Identification
HMDB Protein ID CDBP03436
Secondary Accession Numbers Not Available
Name NADPH oxidase 3
Description Not Available
Synonyms
  1. GP91-3
  2. MOX-2
  3. Mitogenic oxidase 2
  4. gp91phox homolog 3
Gene Name NOX3
Protein Type Enzyme
Biological Properties
General Function Involved in oxidoreductase activity
Specific Function NADPH oxidase which constitutively produces superoxide upon formation of a complex with CYBA/p22phox. Plays a role in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity
GO Classification
Component
membrane
cell part
membrane part
intrinsic to membrane
integral to membrane
Function
oxidoreductase activity
fad or fadh2 binding
ion binding
cation binding
metal ion binding
binding
catalytic activity
transition metal ion binding
nucleoside binding
purine nucleoside binding
adenyl nucleotide binding
electron carrier activity
iron ion binding
Process
metabolic process
oxidation reduction
Cellular Location
  1. Membrane
  2. Multi-pass membrane protein (Potential)
Pathways
Gene Properties
Chromosome Location Chromosome:6
Locus 6q25.3
SNPs NOX3
Gene Sequence
>1707 bp
ATGATGGGGTGCTGGATTTTGAATGAGGGTCTCTCCACCATATTAGTACTCTCATGGCTG
GGAATAAATTTTTATCTGTTTATTGACACGTTCTACTGGTATGAAGAGGAGGAGTCTTTC
CATTACACACGAGTTATTTTGGGTTCAACACTGGCTTGGGCACGAGCATCCGCACTGTGC
CTGAATTTTAACTGCATGCTAATTCTAATACCTGTCAGTCGAAACCTTATTTCATTCATA
AGAGGAACAAGTATTTGCTGCAGAGGACCGTGGAGGAGGCAATTAGACAAAAACCTCAGA
TTTCACAAACTGGTCGCCTATGGGATAGCTGTTAATGCAACCATCCACATCGTGGCGCAT
TTCTTCAACCTGGAACGCTACCACTGGAGCCAGTCCGAGGAGGCCCAGGGACTTCTGGCC
GCACTTTCCAAGCTGGGCAACACCCCTAACGAGAGCTACCTCAACCCTGTCCGGACCTTC
CCCACAAACACAACCACTGAATTGCTAAGGACAATAGCAGGCGTCACCGGTCTGGTGATC
TCTCTGGCTTTAGTCTTGATCATGACCTCGTCAACTGAGTTCATCAGACAGGCCTCCTAT
GAGTTGTTCTGGTACACACACCATGTTTTCATCGTCTTCTTTCTCAGCCTGGCCATCCAT
GGGACGGGTCGGATTGTTCGAGGCCAAACCCAAGACAGTCTCTCTCTGCACAACATCACC
TTCTGTAGAGACCGCTATGCAGAATGGCAGACAGTGGCCCAATGCCCCGTGCCTCAATTT
TCTGGCAAGGAACCCTCGGCTTGGAAATGGATTTTAGGCCCTGTGGTCTTGTATGCATGT
GAAAGAATAATTAGGTTCTGGCGATTTCAACAAGAAGTTGTCATTACCAAGGTGGTAAGC
CACCCCTCTGGAGTCCTGGAACTTCACATGAAAAAGCGTGGCTTTAAAATGGCGCCAGGG
CAGTACATCTTGGTGCAGTGCCCAGCCATATCTTCGCTGGAGTGGCACCCCTTCACCCTT
ACCTCTGCCCCCCAGGAAGACTTTTTCAGCGTGCACATCCGGGCAGCAGGAGACTGGACA
GCAGCGCTACTGGAGGCCTTTGGGGCAGAGGGACAGGCCCTCCAGGAGCCCTGGAGCCTG
CCAAGGCTGGCAGTGGACGGGCCCTTTGGAACTGCCCTGACAGATGTATTTCACTACCCA
GTGTGTGTGTGCGTTGCCGCGGGGATCGGAGTCACTCCCTTCGCTGCTCTTCTGAAATCT
ATATGGTACAAATGCAGTGAGGCACAGACCCCACTGAAGCTGAGCAAGGTGTATTTCTAC
TGGATTTGCCGGGATGCAAGAGCTTTTGAGTGGTTTGCTGATCTCTTACTCTCCCTGGAA
ACACGGATGAGTGAGCAGGGGAAAACTCACTTTCTGAGTTATCATATATTTCTTACCGGC
TGGGATGAAAATCAGGCTCTTCACATAGCTTTACACTGGGACGAAAATACTGACGTGATT
ACAGGCTTAAAGCAGAAGACCTTCTATGGGAGGCCCAACTGGAACAATGAGTTCAAGCAG
ATTGCCTACAATCACCCCAGCAGCAGTATTGGCGTGTTCTTCTGTGGACCTAAAGCTCTC
TCGAGGACACTTCAAAAGATGTGCCACTTGTATTCATCAGCTGACCCCAGAGGTGTTCAT
TTCTATTACAACAAGGAGAGCTTCTAG
Protein Properties
Number of Residues 568
Molecular Weight 64934.3
Theoretical pI 8.07
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["14-34", "52-72", "104-124", "168-188", "202-222", "396-416"]
Protein Sequence
>NADPH oxidase 3
MMGCWILNEGLSTILVLSWLGINFYLFIDTFYWYEEEESFHYTRVILGSTLAWARASALC
LNFNCMLILIPVSRNLISFIRGTSICCRGPWRRQLDKNLRFHKLVAYGIAVNATIHIVAH
FFNLERYHWSQSEEAQGLLAALSKLGNTPNESYLNPVRTFPTNTTTELLRTIAGVTGLVI
SLALVLIMTSSTEFIRQASYELFWYTHHVFIVFFLSLAIHGTGRIVRGQTQDSLSLHNIT
FCRDRYAEWQTVAQCPVPQFSGKEPSAWKWILGPVVLYACERIIRFWRFQQEVVITKVVS
HPSGVLELHMKKRGFKMAPGQYILVQCPAISSLEWHPFTLTSAPQEDFFSVHIRAAGDWT
AALLEAFGAEGQALQEPWSLPRLAVDGPFGTALTDVFHYPVCVCVAAGIGVTPFAALLKS
IWYKCSEAQTPLKLSKVYFYWICRDARAFEWFADLLLSLETRMSEQGKTHFLSYHIFLTG
WDENQALHIALHWDENTDVITGLKQKTFYGRPNWNNEFKQIAYNHPSSSIGVFFCGPKAL
SRTLQKMCHLYSSADPRGVHFYYNKESF
GenBank ID Protein 10441613
UniProtKB/Swiss-Prot ID Q9HBY0
UniProtKB/Swiss-Prot Entry Name NOX3_HUMAN
PDB IDs Not Available
GenBank Gene ID AF190122
GeneCard ID NOX3
GenAtlas ID NOX3
HGNC ID HGNC:7890
References
General References Not Available