Cannabis Compound Database: Showing Protein Cystathionine beta-synthase (CDBP00724)

Identification Biological properties Gene properties Protein properties External links References XML Show 11 compounds

Identification

HMDB Protein ID

CDBP00724

Secondary Accession Numbers

Not Available

Name

Cystathionine beta-synthase

Description

Not Available

Synonyms

Beta-thionase
Serine sulfhydrase

Gene Name

CBS

Protein Type

Enzyme

Biological Properties

General Function

Involved in cysteine biosynthetic process from serine

Specific Function

Only known pyridoxal phosphate-dependent enzyme that contains heme. Important regulator of hydrogen sulfide, especially in the brain, utilizing cysteine instead of serine to catalyze the formation of hydrogen sulfide. Hydrogen sulfide is a gastratransmitter with signaling and cytoprotective effects such as acting as a neuromodulator in the brain to protect neurons against hypoxic injury (By similarity).

GO Classification

Biological Process
cerebellum morphogenesis
cysteine biosynthetic process from serine
cysteine biosynthetic process via cystathionine
endochondral ossification
homocysteine catabolic process
hydrogen sulfide biosynthetic process
L-serine catabolic process
L-cysteine catabolic process
regulation of cGMP metabolic process
regulation of JUN kinase activity
response to folic acid
superoxide metabolic process
transsulfuration
cellular nitrogen compound metabolic process
regulation of blood vessel size
blood vessel remodeling
maternal process involved in female pregnancy
cartilage development involved in endochondral bone morphogenesis
Cellular Component
cytosol
nucleolus
Component
cell part
intracellular part
cytoplasm
Function
hydro-lyase activity
cofactor binding
pyridoxal phosphate binding
cystathionine beta-synthase activity
binding
catalytic activity
lyase activity
carbon-oxygen lyase activity
Molecular Function
metal ion binding
pyridoxal phosphate binding
heme binding
protein homodimerization activity
cystathionine beta-synthase activity
modified amino acid binding
Process
cysteine biosynthetic process via cystathionine
l-serine metabolic process
cysteine biosynthetic process from serine
cellular amino acid and derivative metabolic process
cellular amino acid metabolic process
metabolic process
cellular metabolic process
sulfur amino acid metabolic process
sulfur amino acid biosynthetic process
serine family amino acid metabolic process
cysteine biosynthetic process

Cellular Location

Nucleus
Cytoplasm

Pathways

Name	SMPDB/Pathwhiz	KEGG
L-cysteine biosynthesis	Not Available	Not Available
Glycine, serine and threonine metabolism	Not Available
Cysteine and methionine metabolism	Not Available
Selenoamino Acid Metabolism
Homocysteine Degradation		Not Available

Gene Properties

Chromosome Location

Locus

21q22.3

SNPs

CBS

Gene Sequence

>1656 bp
ATGCCTTCTGAGACCCCCCAGGCAGAAGTGGGGCCCACAGGCTGCCCCCACCGCTCAGGG
CCACACTCGGCGAAGGGGAGCCTGGAGAAGGGGTCCCCAGAGGATAAGGAAGCCAAGGAG
CCCCTGTGGATCCGGCCCGATGCTCCGAGCAGGTGCACCTGGCAGCTGGGCCGGCCTGCC
TCCGAGTCCCCACATCACCACACTGCCCCGGCAAAATCTCCAAAAATCTTGCCAGATATT
CTGAAGAAAATCGGGGACACCCCTATGGTCAGAATCAACAAGATTGGGAAGAAGTTCGGC
CTGAAGTGTGAGCTCTTGGCCAAGTGTGAGTTCTTCAACGCGGGCGGGAGCGTGAAGGAC
CGCATCAGCCTGCGGATGATTGAGGATGCTGAGCGCGACGGGACGCTGAAGCCCGGGGAC
ACGATTATCGAGCCGACATCCGGGAACACCGGGATCGGGCTGGCCCTGGCTGCGGCAGTG
AGGGGCTATCGCTGCATCATCGTGATGCCAGAGAAGATGAGCTCCGAGAAGGTGGACGTG
CTGCGGGCACTGGGGGCTGAGATTGTGAGGACGCCCACCAATGCCAGGTTCGACTCCCCG
GAGTCACACGTGGGGGTGGCCTGGCGGCTGAAGAACGAAATCCCCAATTCTCACATCCTA
GACCAGTACCGCAACGCCAGCAACCCCCTGGCTCACTACGACACCACCGCTGATGAGATC
CTGCAGCAGTGTGATGGGAAGCTGGACATGCTGGTGGCTTCAGTGGGCACGGGCGGCACC
ATCACGGGCATTGCCAGGAAGCTGAAGGAGAAGTGTCCTGGATGCAGGATCATTGGGGTG
GATCCCGAAGGGTCCATCCTCGCAGAGCCGGAGGAGCTGAACCAGACGGAGCAGACAACC
TACGAGGTGGAAGGGATCGGCTACGACTTCATCCCCACGGTGCTGGACAGGACGGTGGTG
GACAAGTGGTTCAAGAGCAACGATGAGGAGGCGTTCACCTTTGCCCGCATGCTGATCGCG
CAAGAGGGGCTGCTGTGCGGTGGCAGTGCTGGCAGCACGGTGGCGGTGGCCGTGAAGGCT
GCGCAGGAGCTGCAGGAGGGCCAGCGCTGCGTGGTCATTCTGCCCGACTCAGTGCGGAAC
TACATGACCAAGTTCCTGAGCGACAGGTGGATGCTGCAGAAGGGCTTTCTGAAGGAGGAG
GACCTCACGGAGAAGAAGCCCTGGTGGTGGCACCTCCGTGTTCAGGAGCTGGGCCTGTCA
GCCCCGCTGACCGTGCTCCCGACCATCACCTGTGGGCACACCATCGAGATCCTCCGGGAG
AAGGGCTTCGACCAGGCGCCCGTGGTGGATGAGGCGGGGGTAATCCTGGGAATGGTGACG
CTTGGGAACATGCTCTCGTCCCTGCTTGCCGGGAAGGTGCAGCCGTCAGACCAAGTTGGC
AAAGTCATCTACAAGCAGTTCAAACAGATCCGCCTCACGGACACGCTGGGCAGGCTCTCG
CACATCCTGGAGATGGACCACTTCGCCCTGGTGGTGCACGAGCAGATCCAGTACCACAGC
ACCGGGAAGTCCAGTCAGCGGCAGATGGTGTTCGGGGTGGTCACCGCCATTGACTTGCTG
AACTTCGTGGCCGCCCAGGAGCGGGACCAGAAGTGA

Protein Properties

Number of Residues

551

Molecular Weight

60586.05

Theoretical pI

6.648

Pfam Domain Function

PALP (PF00291 )
CBS (PF00571 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Cystathionine beta-synthase
MPSETPQAEVGPTGCPHRSGPHSAKGSLEKGSPEDKEAKEPLWIRPDAPSRCTWQLGRPA
SESPHHHTAPAKSPKILPDILKKIGDTPMVRINKIGKKFGLKCELLAKCEFFNAGGSVKD
RISLRMIEDAERDGTLKPGDTIIEPTSGNTGIGLALAAAVRGYRCIIVMPEKMSSEKVDV
LRALGAEIVRTPTNARFDSPESHVGVAWRLKNEIPNSHILDQYRNASNPLAHYDTTADEI
LQQCDGKLDMLVASVGTGGTITGIARKLKEKCPGCRIIGVDPEGSILAEPEELNQTEQTT
YEVEGIGYDFIPTVLDRTVVDKWFKSNDEEAFTFARMLIAQEGLLCGGSAGSTVAVAVKA
AQELQEGQRCVVILPDSVRNYMTKFLSDRWMLQKGFLKEEDLTEKKPWWWHLRVQELGLS
APLTVLPTITCGHTIEILREKGFDQAPVVDEAGVILGMVTLGNMLSSLLAGKVQPSDQVG
KVIYKQFKQIRLTDTLGRLSHILEMDHFALVVHEQIQYHSTGKSSQRQMVFGVVTAIDLL
NFVAAQERDQK

External Links

GenBank ID Protein

388716

UniProtKB/Swiss-Prot ID

P35520

UniProtKB/Swiss-Prot Entry Name

CBS_HUMAN

PDB IDs