| Identification |
|---|
| HMDB Protein ID
| CDBP03481 |
| Secondary Accession Numbers
| Not Available |
| Name
| tRNA-dihydrouridine synthase 3-like |
| Description
| Not Available |
| Synonyms
|
Not Available
|
| Gene Name
| DUS3L |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in catalytic activity |
| Specific Function
| Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs |
| GO Classification
|
| Function |
| adenyl nucleotide binding |
| nucleic acid binding |
| oxidoreductase activity |
| fad or fadh2 binding |
| trna dihydrouridine synthase activity |
| oxidoreductase activity, acting on the ch-ch group of donors |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| catalytic activity |
| transition metal ion binding |
| zinc ion binding |
| nucleoside binding |
| purine nucleoside binding |
| Process |
| rna metabolic process |
| ncrna metabolic process |
| trna metabolic process |
| trna processing |
| metabolic process |
| macromolecule metabolic process |
| cellular macromolecule metabolic process |
| oxidation reduction |
|
| Cellular Location
|
- Cytoplasmic
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 19p13.3 |
| SNPs
| DUS3L |
| Gene Sequence
|
>1953 bp
ATGGCGGAGGGAACGGCGGAGGCTCCTCTAGAGAATGGTGGTGGTGGCGACTCGGGAGCC
GGAGCTTTGGAACGAGGAGTGGCGCCCATTAAGCGTCAATACCTCACCACCAAGGAGCAG
TTTCACCAATTCCTGGAAGCCAAAGGGCAGGAGAAGACTTGCCGGGAAACCGAGGTAGGA
GACCCTGCTGGCAATGAGCTGGCTGAGCCTGAGGCTAAGCGGATCCGACTGGAGGATGGA
CAGACGGCGGACGGGCAGACGGAGGAGGCAGCAGAGCCCGGGGAGCAGCTACAGACTCAG
AAGAGGGCCCGGGGACAAAACAAGGGCCGGCCCCATGTGAAGCCCACGAACTACGACAAG
AACAGGCTGTGTCCCTCCCTAATCCAGGAGTCGGCTGCTAATTGTTTCTTCGGTGATCGC
TGCCGCTTTCTGCACGACGTGGGGCGCTACCTGGAGACCAAGCCGGCCGACCTGGGCCCC
CGCTGCGTGCTCTTCGAGACCTTCGGCCGGTGCCCCTACGGCGTGACCTGCCGCTTCGCT
GGGGCCCACCTGAGGCCCGAGGGACAGAACCTGGTGCAGGAGGAGTTGGCGGCCCGCGGG
ACCCAGCCCCCGTCCATCCGCAACGGCCTGGACAAAGCCCTGCAGCAGCAGCTGCGGAAG
CGCGAGGTCCGCTTCGAGCGAGCTGAGCAGGCCCTGCGCCGGTTCAGCCAGGGCCCCACA
CCCGCTGCCGCTGTCCCCGAGGGCACGGCAGCCGAGGGCGCTCCCAGGCAGGAAAACTGT
GGTGCCCAGCAGGTCCCCGCAGGGCCGGGCACTAGCACCCCTCCCAGCAGCCCCGTGCGG
ACCTGCGGGCCCCTGACGGATGAGGACGTGGTCAGGCTGCGGCCCTGTGAGAAGAAGCGG
CTGGACATCCGTGGCAAACTTTACCTGGCCCCCCTCACCACGTGTGGGAACCTGCCCTTC
CGACGGATCTGCAAGCGCTTCGGGGCGGATGTGACATGTGGAGAGATGGCCGTCTGCACC
AACCTGCTGCAGGGCCAGATGTCCGAGTGGGCCCTACTCAAACGCCACCAGTGTGAGGAC
ATCTTTGGCGTCCAGCTGGAGGGCGCCTTCCCCGACACCATGACCAAGTGTGCCGAGCTG
CTGAGCCGCACCGTGGAGGTGGACTTTGTGGACATCAACGTCGGCTGCCCCATCGACCTC
GTGTACAAGAAGGGTGGGGGCTGTGCCCTCATGAATCGCTCCACCAAGTTCCAGCAGATC
GTCCGTGGCATGAACCAGGTGCTGGATGTGCCGCTGACTGTGAAGATCCGCACAGGCGTC
CAGGAGCGTGTGAACCTGGCGCACCGCCTGCTGCCCGAGCTGCGGGACTGGGGCGTGGCA
CTCGTCACGCTCCACGGCCGCTCTCGGGAGCAGCGCTACACCAAGCTAGCCGACTGGCAG
TACATCGAGGAGTGCGTGCAGGCCGCCAGCCCCATGCCCCTGTTCGGAAATGGGGACATC
TTGTCATTTGAGGATGCCAACCGCGCCATGCAGACTGGTGTCACCGGGATCATGATTGCC
CGTGGCGCCCTGCTCAAGCCGTGGCTCTTCACGGAGATCAAGGAGCAGCGGCACTGGGAC
ATCTCGTCGTCCGAGCGCCTGGACATCCTGCGGGACTTCACCAACTACGGCCTGGAGCAC
TGGGGCTCGGACACGCAGGGCGTGGAGAAGACCCGGCGCTTTCTGCTCGAGTGGCTGTCC
TTCCTGTGCCGGTACGTGCCCGTGGGGCTGCTGGAGCGGCTCCCACAGAGGATCAACGAG
CGGCCGCCCTACTACCTGGGCCGCGACTACCTGGAGACGCTGATGGCCAGCCAGAAGGCA
GCCGACTGGATCCGCATCAGCGAGATGCTCCTTGGGCCAGTGCCCCCCAGCTTCGCCTTC
TTGCCGAAGCACAAGGCCAACGCGTACAAGTAG
|
| Protein Properties |
|---|
| Number of Residues
| 650 |
| Molecular Weight
| 72593.3 |
| Theoretical pI
| 8.11 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>tRNA-dihydrouridine synthase 3-like
MAEGTAEAPLENGGGGDSGAGALERGVAPIKRQYLTTKEQFHQFLEAKGQEKTCRETEVG
DPAGNELAEPEAKRIRLEDGQTADGQTEEAAEPGEQLQTQKRARGQNKGRPHVKPTNYDK
NRLCPSLIQESAAKCFFGDRCRFLHDVGRYLETKPADLGPRCVLFETFGRCPYGVTCRFA
GAHLRPEGQNLVQEELAARGTQPPSIRNGLDKALQQQLRKREVRFERAEQALRRFSQGPT
PAAAVPEGTAAEGAPRQENCGAQQVPAGPGTSTPPSSPVRTCGPLTDEDVVRLRPCEKKR
LDIRGKLYLAPLTTCGNLPFRRICKRFGADVTCGEMAVCTNLLQGQMSEWALLKRHQCED
IFGVQLEGAFPDTMTKCAELLSRTVEVDFVDINVGCPIDLVYKKGGGCALMNRSTKFQQI
VRGMNQVLDVPLTVKIRTGVQERVNLAHRLLPELRDWGVALVTLHGRSREQRYTKLADWQ
YIEECVQAASPMPLFGNGDILSFEDANRAMQTGVTGIMIARGALLKPWLFTEIKEQRHWD
ISSSERLDILRDFTNYGLEHWGSDTQGVEKTRRFLLEWLSFLCRYVPVGLLERLPQRINE
RPPYYLGRDYLETLMASQKAADWIRISEMLLGPVPPSFAFLPKHKANAYK
|
| External Links |
|---|
| GenBank ID Protein
| 10436076 |
| UniProtKB/Swiss-Prot ID
| Q96G46 |
| UniProtKB/Swiss-Prot Entry Name
| DUS3L_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AK023958 |
| GeneCard ID
| DUS3L |
| GenAtlas ID
| DUS3L |
| HGNC ID
| HGNC:26920 |
| References |
|---|
| General References
| Not Available |