| Identification |
|---|
| HMDB Protein ID
| CDBP03846 |
| Secondary Accession Numbers
| Not Available |
| Name
| Cytochrome P450 26B1 |
| Description
| Not Available |
| Synonyms
|
- Cytochrome P450 26A2
- Cytochrome P450 retinoic acid-inactivating 2
- Cytochrome P450RAI-2
- Retinoic acid-metabolizing cytochrome
|
| Gene Name
| CYP26B1 |
| Protein Type
| Metal Binding |
| Biological Properties |
|---|
| General Function
| Involved in monooxygenase activity |
| Specific Function
| Plays a key role in retinoic acid metabolism. Involved in the specific inactivation of all-trans-retinoic acid (RA). Responsible for generation of several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA, and 18-OH-RA |
| GO Classification
|
| Function |
| oxidoreductase activity |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| catalytic activity |
| transition metal ion binding |
| electron carrier activity |
| iron ion binding |
| monooxygenase activity |
| heme binding |
|
| Cellular Location
|
- Peripheral membrane protein
- Peripheral membrane protein
- Endoplasmic reticulum membrane
- Microsome membrane
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:2 |
| Locus
| 2p13.2 |
| SNPs
| CYP26B1 |
| Gene Sequence
|
>1539 bp
ATGCTCTTTGAGGGCTTGGATCTGGTGTCGGCGCTGGCCACCCTCGCCGCGTGCCTGGTG
TCCGTGACGCTGCTGCTGGCCGTGTCGCAGCAGCTGTGGCAGCTGCGCTGGGCCGCCACT
CGCGACAAGAGCTGCAAGCTGCCCATCCCCAAGGGATCCATGGGCTTCCCGCTCATCGGA
GAGACCGGCCACTGGCTGCTGCAGGGTTCTGGCTTCCAGTCGTCGCGGAGGGAGAAGTAT
GGCAACGTGTTCAAGACGCATTTGTTGGGGCGGCCGCTGATACGCGTGACCGGCGCGGAG
AACGTGCGCAAGATCCTCATGGGCGAGCACCACCTCGTGAGCACCGAGTGGCCTCGCAGC
ACCCGCATGTTGCTGGGCCCCAACACGGTGTCCAATTCCATTGGCGACATCCACCGCAAC
AAGCGCAAGGTCTTCTCCAAGATCTTCAGCCACGAGGCCCTGGAGAGTTACCTGCCCAAG
ATCCAGCTGGTGATCCAGGACACACTGCGCGCCTGGAGCAGCCACCCCGAGGCCATCAAC
GTGTACCAGGAGGCGCAGAAGCTGACCTTCCGCATGGCCATCCGGGTGCTGCTGGGCTTC
AGCATCCCTGAGGAGGACCTTGGGCACCTCTTTGAGGTCTACCAGCAGTTTGTGGACAAT
GTCTTCTCCCTGCCTGTCGACCTGCCCTTCAGTGGCTACCGGCGGGGCATTCAGGCTCGG
CAGATCCTGCAGAAGGGGCTGGAGAAGGCCATCCGGGAGAAGCTGCAGTGCACACAGGGC
AAGGACTACTTGGACGCCCTGGACCTCCTCATTGAGAGCAGCAAGGAGCACGGGAAGGAG
ATGACCATGCAGGAGCTGAAGGACGGGACCCTGGAGCTGATCTTTGCGGCCTATGCCACC
ACGGCCAGCGCCAGCACCTCACTCATCATGCAGCTGCTGAAGCACCCCACTGTGCTGGAG
AAGCTGCGGGATGAGCTGCGGGCTCATGGCATCCTGCACAGTGGCGGCTGCCCCTGCGAG
GGCACACTGCGCCTGGACACGCTCAGTGGGCTGCGCTACCTGGACTGCGTCATCAAGGAG
GTCATGCGCCTGTTCACGCCCATTTCCGGCGGCTACCGCACTGTGCTGCAGACCTTCGAG
CTTGATGGTTTCCAGATCCCCAAAGGCTGGAGTGTCATGTATAGCATCCGGGACACCCAT
GACACAGCGCCCGTGTTCAAAGACGTGAACGTGTTCGACCCCGATCGCTTCAGCCAGGCG
CGGAGCGAGGACAAGGATGGCCGCTTCCATTACCTCCCGTTCGGTGGCGGTGTCCGGACC
TGCCTGGGCAAGCACCTGGCCAAGCTGTTCCTGAAGGTGCTGGCGGTGGAGCTGGCTAGC
ACCAGCCGCTTTGAGCTGGCCACACGGACCTTCCCCCGCATCACCTTGGTCCCCGTCCTG
CACCCCGTGGATGGCCTCAGCGTCAAGTTCTTTGGCCTGGACTCCAACCAGAACGAGATC
CTGCCGGAGACGGAGGCCATGCTGAGCGCCACAGTCTAA
|
| Protein Properties |
|---|
| Number of Residues
| 512 |
| Molecular Weight
| 57512.1 |
| Theoretical pI
| 8.63 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Cytochrome P450 26B1
MLFEGLDLVSALATLAACLVSVTLLLAVSQQLWQLRWAATRDKSCKLPIPKGSMGFPLIG
ETGHWLLQGSGFQSSRREKYGNVFKTHLLGRPLIRVTGAENVRKILMGEHHLVSTEWPRS
TRMLLGPNTVSNSIGDIHRNKRKVFSKIFSHEALESYLPKIQLVIQDTLRAWSSHPEAIN
VYQEAQKLTFRMAIRVLLGFSIPEEDLGHLFEVYQQFVDNVFSLPVDLPFSGYRRGIQAR
QILQKGLEKAIREKLQCTQGKDYLDALDLLIESSKEHGKEMTMQELKDGTLELIFAAYAT
TASASTSLIMQLLKHPTVLEKLRDELRAHGILHSGGCPCEGTLRLDTLSGLRYLDCVIKE
VMRLFTPISGGYRTVLQTFELDGFQIPKGWSVMYSIRDTHDTAPVFKDVNVFDPDRFSQA
RSEDKDGRFHYLPFGGGVRTCLGKHLAKLFLKVLAVELASTSRFELATRTFPRITLVPVL
HPVDGLSVKFFGLDSNQNEILPETEAMLSATV
|
| External Links |
|---|
| GenBank ID Protein
| 62822141 |
| UniProtKB/Swiss-Prot ID
| Q9NR63 |
| UniProtKB/Swiss-Prot Entry Name
| CP26B_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AC007002 |
| GeneCard ID
| CYP26B1 |
| GenAtlas ID
| CYP26B1 |
| HGNC ID
| HGNC:20581 |
| References |
|---|
| General References
| Not Available |