Showing Protein D-2-hydroxyglutarate dehydrogenase, mitochondrial (CDBP01939)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 5 compounds
Identification
HMDB Protein ID CDBP01939
Secondary Accession Numbers Not Available
Name D-2-hydroxyglutarate dehydrogenase, mitochondrial
Description Not Available
Synonyms Not Available
Gene Name D2HGDH
Protein Type Enzyme
Biological Properties
General Function Involved in catalytic activity
Specific Function Catalyzes the oxidation of D-2-hydroxyglutarate to alpha-ketoglutarate.
GO Classification
Biological Process
response to zinc ion
cellular protein metabolic process
2-oxoglutarate metabolic process
response to manganese ion
response to cobalt ion
Cellular Component
mitochondrial matrix
Function
binding
catalytic activity
nucleoside binding
purine nucleoside binding
adenyl nucleotide binding
oxidoreductase activity
fad or fadh2 binding
Molecular Function
flavin adenine dinucleotide binding
(R)-2-hydroxyglutarate dehydrogenase activity
UDP-N-acetylmuramate dehydrogenase activity
Cellular Location
  1. Mitochondrion (Probable)
Pathways
Gene Properties
Chromosome Location 2
Locus 2q37.3
SNPs D2HGDH
Gene Sequence 
>1566 bp
ATGCTGCCCCGTCGGCCTCTGGCGTGGCCCGCGTGGCTGTTGCGGGGTGCTCCGGGAGCC
GCGGGTTCTTGGGGTCGGCCGGTTGGCCCCCTGGCCCGCAGAGGCTGCTGCTCCGCCCCG
GGGACCCCCGAGGTGCCGCTGACCCGGGAGCGCTACCCCGTGCAGCGCTTGCCGTTCTCC
ACGGTGTCTAAGCAGGACCTGGCCGCCTTTGAGCGCATCGTGCCCGGCGGGGTCGTCACG
GACCCGGAAGCGCTGCAGGCTCCCAACGTGGACTGGTTGCGGACGCTGCGAGGCTGTAGC
AAGGTGCTGCTGAGGCCACGGACGTCGGAGGAGGTGTCCCACATCCTCAGGCACTGCCAC
GAGAGGAACCTGGCCGTGAACCCACAGGGGGGCAACACAGGCATGGTGGGTGGCAGCGTC
CCCGTCTTTGACGAGATCATCCTCTCCACTGCCCGCATGAACCGGGTCCTCAGCTTCCAC
AGCGTGTCTGGAATTCTGGTTTGCCAGGCGGGCTGCGTCCTGGAGGAGCTGAGCCGGTAT
GTGGAGGAACGGGACTTCATCATGCCGCTGGACTTAGGAGCCAAGGGCAGCTGCCACATC
GGGGGAAACGTGGCAACCAACGCTGGAGGCCTGCGGTTTCTTCGATATGGCTCACTGCAT
GGGACTGTCCTGGGCCTGGAAGTGGTGCTGGCCGACGGCACTGTCCTGGACTGCCTGACC
TCCCTGAGGAAGGACAACACGGGCTATGACCTGAAGCAGCTGTTCATCGGGTCGGAGGGC
ACTTTGGGGATCATCACCACGGTGTCCATCTTGTGTCCACCCAAGCCCAGGGCTGTGAAC
GTGGCTTTCCTCGGCTGCCCAGGCTTTGCTGAGGTTCTGCAGACCTTCAGCACCTGCAAG
GGGATGCTGGGTGAGATCCTGTCTGCATTCGAGTTCATGGATGCTGTGTGCATGCAGCTG
GTCGGGCGCCATCTCCACCTGGCCAGCCCGGTGCAAGAGAGTCCGTTTTACGTCCTCATC
GAGACTTCAGGCTCCAACGCAGGCCATGACGCTGAGAAGCTGGGCCACTTCCTGGAGCAC
GCGCTGGGCTCCGGCCTGGTGACCGATGGGACCATGGCCACCGACCAGAGGAAAGTCAAG
ATGCTGTGGGCCCTGAGGGAAAGGATCACAGAGGCGCTGAGCCGGGATGGCTACGTGTAC
AAGTACGACCTCTCCCTCCCTGTGGAGCGGCTCTACGACATCGTGACTGACCTGCGCGCC
CGCCTCGGCCCGCACGCCAAGCACGTGGTGGGCTATGGCCACCTTGGAGATGGTAACCTG
CACCTCAATGTGACGGCGGAGGCCTTCAGCCCCTCGCTCCTGGCTGCCCTGGAGCCCCAC
GTGTACGAGTGGACGGCCGGGCAGCAGGGCAGCGTCAGCGCGGAGCACGGAGTGGGCTTC
AGGAAGAGGGACGTCCTGGGCTACAGCAAGCCACCGGGGGCCCTGCAGCTCATGCAGCAG
CTCAAGGCCCTGCTGGACCCCAAGGGCATCCTCAACCCCTACAAGACGCTGCCCAGCCAG
GCCTGA
Protein Properties
Number of Residues 521
Molecular Weight 56415.58
Theoretical pI 7.98
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence 
>D-2-hydroxyglutarate dehydrogenase, mitochondrial
MLPRRPLAWPAWLLRGAPGAAGSWGRPVGPLARRGCCSAPGTPEVPLTRERYPVRRLPFS
TVSKQDLAAFERIVPGGVVTDPEALQAPNVDWLRTLRGCSKVLLRPRTSEEVSHILRHCH
ERNLAVNPQGGNTGMVGGSVPVFDEIILSTARMNRVLSFHSVSGILVCQAGCVLEELSRY
VEERDFIMPLDLGAKGSCHIGGNVATNAGGLRFLRYGSLHGTVLGLEVVLADGTVLDCLT
SLRKDNTGYDLKQLFIGSEGTLGIITTVSILCPPKPRAVNVAFLGCPGFAEVLQTFSTCK
GMLGEILSAFEFMDAVCMQLVGRHLHLASPVQESPFYVLIETSGSNAGHDAEKLGHFLEH
ALGSGLVTDGTMATDQRKVKMLWALRERITEALSRDGYVYKYDLSLPVERLYDIVTDLRA
RLGPHAKHVVGYGHLGDGNLHLNVTAEAFSPSLLAALEPHVYEWTAGQQGSVSAEHGVGF
RKRDVLGYSKPPGALQLMQQLKALLDPKGILNPYKTLPSQA
GenBank ID Protein 34192567
UniProtKB/Swiss-Prot ID Q8N465
UniProtKB/Swiss-Prot Entry Name D2HDH_HUMAN
PDB IDs Not Available
GenBank Gene ID BC036604
GeneCard ID D2HGDH
GenAtlas ID D2HGDH
HGNC ID HGNC:28358
References
General References Not Available