Cannabis Compound Database: Showing Protein Porphobilinogen deaminase (CDBP00351)

Identification Biological properties Gene properties Protein properties External links References XML Show 3 compounds

Identification

HMDB Protein ID

CDBP00351

Secondary Accession Numbers

Not Available

Name

Porphobilinogen deaminase

Description

Not Available

Synonyms

HMBS
Hydroxymethylbilane synthase
PBG-D
Pre-uroporphyrinogen synthase

Gene Name

HMBS

Protein Type

Enzyme

Biological Properties

General Function

Involved in hydroxymethylbilane synthase activity

Specific Function

Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.

GO Classification

Biological Process
cellular response to cytokine stimulus
cellular response to lead ion
peptidyl-pyrromethane cofactor linkage
response to carbohydrate stimulus
response to vitamin
response to estradiol stimulus
small molecule metabolic process
cellular response to dexamethasone stimulus
response to zinc ion
response to hypoxia
cellular response to arsenic-containing substance
response to methylmercury
response to amino acid stimulus
response to cobalt ion
heme biosynthetic process
protoporphyrinogen IX biosynthetic process
organ regeneration
cellular response to antibiotic
cellular response to amine stimulus
response to drug
astrocyte differentiation
Cellular Component
cytosol
condensed chromosome
nucleus
axon
Function
hydroxymethylbilane synthase activity
transferase activity, transferring alkyl or aryl (other than methyl) groups
catalytic activity
transferase activity
Molecular Function
amine binding
carboxylic acid binding
hydroxymethylbilane synthase activity
uroporphyrinogen-III synthase activity
coenzyme binding
Process
macromolecule modification
protein modification process
metabolic process
macromolecule metabolic process
post-translational protein modification
protein-cofactor linkage
peptidyl-pyrromethane cofactor linkage
biosynthetic process
cellular biosynthetic process
heterocycle biosynthetic process
tetrapyrrole biosynthetic process

Cellular Location

Cytoplasm (Probable)

Pathways

Name	SMPDB/Pathwhiz	KEGG
protoporphyrin-IX biosynthesis	Not Available	Not Available
Porphyrin and chlorophyll metabolism	Not Available
Porphyrin Metabolism
Acute Intermittent Porphyria		Not Available
Porphyria Variegata (PV)		Not Available

Gene Properties

Chromosome Location

Locus

11q23.3

SNPs

HMBS

Gene Sequence

>1086 bp
ATGTCTGGTAACGGCAATGCGGCTGCAACGGCGGAAGAAAACAGCCCAAAGATGAGAGTG
ATTCGCGTGGGTACCCGCAAGAGCCAGCTTGCTCGCATACAGACGGACAGTGTGGTGGCA
ACATTGAAAGCCTCGTACCCTGGCCTGCAGTTTGAAATCATTGCTATGTCCACCACAGGG
GACAAGATTCTTGATACTGCACTCTCTAAGATTGGAGAGAAAAGCCTGTTTACCAAGGAG
CTTGAACATGCCCTGGAGAAGAATGAAGTGGACCTGGTTGTTCACTCCTTGAAGGACCTG
CCCACTGTGCTTCCTCCTGGCTTCACCATCGGAGCCATCTGCAAGCGGGAAAACCCTCAT
GATGCTGTTGTCTTTCACCCAAAATTTGTTGGGAAGACCCTAGAAACCCTGCCAGAGAAG
AGTGTGGTGGGAACCAGCTCCCTGCGAAGAGCAGCCCAGCTGCAGAGAAAGTTCCCGCAT
CTGGAGTTCAGGAGTATTCGGGGAAACCTCAACACCCGGCTTCGGAAGCTGGACGAGCAG
CAGGAGTTCAGTGCCATCATCCTGGCAACAGCTGGCCTGCAGCGCATGGGCTGGCACAAC
CGGGTGGGGCAGATCCTGCACCCTGAGGAATGCATGTATGCTGTGGGCCAGGGGGCCTTG
GGCGTGGAAGTGCGAGCCAAGGACCAGGACATCTTGGATCTGGTGGGTGTGCTGCACGAT
CCCGAGACTCTGCTTCGCTGCATCGCTGAAAGGGCCTTCCTGAGGCACCTGGAAGGAGGC
TGCAGTGTGCCAGTAGCCGTGCATACAGCTATGAAGGATGGGCAACTGTACCTGACTGGA
GGAGTCTGGAGTCTAGACGGCTCAGATAGCATACAAGAGACCATGCAGGCTACCATCCAT
GTCCCTGCCCAGCATGAAGATGGCCCTGAGGATGACCCACAGTTGGTAGGCATCACTGCT
CGTAACATTCCACGAGGGCCCCAGTTGGCTGCCCAGAACTTGGGCATCAGCCTGGCCAAC
TTGTTGCTGAGCAAAGGAGCCAAAAACATCCTGGATGTTGCACGGCAGCTTAACGATGCC
CATTAA

Protein Properties

Number of Residues

361

Molecular Weight

39329.74

Theoretical pI

7.174

Pfam Domain Function

Porphobil_deam (PF01379 )
Porphobil_deamC (PF03900 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Porphobilinogen deaminase
MSGNGNAAATAEENSPKMRVIRVGTRKSQLARIQTDSVVATLKASYPGLQFEIIAMSTTG
DKILDTALSKIGEKSLFTKELEHALEKNEVDLVVHSLKDLPTVLPPGFTIGAICKRENPH
DAVVFHPKFVGKTLETLPEKSVVGTSSLRRAAQLQRKFPHLEFRSIRGNLNTRLRKLDEQ
QEFSAIILATAGLQRMGWHNRVGQILHPEECMYAVGQGALGVEVRAKDQDILDLVGVLHD
PETLLRCIAERAFLRHLEGGCSVPVAVHTAMKDGQLYLTGGVWSLDGSDSIQETMQATIH
VPAQHEDGPEDDPQLVGITARNIPRGPQLAAQNLGISLANLLLSKGAKNILDVARQLNDA
H

External Links

GenBank ID Protein

158261573

UniProtKB/Swiss-Prot ID

P08397

UniProtKB/Swiss-Prot Entry Name

HEM3_HUMAN

PDB IDs