Record Information
Version1.0
Created at2020-04-17 18:48:16 UTC
Updated at2020-12-07 19:11:13 UTC
CannabisDB IDCDB004898
Secondary Accession NumbersNot Available
Cannabis Compound Identification
Common NameFAD
DescriptionFAD, also known as adeflavin or flamitajin b, belongs to the class of organic compounds known as flavin nucleotides. These are nucleotides containing a flavin moiety. Flavin is a compound that contains the tricyclic isoalloxazine ring system, which bears 2 oxo groups at the 2- and 4-positions. FAD is a drug which is used to treat eye diseases caused by vitamin b2 deficiency, such as keratitis and blepharitis. FAD is a strong basic compound (based on its pKa). FAD exists in all living species, ranging from bacteria to humans. In humans, FAD is involved in the metabolic disorder called the medium chain acyl-coa dehydrogenase deficiency (mcad) pathway. Outside of the human body, FAD has been detected, but not quantified in, several different foods, such as other bread, passion fruits, asparagus, kelps, and green bell peppers. This could make FAD a potential biomarker for the consumption of these foods. A FAD in which the substituent at position 10 of the flavin nucleus is a 5'-adenosyldiphosphoribityl group. FAD is expected to be in Cannabis as all living plants are known to produce and metabolize it.
Structure
Thumb
Synonyms
ValueSource
Adenosine 5'-(trihydrogen pyrophosphate), 5'-5'-ester with riboflavineChEBI
Adenosine 5'-[3-(riboflavin-5'-yl) dihydrogen diphosphate]ChEBI
Flavin adenine dinucleotideChEBI
FLAVIN-adenine dinucleotideChEBI
Riboflavin 5'-(trihydrogen diphosphate), 5'-5'-ester with adenosineChEBI
Riboflavin 5'-adenosine diphosphateChEBI
AdeflavinKegg
Adenosine 5'-(trihydrogen pyrophosphoric acid), 5'-5'-ester with riboflavineGenerator
Adenosine 5'-[3-(riboflavin-5'-yl) dihydrogen diphosphoric acid]Generator
Riboflavin 5'-(trihydrogen diphosphoric acid), 5'-5'-ester with adenosineGenerator
Riboflavin 5'-adenosine diphosphoric acidGenerator
1H-Purin-6-amine flavin dinucleotideHMDB
1H-Purin-6-amine flavine dinucleotideHMDB
Adenine-flavin dinucleotideHMDB
Adenine-flavine dinucleotideHMDB
Adenine-riboflavin dinuceotideHMDB
Adenine-riboflavin dinucleotideHMDB
Adenine-riboflavine dinucleotideHMDB
Flamitajin bHMDB
Flanin FHMDB
Flavin adenine dinucleotide oxidizedHMDB
Flavine adenosine diphosphateHMDB
Flavine-adenine dinucleotideHMDB
FlavitanHMDB
FlazirenHMDB
Isoalloxazine-adenine dinucleotideHMDB
Riboflavin-adenine dinucleotideHMDB
Riboflavine-adenine dinucleotideHMDB
Dinucleotide, flavin-adenineHMDB
Chemical FormulaC27H33N9O15P2
Average Molecular Weight785.55
Monoisotopic Molecular Weight785.1571
IUPAC Name{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}[({[(2R,3S,4S)-5-{7,8-dimethyl-2,4-dioxo-2H,3H,4H,10H-benzo[g]pteridin-10-yl}-2,3,4-trihydroxypentyl]oxy}(hydroxy)phosphoryl)oxy]phosphinic acid
Traditional Nameflavine-adenine dinucleotide
CAS Registry Number146-14-5
SMILES
CC1=CC2=C(C=C1C)N(C[C@H](O)[C@H](O)[C@H](O)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC3=C1N=CN=C3N)C1=NC(=O)NC(=O)C1=N2
InChI Identifier
InChI=1S/C27H33N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H,34,42,43)/t14-,15+,16+,19-,20+,21+,26+/m0/s1
InChI KeyVWWQXMAJTJZDQX-UYBVJOGSSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as flavin nucleotides. These are nucleotides containing a flavin moiety. Flavin is a compound that contains the tricyclic isoalloxazine ring system, which bears 2 oxo groups at the 2- and 4-positions.
KingdomOrganic compounds
Super ClassNucleosides, nucleotides, and analogues
ClassFlavin nucleotides
Sub ClassNot Available
Direct ParentFlavin nucleotides
Alternative Parents
Substituents
  • Flavin nucleotide
  • (3'->5')-dinucleotide
  • (3'->5')-dinucleotide or analogue
  • Purine ribonucleoside diphosphate
  • Purine ribonucleoside monophosphate
  • Flavin
  • Isoalloxazine
  • Pentose-5-phosphate
  • Pentose phosphate
  • Glycosyl compound
  • N-glycosyl compound
  • Diazanaphthalene
  • Pentose monosaccharide
  • Pteridine
  • 6-aminopurine
  • Quinoxaline
  • Organic pyrophosphate
  • Monosaccharide phosphate
  • Imidazopyrimidine
  • Purine
  • Monoalkyl phosphate
  • Aminopyrimidine
  • Pyrimidone
  • Monosaccharide
  • N-substituted imidazole
  • Organic phosphoric acid derivative
  • Imidolactam
  • Benzenoid
  • Alkyl phosphate
  • Phosphoric acid ester
  • Pyrimidine
  • Pyrazine
  • Tetrahydrofuran
  • Azole
  • Vinylogous amide
  • Heteroaromatic compound
  • Imidazole
  • Secondary alcohol
  • Lactam
  • Polyol
  • Oxacycle
  • Azacycle
  • Organoheterocyclic compound
  • Organic oxide
  • Organic oxygen compound
  • Organopnictogen compound
  • Organonitrogen compound
  • Hydrocarbon derivative
  • Primary amine
  • Alcohol
  • Amine
  • Organic nitrogen compound
  • Organooxygen compound
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Ontology
Physiological effect

Health effect:

Disposition

Route of exposure:

Source:

Biological location:

Role

Industrial application:

Physical Properties
StateSolid
Experimental Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water Solubility5 mg/mLNot Available
logP-1.336Wikipedia
Predicted Properties
PropertyValueSource
logP-0.78ALOGPS
logP-4.7ChemAxon
logS-2.3ALOGPS
pKa (Strongest Acidic)1.85ChemAxon
pKa (Strongest Basic)4.01ChemAxon
Physiological Charge-3ChemAxon
Hydrogen Acceptor Count19ChemAxon
Hydrogen Donor Count9ChemAxon
Polar Surface Area356.42 ŲChemAxon
Rotatable Bond Count13ChemAxon
Refractivity177.43 m³·mol⁻¹ChemAxon
Polarizability70.53 ųChemAxon
Number of Rings6ChemAxon
BioavailabilityNoChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Spectra
EI-MS/GC-MS
TypeDescriptionSplash KeyView
Predicted GC-MSFAD, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positivesplash10-0170-1032960400-cdd3286ebb1dea7c4f54Spectrum
MS/MS
TypeDescriptionSplash KeyView
MS/MSLC-MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)splash10-000i-0001200900-b0740b3d33d50996ccdeSpectrum
MS/MSLC-MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated)splash10-000m-0105900000-3abff26d5bb35f8527b8Spectrum
MS/MSLC-MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated)splash10-000i-0931700000-73f360589a13230eea7aSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positivesplash10-000j-0908600300-b1eccda8ebae8b9e4cc1Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positivesplash10-000i-0900000000-bdb826f9c3cbc09eff9bSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positivesplash10-00di-0019800000-00ad56b6b6a3bb4516e6Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positivesplash10-000b-0009400000-667064ca470a5c341974Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positivesplash10-000j-0509700500-8766cb874f927ed5a795Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positivesplash10-000i-0900000000-3125e04c09a14c62f22aSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positivesplash10-00di-0019700000-78c46ea4b4f562757e56Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positivesplash10-000b-0009400000-94b845d2c8d082b9484cSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negativesplash10-001i-0000100900-6bac7b7f631dfc074a0cSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negativesplash10-001i-0920000000-49c9d4fb9b57a59f45a5Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negativesplash10-000i-0003900000-572f0b1bd59f71ab3c5fSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negativesplash10-000i-0003900000-d2ede6a2e7183f1c32a3Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negativesplash10-001i-0000100900-78554afbc26abe26af35Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negativesplash10-001i-0930000000-274da0a01c651b791733Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negativesplash10-000i-0003900000-55939cda9e14fc582757Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negativesplash10-000i-0003900000-db784762434fac3d351fSpectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-000i-0932110400-f05626487523221c34deSpectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-000i-0930000000-86c3d6490bc3a27e053aSpectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-052r-0980000000-58a46c839e0e520474d7Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-0006-8482400900-2c4839849821d2807c57Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-001l-5920100000-b38889aa3d09576e2f3eSpectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-0a7l-3900000000-f7144f6355fab252a516Spectrum
NMR
TypeDescriptionView
1D NMR1H NMR SpectrumSpectrum
2D NMR[1H,1H] 2D NMR SpectrumSpectrum
2D NMR[1H,13C] 2D NMR SpectrumSpectrum
Pathways
Pathways
Protein Targets
Enzymes
Protein NameGene NameLocusUniprot IDDetails
Dihydrolipoyl dehydrogenase, mitochondrialDLD7q31-q32P09622 details
Long-chain specific acyl-CoA dehydrogenase, mitochondrialACADL2q34P28330 details
Short-chain specific acyl-CoA dehydrogenase, mitochondrialACADS12q24.31P16219 details
Medium-chain specific acyl-CoA dehydrogenase, mitochondrialACADM1p31P11310 details
NADH-ubiquinone oxidoreductase chain 1MT-ND1P03886 details
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1NDUFB114q32.12O75438 details
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1ENPP16q22-q23P22413 details
NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrialNDUFS21q23O75306 details
Succinate dehydrogenase cytochrome b560 subunit, mitochondrialSDHC1q23.3Q99643 details
Peroxisomal sarcosine oxidasePIPOX17q11.2Q9P0Z9 details
Peroxisomal N(1)-acetyl-spermine/spermidine oxidasePAOX10q26.3Q6QHF9 details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12NDUFA1212q22Q9UI09 details
NADH-cytochrome b5 reductase 3CYB5R322q13.2P00387 details
Aldehyde oxidaseAOX12q33Q06278 details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1NDUFA1O15239 details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2NDUFA4L212q13.3Q9NRX3 details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3NDUFA319q13.42O95167 details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8NDUFA89q33.2P51970 details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4NDUFA47p21.3O00483 details
NADH-ubiquinone oxidoreductase chain 4LMT-ND4LP03901 details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11NDUFA1119p13.3Q86Y39 details
Thioredoxin reductase 1, cytoplasmicTXNRD112q23-q24.1Q16881 details
Lathosterol oxidaseSC5DL11q23.3O75845 details
NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrialNDUFS45q11.1O43181 details
Ribosyldihydronicotinamide dehydrogenase [quinone]NQO26p25.2P16083 details
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrialNDUFS311p11.11O75489 details
NADH dehydrogenase [ubiquinone] iron-sulfur protein 5NDUFS51p34.2-p33O43920 details
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrialNDUFV218p11.22P19404 details
Dimethylaniline monooxygenase [N-oxide-forming] 5FMO51q21.1P49326 details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrialNDUFA102q37.3O95299 details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6NDUFA622q13.2P56556 details
Peroxisomal acyl-coenzyme A oxidase 1ACOX117q25.1Q15067 details
D-aspartate oxidaseDDO6q21Q99489 details
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4NDUFB43q13.33O95168 details
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrialSDHA5p15P31040 details
Heme oxygenase 2HMOX216p13.3P30519 details
NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrialNDUFS811q13O00217 details
Squalene monooxygenaseSQLE8q24.1Q14534 details
NADH-ubiquinone oxidoreductase chain 2MT-ND2P03891 details
Dimethylaniline monooxygenase [N-oxide-forming] 2FMO21q24.3Q99518 details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7NDUFA719p13.2O95182 details
Thioredoxin reductase 2, mitochondrialTXNRD222q11.21Q9NNW7 details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2NDUFA25q31O43678 details
Methionine synthaseMTR1q43Q99707 details
Amine oxidase [flavin-containing] BMAOBXp11.23P27338 details
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrialNDUFS12q33-q34P28331 details
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrialNDUFB53q26.33O43674 details
Peroxisomal acyl-coenzyme A oxidase 2ACOX23p14.3Q99424 details
Dimethylaniline monooxygenase [N-oxide-forming] 4FMO41q24.3P31512 details
Isovaleryl-CoA dehydrogenase, mitochondrialIVD15q14-q15P26440 details
Amine oxidase [flavin-containing] AMAOAXp11.3P21397 details
NADH dehydrogenase [ubiquinone] 1 subunit C2NDUFC211q14.1O95298 details
Dimethylaniline monooxygenase [N-oxide-forming] 3FMO31q24.3P31513 details
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3NDUFB32q31.3O43676 details
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7NDUFB719p13.12P17568 details
Acyl carrier protein, mitochondrialNDUFAB116p12.2O14561 details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5NDUFA57q32Q16718 details
Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrialETFDH4q32-q35Q16134 details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrialNDUFA912p13.3Q16795 details
NADH-ubiquinone oxidoreductase chain 4MT-ND4P03905 details
Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrialSDHD11q23O14521 details
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrialNDUFS719p13.3O75251 details
Xanthine dehydrogenase/oxidaseXDH2p23.1P47989 details
NADPH--cytochrome P450 reductasePOR7q11.2P16435 details
Dihydroorotate dehydrogenase (quinone), mitochondrialDHODH16q22Q02127 details
Dimethylaniline monooxygenase [N-oxide-forming] 1FMO11q24.3Q01740 details
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrialNDUFV111q13P49821 details
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9NDUFB98q13.3Q9Y6M9 details
Methylenetetrahydrofolate reductaseMTHFR1p36.3P42898 details
NADH-ubiquinone oxidoreductase chain 6MT-ND6P03923 details
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13NDUFA1319p13.2Q9P0J0 details
NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrialNDUFS65p15.33O75380 details
Peroxisomal acyl-coenzyme A oxidase 3ACOX34p15.3O15254 details
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrialSDHB1p36.1-p35P21912 details
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3ENPP36q22O14638 details
Glutathione reductase, mitochondrialGSR8p21.1P00390 details
Glycerol-3-phosphate dehydrogenase, mitochondrialGPD22q24.1P43304 details
Heme oxygenase 1HMOX122q13.1P09601 details
Retinal dehydrogenase 1ALDH1A19q21.13P00352 details
Choline dehydrogenase, mitochondrialCHDH3p21.1Q8NE62 details
Glutaryl-CoA dehydrogenase, mitochondrialGCDH19p13.2Q92947 details
Dimethylglycine dehydrogenase, mitochondrialDMGDH5q14.1Q9UI17 details
NADPH:adrenodoxin oxidoreductase, mitochondrialFDXR17q24-q25P22570 details
Retinal dehydrogenase 2ALDH1A215q21.3O94788 details
D-amino-acid oxidaseDAO12q24P14920 details
Methionine synthase reductaseMTRR5p15.31Q9UBK8 details
tRNA-dihydrouridine synthase 2-likeDUS2L16q22.1Q9NX74 details
Flavin reductase (NADPH)BLVRB19q13.1-q13.2P30043 details
Dihydropyrimidine dehydrogenase [NADP(+)]DPYD1p22Q12882 details
Sarcosine dehydrogenase, mitochondrialSARDH9q33-q34Q9UL12 details
Nitric oxide synthase, inducibleNOS217q11.2-q12P35228 details
Nitric oxide synthase, brainNOS112q24.2-q24.31P29475 details
Nitric oxide synthase, endothelialNOS37q36P29474 details
Protoporphyrinogen oxidasePPOX1q22P50336 details
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrialNDUFB11Q9NX14 details
Alkyldihydroxyacetonephosphate synthase, peroxisomalAGPS2q31.2O00116 details
Short/branched chain specific acyl-CoA dehydrogenase, mitochondrialACADSB10q26.13P45954 details
NAD(P)H dehydrogenase [quinone] 1NQO116q22.1P15559 details
Putative dimethylaniline monooxygenase [N-oxide-forming] 6FMO6PO60774 details
Delta(24)-sterol reductaseDHCR241p32.3Q15392 details
Proline dehydrogenase 1, mitochondrialPRODH22q11.21O43272 details
D-2-hydroxyglutarate dehydrogenase, mitochondrialD2HGDH2q37.3Q8N465 details
L-2-hydroxyglutarate dehydrogenase, mitochondrialL2HGDH14q21.3Q9H9P8 details
Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing)DAK11q12.2Q3LXA3 details
Kynurenine 3-monooxygenaseKMO1q42-q44O15229 details
Spermine oxidaseSMOX20p13Q9NWM0 details
Dual oxidase 2DUOX215q15.3Q9NRD8 details
Probable D-lactate dehydrogenase, mitochondrialLDHD16q23.1Q86WU2 details
Isobutyryl-CoA dehydrogenase, mitochondrialACAD811q25Q9UKU7 details
Acyl-CoA dehydrogenase family member 9, mitochondrialACAD93q21.3Q9H845 details
Probable proline dehydrogenase 2PRODH219q13.1Q9UF12 details
Dual oxidase 1DUOX115q15.3Q9NRD9 details
Thioredoxin reductase 3TXNRD33q21.3Q86VQ6 details
NADH-cytochrome b5 reductase 1CYB5R11q32.1Q9UHQ9 details
NADH-cytochrome b5 reductase 2CYB5R211p15.4Q6BCY4 details
Cytochrome b5 reductase 4CYB5R46pter-q22.33Q7L1T6 details
NADH-cytochrome b5 reductase-likeCYB5RL1p32.3Q6IPT4 details
Putative uncharacterized protein DKFZp686B0215DKFZp686B0215Q5HYI4 details
FAD synthaseFLAD11q21.3Q8NFF5 details
Ubiquinone biosynthesis monooxygenase COQ6COQ6Q9Y2Z9 details
NADPH oxidase 5NOX515q23Q96PH1 details
NADPH oxidase 3NOX36q25.3Q9HBY0 details
Metalloreductase STEAP3STEAP32q14.2Q658P3 details
Very long-chain specific acyl-CoA dehydrogenase, mitochondrialACADVL17p13.1P49748 details
Acyl-coenzyme A oxidase-like proteinACOXL2q13Q9NUZ1 details
FAD-linked sulfhydryl oxidase ALRGFER16p13.3-p13.12P55789 details
Lysine-specific histone demethylase 1BKDM1B6p22.3Q8NB78 details
tRNA-dihydrouridine synthase 1-likeDUS1L17q25.3Q6P1R4 details
tRNA-dihydrouridine synthase 3-likeDUS3L19p13.3Q96G46 details
tRNA-dihydrouridine synthase 4-likeDUS4L7q22-q31O95620 details
FAD-dependent oxidoreductase domain-containing protein 1FOXRED111q24.2Q96CU9 details
FAD-dependent oxidoreductase domain-containing protein 2FOXRED222q12.3Q8IWF2 details
Lysine-specific histone demethylase 1AKDM1A1p36.12O60341 details
Protein-methionine sulfoxide oxidase MICAL1MICAL16q21Q8TDZ2 details
Protein-methionine sulfoxide oxidase MICAL2MICAL211p15.3O94851 details
Protein-methionine sulfoxide oxidase MICAL3MICAL322q11.21Q7RTP6 details
NADPH-dependent diflavin oxidoreductase 1NDOR19q34.3Q9UHB4 details
NADPH oxidase 1NOX1Q9Y5S8 details
NADPH oxidase 4NOX411q14.2-q21Q9NPH5 details
L-amino-acid oxidaseIL4I119q13.3-q13.4Q96RQ9 details
Oxidoreductase NAD-binding domain-containing protein 1OXNAD13p25-p24Q96HP4 details
Prenylcysteine oxidase 1PCYOX12p13.3Q9UHG3 details
Prenylcysteine oxidase-likePCYOX1L5q32Q8NBM8 details
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrialPDP216q22.1Q9P2J9 details
Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1PYROXD112p12.1Q8WU10 details
Sulfhydryl oxidase 1QSOX11q24O00391 details
Sulfhydryl oxidase 2QSOX29q34.3Q6ZRP7 details
RenalaseRNLS10q23.31Q5VYX0 details
All-trans-retinol 13,14-reductaseRETSAT2p11.2Q6NUM9 details
Sulfide:quinone oxidoreductase, mitochondrialSQRDL15q15Q9Y6N5 details
Metalloreductase STEAP1STEAP17q21Q9UHE8 details
Metalloreductase STEAP2STEAP27q21Q8NFT2 details
Metalloreductase STEAP4STEAP47q21.12Q687X5 details
NADH dehydrogenase (Ubiquinone) 1 beta subcomplex, 2, 8kDaNDUFB27q34A4D1T5 details
Transporters
Protein NameGene NameLocusUniprot IDDetails
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11NDUFA1119p13.3Q86Y39 details
Acyl carrier protein, mitochondrialNDUFAB116p12.2O14561 details
Nitric oxide synthase, inducibleNOS217q11.2-q12P35228 details
Metal Bindings
Protein NameGene NameLocusUniprot IDDetails
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1ENPP16q22-q23P22413 details
NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrialNDUFS21q23O75306 details
Succinate dehydrogenase cytochrome b560 subunit, mitochondrialSDHC1q23.3Q99643 details
Aldehyde oxidaseAOX12q33Q06278 details
Lathosterol oxidaseSC5DL11q23.3O75845 details
Ribosyldihydronicotinamide dehydrogenase [quinone]NQO26p25.2P16083 details
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrialNDUFV218p11.22P19404 details
Heme oxygenase 2HMOX216p13.3P30519 details
NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrialNDUFS811q13O00217 details
Methionine synthaseMTR1q43Q99707 details
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrialNDUFS12q33-q34P28331 details
Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrialETFDH4q32-q35Q16134 details
Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrialSDHD11q23O14521 details
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrialNDUFS719p13.3O75251 details
Xanthine dehydrogenase/oxidaseXDH2p23.1P47989 details
NADPH--cytochrome P450 reductasePOR7q11.2P16435 details
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrialNDUFV111q13P49821 details
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrialSDHB1p36.1-p35P21912 details
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3ENPP36q22O14638 details
Glycerol-3-phosphate dehydrogenase, mitochondrialGPD22q24.1P43304 details
Heme oxygenase 1HMOX122q13.1P09601 details
Methionine synthase reductaseMTRR5p15.31Q9UBK8 details
Dihydropyrimidine dehydrogenase [NADP(+)]DPYD1p22Q12882 details
Nitric oxide synthase, inducibleNOS217q11.2-q12P35228 details
Nitric oxide synthase, brainNOS112q24.2-q24.31P29475 details
Nitric oxide synthase, endothelialNOS37q36P29474 details
Cytochrome b-245 heavy chainCYBBP04839 details
Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing)DAK11q12.2Q3LXA3 details
Dual oxidase 2DUOX215q15.3Q9NRD8 details
Dual oxidase 1DUOX115q15.3Q9NRD9 details
Cytochrome b5 reductase 4CYB5R46pter-q22.33Q7L1T6 details
NADPH oxidase 5NOX515q23Q96PH1 details
NADPH oxidase 3NOX36q25.3Q9HBY0 details
Metalloreductase STEAP3STEAP32q14.2Q658P3 details
Lysine-specific histone demethylase 1BKDM1B6p22.3Q8NB78 details
tRNA-dihydrouridine synthase 3-likeDUS3L19p13.3Q96G46 details
Protein-methionine sulfoxide oxidase MICAL1MICAL16q21Q8TDZ2 details
Protein-methionine sulfoxide oxidase MICAL2MICAL211p15.3O94851 details
Protein-methionine sulfoxide oxidase MICAL3MICAL322q11.21Q7RTP6 details
NADPH-dependent diflavin oxidoreductase 1NDOR19q34.3Q9UHB4 details
NADPH oxidase 1NOX1Q9Y5S8 details
NADPH oxidase 4NOX411q14.2-q21Q9NPH5 details
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrialPDP216q22.1Q9P2J9 details
Metalloreductase STEAP1STEAP17q21Q9UHE8 details
Metalloreductase STEAP2STEAP27q21Q8NFT2 details
Metalloreductase STEAP4STEAP47q21.12Q687X5 details
Receptors
Protein NameGene NameLocusUniprot IDDetails
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1ENPP16q22-q23P22413 details
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3ENPP36q22O14638 details
Retinal dehydrogenase 2ALDH1A215q21.3O94788 details
Nitric oxide synthase, brainNOS112q24.2-q24.31P29475 details
Transcriptional Factors
Protein NameGene NameLocusUniprot IDDetails
Heme oxygenase 1HMOX122q13.1P09601 details
Nitric oxide synthase, brainNOS112q24.2-q24.31P29475 details
Isobutyryl-CoA dehydrogenase, mitochondrialACAD811q25Q9UKU7 details
Lysine-specific histone demethylase 1AKDM1A1p36.12O60341 details
Concentrations Data
Not Available
HMDB IDHMDB0001248
DrugBank IDDB03147
Phenol Explorer Compound IDNot Available
FoodDB IDFDB022511
KNApSAcK IDC00001500
Chemspider ID559059
KEGG Compound IDC00016
BioCyc IDFAD
BiGG ID33521
Wikipedia LinkFlavin_adenine_dinucleotide
METLIN ID6106
PubChem Compound643975
PDB IDNot Available
ChEBI ID16238
References
General ReferencesNot Available

Only showing the first 10 proteins. There are 211 proteins in total.

Enzymes

General function:
Involved in oxidoreductase activity
Specific function:
Lipoamide dehydrogenase is a component of the glycine cleavage system as well as of the alpha-ketoacid dehydrogenase complexes. Involved in the hyperactivation of spermatazoa during capacitation and in the spermatazoal acrosome reaction.
Gene Name:
DLD
Uniprot ID:
P09622
Molecular weight:
54176.91
General function:
Involved in acyl-CoA dehydrogenase activity
Specific function:
Not Available
Gene Name:
ACADL
Uniprot ID:
P28330
Molecular weight:
47655.275
General function:
Involved in acyl-CoA dehydrogenase activity
Specific function:
Not Available
Gene Name:
ACADS
Uniprot ID:
P16219
Molecular weight:
44296.705
General function:
Involved in acyl-CoA dehydrogenase activity
Specific function:
This enzyme is specific for acyl chain lengths of 4 to 16.
Gene Name:
ACADM
Uniprot ID:
P11310
Molecular weight:
46587.98
General function:
Involved in oxidation reduction
Specific function:
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
Gene Name:
MT-ND1
Uniprot ID:
P03886
Molecular weight:
35660.055
General function:
Involved in NADH dehydrogenase activity
Specific function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Gene Name:
NDUFB1
Uniprot ID:
O75438
Molecular weight:
6961.2
General function:
Involved in catalytic activity
Specific function:
Involved primarily in ATP hydrolysis at the plasma membrane. Plays a role in regulating pyrophosphate levels, and functions in bone mineralization and soft tissue calcification. In vitro, has a broad specificity, hydrolyzing other nucleoside 5' triphosphates such as GTP, CTP, TTP and UTP to their corresponding monophosphates with release of pyrophosphate and diadenosine polyphosphates, and also 3',5'-cAMP to AMP. May also be involved in the regulation of the availability of nucleotide sugars in the endoplasmic reticulum and Golgi, and the regulation of purinergic signaling. Appears to modulate insulin sensitivity.
Gene Name:
ENPP1
Uniprot ID:
P22413
Molecular weight:
104923.58
General function:
Involved in oxidoreductase activity, acting on NADH or NADPH
Specific function:
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
Gene Name:
NDUFS2
Uniprot ID:
O75306
Molecular weight:
51851.59
General function:
Involved in succinate dehydrogenase activity
Specific function:
Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
Gene Name:
SDHC
Uniprot ID:
Q99643
Molecular weight:
16650.185
General function:
Involved in oxidoreductase activity
Specific function:
Metabolizes sarcosine, L-pipecolic acid and L-proline.
Gene Name:
PIPOX
Uniprot ID:
Q9P0Z9
Molecular weight:
44065.515

Transporters

General function:
Involved in protein transporter activity
Specific function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Gene Name:
NDUFA11
Uniprot ID:
Q86Y39
Molecular weight:
14852.0
General function:
Involved in acyl carrier activity
Specific function:
Carrier of the growing fatty acid chain in fatty acid biosynthesis in mitochondria. Accessory and non-catalytic subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain
Gene Name:
NDUFAB1
Uniprot ID:
O14561
Molecular weight:
17417.1
General function:
Involved in oxidoreductase activity
Specific function:
Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2.
Gene Name:
NOS2
Uniprot ID:
P35228
Molecular weight:
131116.3

Only showing the first 10 proteins. There are 211 proteins in total.