Identification
HMDB Protein ID CDBP03481
Secondary Accession Numbers Not Available
Name tRNA-dihydrouridine synthase 3-like
Description Not Available
Synonyms Not Available
Gene Name DUS3L
Protein Type Enzyme
Biological Properties
General Function Involved in catalytic activity
Specific Function Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs
GO Classification
Function
adenyl nucleotide binding
nucleic acid binding
oxidoreductase activity
fad or fadh2 binding
trna dihydrouridine synthase activity
oxidoreductase activity, acting on the ch-ch group of donors
ion binding
cation binding
metal ion binding
binding
catalytic activity
transition metal ion binding
zinc ion binding
nucleoside binding
purine nucleoside binding
Process
rna metabolic process
ncrna metabolic process
trna metabolic process
trna processing
metabolic process
macromolecule metabolic process
cellular macromolecule metabolic process
oxidation reduction
Cellular Location
  1. Cytoplasmic
Pathways
Gene Properties
Chromosome Location Chromosome:1
Locus 19p13.3
SNPs DUS3L
Gene Sequence
>1953 bp
ATGGCGGAGGGAACGGCGGAGGCTCCTCTAGAGAATGGTGGTGGTGGCGACTCGGGAGCC
GGAGCTTTGGAACGAGGAGTGGCGCCCATTAAGCGTCAATACCTCACCACCAAGGAGCAG
TTTCACCAATTCCTGGAAGCCAAAGGGCAGGAGAAGACTTGCCGGGAAACCGAGGTAGGA
GACCCTGCTGGCAATGAGCTGGCTGAGCCTGAGGCTAAGCGGATCCGACTGGAGGATGGA
CAGACGGCGGACGGGCAGACGGAGGAGGCAGCAGAGCCCGGGGAGCAGCTACAGACTCAG
AAGAGGGCCCGGGGACAAAACAAGGGCCGGCCCCATGTGAAGCCCACGAACTACGACAAG
AACAGGCTGTGTCCCTCCCTAATCCAGGAGTCGGCTGCTAATTGTTTCTTCGGTGATCGC
TGCCGCTTTCTGCACGACGTGGGGCGCTACCTGGAGACCAAGCCGGCCGACCTGGGCCCC
CGCTGCGTGCTCTTCGAGACCTTCGGCCGGTGCCCCTACGGCGTGACCTGCCGCTTCGCT
GGGGCCCACCTGAGGCCCGAGGGACAGAACCTGGTGCAGGAGGAGTTGGCGGCCCGCGGG
ACCCAGCCCCCGTCCATCCGCAACGGCCTGGACAAAGCCCTGCAGCAGCAGCTGCGGAAG
CGCGAGGTCCGCTTCGAGCGAGCTGAGCAGGCCCTGCGCCGGTTCAGCCAGGGCCCCACA
CCCGCTGCCGCTGTCCCCGAGGGCACGGCAGCCGAGGGCGCTCCCAGGCAGGAAAACTGT
GGTGCCCAGCAGGTCCCCGCAGGGCCGGGCACTAGCACCCCTCCCAGCAGCCCCGTGCGG
ACCTGCGGGCCCCTGACGGATGAGGACGTGGTCAGGCTGCGGCCCTGTGAGAAGAAGCGG
CTGGACATCCGTGGCAAACTTTACCTGGCCCCCCTCACCACGTGTGGGAACCTGCCCTTC
CGACGGATCTGCAAGCGCTTCGGGGCGGATGTGACATGTGGAGAGATGGCCGTCTGCACC
AACCTGCTGCAGGGCCAGATGTCCGAGTGGGCCCTACTCAAACGCCACCAGTGTGAGGAC
ATCTTTGGCGTCCAGCTGGAGGGCGCCTTCCCCGACACCATGACCAAGTGTGCCGAGCTG
CTGAGCCGCACCGTGGAGGTGGACTTTGTGGACATCAACGTCGGCTGCCCCATCGACCTC
GTGTACAAGAAGGGTGGGGGCTGTGCCCTCATGAATCGCTCCACCAAGTTCCAGCAGATC
GTCCGTGGCATGAACCAGGTGCTGGATGTGCCGCTGACTGTGAAGATCCGCACAGGCGTC
CAGGAGCGTGTGAACCTGGCGCACCGCCTGCTGCCCGAGCTGCGGGACTGGGGCGTGGCA
CTCGTCACGCTCCACGGCCGCTCTCGGGAGCAGCGCTACACCAAGCTAGCCGACTGGCAG
TACATCGAGGAGTGCGTGCAGGCCGCCAGCCCCATGCCCCTGTTCGGAAATGGGGACATC
TTGTCATTTGAGGATGCCAACCGCGCCATGCAGACTGGTGTCACCGGGATCATGATTGCC
CGTGGCGCCCTGCTCAAGCCGTGGCTCTTCACGGAGATCAAGGAGCAGCGGCACTGGGAC
ATCTCGTCGTCCGAGCGCCTGGACATCCTGCGGGACTTCACCAACTACGGCCTGGAGCAC
TGGGGCTCGGACACGCAGGGCGTGGAGAAGACCCGGCGCTTTCTGCTCGAGTGGCTGTCC
TTCCTGTGCCGGTACGTGCCCGTGGGGCTGCTGGAGCGGCTCCCACAGAGGATCAACGAG
CGGCCGCCCTACTACCTGGGCCGCGACTACCTGGAGACGCTGATGGCCAGCCAGAAGGCA
GCCGACTGGATCCGCATCAGCGAGATGCTCCTTGGGCCAGTGCCCCCCAGCTTCGCCTTC
TTGCCGAAGCACAAGGCCAACGCGTACAAGTAG
Protein Properties
Number of Residues 650
Molecular Weight 72593.3
Theoretical pI 8.11
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["None"]
Protein Sequence
>tRNA-dihydrouridine synthase 3-like
MAEGTAEAPLENGGGGDSGAGALERGVAPIKRQYLTTKEQFHQFLEAKGQEKTCRETEVG
DPAGNELAEPEAKRIRLEDGQTADGQTEEAAEPGEQLQTQKRARGQNKGRPHVKPTNYDK
NRLCPSLIQESAAKCFFGDRCRFLHDVGRYLETKPADLGPRCVLFETFGRCPYGVTCRFA
GAHLRPEGQNLVQEELAARGTQPPSIRNGLDKALQQQLRKREVRFERAEQALRRFSQGPT
PAAAVPEGTAAEGAPRQENCGAQQVPAGPGTSTPPSSPVRTCGPLTDEDVVRLRPCEKKR
LDIRGKLYLAPLTTCGNLPFRRICKRFGADVTCGEMAVCTNLLQGQMSEWALLKRHQCED
IFGVQLEGAFPDTMTKCAELLSRTVEVDFVDINVGCPIDLVYKKGGGCALMNRSTKFQQI
VRGMNQVLDVPLTVKIRTGVQERVNLAHRLLPELRDWGVALVTLHGRSREQRYTKLADWQ
YIEECVQAASPMPLFGNGDILSFEDANRAMQTGVTGIMIARGALLKPWLFTEIKEQRHWD
ISSSERLDILRDFTNYGLEHWGSDTQGVEKTRRFLLEWLSFLCRYVPVGLLERLPQRINE
RPPYYLGRDYLETLMASQKAADWIRISEMLLGPVPPSFAFLPKHKANAYK
GenBank ID Protein 10436076
UniProtKB/Swiss-Prot ID Q96G46
UniProtKB/Swiss-Prot Entry Name DUS3L_HUMAN
PDB IDs Not Available
GenBank Gene ID AK023958
GeneCard ID DUS3L
GenAtlas ID DUS3L
HGNC ID HGNC:26920
References
General References Not Available