Identification |
HMDB Protein ID
| CDBP03838 |
Secondary Accession Numbers
| Not Available |
Name
| ATP-binding cassette sub-family B member 10, mitochondrial |
Description
| Not Available |
Synonyms
|
- ABC transporter 10 protein
- ATP-binding cassette transporter 10
- M-ABC2
- Mitochondrial ATP-binding cassette 2
|
Gene Name
| ABCB10 |
Protein Type
| Transporter |
Biological Properties |
General Function
| Involved in ATP binding |
Specific Function
| May mediate critical mitochondrial transport functions related to heme biosynthesis |
GO Classification
|
Component |
cell part |
membrane part |
intrinsic to membrane |
integral to membrane |
Function |
hydrolase activity |
nucleoside binding |
purine nucleoside binding |
adenyl nucleotide binding |
adenyl ribonucleotide binding |
atp binding |
transmembrane transporter activity |
atpase activity |
transporter activity |
active transmembrane transporter activity |
nucleoside-triphosphatase activity |
primary active transmembrane transporter activity |
hydrolase activity, acting on acid anhydrides |
p-p-bond-hydrolysis-driven transmembrane transporter activity |
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides |
atpase activity, coupled to transmembrane movement of substances |
pyrophosphatase activity |
binding |
nucleotide binding |
catalytic activity |
Process |
establishment of localization |
transport |
transmembrane transport |
|
Cellular Location
|
- Mitochondrion inner membrane
- Multi-pass membrane protein
|
Pathways
|
Not Available
|
Gene Properties |
Chromosome Location
| Chromosome:1 |
Locus
| 1q42.13 |
SNPs
| ABCB10 |
Gene Sequence
|
>2217 bp
ATGCGAGGCCCCCCTGCCTGGCCGCTGCGGCTGCTCGAGCCACCGAGCCCTGCCGAGCCA
GGTCGGCTCCTGCCGGTAGCCTGCGTGTGGGCCGCGGCCAGCCGCGTTCCCGGGTCCCTA
TCGCCGTTCACTGGCCTGAGGCCGGCGCGGCTATGGGGCGCGGGGCCCGCGCTGCTCTGG
GGCGTTGGAGCCGCGCGCCGCTGGAGGAGCGGCTGCCGGGGCGGGGGTCCGGGCGCCTCG
CGGGGCGTCCTGGGCCTCGCGCGGCTCCTGGGGCTGTGGGCTCGCGGCCCCGGCAGCTGC
AGGTGCGGGGCTTTTGCCGGGCCAGGCGCTCCTCGGCTCCCGCGCGCCCGGTTCCCGGGC
GGTCCCGCAGCCGCTGCCTGGGCAGGGGACGAGGCCTGGCGGCGCGGGCCGGCGGCGCCT
CCCGGGGACAAGGGGCGGCTGCGCCCCGCAGCGGCCGGACTCCCGGAGGCCCGGAAGCTC
CTGGGGCTGGCGTACCCTGAGCGCCGGAGGCTGGCAGCTGCGGTTGGATTTCTCACGATG
TCCAGTGTTATCTCCATGTCTGCCCCTTTCTTCCTGGGGAAGATCATTGATGTCATCTAT
ACCAACCCCACTGTGGACTACAGCGACAACCTGACCCGCCTCTGCCTAGGGCTCAGTGCC
GTGTTTCTGTGTGGTGCTGCCGCCAATGCCATTCGTGTCTACCTCATGCAAACTTCAGGT
CAGCGCATTGTGAATAGGCTGAGAACTTCATTATTCTCCTCCATTCTGAGGCAGGAGGTT
GCTTTCTTTGACAAGACTCGCACAGGAGAATTGATTAACCGCCTCTCATCAGACACTGCA
CTCCTGGGGCGCTCAGTGACTGAAAACCTCTCAGATGGGCTCAGGGCCGGGGCCCAGGCT
TCCGTAGGCATCAGTATGATGTTTTTTGTCTCACCTAATCTGGCCACCTTTGTTTTGAGC
GTGGTGCCTCCAGTGTCAATCATTGCTGTAATTTATGGGCGATATCTACGGAAACTGACC
AAAGTCACTCAGGATTCCCTGGCACAAGCCACTCAGCTAGCTGAGGAACGTATTGGAAAT
GTAAGAACTGTTCGAGCTTTTGGGAAAGAAATGACTGAAATCGAGAAATATGCCAGCAAA
GTGGACCATGTAATGCAGTTAGCAAGGAAAGAGGCATTCGCCCGGGCTGGTTTCTTTGGA
GCAACTGGGCTCTCCGGAAACCTGATCGTGCTTTCTGTCCTGTACAAAGGAGGGCTGCTG
ATGGGCAGTGCCCACATGACCGTGGGTGAACTCTCTTCCTTCCTAATGTATGCTTTCTGG
GTTGGAATAAGCATTGGAGGTCTGAGCTCTTTCTACTCGGAGCTGATGAAAGGACTGGGT
GCAGGGGGGCGCCTCTGGGAGCTCCTGGAGAGAGAGCCCAAGCTGCCTTTTAACGAGGGG
GTCATCTTAAATGAGAAAAGCTTCCAGGGTGCTTTGGAGTTTAAGAACGTGCATTTTGCC
TATCCAGCTCGCCCAGAGGTGCCCATATTTCAGGATTTCAGCCTTTCCATTCCGTCAGGA
TCTGTCACGGCACTGGTTGGCCCAAGTGGTTCTGGCAAATCAACAGTGCTTTCACTCCTG
CTGAGGTTGTACGACCCTGCTTCTGGAACTATTAGTCTTGATGGCCATGACATCCGTCAG
CTAAACCCAGTGTGGCTGAGATCCAAAATTGGGACAGTGAGTCAGGAACCCATTTTGTTT
TCTTGCTCTATTGCTGAGAACATTGCTTATGGTGCTGATGACCCTTCCTCTGTGACCGCT
GAGGAAATCCAGAGAGTGGCTGAAGTGGCCAATGCAGTGGCCTTCATCCGGAATTTCCCC
CAAGGGTTCAACACTGTGGTTGGAGAAAAGGGTGTTCTCCTCTCAGGTGGGCAGAAACAG
CGGATTGCGATTGCCCGTGCTCTGCTAAAGAATCCCAAAATTCTTCTCCTAGATGAAGCA
ACCAGTGCGCTGGATGCCGAAAATGAGTACCTTGTTCAAGAAGCTCTAGATCGACTGATG
GATGGAAGAACGGTGTTAGTTATTGCCCATCGTCTGTCCACCATTAAGAATGCTAATATG
GTTGCTGTTCTTGACCAAGGAAAAATTACTGAATATGGAAAACATGAAGAGCTGCTTTCA
AAACCAAATGGGATATACAGAAAACTAATGAACAAACAAAGTTTTATTTCAGCATAA
|
Protein Properties |
Number of Residues
| 738 |
Molecular Weight
| 79146.9 |
Theoretical pI
| 10.37 |
Pfam Domain Function
|
|
Signals
|
|
Transmembrane Regions
|
- ["171-191", "216-236", "313-333", "408-428", "431-451"]
|
Protein Sequence
|
>ATP-binding cassette sub-family B member 10, mitochondrial
MRGPPAWPLRLLEPPSPAEPGRLLPVACVWAAASRVPGSLSPFTGLRPARLWGAGPALLW
GVGAARRWRSGCRGGGPGASRGVLGLARLLGLWARGPGSCRCGAFAGPGAPRLPRARFPG
GPAAAAWAGDEAWRRGPAAPPGDKGRLRPAAAGLPEARKLLGLAYPERRRLAAAVGFLTM
SSVISMSAPFFLGKIIDVIYTNPTVDYSDNLTRLCLGLSAVFLCGAAANAIRVYLMQTSG
QRIVNRLRTSLFSSILRQEVAFFDKTRTGELINRLSSDTALLGRSVTENLSDGLRAGAQA
SVGISMMFFVSPNLATFVLSVVPPVSIIAVIYGRYLRKLTKVTQDSLAQATQLAEERIGN
VRTVRAFGKEMTEIEKYASKVDHVMQLARKEAFARAGFFGATGLSGNLIVLSVLYKGGLL
MGSAHMTVGELSSFLMYAFWVGISIGGLSSFYSELMKGLGAGGRLWELLEREPKLPFNEG
VILNEKSFQGALEFKNVHFAYPARPEVPIFQDFSLSIPSGSVTALVGPSGSGKSTVLSLL
LRLYDPASGTISLDGHDIRQLNPVWLRSKIGTVSQEPILFSCSIAENIAYGADDPSSVTA
EEIQRVAEVANAVAFIRNFPQGFNTVVGEKGVLLSGGQKQRIAIARALLKNPKILLLDEA
TSALDAENEYLVQEALDRLMDGRTVLVIAHRLSTIKNANMVAVLDQGKITEYGKHEELLS
KPNGIYRKLMNKQSFISA
|
External Links |
GenBank ID Protein
| 171184400 |
UniProtKB/Swiss-Prot ID
| Q9NRK6 |
UniProtKB/Swiss-Prot Entry Name
| ABCBA_HUMAN |
PDB IDs
|
Not Available |
GenBank Gene ID
| NM_012089.2 |
GeneCard ID
| ABCB10 |
GenAtlas ID
| ABCB10 |
HGNC ID
| HGNC:41 |
References |
General References
| Not Available |