Record Information
Version1.0
Created at2020-04-17 19:16:52 UTC
Updated at2020-11-18 16:39:28 UTC
CannabisDB IDCDB005175
Secondary Accession NumbersNot Available
Cannabis Compound Identification
Common NameHeme
DescriptionHeme is also known as protoheme or [fe(ppix)]. Heme is a weakly acidic compound (based on its pKa). Heme exists in all living organisms, ranging from bacteria to humans. In humans, heme is involved in ibuprofen action pathway. Outside of the human body, Heme has been detected, but not quantified in, several different foods, such as triticales, chicories, quinces, black mulberries, and japanese walnuts. This could make heme a potential biomarker for the consumption of these foods. Heme in which the iron has oxidation state +2. Heme is expected to be in Cannabis as all living plants are known to produce and metabolize it.
Structure
Thumb
Synonyms
ValueSource
[3,7,12,17-Tetramethyl-8,13-divinylporphyrin-2,18-dipropanoato(2-)]iron(II)ChEBI
[Fe(ppix)]ChEBI
Fe(ppix)ChEBI
FerroprotohemeChEBI
Ferroprotoporphyrin IXChEBI
Ferrous protohemeChEBI
Ferrous protoheme IXChEBI
HaemChEBI
Iron(II) protoporphyrin IXChEBI
ProtoferrohemeChEBI
ProtohemeChEBI
Heme bKegg
Protoheme IXKegg
HemeChEBI
Chemical FormulaC34H32FeN4O4
Average Molecular Weight616.49
Monoisotopic Molecular Weight616.1773
IUPAC Name4,20-bis(2-carboxyethyl)-10,15-diethenyl-5,9,14,19-tetramethyl-2lambda5,22,23lambda5,25-tetraaza-1-ferraoctacyclo[11.9.1.1^{1,8}.1^{3,21}.0^{2,6}.0^{16,23}.0^{18,22}.0^{11,25}]pentacosa-2,4,6,8,10,12,14,16(23),17,19,21(24)-undecaene-2,23-bis(ylium)-1,1-diuide
Traditional Name4,20-bis(2-carboxyethyl)-10,15-diethenyl-5,9,14,19-tetramethyl-2lambda5,22,23lambda5,25-tetraaza-1-ferraoctacyclo[11.9.1.1^{1,8}.1^{3,21}.0^{2,6}.0^{16,23}.0^{18,22}.0^{11,25}]pentacosa-2,4,6,8,10,12,14,16(23),17,19,21(24)-undecaene-2,23-bis(ylium)-1,1-diuide
CAS Registry Number14875-96-8
SMILES
CC1=C(CCC(O)=O)C2=CC3=[N+]4C(=CC5=C(C)C(C=C)=C6C=C7C(C)=C(C=C)C8=[N+]7[Fe--]4(N2C1=C8)N56)C(C)=C3CCC(O)=O
InChI Identifier
InChI=1S/C34H34N4O4.Fe/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25;/h7-8,13-16H,1-2,9-12H2,3-6H3,(H4,35,36,37,38,39,40,41,42);/q;+2/p-2/b25-13-,26-13-,27-14-,28-15-,29-14-,30-15-,31-16-,32-16-;
InChI KeyKABFMIBPWCXCRK-RGGAHWMASA-L
Chemical Taxonomy
ClassificationNot classified
Ontology
Disposition

Route of exposure:

Source:

Biological location:

Physical Properties
StateSolid
Experimental Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
logPNot AvailableNot Available
Predicted Properties
PropertyValueSource
logP-1ALOGPS
logP2.19ChemAxon
logS-5.5ALOGPS
pKa (Strongest Acidic)3.35ChemAxon
Physiological Charge-2ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area92.22 ŲChemAxon
Rotatable Bond Count8ChemAxon
Refractivity169.77 m³·mol⁻¹ChemAxon
Polarizability69.44 ųChemAxon
Number of Rings8ChemAxon
BioavailabilityYesChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Spectra
EI-MS/GC-MS
TypeDescriptionSplash KeyView
Predicted GC-MSHeme, 1 TMS, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
Predicted GC-MSHeme, 1 TMS, Predicted GC-MS Spectrum - 70eV, PositiveNot AvailableSpectrum
MS/MS
TypeDescriptionSplash KeyView
Predicted MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-066r-0000095000-501c4a776d38d61ab89aSpectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-0gi4-0000092000-64c21d0a0f8daa069fb9Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-03gs-4000590000-15136ce22e51bdc57377Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-014i-0000049000-69ee302652cebc40f13bSpectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-00r2-1000091000-d178bb83079a203a48dcSpectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-0a4i-1000090000-f6e437751fbc08f12d1fSpectrum
NMRNot Available
Pathways
Pathways
Protein Targets
Enzymes
Protein NameGene NameLocusUniprot IDDetails
5-aminolevulinate synthase, erythroid-specific, mitochondrialALAS2Xp11.21P22557 details
5-aminolevulinate synthase, nonspecific, mitochondrialALAS13p21.1P13196 details
Succinate dehydrogenase cytochrome b560 subunit, mitochondrialSDHC1q23.3Q99643 details
Aldehyde oxidaseAOX12q33Q06278 details
Heme oxygenase 2HMOX216p13.3P30519 details
Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrialSDHD11q23O14521 details
NADPH--cytochrome P450 reductasePOR7q11.2P16435 details
Heme oxygenase 1HMOX122q13.1P09601 details
Uroporphyrinogen decarboxylaseUROD1p34P06132 details
Coproporphyrinogen-III oxidase, mitochondrialCPOX3q12P36551 details
Lanosterol 14-alpha demethylaseCYP51A17q21.2Q16850 details
Thyroid peroxidaseTPO2p25P07202 details
LactoperoxidaseLPO17q23.1P22079 details
MyeloperoxidaseMPO17q23.1P05164 details
Eosinophil peroxidaseEPX17q23.1P11678 details
Uroporphyrinogen-III synthaseUROS10q25.2-q26.3P10746 details
Porphobilinogen deaminaseHMBS11q23.3P08397 details
Indoleamine 2,3-dioxygenase 1IDO18p12-p11P14902 details
Cholesterol 7-alpha-monooxygenaseCYP7A18q11-q12P22680 details
Biliverdin reductase ABLVRA7p13P53004 details
Flavin reductase (NADPH)BLVRB19q13.1-q13.2P30043 details
Cystathionine beta-synthaseCBS21q22.3P35520 details
Nitric oxide synthase, inducibleNOS217q11.2-q12P35228 details
Nitric oxide synthase, brainNOS112q24.2-q24.31P29475 details
Nitric oxide synthase, endothelialNOS37q36P29474 details
Succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrialSUCLA213q12.2-q13.3Q9P2R7 details
Prostaglandin G/H synthase 2PTGS21q25.2-q25.3P35354 details
Prostaglandin G/H synthase 1PTGS19q32-q33.3P23219 details
Leukotriene-B(4) omega-hydroxylase 1CYP4F219p13.12P78329 details
Leukotriene-B(4) omega-hydroxylase 2CYP4F319p13.2Q08477 details
Protoporphyrinogen oxidasePPOX1q22P50336 details
Sterol 26-hydroxylase, mitochondrialCYP27A12q33-qterQ02318 details
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrialCYP27B112q13.1-q13.3O15528 details
Steroid 17-alpha-hydroxylase/17,20 lyaseCYP17A110q24.3P05093 details
Sulfite oxidase, mitochondrialSUOX12q13.2P51687 details
Ferrochelatase, mitochondrialFECH18q21.3P22830 details
Delta-aminolevulinic acid dehydrataseALAD9q33.1P13716 details
Guanylate cyclase soluble subunit beta-1GUCY1B34q31.3-q33Q02153 details
Guanylate cyclase soluble subunit beta-2GUCY1B2O75343 details
Prostacyclin synthasePTGIS20q13.13Q16647 details
CatalaseCAT11p13P04040 details
Thromboxane-A synthaseTBXAS17q34-q35P24557 details
25-hydroxycholesterol 7-alpha-hydroxylaseCYP7B18q21.3O75881 details
Cytochrome c oxidase subunit 1MT-CO1P00395 details
Protoheme IX farnesyltransferase, mitochondrialCOX10Q12887 details
Cytochrome c-type heme lyaseHCCSXp22.3P53701 details
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrialCYP24A120q13Q07973 details
Fatty acid desaturase 1FADS111q12.2-q13.1O60427 details
Vitamin D 25-hydroxylaseCYP2R111p15.2Q6VVX0 details
Cytochrome b reductase 1CYBRD12q31.1Q53TN4 details
Cytochrome c oxidase subunit 5A, mitochondrialCOX5A15q24.1P20674 details
Fatty acid desaturase 2FADS211q12.2O95864 details
Cholesterol 24-hydroxylaseCYP46A114q32.1Q9Y6A2 details
24-hydroxycholesterol 7-alpha-hydroxylaseCYP39A16p21.1-p11.2Q9NYL5 details
7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylaseCYP8B13p22.1Q9UNU6 details
Cytochrome b5 reductase 4CYB5R46pter-q22.33Q7L1T6 details
Indoleamine 2,3-dioxygenase 2IDO28p11.21Q6ZQW0 details
Cytochrome P450, family 1, subfamily A, polypeptide 1CYP1A115q24.1A0N0X8 details
NADPH oxidase 5NOX515q23Q96PH1 details
Metalloreductase STEAP3STEAP32q14.2Q658P3 details
NADPH oxidase 1NOX1Q9Y5S8 details
NADPH oxidase 4NOX411q14.2-q21Q9NPH5 details
Metalloreductase STEAP1STEAP17q21Q9UHE8 details
Metalloreductase STEAP2STEAP27q21Q8NFT2 details
Metalloreductase STEAP4STEAP47q21.12Q687X5 details
Cytochrome c oxidase assembly protein COX15 homologCOX15Q7KZN9 details
Eukaryotic translation initiation factor 2-alpha kinase 1EIF2AK17p22Q9BQI3 details
Fatty acid 2-hydroxylaseFA2H16q23Q7L5A8 details
Fatty acid desaturase 2-like proteinA8MWK0 details
Fatty acid desaturase 3FADS311q12-q13.1Q9Y5Q0 details
Ferric-chelate reductase 1FRRS11p21.2Q6ZNA5 details
E3 ubiquitin-protein ligase HERC2HERC215q13O95714 details
Cytochrome P450, family 21, subfamily A, polypeptide 2CYP21A26p21.3Q08AG9 details
Transporters
Protein NameGene NameLocusUniprot IDDetails
Nitric oxide synthase, inducibleNOS217q11.2-q12P35228 details
Cytochrome b-c1 complex subunit 9UQCR1022cen-q12.3Q9UDW1 details
Cytochrome b-c1 complex subunit 6, mitochondrialUQCRH1p34.1P07919 details
Protein AMBPAMBP9q32-q33P02760 details
Calcium-activated potassium channel subunit alpha-1KCNMA110q22.3Q12791 details
Proton-coupled folate transporterSLC46A117q11.2Q96NT5 details
ATP-binding cassette sub-family B member 6, mitochondrialABCB62q36Q9NP58 details
ATP-binding cassette sub-family B member 7, mitochondrialABCB7O75027 details
ATP-binding cassette sub-family B member 10, mitochondrialABCB101q42.13Q9NRK6 details
Heme transporter HRG1SLC48A112q13.11Q6P1K1 details
Metal Bindings
Protein NameGene NameLocusUniprot IDDetails
Succinate dehydrogenase cytochrome b560 subunit, mitochondrialSDHC1q23.3Q99643 details
Aldehyde oxidaseAOX12q33Q06278 details
Heme oxygenase 2HMOX216p13.3P30519 details
Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrialSDHD11q23O14521 details
NADPH--cytochrome P450 reductasePOR7q11.2P16435 details
Heme oxygenase 1HMOX122q13.1P09601 details
Lanosterol 14-alpha demethylaseCYP51A17q21.2Q16850 details
Thyroid peroxidaseTPO2p25P07202 details
LactoperoxidaseLPO17q23.1P22079 details
MyeloperoxidaseMPO17q23.1P05164 details
Eosinophil peroxidaseEPX17q23.1P11678 details
Cytochrome P450 4A11CYP4A111p33Q02928 details
Indoleamine 2,3-dioxygenase 1IDO18p12-p11P14902 details
Cytochrome P450 11B1, mitochondrialCYP11B18q21P15538 details
Cholesterol 7-alpha-monooxygenaseCYP7A18q11-q12P22680 details
Biliverdin reductase ABLVRA7p13P53004 details
Cholesterol side-chain cleavage enzyme, mitochondrialCYP11A115q23-q24P05108 details
Cystathionine beta-synthaseCBS21q22.3P35520 details
Nitric oxide synthase, inducibleNOS217q11.2-q12P35228 details
Nitric oxide synthase, brainNOS112q24.2-q24.31P29475 details
Nitric oxide synthase, endothelialNOS37q36P29474 details
Succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrialSUCLA213q12.2-q13.3Q9P2R7 details
Prostaglandin G/H synthase 2PTGS21q25.2-q25.3P35354 details
Prostaglandin G/H synthase 1PTGS19q32-q33.3P23219 details
Cytochrome c1, heme protein, mitochondrialCYC18q24.3P08574 details
Leukotriene-B(4) omega-hydroxylase 1CYP4F219p13.12P78329 details
Leukotriene-B(4) omega-hydroxylase 2CYP4F319p13.2Q08477 details
Cytochrome P450 3A4CYP3A47q21.1P08684 details
Cytochrome P450 2C9CYP2C910q24P11712 details
Sterol 26-hydroxylase, mitochondrialCYP27A12q33-qterQ02318 details
Cytochrome P450 2C19CYP2C1910q24P33261 details
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrialCYP27B112q13.1-q13.3O15528 details
Steroid 17-alpha-hydroxylase/17,20 lyaseCYP17A110q24.3P05093 details
Sulfite oxidase, mitochondrialSUOX12q13.2P51687 details
Delta-aminolevulinic acid dehydrataseALAD9q33.1P13716 details
Guanylate cyclase soluble subunit beta-1GUCY1B34q31.3-q33Q02153 details
Guanylate cyclase soluble subunit beta-2GUCY1B2O75343 details
Prostacyclin synthasePTGIS20q13.13Q16647 details
Cytochrome P450 2E1CYP2E110q24.3-qterP05181 details
Cytochrome P450 4F11CYP4F1119p13.1Q9HBI6 details
Cytochrome P450 3A43CYP3A437q21.1Q9HB55 details
Cytochrome P450 1B1CYP1B12p22.2Q16678 details
Cytochrome P450 2D6CYP2D622q13.1P10635 details
Cytochrome P450 2C18CYP2C1810q24P33260 details
Cytochrome P450 4F12CYP4F1219p13.1Q9HCS2 details
Cytochrome P450 2F1CYP2F119q13.2P24903 details
Cytochrome P450 4X1CYP4X11Q8N118 details
Cytochrome P450 2B6CYP2B619q13.2P20813 details
Cytochrome P450 3A5CYP3A57q21.1P20815 details
Cytochrome P450 1A1CYP1A115q24.1P04798 details
Cytochrome P450 2A13CYP2A1319q13.2Q16696 details
Cytochrome P450 3A7CYP3A77q21-q22.1P24462 details
Cytochrome P450 4B1CYP4B11p34-p12P13584 details
Cytochrome P450 4Z1CYP4Z11p33Q86W10 details
Cytochrome P450 1A2CYP1A215q24.1P05177 details
Cytochrome P450 19A1CYP19A115q21.1P11511 details
Cytochrome P450 2C8CYP2C810q23.33P10632 details
Cytochrome P450 2S1CYP2S119q13.1Q96SQ9 details
Cytochrome P450 4F8CYP4F819p13.1P98187 details
Cytochrome P450 2J2CYP2J21p31.3-p31.2P51589 details
Cytochrome P450 2A7CYP2A719q13.2P20853 details
Cytochrome P450 2A6CYP2A619q13.2P11509 details
CatalaseCAT11p13P04040 details
Thromboxane-A synthaseTBXAS17q34-q35P24557 details
Hemoglobin subunit betaHBB11p15.5P68871 details
Hemoglobin subunit alphaHBA116p13.3P69905 details
Hemoglobin subunit gamma-1HBG111p15.5P69891 details
25-hydroxycholesterol 7-alpha-hydroxylaseCYP7B18q21.3O75881 details
Cytochrome c oxidase subunit 1MT-CO1P00395 details
Cytochrome cCYCS7p15.3P99999 details
Cytochrome b-245 heavy chainCYBBP04839 details
Cytochrome c-type heme lyaseHCCSXp22.3P53701 details
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrialCYP24A120q13Q07973 details
PR domain zinc finger protein 2PRDM21p36.21Q13029 details
Cytochrome P450 26A1CYP26A110q23-q24O43174 details
SerotransferrinTF3q22.1P02787 details
MyoglobinMB22q13.1P02144 details
Cytochrome b-245 light chainCYBA16q24P13498 details
Fatty acid desaturase 1FADS111q12.2-q13.1O60427 details
Vitamin D 25-hydroxylaseCYP2R111p15.2Q6VVX0 details
Hemoglobin subunit gamma-2HBG211p15.5P69892 details
Cytochrome b5CYB5A18q23P00167 details
Fatty acid desaturase 2FADS211q12.2O95864 details
Cholesterol 24-hydroxylaseCYP46A114q32.1Q9Y6A2 details
24-hydroxycholesterol 7-alpha-hydroxylaseCYP39A16p21.1-p11.2Q9NYL5 details
7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylaseCYP8B13p22.1Q9UNU6 details
Cytochrome b5 reductase 4CYB5R46pter-q22.33Q7L1T6 details
Cytochrome P450 4A22CYP4A221p33Q5TCH4 details
Indoleamine 2,3-dioxygenase 2IDO28p11.21Q6ZQW0 details
Cytochrome P450, family 1, subfamily A, polypeptide 1CYP1A115q24.1A0N0X8 details
NADPH oxidase 5NOX515q23Q96PH1 details
Peroxidasin homologPXDN2p25Q92626 details
Peroxidasin-like proteinPXDNL8q11.22-q11.23A1KZ92 details
Metalloreductase STEAP3STEAP32q14.2Q658P3 details
NADPH oxidase 1NOX1Q9Y5S8 details
NADPH oxidase 4NOX411q14.2-q21Q9NPH5 details
Metalloreductase STEAP1STEAP17q21Q9UHE8 details
Metalloreductase STEAP2STEAP27q21Q8NFT2 details
Metalloreductase STEAP4STEAP47q21.12Q687X5 details
Cytochrome P450 27C1CYP27C12q14.3Q4G0S4 details
Cytochrome b5 domain-containing protein 1CYB5D117p13.1Q6P9G0 details
NeuferricinCYB5D217p13.2Q8WUJ1 details
Cytochrome P450 20A1CYP20A12q33.2Q6UW02 details
Cytochrome P450 26B1CYP26B12p13.2Q9NR63 details
Cytochrome P450 26C1CYP26C110q23.33Q6V0L0 details
Cytochrome P450 2U1CYP2U14q25Q7Z449 details
Cytochrome P450 2W1CYP2W17p22.3Q8TAV3 details
Cytochrome P450 4F22CYP4F22Q6NT55 details
Cytochrome P450 4V2CYP4V24q35.2Q6ZWL3 details
Cytochrome b5 type BCYB5B16q22.1O43169 details
CytoglobinCYGB17q25.3Q8WWM9 details
Fatty acid 2-hydroxylaseFA2H16q23Q7L5A8 details
Fatty acid desaturase 2-like proteinA8MWK0 details
Fatty acid desaturase 3FADS311q12-q13.1Q9Y5Q0 details
Hemoglobin subunit theta-1HBQ116p13.3P09105 details
Hemoglobin subunit zetaHBZ16p13.3P02008 details
Hemoglobin subunit deltaHBD11p15.5P02042 details
Hemoglobin subunit epsilonHBE111p15.5P02100 details
Hemoglobin subunit muHBM16p13.3Q6B0K9 details
E3 ubiquitin-protein ligase HERC2HERC215q13O95714 details
NeudesinNENF1q32.3Q9UMX5 details
NeuroglobinNGB14q24.3Q9NPG2 details
Membrane-associated progesterone receptor component 1PGRMC1O00264 details
Membrane-associated progesterone receptor component 2PGRMC24q26O15173 details
Cytochrome P450, family 21, subfamily A, polypeptide 2CYP21A26p21.3Q08AG9 details
Receptors
Protein NameGene NameLocusUniprot IDDetails
Nitric oxide synthase, brainNOS112q24.2-q24.31P29475 details
Prostaglandin G/H synthase 1PTGS19q32-q33.3P23219 details
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrialCYP27B112q13.1-q13.3O15528 details
Guanylate cyclase soluble subunit beta-1GUCY1B34q31.3-q33Q02153 details
Prostacyclin synthasePTGIS20q13.13Q16647 details
25-hydroxycholesterol 7-alpha-hydroxylaseCYP7B18q21.3O75881 details
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrialCYP24A120q13Q07973 details
Feline leukemia virus subgroup C receptor-related protein 1FLVCR11q32.3Q9Y5Y0 details
Scavenger receptor cysteine-rich type 1 protein M130CD16312p13.3Q86VB7 details
Peroxidasin homologPXDN2p25Q92626 details
Membrane-associated progesterone receptor component 1PGRMC1O00264 details
Membrane-associated progesterone receptor component 2PGRMC24q26O15173 details
Transcriptional Factors
Protein NameGene NameLocusUniprot IDDetails
Heme oxygenase 1HMOX122q13.1P09601 details
Nitric oxide synthase, brainNOS112q24.2-q24.31P29475 details
Prostacyclin synthasePTGIS20q13.13Q16647 details
CatalaseCAT11p13P04040 details
PR domain zinc finger protein 2PRDM21p36.21Q13029 details
Transcription factor NF-E2 45 kDa subunitNFE212q13Q16621 details
Nuclear factor erythroid 2-related factor 1NFE2L117q21.3Q14494 details
Concentrations Data
Not Available
HMDB IDHMDB0003178
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FoodDB IDFDB031136
KNApSAcK IDNot Available
Chemspider IDNot Available
KEGG Compound IDC00032
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkHeme
METLIN IDNot Available
PubChem CompoundNot Available
PDB IDNot Available
ChEBI ID17627
References
General ReferencesNot Available

Only showing the first 10 proteins. There are 227 proteins in total.

Enzymes

General function:
Involved in 5-aminolevulinate synthase activity
Specific function:
Not Available
Gene Name:
ALAS2
Uniprot ID:
P22557
Molecular weight:
64632.86
General function:
Involved in 5-aminolevulinate synthase activity
Specific function:
Not Available
Gene Name:
ALAS1
Uniprot ID:
P13196
Molecular weight:
70580.325
General function:
Involved in succinate dehydrogenase activity
Specific function:
Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
Gene Name:
SDHC
Uniprot ID:
Q99643
Molecular weight:
16650.185
General function:
Involved in oxidoreductase activity
Specific function:
Not Available
Gene Name:
AOX1
Uniprot ID:
Q06278
Molecular weight:
147916.735
General function:
Involved in heme oxygenase (decyclizing) activity
Specific function:
Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Heme oxygenase 2 could be implicated in the production of carbon monoxide in brain where it could act as a neurotransmitter.
Gene Name:
HMOX2
Uniprot ID:
P30519
Molecular weight:
36032.615
General function:
Involved in iron ion binding
Specific function:
Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (By similarity).
Gene Name:
SDHD
Uniprot ID:
O14521
Molecular weight:
17042.82
General function:
Involved in oxidoreductase activity
Specific function:
This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5.
Gene Name:
POR
Uniprot ID:
P16435
Molecular weight:
77047.575
General function:
Involved in heme oxygenase (decyclizing) activity
Specific function:
Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed.
Gene Name:
HMOX1
Uniprot ID:
P09601
Molecular weight:
32818.345
General function:
Involved in uroporphyrinogen decarboxylase activity
Specific function:
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
Gene Name:
UROD
Uniprot ID:
P06132
Molecular weight:
40786.58
General function:
Involved in coproporphyrinogen oxidase activity
Specific function:
Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III.
Gene Name:
CPOX
Uniprot ID:
P36551
Molecular weight:
50151.605

Transporters

General function:
Involved in oxidoreductase activity
Specific function:
Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2.
Gene Name:
NOS2
Uniprot ID:
P35228
Molecular weight:
131116.3
General function:
Involved in ubiquinol-cytochrome-c reductase activity
Specific function:
This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This subunit interacts with cytochrome c1
Gene Name:
UQCR10
Uniprot ID:
Q9UDW1
Molecular weight:
7308.4
General function:
Involved in ubiquinol-cytochrome-c reductase activity
Specific function:
This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1
Gene Name:
UQCRH
Uniprot ID:
P07919
Molecular weight:
10738.7
General function:
Involved in transporter activity
Specific function:
Trypstatin is a trypsin inhibitor
Gene Name:
AMBP
Uniprot ID:
P02760
Molecular weight:
38999.2
General function:
Involved in ion channel activity
Specific function:
Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. In smooth muscles, its activation by high level of Ca(2+), caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. Kinetics of KCNMA1 channels are determined by alternative splicing, phosphorylation status and its combination with modulating beta subunits. Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX)
Gene Name:
KCNMA1
Uniprot ID:
Q12791
Molecular weight:
137558.1
General function:
Involved in transmembrane transport
Specific function:
Has been shown to act both as an intestinal proton- coupled high-affinity folate transporter and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. The iron is then released from heme and may be transported into the bloodstream. Dietary heme iron is an important nutritional source of iron. Shows a higher affinity for folate than heme
Gene Name:
SLC46A1
Uniprot ID:
Q96NT5
Molecular weight:
49770.0
General function:
Involved in ATP binding
Specific function:
Binds heme and porphyrins and functions in their ATP- dependent uptake into the mitochondria. Plays a crucial role in heme synthesis
Gene Name:
ABCB6
Uniprot ID:
Q9NP58
Molecular weight:
93884.7
General function:
Involved in ATP binding
Specific function:
Could be involved in the transport of heme from the mitochondria to the cytosol. Plays a central role in the maturation of cytosolic iron-sulfur (Fe/S) cluster-containing proteins
Gene Name:
ABCB7
Uniprot ID:
O75027
Molecular weight:
82640.6
General function:
Involved in ATP binding
Specific function:
May mediate critical mitochondrial transport functions related to heme biosynthesis
Gene Name:
ABCB10
Uniprot ID:
Q9NRK6
Molecular weight:
79146.9
General function:
Involved in transport
Specific function:
Heme transporter that regulates intracellular heme availability through the endosomal or lysosomal compartment.
Gene Name:
SLC48A1
Uniprot ID:
Q6P1K1
Molecular weight:
16419.045

Only showing the first 10 proteins. There are 227 proteins in total.