| Identification |
|---|
| HMDB Protein ID
| CDBP03503 |
| Secondary Accession Numbers
| Not Available |
| Name
| Renalase |
| Description
| Not Available |
| Synonyms
|
- MAO-C
- Monoamine oxidase-C
|
| Gene Name
| RNLS |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in oxidoreductase activity |
| Specific Function
| Probable FAD-dependent amine oxidase secreted by the kidney, which circulates in blood and modulates cardiac function and systemic blood pressure. Degrades catecholamines such as dopamine, norepinephrine and epinephrine in vitro. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis. According to PubMed:17385068, is unlikely that renalase has physiologically relevant catecholamine-oxidizing activity |
| GO Classification
|
Not Available
|
| Cellular Location
|
- Secreted
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 10q23.31 |
| SNPs
| RNLS |
| Gene Sequence
|
>1029 bp
ATGGCGCAGGTGCTGATCGTGGGCGCCGGGATGACAGGAAGCTTGTGCGCTGCGCTGCTG
AGGAGGCAGACGTCCGGTCCCTTGTACCTTGCTGTGTGGGACAAGGCTGAGGACTCAGGG
GGAAGAATGACTACAGCCTGCAGTCCTCATAATCCTCAGTGCACAGCTGACTTGGGTGCT
CAGTACATCACCTGCACTCCTCATTATGCCAAAAAACACCAACGTTTTTATGATGAACTG
TTAGCCTATGGCGTTTTGAGGCCTCTAAGCTCGCCTATTGAAGGAATGGTGATGAAAGAA
GGAGACTGTAACTTTGTGGCACCTCAAGGAATTTCTTCAATTATTAAGCATTACTTGAAA
GAATCAGGTGCAGAAGTCTACTTCAGACATCGTGTGACACAGATCAACCTAAGAGATGAC
AAATGGGAAGTATCCAAACAAACAGGCTCCCCTGAGCAGTTTGATCTTATTGTTCTCACA
ATGCCAGTTCCTGAGATTCTGCAGCTTCAAGGTGACATCACCACCTTAATTAGTGAATGC
CAAAGGCAGCAACTGGAGGCTGTGAGCTACTCCTCTCGATATGCTCTGGGCCTCTTTTAT
GAAGCTGGTACGAAGATTGATGTCCCTTGGGCTGGGCAGTACATCACCAGTAATCCCTGC
ATACGCTTCGTCTCCATTGATAATAAGAAGCGCAATATAGAGTCATCAGAAATTGGGCCT
TCCCTCGTGATTCACACCACTGTCCCATTTGGAGTTACATACTTGGAACACAGCATTGAG
GATGTGCAAGAGTTAGTCTTCCAGCAGCTGGAAAACATTTTGCCGGGTTTGCCTCAGCCA
ATTGCTACCAAATGCCAAAAATGGAGACATTCACAGGTTACAAATGCTGCTGCCAACTGT
CCTGGCCAAATGACTCTGCATCACAAACCTTTCCTTGCATGTGGAGGGGATGGATTTACT
CAGTCCAACTTTGATGGCTGCATCACTTCTGCCCTATGTGTTCTGGAAGCTTTAAAGAAT
TATATTTAG
|
| Protein Properties |
|---|
| Number of Residues
| 342 |
| Molecular Weight
| 37847.0 |
| Theoretical pI
| 6.5 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Renalase
MAQVLIVGAGMTGSLCAALLRRQTSGPLYLAVWDKAEDSGGRMTTACSPHNPQCTADLGA
QYITCTPHYAKKHQRFYDELLAYGVLRPLSSPIEGMVMKEGDCNFVAPQGISSIIKHYLK
ESGAEVYFRHRVTQINLRDDKWEVSKQTGSPEQFDLIVLTMPVPEILQLQGDITTLISEC
QRQQLEAVSYSSRYALGLFYEAGTKIDVPWAGQYITSNPCIRFVSIDNKKRNIESSEIGP
SLVIHTTVPFGVTYLEHSIEDVQELVFQQLENILPGLPQPIATKCQKWRHSQVTNAAANC
PGQMTLHHKPFLACGGDGFTQSNFDGCITSALCVLEALKNYI
|
| External Links |
|---|
| GenBank ID Protein
| 237649117 |
| UniProtKB/Swiss-Prot ID
| Q5VYX0 |
| UniProtKB/Swiss-Prot Entry Name
| RNLS_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_001031709.2 |
| GeneCard ID
| RNLS |
| GenAtlas ID
| RNLS |
| HGNC ID
| HGNC:25641 |
| References |
|---|
| General References
| Not Available |