Cannabis Compound Database: Showing Protein NADPH--cytochrome P450 reductase (CDBP00178)

Identification Biological properties Gene properties Protein properties External links References XML Show 6 compounds

Identification

HMDB Protein ID

CDBP00178

Secondary Accession Numbers

Not Available

Name

NADPH--cytochrome P450 reductase

Description

Not Available

Synonyms

CPR
P450R

Gene Name

POR

Protein Type

Enzyme

Biological Properties

General Function

Involved in oxidoreductase activity

Specific Function

This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5.

GO Classification

Biological Process
negative regulation of lipase activity
nitrate catabolic process
nitric oxide catabolic process
positive regulation of cholesterol biosynthetic process
negative regulation of apoptotic process
positive regulation of monooxygenase activity
cellular response to follicle-stimulating hormone stimulus
positive regulation of smoothened signaling pathway
cellular response to peptide hormone stimulus
regulation of growth plate cartilage chondrocyte proliferation
positive regulation of steroid hormone biosynthetic process
carnitine metabolic process
response to drug
response to nutrient
flavonoid metabolic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of chondrocyte differentiation
cellular organofluorine metabolic process
fatty acid oxidation
demethylation
internal peptidyl-lysine acetylation
Cellular Component
endoplasmic reticulum membrane
endoplasmic reticulum
mitochondrion
Function
catalytic activity
transition metal ion binding
iron ion binding
fmn binding
oxidoreductase activity
ion binding
cation binding
metal ion binding
binding
nucleotide binding
Molecular Function
electron carrier activity
NADP binding
cytochrome-b5 reductase activity
iron ion binding
FMN binding
iron-cytochrome-c reductase activity
NADPH-hemoprotein reductase activity
flavin adenine dinucleotide binding
hydrolase activity
Process
metabolic process
oxidation reduction

Cellular Location

Peripheral membrane protein
Endoplasmic reticulum membrane

Pathways

Name	SMPDB/Pathwhiz	KEGG
Doxorubicin Metabolism Pathway		Not Available

Gene Properties

Chromosome Location

Locus

7q11.2

SNPs

POR

Gene Sequence

>2034 bp
ATGGGAGACTCCCACGTGGACACCAGCTCCACCGTGTCCGAGGCGGTGGCCGAAGAAGTA
TCTCTTTTCAGCATGACGGACATGATTCTGTTTTCGCTCATCGTGGGTCTCCTAACCTAC
TGGTTCCTCTTCAGAAAGAAAAAAGAAGAAGTCCCCGAGTTCACCAAAATTCAGACATTG
ACCTCCTCTGTCAGAGAGAGCAGCTTTGTGGAAAAGATGAAGAAAACGGGGAGGAACATC
ATCGTGTTCTACGGCTCCCAGACGGGGACTGCAGAGGAGTTTGCCAACCGCCTGTCCAAG
GACGCCCACCGCTACGGGATGCGAGGCATGTCAGCGGACCCTGAGGAGTATGACCTGGCC
GACCTGAGCAGCCTGCCAGAGATCGACAACGCCCTGGTGGTTTTCTGCATGGCCACCTAC
GGTGAGGGAGACCCCACCGACAATGCCCAGGACTTCTACGACTGGCTGCAGGAGACAGAC
GTGGATCTCTCTGGGGTCAAGTTCGCGGTGTTTGGTCTTGGGAACAAGACCTACGAGCAC
TTCAATGCCATGGGCAAGTACGTGGACAAGCGGCTGGAGCAGCTCGGCGCCCAGCGCATC
TTTGAGCTGGGGTTGGGCGACGACGATGGGAACTTGGAGGAGGACTTCATCACCTGGCGA
GAGCAGTTCTGGCCGGCCGTGTGTGAACACTTTGGGGTGGAAGCCACTGGCGAGGAGTCC
AGCATTCGCCAGTACGAGCTTGTGGTCCACACCGACATAGATGCGGCCAAGGTGTACATG
GGGGAGATGGGCCGGCTGAAGAGCTACGAGAACCAGAAGCCCCCCTTTGATGCCAAGAAT
CCGTTCCTGGCTGCAGTCACCACCAACCGGAAGCTGAACCAGGGAACCGAGCGCCACCTC
ATGCACCTGGAATTGGACATCTCGGACTCCAAAATCAGGTATGAATCTGGGGACCACGTG
GCTGTGTACCCAGCCAACGACTCTGCTCTCGTCAACCAGCTGGGCAAAATCCTGGGTGCC
GACCTGGACGTCGTCATGTCCCTGAACAACCTGGATGAGGAGTCCAACAAGAAGCACCCA
TTCCCGTGCCCTACGTCCTACCGCACGGCCCTCACCTACTACCTGGACATCACCAACCCG
CCGCGTACCAACGTGCTGTACGAGCTGGCGCAGTACGCCTCGGAGCCCTCGGAGCAGGAG
CTGCTGCGCAAGCTGGCCTCCTCCTCCGGCGAGGGCAAGGAGCTGTACCTGAGCTGGGTG
GTGGAGGCCCGGAGGCACATCCTGGCCATCCTGCAGGACTGCCCGTCCCTGCGGCCCCCC
ATCGACCACCTGTGTGAGCTGCTGCCGCGCCTGCAGGCCCGCTACTACTCCATCGCCTCA
TCCTCCAAGGTCCACCCCAACTCTGTGCACATCTGTGCGGTGGTTGTGGAGTACGAGACC
AAGGCCGGCCGCATCAACAAGGGCGTGGCCACCAACTGGCTGCGGGCCAAGGAGCCTGCC
GGGGAGAACGGCGGCCGTGCGCTGGTGCCCATGTTCGTGCGCAAGTCCCAGTTACGCCTG
CCCTTCAAGGCCACCACGCCTGTCATCATGGTGGGCCCCGGCACCGGGGTGGCACCCTTC
ATAGGCTTCATCCAGGAGCGGGCCTGGCTGCGACAGCAGGGCAAGGAGGTGGGGGAGACG
CTGCTGTACTACGGCTGCCGCCGCTCAGATGAGGACTACCTGTACCGGGAGGAGCTGGCG
CAGTTCCACAGGGACGGTGCGCTCACCCAGCTCAACGTGGCCTTCTCCCGGGAGCAGTCC
CACAAGGTCTACGTCCAGCACCTGCTAAAGCAAGACCGAGAGCACCTGTGGAAGTTGATC
GAAGGCGGTGCCCACATCTACGTCTGTGGGGATGCACGGAACATGGCCAGGGATGTGCAG
AACACCTTCTACGACATCGTGGCTGAGCTCGGGGCCATGGAGCACGCGCAGGCGGTGGAC
TACATCAAGAAACTGATGACCAAGGGCCGCTACTCCCTGGACGTGTGGAGCTAG

Protein Properties

Number of Residues

677

Molecular Weight

77047.575

Theoretical pI

5.578

Pfam Domain Function

NAD_binding_1 (PF00175 )
FAD_binding_1 (PF00667 )
Flavodoxin_1 (PF00258 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>NADPH--cytochrome P450 reductase
MGDSHVDTSSTVSEAVAEEVSLFSMTDMILFSLIVGLLTYWFLFRKKKEEVPEFTKIQTL
TSSVRESSFVEKMKKTGRNIIVFYGSQTGTAEEFANRLSKDAHRYGMRGMSADPEEYDLA
DLSSLPEIDNALVVFCMATYGEGDPTDNAQDFYDWLQETDVDLSGVKFAVFGLGNKTYEH
FNAMGKYVDKRLEQLGAQRIFELGLGDDDGNLEEDFITWREQFWPAVCEHFGVEATGEES
SIRQYELVVHTDIDAAKVYMGEMGRLKSYENQKPPFDAKNPFLAAVTTNRKLNQGTERHL
MHLELDISDSKIRYESGDHVAVYPANDSALVNQLGKILGADLDVVMSLNNLDEESNKKHP
FPCPTSYRTALTYYLDITNPPRTNVLYELAQYASEPSEQELLRKMASSSGEGKELYLSWV
VEARRHILAILQDCPSLRPPIDHLCELLPRLQARYYSIASSSKVHPNSVHICAVVVEYET
KAGRINKGVATNWLRAKEPAGENGGRALVPMFVRKSQFRLPFKATTPVIMVGPGTGVAPF
IGFIQERAWLRQQGKEVGETLLYYGCRRSDEDYLYREELAQFHRDGALTQLNVAFSREQS
HKVYVQHLLKQDREHLWKLIEGGAHIYVCGDARNMARDVQNTFYDIVAELGAMEHAQAVD
YIKKLMTKGRYSLDVWS

External Links

GenBank ID Protein

11414998

UniProtKB/Swiss-Prot ID

P16435

UniProtKB/Swiss-Prot Entry Name

NCPR_HUMAN

PDB IDs

GenBank Gene ID

GeneCard ID

GenAtlas ID

HGNC ID

References

General References

Not Available