Identification |
HMDB Protein ID
| CDBP00201 |
Secondary Accession Numbers
| Not Available |
Name
| D-amino-acid oxidase |
Description
| Not Available |
Synonyms
|
- DAAO
- DAMOX
- DAO
|
Gene Name
| DAO |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in D-amino-acid oxidase activity |
Specific Function
| Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids.
|
GO Classification
|
Biological Process |
D-alanine catabolic process |
D-serine catabolic process |
leucine metabolic process |
proline catabolic process |
cellular nitrogen compound metabolic process |
glyoxylate metabolic process |
dopamine biosynthetic process |
Cellular Component |
cytosol |
peroxisomal matrix |
peroxisomal membrane |
Function |
binding |
catalytic activity |
oxidoreductase activity, acting on the ch-nh2 group of donors |
oxidoreductase activity, acting on the ch-nh2 group of donors, oxygen as acceptor |
d-amino-acid oxidase activity |
oxidoreductase activity |
Molecular Function |
D-amino-acid oxidase activity |
FAD binding |
protein dimerization activity |
Process |
metabolic process |
oxidation reduction |
|
Cellular Location
|
- Peroxisome
|
Pathways
|
Name | SMPDB/Pathwhiz | KEGG | Glycine, serine and threonine metabolism | Not Available | ![Map00260](https://www.genome.jp/kegg/misc/thumbnail/map00260.gif) | Peroxisome | Not Available | ![Map04146](https://www.genome.jp/kegg/misc/thumbnail/map04146.gif) | D-Arginine and D-Ornithine Metabolism | ![Thumb](https://smpdb.ca/super_pathway_visualizations/PW000019/thumb) ![Thumb?image type=greyscale](https://smpdb.ca/super_pathway_visualizations/PW000019/thumb?image_type=greyscale) ![Thumb?image type=simple](https://smpdb.ca/super_pathway_visualizations/PW000019/thumb?image_type=simple) | ![Map00472](https://www.genome.jp/kegg/misc/thumbnail/map00472.gif) | Arginine and Proline Metabolism | ![Thumb](https://smpdb.ca/super_pathway_visualizations/PW000010/thumb) ![Thumb?image type=greyscale](https://smpdb.ca/super_pathway_visualizations/PW000010/thumb?image_type=greyscale) ![Thumb?image type=simple](https://smpdb.ca/super_pathway_visualizations/PW000010/thumb?image_type=simple) | ![Map00330](https://www.genome.jp/kegg/misc/thumbnail/map00330.gif) | Prolidase Deficiency (PD) | ![Thumb](https://smpdb.ca/super_pathway_visualizations/PW000083/thumb) ![Thumb?image type=greyscale](https://smpdb.ca/super_pathway_visualizations/PW000083/thumb?image_type=greyscale) ![Thumb?image type=simple](https://smpdb.ca/super_pathway_visualizations/PW000083/thumb?image_type=simple) | Not Available |
|
Gene Properties |
Chromosome Location
| 12 |
Locus
| 12q24 |
SNPs
| DAO |
Gene Sequence
|
>1044 bp
ATGCGTGTGGTGGTGATTGGAGCAGGAGTCATCGGGCTGTCCACCGCCCTCTGCATCCAT
GAGCGCTACCACTCAGTCCTGCAGCCACTGCACATAAAGGTCTACGCGGACCGCTTCACC
CCACTCACCACCACCGACGTGGCTGCCGGCCTCTGGCAGCCCTACCTTTCTGACCCCAAC
AACCCACAGGAGGCGGACTGGAGCCAACAGACCTTTGACTATCTCCTGAGCCATGTCCAT
TCTCCCAACGCTGAAAACCTGGGCCTGTTCCTAATCTCGGGCTACAACCTCTTCCATGAA
GCCATTCCGGACCCTTCCTGGAAGGACACAGTTCTGGGATTTCGGAAGCTGACCCCCAGA
GAGCTGGATATGTTCCCAGATTACGGCTATGGCTGGTTCCACACAAGCCTAATTCTGGAG
GGAAAGAACTATCTACAGTGGCTGACTGAAAGGTTAACTGAGAGGGGAGTGAAGTTCTTC
CAGCGGAAAGTGGAGTCTTTTGAGGAGGTGGCAAGAGAAGGCGCAGACGTGATTGTCAAC
TGCACTGGGGTATGGGCTGGGGCGCTACAACGAGACCCCCTGCTGCAGCCAGGCCGGGGG
CAGATCATGAAGGTGGACGCCCCTTGGATGAAGCACTTCATTCTCACCCATGACCCAGAG
AGAGGCATCTACAATTCCCCGTACATCATCCCAGGGACCCAGACAGTTACTCTTGGAGGC
ATCTTCCAGTTGGGAAACTGGAGTGAACTAAACAATATCCAGGACCACAACACCATTTGG
GAAGGCTGCTGCAGACTGGAGCCCACACTGAAGAATGCAAGAATTATTGGTGAAGCAACT
GGCTTCCGGCCAGTACGCCCCCAGATTCGGCTAGAAAGAGAACAGCTTCGCACTGGACCT
TCAAACACAGAGGTCATCCACAACTATGGCCATGGAGGCTACGGGCTCACCATCCACTGG
GGATGTGCCCTGGAGGCAGCCAAGCTCTTTGGGAGAATCCTGGAAGAAAAGAAATTGTCC
AGAATGCCACCATCCCACCTCTGA
|
Protein Properties |
Number of Residues
| 347 |
Molecular Weight
| 39473.75 |
Theoretical pI
| 6.844 |
Pfam Domain Function
|
|
Signals
|
Not Available
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
>D-amino-acid oxidase
MRVVVIGAGVIGLSTALCIHERYHSVLQPLDIKVYADRFTPLTTTDVAAGLWQPYLSDPN
NPQEADWSQQTFDYLLSHVHSPNAENLGLFLISGYNLFHEAIPDPSWKDTVLGFRKLTPR
ELDMFPDYGYGWFHTSLILEGKNYLQWLTERLTERGVKFFQRKVESFEEVAREGADVIVN
CTGVWAGALQRDPLLQPGRGQIMKVDAPWMKHFILTHDPERGIYNSPYIIPGTQTVTLGG
IFQLGNWSELNNIQDHNTIWEGCCRLEPTLKNARIIGERTGFRPVRPQIRLEREQLRTGP
SNTEVIHNYGHGGYGLTIHWGCALEAAKLFGRILEEKKLSRMPPSHL
|
External Links |
GenBank ID Protein
| 30446 |
UniProtKB/Swiss-Prot ID
| P14920 |
UniProtKB/Swiss-Prot Entry Name
| OXDA_HUMAN |
PDB IDs
|
|
GenBank Gene ID
| X13227 |
GeneCard ID
| DAO |
GenAtlas ID
| DAO |
HGNC ID
| HGNC:2671 |
References |
General References
| Not Available |