGAGCCCCACAGACCGAATGTGAAGACAGCAGTGCCATTGTCTTTGGAAAGCTATCAC
ATATCTGAAGAGTATGGCTTTCTTCTTCCAGATTCTCTGAAAGAACTTCCAGATCATTAT
AGGCCTTGGATGGAAATTGCCAACAAACTTCCTCAATTGATTGATGCTCACCAGCTTCAA
GCTCATGTGGACAAGATGCCCCTGCTGAGCTGCCAGTTCCTGAAGGGTCACCGGGAGCAG
CGCCTGGCCCACCTGGTCCTGAGCTTCCTCACCATGGGTTATGTCTGGCAGGAAGGAGAG
GCGCAGCCTGCAGAGGTCCTGCCAAGGAATCTTGCCCTTCCATTTGTCGAAGTCTCCAGG
AACTTGGGGCTCCCTCCTATCCTGGTCCACTCAGACTTGGTGCTGACGAACTGGACCAAA
AAAGATCCAGACGGATTCCTGGAAATTGGGAACCTGGAGACCATCATCTCATTTCCTGGG
GGAGAGAGCCTGCATGGTTTTATACTGGTGACTGCTTTGGTAGAGAAAGAAGCAGTGCCT
GGGATAAAGGCTCTTGTTCAGGCCACGAATGCTATCTTGCAGCCCAACCAGGAGGCCCTG
CTCCAAGCCCTGCAGCGACTGAGACTGTCTATTCAGGACATCACCAAAACCTTAGGACAG
ATGCATGATTATGTAGATCCAGACATATTTTATGCAGGCATCCGGATCTTTCTCTCTGGA
TGGAAAGACAACCCAGCAATGCCTGCAGGGCTGATGTATGAAGGAGTTTCCCAAGAGCCC
CTGAAATACTCCGGCGGGAGTGCAGCTCAGAGCACAGTGCTTCATGCCTTTGATGAGTTC
TTAGGCATTCGTCATAGCAAGGAAAGTGGTGACTTTCTGTACAGAATGAGGGATTACATG
CCTCCTTCCCATAAGGCCTTCATAGAAGACATCCACTCAGCACCTTCCCTGAGGGACTAC
ATCCTGTCCTCTGGACAGGACCACTTGCTGACAGCTTATAACCAGTGTGTGCAGGCCCTG
GCAGAGCTGCGGAGCTATCACATCACCATGGTCACCAAATACCTCATCACAGCTGCAGCC
AAGGCAAAGCATGGGAAGCCAAACCATCTCCCAGGGCCTCCTCAGGCTTTAAAAGACAGG
GGCACAGGTGGAACCGCAGTTATGAGCTTTCTTAAGAGTGTCAGGGATAAGACCTTGGAG
TCAATCCTTCACCCACGTGGTTAG
|
| Protein Properties |
|---|
| Number of Residues
| 407 |
| Molecular Weight
| 47074.745 |
| Theoretical pI
| 6.897 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Indoleamine 2,3-dioxygenase 2
MEPHRPNVKTAVPLSLESYHISEEYGFLLPDSLKELPDHYRPWMEIANKLPQLIDAHQLQ
AHVDKMPLLSCQFLKGHREQRLAHLVLSFLTMGYVWQEGEAQPAEVLPRNLALPFVEVSR
NLGLPPILVHSDLVLTNWTKKDPDGFLEIGNLETIISFPGGESLHGFILVTALVEKEAVP
GIKALVQATNAILQPNQEALLQALQRLRLSIQDITKTLGQMHDYVDPDIFYAGIRIFLSG
WKDNPAMPAGLMYEGVSQEPLKYSGGSAAQSTVLHAFDEFLGIRHSKESGDFLYRMRDYM
PPSHKAFIEDIHSAPSLRDYILSSGQDHLLTAYNQCVQALAELRSYHITMVTKYLITAAA
KAKHGKPNHLPGPPQALKDRGTGGTAVMSFLKSVRDKTLESILHPRG
|
| External Links |
|---|
| GenBank ID Protein
| 145204985 |
| UniProtKB/Swiss-Prot ID
| Q6ZQW0 |
| UniProtKB/Swiss-Prot Entry Name
| I23O2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| EF052681 |
| GeneCard ID
| IDO2 |
| GenAtlas ID
| IDO2 |
| HGNC ID
| HGNC:27269 |
| References |
|---|
| General References
| Not Available |