Identification
HMDB Protein ID CDBP02634
Secondary Accession Numbers Not Available
Name Indoleamine 2,3-dioxygenase 2
Description Not Available
Synonyms
  1. IDO-2
  2. Indoleamine 2,3-dioxygenase-like protein 1
  3. Indoleamine-pyrrole 2,3-dioxygenase-like protein 1
Gene Name IDO2
Protein Type Enzyme
Biological Properties
General Function Involved in heme binding
Specific Function Catalyzes the first and rate-limiting step in the kynurenine pathway of tryptophan catabolism.
GO Classification
Biological Process
tryptophan catabolic process to kynurenine
Cellular Component
cytosol
Function
ion binding
cation binding
metal ion binding
binding
transition metal ion binding
iron ion binding
heme binding
Molecular Function
metal ion binding
indoleamine 2,3-dioxygenase activity
tryptophan 2,3-dioxygenase activity
heme binding
Cellular Location Not Available
Pathways
Gene Properties
Chromosome Location 8
Locus 8p11.21
SNPs IDO2
Gene Sequence
>1224 bp
ATGGAGCCCCACAGACCGAATGTGAAGACAGCAGTGCCATTGTCTTTGGAAAGCTATCAC
ATATCTGAAGAGTATGGCTTTCTTCTTCCAGATTCTCTGAAAGAACTTCCAGATCATTAT
AGGCCTTGGATGGAAATTGCCAACAAACTTCCTCAATTGATTGATGCTCACCAGCTTCAA
GCTCATGTGGACAAGATGCCCCTGCTGAGCTGCCAGTTCCTGAAGGGTCACCGGGAGCAG
CGCCTGGCCCACCTGGTCCTGAGCTTCCTCACCATGGGTTATGTCTGGCAGGAAGGAGAG
GCGCAGCCTGCAGAGGTCCTGCCAAGGAATCTTGCCCTTCCATTTGTCGAAGTCTCCAGG
AACTTGGGGCTCCCTCCTATCCTGGTCCACTCAGACTTGGTGCTGACGAACTGGACCAAA
AAAGATCCAGACGGATTCCTGGAAATTGGGAACCTGGAGACCATCATCTCATTTCCTGGG
GGAGAGAGCCTGCATGGTTTTATACTGGTGACTGCTTTGGTAGAGAAAGAAGCAGTGCCT
GGGATAAAGGCTCTTGTTCAGGCCACGAATGCTATCTTGCAGCCCAACCAGGAGGCCCTG
CTCCAAGCCCTGCAGCGACTGAGACTGTCTATTCAGGACATCACCAAAACCTTAGGACAG
ATGCATGATTATGTAGATCCAGACATATTTTATGCAGGCATCCGGATCTTTCTCTCTGGA
TGGAAAGACAACCCAGCAATGCCTGCAGGGCTGATGTATGAAGGAGTTTCCCAAGAGCCC
CTGAAATACTCCGGCGGGAGTGCAGCTCAGAGCACAGTGCTTCATGCCTTTGATGAGTTC
TTAGGCATTCGTCATAGCAAGGAAAGTGGTGACTTTCTGTACAGAATGAGGGATTACATG
CCTCCTTCCCATAAGGCCTTCATAGAAGACATCCACTCAGCACCTTCCCTGAGGGACTAC
ATCCTGTCCTCTGGACAGGACCACTTGCTGACAGCTTATAACCAGTGTGTGCAGGCCCTG
GCAGAGCTGCGGAGCTATCACATCACCATGGTCACCAAATACCTCATCACAGCTGCAGCC
AAGGCAAAGCATGGGAAGCCAAACCATCTCCCAGGGCCTCCTCAGGCTTTAAAAGACAGG
GGCACAGGTGGAACCGCAGTTATGAGCTTTCTTAAGAGTGTCAGGGATAAGACCTTGGAG
TCAATCCTTCACCCACGTGGTTAG
Protein Properties
Number of Residues 407
Molecular Weight 47074.745
Theoretical pI 6.897
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Indoleamine 2,3-dioxygenase 2
MEPHRPNVKTAVPLSLESYHISEEYGFLLPDSLKELPDHYRPWMEIANKLPQLIDAHQLQ
AHVDKMPLLSCQFLKGHREQRLAHLVLSFLTMGYVWQEGEAQPAEVLPRNLALPFVEVSR
NLGLPPILVHSDLVLTNWTKKDPDGFLEIGNLETIISFPGGESLHGFILVTALVEKEAVP
GIKALVQATNAILQPNQEALLQALQRLRLSIQDITKTLGQMHDYVDPDIFYAGIRIFLSG
WKDNPAMPAGLMYEGVSQEPLKYSGGSAAQSTVLHAFDEFLGIRHSKESGDFLYRMRDYM
PPSHKAFIEDIHSAPSLRDYILSSGQDHLLTAYNQCVQALAELRSYHITMVTKYLITAAA
KAKHGKPNHLPGPPQALKDRGTGGTAVMSFLKSVRDKTLESILHPRG
GenBank ID Protein 145204985
UniProtKB/Swiss-Prot ID Q6ZQW0
UniProtKB/Swiss-Prot Entry Name I23O2_HUMAN
PDB IDs Not Available
GenBank Gene ID EF052681
GeneCard ID IDO2
GenAtlas ID IDO2
HGNC ID HGNC:27269
References
General References Not Available