Identification
HMDB Protein ID CDBP01452
Secondary Accession Numbers Not Available
Name Cytochrome P450 4F8
Description Not Available
Synonyms
  1. CYPIVF8
Gene Name CYP4F8
Protein Type Metal Binding
Biological Properties
General Function Secondary metabolites biosynthesis, transport and catabolism
Specific Function Hydroxylates arachidonic acid (20:4n-6) to (18R)-hydroxyarachidonate. Shows little activity against prostaglandin (PG) D2, PGE1, PGE2, PGF2alpha, and leukotriene B4. Catalyzes omega-2 and omega-3-hydroxylation of PGH1 and PGH2. Catalyzes epoxidation of 4,7,10,13,16,19-(Z)-docosahexaenoic acid (22:6n-3) and 7,10,13,16,19-(Z)-docosapentaenoic acid (22:5n-3) and omega-3-hydroxylation of 4,7,10,13,16-(Z)-docosapentaenoic acid (22:5n-6). Catalyzes hydroxylation of PGI2 and carbaprostacyclin.
GO Classification
Biological Process
prostaglandin metabolic process
xenobiotic metabolic process
Cellular Component
endoplasmic reticulum membrane
integral to membrane
Function
ion binding
cation binding
metal ion binding
binding
catalytic activity
transition metal ion binding
electron carrier activity
iron ion binding
monooxygenase activity
heme binding
oxidoreductase activity
Molecular Function
heme binding
alkane 1-monooxygenase activity
electron carrier activity
aromatase activity
iron ion binding
Process
metabolic process
oxidation reduction
Cellular Location
  1. Endoplasmic reticulum membrane
  2. Single-pass membrane protein
  3. Microsome membrane
Pathways
Gene Properties
Chromosome Location 19
Locus 19p13.1
SNPs CYP4F8
Gene Sequence
>1563 bp
ATGTCGCTGCTGAGCCTGTCTTGGCTGGGCCTCAGGCCGGTGGCAGCATCCCCGTGGCTG
CTCCTGCTGGTGGTCGGGGCCTCCTGGCTCCTGGCCCGCATCCTGGCCTGGACCTATGCC
TTCTATCACAACGGCCGCCGCCTCCGGTGTTTCCCGCAGCCCCGGAAACAGAACTGGTTC
TTGGGTCACCTGGGCCTGGTCACTCCCACAGAGGAGGGCTTGAGGGTCCTGACCCAGCTG
GTGGCCACCTACCCCCAGGGCTTTGTGAGGTGGTTGGGCCCCATCACTCCCATCATCAAC
TTGTGCCACCCTGACATCGTCCGATCTGTCATCAATACCTCAGATGCCATTACAGACAAG
GACATAGTCTTCTACAAGACCCTGAAGCCCTGGCTGGGGGATGGGCTCTTGTTAAGTGTT
GGTGACAAGTGGAGACACCACCGTCGCTTGCTGACGCCTGCCTTCCATTTCAACATCCTG
AAGCCCTATATAAAGATTTTCAGCAAGAGTGCAAACATCATGCATGCCAAGTGGCAACGC
CTGGCCATGGAGGGCAGCACCTGTCTGGATGTGTTTGAGCACATCAGCCTTATGACCCTG
GACAGTCTGCAGAAATGCATCTTCAGCTTTGACAGCAATTGTCAGGAGAAGCCCAGTGAA
TATATTACTGCGATCATGGAGCTCAGTGCCCTTGTAGTGAAACGGAATAACCAGTTCTTC
CGGTACAAGGACTTCCTGTACTTCCTCACTCCCTGTGGACGGCGCTTCCACAGGGCCTGC
AGACTGGTGCACGACTTCACAGATGCCGTCATCCAGGAGCGGCGCCGCACCCTCACTAGC
CAGGGTGTTGATGACTTCCTCCAAGCCAAGGCCAAGTCCAAGACTTTGGACTTTATTGAT
GTGCTCCTGCTGAGCGAGGATAAAAATGGTAAAGAGTTGTCAGATGAGGACATAAGAGCA
GAAGCTGACACTTTCATGTTTGGAGGCCATGACACCACGGCCAGTGGCCTCTCCTGGGTC
TTGTACAACCTCGCGAGGCACCCAGAATACCAAGAACGCTGCCGGCAGGAGGTGCAAGAG
CTTCTGAAGGACCGTGAGCCTAAAGAGATTGAATGGGACGACCTGGCCCAGTTGCCCTTC
CTGACCATGTGCCTGAAGGAGAGCCTGCGGTTGCATCCCCCAATCCCTACATTCGCCCGC
GGCTGCACCCAGGACGTGGTGCTCCCAGACAGCCGAGTCATCCCCAAAGGGAATGTCTGT
AACATCAACATCTTCGCAATCCATCACAACCCCTCAGTCTGGCCAGACCCTGAGGTCTAT
GACCCCTTCCGCTTCGACCCCGAAAACGCCCAGAAGAGGTCACCTATGGCTTTTATTCCT
TTCTCGGCGGGGCCCAGGAACTGCATCGGGCAGAAGTTCGCGATGGCAGAGATGAAGGTG
GTCCTGGCGCTCACGCTGCTGCGCTTCCGCATCCTGCCCGACCACAGGGAGCCACGCAGG
ACGCCGGAGATTGTTTTGCGTGCGGAGGACGGACTTTGGCTGCGAGTAGAACCCCTGGGC
TGA
Protein Properties
Number of Residues 520
Molecular Weight 59993.995
Theoretical pI 8.429
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Cytochrome P450 4F8
MSLLSLSWLGLRPVAASPWLLLLVVGASWLLARILAWTYAFYHNGRRLRCFPQPRKQNWF
LGHLGLVTPTEEGLRVLTQLVATYPQGFVRWLGPITPIINLCHPDIVRSVINTSDAITDK
DIVFYKTLKPWLGDGLLLSVGDKWRHHRRLLTPAFHFNILKPYIKIFSKSANIMHAKWQR
LAMEGSTCLDVFEHISLMTLDSLQKCIFSFDSNCQEKPSEYITAIMELSALVVKRNNQFF
RYKDFLYFLTPCGRRFHRACRLVHDFTDAVIQERRRTLTSQGVDDFLQAKAKSKTLDFID
VLLLSEDKNGKELSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQE
LLKDREPKEIEWDDLAQLPFLTMCLKESLRLHPPIPTFARGCTQDVVLPDSRVIPKGNVC
NINIFAIHHNPSVWPDPEVYDPFRFDPENAQKRSPMAFIPFSAGPRNCIGQKFAMAEMKV
VLALTLLRFRILPDHREPRRTPEIVLRAEDGLWLRVEPLG
GenBank ID Protein 5733409
UniProtKB/Swiss-Prot ID P98187
UniProtKB/Swiss-Prot Entry Name CP4F8_HUMAN
PDB IDs Not Available
GenBank Gene ID AF133298
GeneCard ID CYP4F8
GenAtlas ID Not Available
HGNC ID HGNC:2648
References
General References Not Available