Identification
HMDB Protein ID CDBP01587
Secondary Accession Numbers Not Available
Name Cytochrome c
Description Not Available
Synonyms Not Available
Gene Name CYCS
Protein Type Metal Binding
Biological Properties
General Function Involved in iron ion binding
Specific Function Plays a role in apoptosis. Suppression of the anti- apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases
GO Classification
Function
ion binding
cation binding
metal ion binding
binding
transition metal ion binding
electron carrier activity
iron ion binding
heme binding
Cellular Location
  1. Mitochondrion matrix
Pathways
Gene Properties
Chromosome Location Chromosome:7
Locus 7p15.3
SNPs CYCS
Gene Sequence
>318 bp
ATGGGTGATGTTGAGAAAGGCAAGAAGATTTTTATTATGAAGTGTTCCCAGTGCCACACC
GTTGAAAAGGGAGGCAAGCACAAGACTGGGCCAAATCTCCATGGTCTCTTTGGGCGGAAG
ACAGGTCAGGCCCCTGGATACTCTTACACAGCCGCCAATAAGAACAAAGGCATCATCTGG
GGAGAGGATACACTGATGGAGTATTTGGAGAATCCCAAGAAGTACATCCCTGGAACAAAA
ATGATCTTTGTCGGCATTAAGAAGAAGGAAGAAAGGGCAGACTTAATAGCTTATCTCAAA
AAAGCTACTAATGAGTAG
Protein Properties
Number of Residues 105
Molecular Weight 11748.7
Theoretical pI 10.16
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["None"]
Protein Sequence
>Cytochrome c
MGDVEKGKKIFIMKCSQCHTVEKGGKHKTGPNLHGLFGRKTGQAPGYSYTAANKNKGIIW
GEDTLMEYLENPKKYIPGTKMIFVGIKKKEERADLIAYLKKATNE
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P99999
UniProtKB/Swiss-Prot Entry Name CYC_HUMAN
PDB IDs
GenBank Gene ID BT006946
GeneCard ID CYCS
GenAtlas ID CYCS
HGNC ID HGNC:19986
References
General References Not Available