Cannabis Compound Database: Showing Compound Card for S-Adenosylmethionine (CDB004888)

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Identification Taxonomy Ontology Physical properties Spectra Protein target Pathways Concentrations Links References enzymes (114)transporters (3) Show 211 proteins XML

Record Information

Version

1.0

Created at

2020-04-17 18:47:12 UTC

Updated at

2020-12-07 19:11:12 UTC

CannabisDB ID

CDB004888

Secondary Accession Numbers

Not Available

Cannabis Compound Identification

Common Name

S-Adenosylmethionine

Description

S-Adenosylmethionine, also known as SAM or adomet, belongs to the class of organic compounds known as 5'-deoxy-5'-thionucleosides. These are 5'-deoxyribonucleosides in which the ribose is thio-substituted at the 5'position by a S-alkyl group. S-Adenosylmethionine is a very strong basic compound (based on its pKa). S-Adenosylmethionine exists in all living species, ranging from bacteria to humans. Within humans, S-adenosylmethionine participates in a number of enzymatic reactions. In particular, S-adenosylmethionine and glycine can be converted into S-adenosylhomocysteine and sarcosine; which is catalyzed by the enzyme dna (cytosine-5)-methyltransferase 1. In addition, S-adenosylmethionine can be converted into S-adenosylmethioninamine; which is catalyzed by the enzyme S-adenosylmethionine decarboxylase proenzyme. In humans, S-adenosylmethionine is involved in the metabolic disorder called the glycine n-methyltransferase deficiency pathway. Outside of the human body, S-Adenosylmethionine has been detected, but not quantified in, several different foods, such as malabar plums, sunflowers, purple mangosteens, cherry tomato, and pigeon pea. This could make S-adenosylmethionine a potential biomarker for the consumption of these foods. S-Adenosylmethionine is a potentially toxic compound. A sulfonium compound that is the S-adenosyl derivative of L-methionine. S-Adenosylmethionine is expected to be in Cannabis as all living plants are known to produce and metabolize it.

Structure

MOL SDF 3D-SDF PDB SMILES InChI View 3D Structure

Synonyms

Value	Source
(3S)-5'-[(3-Amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine, inner salt	ChEBI
[1-(Adenin-9-yl)-1,5-dideoxy-beta-D-ribofuranos-5-yl][(3S)-3-amino-3-carboxypropyl](methyl)sulfonium	ChEBI
Acylcarnitine	ChEBI
AdoMet	ChEBI
S-(5'-Deoxyadenosin-5'-yl)-L-methionine	ChEBI
SAM	ChEBI
SAMe	ChEBI
(3S)-5'-[(3-Amino-3-carboxypropyl)methylsulphonio]-5'-deoxyadenosine, inner salt	Generator
[1-(Adenin-9-yl)-1,5-dideoxy-b-D-ribofuranos-5-yl][(3S)-3-amino-3-carboxypropyl](methyl)sulfonium	Generator
[1-(Adenin-9-yl)-1,5-dideoxy-b-D-ribofuranos-5-yl][(3S)-3-amino-3-carboxypropyl](methyl)sulphonium	Generator
[1-(Adenin-9-yl)-1,5-dideoxy-beta-D-ribofuranos-5-yl][(3S)-3-amino-3-carboxypropyl](methyl)sulphonium	Generator
[1-(Adenin-9-yl)-1,5-dideoxy-β-D-ribofuranos-5-yl][(3S)-3-amino-3-carboxypropyl](methyl)sulfonium	Generator
[1-(Adenin-9-yl)-1,5-dideoxy-β-D-ribofuranos-5-yl][(3S)-3-amino-3-carboxypropyl](methyl)sulphonium	Generator
(3S)-5'-[(3-Amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine	HMDB
2-S-Adenosyl-L-methionine	HMDB
5'-Deoxyadenosine-5'-L-methionine disulfate ditosylate	HMDB
5'-Deoxyadenosine-5'-L-methionine disulphate ditosylate	HMDB
Active methionine	HMDB
Ademetionine	HMDB
Adenosylmethionine	HMDB
Donamet	HMDB
L-S-Adenosylmethionine	HMDB
S-(5'-Adenosyl)-L-methionine	HMDB
S-Adenosyl methionine	HMDB
S-Adenosyl-L-methionine	HMDB
S-Adenosyl-L-methionine disulfate tosylate	HMDB
S-Adenosyl-L-methionine disulphate tosylate	HMDB
S-Adenosyl-methionine	HMDB
ASTA medica brand OF ademetionine tosilate disulfate	HMDB
S Adenosylmethionine sulfate tosylate	HMDB
S-Adenosylmethionine sulfate tosylate	HMDB
Sulfate tosylate, S-adenosylmethionine	HMDB
Ademetionine europharma brand	HMDB
Amet, S	HMDB
Europharma brand OF ademetionine	HMDB
Gumbaral	HMDB
Knoll brand OF brand OF ademetionine tosilate disulfate	HMDB
S Adenosylmethionine	HMDB
S Amet	HMDB
Samyr	HMDB
Tosylate, S-adenosylmethionine sulfate	HMDB
S Adenosyl L methionine	HMDB
SAM-e	HMDB

Chemical Formula

C₁₅H₂₃N₆O₅S

Average Molecular Weight

399.45

Monoisotopic Molecular Weight

399.1451

IUPAC Name

[(3S)-3-amino-3-carboxypropyl]({[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl})methylsulfanium

Traditional Name

SAMe

CAS Registry Number

485-80-3

SMILES

C[S+](CC[C@H](N)C(O)=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C1N=CN=C2N

InChI Identifier

InChI=1S/C15H22N6O5S/c1-27(3-2-7(16)15(24)25)4-8-10(22)11(23)14(26-8)21-6-20-9-12(17)18-5-19-13(9)21/h5-8,10-11,14,22-23H,2-4,16H2,1H3,(H2-,17,18,19,24,25)/p+1/t7-,8+,10+,11+,14+,27?/m0/s1

InChI Key

MEFKEPWMEQBLKI-AIRLBKTGSA-O

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as 5'-deoxy-5'-thionucleosides. These are 5'-deoxyribonucleosides in which the ribose is thio-substituted at the 5'position by a S-alkyl group.

Kingdom

Organic compounds

Super Class

Nucleosides, nucleotides, and analogues

Class

5'-deoxyribonucleosides

Sub Class

5'-deoxy-5'-thionucleosides

Direct Parent

5'-deoxy-5'-thionucleosides

Alternative Parents

Substituents

5'-deoxy-5'-thionucleoside
Methionine or derivatives
N-glycosyl compound
Glycosyl compound
Pentose monosaccharide
6-aminopurine
Alpha-amino acid
L-alpha-amino acid
Alpha-amino acid or derivatives
Imidazopyrimidine
Purine
Aminopyrimidine
Hydroxy fatty acid
Thia fatty acid
N-substituted imidazole
Fatty acyl
Monosaccharide
Imidolactam
Pyrimidine
Azole
Imidazole
Heteroaromatic compound
Tetrahydrofuran
Amino acid or derivatives
1,2-diol
Amino acid
Secondary alcohol
Oxacycle
Azacycle
Carboxylic acid derivative
Carboxylic acid
Organoheterocyclic compound
Monocarboxylic acid or derivatives
Organic oxide
Organopnictogen compound
Alcohol
Carbonyl group
Organic oxygen compound
Organic nitrogen compound
Hydrocarbon derivative
Primary amine
Organosulfur compound
Organooxygen compound
Primary aliphatic amine
Amine
Organonitrogen compound
Organic cation
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

organic cation (CHEBI:59789 )
sulfonium compound (CHEBI:59789 )

Ontology

Ingestion

Source:

Endogenous

Biological location:

Role

Industrial application:

Pharmaceutical industry:

Pharmaceutical

Food and nutrition:

Nutritional supplement

Biological role:

Trace element

Physical Properties

State

Solid

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	78 °C	Not Available
Water Solubility	1.19 g/l	ALOGPS
logP	-5.3	ChemAxon

Predicted Properties

Property	Value	Source
logP	-2	ALOGPS
logP	-5.3	ChemAxon
logS	-2.6	ALOGPS
pKa (Strongest Acidic)	1.7	ChemAxon
pKa (Strongest Basic)	9.41	ChemAxon
Physiological Charge	1	ChemAxon
Hydrogen Acceptor Count	10	ChemAxon
Hydrogen Donor Count	5	ChemAxon
Polar Surface Area	182.63 Å²	ChemAxon
Rotatable Bond Count	7	ChemAxon
Refractivity	96.23 m³·mol⁻¹	ChemAxon
Polarizability	40.37 Å³	ChemAxon
Number of Rings	3	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	Yes	ChemAxon

Spectra

EI-MS/GC-MS

Type	Description	Splash Key	View
Predicted GC-MS	S-Adenosylmethionine, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	splash10-0a5c-5965000000-324e4a3cbf936132bcf1	Spectrum
Predicted GC-MS	S-Adenosylmethionine, 3 TMS, Predicted GC-MS Spectrum - 70eV, Positive	splash10-00ea-7958582000-3dd40cf273f182ee53dd	Spectrum
Predicted GC-MS	S-Adenosylmethionine, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum

MS/MS

Type	Description	Splash Key	View
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ , positive	splash10-0002-0019000000-6dfa0dc65a9863755c2a	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ , positive	splash10-0udj-0293000000-57cc9d4430592060d41d	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ , positive	splash10-0udr-1940000000-ed4985bea80649d27efe	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ , positive	splash10-000b-8920000000-8f05e9898f0d26ddf3f8	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ , positive	splash10-000e-9400000000-e5c5617045d9915e8e46	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-IT , positive	splash10-0udi-0090000000-93017671648813ece8a5	2017-09-14	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-000i-0914000000-95030ceaf1c187dcf656	2017-09-01	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-000i-0900000000-c3fae8b7a68475b614a4	2017-09-01	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-000i-2900000000-44078fd7eaeafcc5bba8	2017-09-01	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-000i-1927000000-02f9d1735282c46e7318	2021-09-24	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-000i-1900000000-aa88bbdd6c68c8e33363	2021-09-24	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-0bti-7900000000-003aba988a5c7e2f6534	2021-09-24	View Spectrum

NMR

Not Available

Pathways

Name	SMPDB/Pathwhiz	KEGG
Betaine Metabolism
Methionine Metabolism
Spermidine and Spermine Biosynthesis		Not Available
Carnitine Synthesis		Not Available
Catecholamine Biosynthesis

Protein Targets

Enzymes

Protein Name	Gene Name	Locus	Uniprot ID	Details
Phosphatidylethanolamine N-methyltransferase	PEMT	17p11.2	Q9UBM1	details
Acetylserotonin O-methyltransferase	ASMT	Xp22.3 or Yp11.3	P46597	details
Methionine synthase	MTR	1q43	Q99707	details
Catechol O-methyltransferase	COMT	22q11.21	P21964	details
Histone-lysine N-methyltransferase, H3 lysine-79 specific	DOT1L	19p13.3	Q8TEK3	details
Glycine N-methyltransferase	GNMT	6p12	Q14749	details
Histone-lysine N-methyltransferase SETD7	SETD7	4q28	Q8WTS6	details
S-adenosylmethionine synthase isoform type-2	MAT2A	2p11.2	P31153	details
Phenylethanolamine N-methyltransferase	PNMT	17q	P11086	details
Diphthine synthase	DPH5	1p21.2	Q9H2P9	details
Arsenite methyltransferase	AS3MT	10q24.32	Q9HBK9	details
Mitochondrial tRNA-specific 2-thiouridylase 1	TRMU	22q13	O75648	details
Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific	NSD1	5q35	Q96L73	details
Histone-lysine N-methyltransferase SETDB1	SETDB1	1q21	Q15047	details
Protein-L-isoaspartate(D-aspartate) O-methyltransferase	PCMT1	6q24-q25	P22061	details
Protein-S-isoprenylcysteine O-methyltransferase	ICMT	1p36.21	O60725	details
Indolethylamine N-methyltransferase	INMT	7p14.3	O95050	details
DNA (cytosine-5)-methyltransferase 3A	DNMT3A	2p23	Q9Y6K1	details
Hexaprenyldihydroxybenzoate methyltransferase, mitochondrial	COQ3	6q16.2	Q9NZJ6	details
S-adenosylmethionine synthase isoform type-1	MAT1A	10q22	Q00266	details
Histone-lysine N-methyltransferase EHMT2	EHMT2	6p21.31	Q96KQ7	details
S-adenosylmethionine decarboxylase proenzyme	AMD1	6q21	P17707	details
Methionine synthase reductase	MTRR	5p15.31	Q9UBK8	details
Histone-lysine N-methyltransferase SUV39H1	SUV39H1	Xp11.23	O43463	details
Nicotinamide N-methyltransferase	NNMT	11q23.1	P40261	details
Histone-lysine N-methyltransferase SUV39H2	SUV39H2	10p13	Q9H5I1	details
Histone-lysine N-methyltransferase EHMT1	EHMT1	9q34.3	Q9H9B1	details
Guanidinoacetate N-methyltransferase	GAMT	19p13.3	Q14353	details
Histamine N-methyltransferase	HNMT	2q22.1	P50135	details
Thiopurine S-methyltransferase	TPMT	6p22.3	P51580	details
N6-adenosine-methyltransferase 70 kDa subunit	METTL3	14q11.1	Q86U44	details
Putative adenosylhomocysteinase 3	AHCYL2	7q32.1	Q96HN2	details
Adenosylhomocysteinase	AHCY	20q11.22	P23526	details
Putative adenosylhomocysteinase 2	AHCYL1	1p13.2	O43865	details
Cystathionine beta-synthase	CBS	21q22.3	P35520	details
Lipoyl synthase, mitochondrial	LIAS	4p14	O43766	details
Protein arginine N-methyltransferase 5	PRMT5	14q11.2	O14744	details
Histone-lysine N-methyltransferase SETD1A	SETD1A	16p11.2	O15047	details
rRNA 2'-O-methyltransferase fibrillarin	FBL	19q13.1	P22087	details
Histone-lysine N-methyltransferase MLL	MLL	11q23	Q03164	details
DNA (cytosine-5)-methyltransferase 3B	DNMT3B	20q11.2	Q9UBC3	details
tRNA (cytosine(38)-C(5))-methyltransferase	TRDMT1	10p15.1	O14717	details
N-lysine methyltransferase SETD8	SETD8	12q24.31	Q9NQR1	details
Histone-lysine N-methyltransferase MLL3	MLL3	7q36.1	Q8NEZ4	details
Methionine adenosyltransferase 2 subunit beta	MAT2B		Q9NZL9	details
DNA (cytosine-5)-methyltransferase 1	DNMT1	19p13.2	P26358	details
Histone-lysine N-methyltransferase SETDB2	SETDB2	13q14	Q96T68	details
S-adenosylmethionine mitochondrial carrier protein	SLC25A26	3p14.1	Q70HW3	details
tRNA (cytosine(34)-C(5))-methyltransferase	NSUN2	5p15.31	Q08J23	details
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial	COQ5	12q24.31	Q5HYK3	details
Histone-lysine N-methyltransferase ASH1L	ASH1L	1q22	Q9NR48	details
N-acetylserotonin O-methyltransferase-like protein	ASMTL		O95671	details
Histone-arginine methyltransferase CARM1	CARM1	19p13.2	Q86X55	details
Histone-lysine N-methyltransferase EZH2	EZH2	7q35-q36	Q15910	details
rRNA/tRNA 2'-O-methyltransferase fibrillarin-like protein 1	FBLL1	5q34	A6NHQ2	details
Leucine carboxyl methyltransferase 2	LCMT2	15q15.3	O60294	details
mRNA cap guanine-N7 methyltransferase	RNMT	18p11.21	O43148	details
Probable S-adenosyl-L-methionine-dependent methyltransferase METT5D1	METT5D1	11p14.1	A6NJ78	details
Histone-lysine N-methyltransferase MLL2	MLL2	12q13.12	O14686	details
Histone-lysine N-methyltransferase MLL4	WBP7	19q13.1	Q9UMN6	details
Histone-lysine N-methyltransferase MLL5	MLL5	7q22.1	Q8IZD2	details
Histone-lysine N-methyltransferase NSD2	WHSC1	4p16.3	O96028	details
Histone-lysine N-methyltransferase NSD3	WHSC1L1	8p11.2	Q9BZ95	details
Putative methyltransferase NSUN5C	NSUN5P2	7q11.23	Q63ZY6	details
Putative methyltransferase NSUN3	NSUN3	3q11.1	Q9H649	details
Putative methyltransferase NSUN4	NSUN4	1p34	Q96CB9	details
Putative methyltransferase NSUN5	NSUN5	7q11.23	Q96P11	details
Putative methyltransferase NSUN6	NSUN6	10p12.31	Q8TEA1	details
Putative methyltransferase NSUN7	NSUN7	4p14	Q8NE18	details
Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase	FTSJ1	Xp11.23	Q9UET6	details
Putative ribosomal RNA methyltransferase 2	FTSJ2	7p22	Q9UI43	details
Histone-lysine N-methyltransferase SETD1B	SETD1B	12q24.31	Q9UPS6	details
Histone-lysine N-methyltransferase SETD2	SETD2	3p21.31	Q9BYW2	details
Histone-lysine N-methyltransferase SETMAR	SETMAR	3p26.1	Q53H47	details
Histone-lysine N-methyltransferase SMYD3	SMYD3	1q44	Q9H7B4	details
Histone-lysine N-methyltransferase SUV420H1	SUV420H1	11q13.2	Q4FZB7	details
Histone-lysine N-methyltransferase SUV420H2	SUV420H2	19q13.42	Q86Y97	details
Probable methyltransferase TARBP1	TARBP1	1q42.3	Q13395	details
Dimethyladenosine transferase 1, mitochondrial	TFB1M	6q25.1-q25.3	Q8WVM0	details
Dimethyladenosine transferase 2, mitochondrial	TFB2M	1q44	Q9H5Q4	details
tRNA guanosine-2'-O-methyltransferase TRM11 homolog	TRMT11	6q11.1-q22.33	Q7Z4G4	details
tRNA (guanine(26)-N(2))-dimethyltransferase	TRMT1	19p13.2	Q9NXH9	details
tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A	TRMT61A	14q32	Q96FX7	details
tRNA (guanine-N(7)-)-methyltransferase	METTL1	12q13	Q9UBP6	details
tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial	TRMT61B	2p23.2	Q9BVS5	details
tRNA (guanine(37)-N1)-methyltransferase	TRMT5	14q23.1	Q32P41	details
Probable S-adenosyl-L-methionine-dependent methyltransferase METT5D2	METT5D2	3q25.31	P0C7V9	details
Transmembrane O-methyltransferase	LRTOMT	11q13.4	Q8WZ04	details
DNA (cytosine-5)-methyltransferase 3-like	DNMT3L		Q9UJW3	details
Histone-lysine N-methyltransferase EZH1	EZH1	17q21.1-q21.3	Q92800	details
Leucine carboxyl methyltransferase 1	LCMT1	16p12.1	Q9UIC8	details
tRNA (uracil(54)-C(5))-methyltransferase homolog	TRMT2B	Xq22.1	Q96GJ1	details
Protein arginine N-methyltransferase 1	PRMT1	19q13.3	Q99873	details
Protein arginine N-methyltransferase 2	PRMT2	21q22.3	P55345	details
Protein arginine N-methyltransferase 6	PRMT6	1p13.3	Q96LA8	details
Protein arginine N-methyltransferase 7	PRMT7	16q22.1	Q9NVM4	details
Calmodulin-lysine N-methyltransferase	CAMKMT	2p21	Q7Z624	details
Probable dimethyladenosine transferase	DIMT1	5q12.1	Q9UNQ2	details
HemK methyltransferase family member 1	HEMK1		Q9Y5R4	details
Small RNA 2'-O-methyltransferase	HENMT1	1p13.3	Q5T8I9	details
Methyltransferase-like protein 2B	METTL2B		Q6P1Q9	details
Methyltransferase-like protein 6	METTL6		Q8TCB7	details
Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1	FTSJD2	6p21.2	Q8N1G2	details
Ribosomal RNA small subunit methyltransferase NEP1	EMG1	12p13.3	Q92979	details
N-terminal Xaa-Pro-Lys N-methyltransferase 1	NTMT1	9q34.11	Q9BV86	details
Alpha N-terminal protein methyltransferase 1B	METTL11B	1q24.2	Q5VVY1	details
Putative histone-lysine N-methyltransferase PRDM6	PRDM6	5q23.2	Q9NQX0	details
Probable histone-lysine N-methyltransferase PRDM7	PRDM7	16q24.3	Q9NQW5	details
Histone-lysine N-methyltransferase PRDM9	PRDM9	5p14	Q9NQV7	details
Histone-lysine N-methyltransferase setd3	SETD3	14q32.2	Q86TU7	details
N-lysine methyltransferase SMYD2	SMYD2	1q32.3	Q9NRG4	details
Trimethylguanosine synthase	TGS1	8q11	Q96RS0	details
Probable tRNA (uracil-O(2)-)-methyltransferase	TRMT44	4p16.1	Q8IYL2	details
Uncharacterized methyltransferase WBSCR22	WBSCR22		O43709	details

Transporters

Protein Name	Gene Name	Locus	Uniprot ID	Details
Putative adenosylhomocysteinase 2	AHCYL1	1p13.2	O43865	details
Histone-lysine N-methyltransferase MLL	MLL	11q23	Q03164	details
S-adenosylmethionine mitochondrial carrier protein	SLC25A26	3p14.1	Q70HW3	details

Metal Bindings

Protein Name	Gene Name	Locus	Uniprot ID	Details
Methionine synthase	MTR	1q43	Q99707	details
Catechol O-methyltransferase	COMT	22q11.21	P21964	details
S-adenosylmethionine synthase isoform type-2	MAT2A	2p11.2	P31153	details
Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific	NSD1	5q35	Q96L73	details
Histone-lysine N-methyltransferase SETDB1	SETDB1	1q21	Q15047	details
DNA (cytosine-5)-methyltransferase 3A	DNMT3A	2p23	Q9Y6K1	details
S-adenosylmethionine synthase isoform type-1	MAT1A	10q22	Q00266	details
Histone-lysine N-methyltransferase EHMT2	EHMT2	6p21.31	Q96KQ7	details
Methionine synthase reductase	MTRR	5p15.31	Q9UBK8	details
Histone-lysine N-methyltransferase SUV39H1	SUV39H1	Xp11.23	O43463	details
Histone-lysine N-methyltransferase SUV39H2	SUV39H2	10p13	Q9H5I1	details
Histone-lysine N-methyltransferase EHMT1	EHMT1	9q34.3	Q9H9B1	details
Cystathionine beta-synthase	CBS	21q22.3	P35520	details
Lipoyl synthase, mitochondrial	LIAS	4p14	O43766	details
PR domain zinc finger protein 2	PRDM2	1p36.21	Q13029	details
Histone-lysine N-methyltransferase MLL	MLL	11q23	Q03164	details
Molybdenum cofactor biosynthesis protein 1	MOCS1	6p21.3	Q9NZB8	details
DNA (cytosine-5)-methyltransferase 3B	DNMT3B	20q11.2	Q9UBC3	details
Histone-lysine N-methyltransferase MLL3	MLL3	7q36.1	Q8NEZ4	details
DNA (cytosine-5)-methyltransferase 1	DNMT1	19p13.2	P26358	details
Histone-lysine N-methyltransferase SETDB2	SETDB2	13q14	Q96T68	details
tRNA wybutosine-synthesizing protein 1 homolog	TYW1	7q11.21	Q9NV66	details
tRNA wybutosine-synthesizing protein 1 homolog B	TYW1B	7q11.23	Q6NUM6	details
Histone-lysine N-methyltransferase ASH1L	ASH1L	1q22	Q9NR48	details
Elongator complex protein 3	ELP3	8p21.1	Q9H9T3	details
Histone-lysine N-methyltransferase MLL2	MLL2	12q13.12	O14686	details
Histone-lysine N-methyltransferase MLL4	WBP7	19q13.1	Q9UMN6	details
Histone-lysine N-methyltransferase MLL5	MLL5	7q22.1	Q8IZD2	details
Histone-lysine N-methyltransferase NSD2	WHSC1	4p16.3	O96028	details
Histone-lysine N-methyltransferase NSD3	WHSC1L1	8p11.2	Q9BZ95	details
Histone-lysine N-methyltransferase SETD2	SETD2	3p21.31	Q9BYW2	details
Histone-lysine N-methyltransferase SETMAR	SETMAR	3p26.1	Q53H47	details
Histone-lysine N-methyltransferase SMYD3	SMYD3	1q44	Q9H7B4	details
tRNA:m(4)X modification enzyme TRM13 homolog	TRMT13	1p21.2	Q9NUP7	details
tRNA (guanine(26)-N(2))-dimethyltransferase	TRMT1	19p13.2	Q9NXH9	details
DNA (cytosine-5)-methyltransferase 3-like	DNMT3L		Q9UJW3	details
Alkylated DNA repair protein alkB homolog 8	ALKBH8	11q22.3	Q96BT7	details
Small RNA 2'-O-methyltransferase	HENMT1	1p13.3	Q5T8I9	details
Putative histone-lysine N-methyltransferase PRDM6	PRDM6	5q23.2	Q9NQX0	details
Histone-lysine N-methyltransferase PRDM9	PRDM9	5p14	Q9NQV7	details
N-lysine methyltransferase SMYD2	SMYD2	1q32.3	Q9NRG4	details
Probable tRNA (uracil-O(2)-)-methyltransferase	TRMT44	4p16.1	Q8IYL2	details

Receptors

Protein Name	Gene Name	Locus	Uniprot ID	Details
Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific	NSD1	5q35	Q96L73	details
Histone-arginine methyltransferase CARM1	CARM1	19p13.2	Q86X55	details
Histone-lysine N-methyltransferase EZH2	EZH2	7q35-q36	Q15910	details
Histone-lysine N-methyltransferase MLL2	MLL2	12q13.12	O14686	details
Histone-lysine N-methyltransferase MLL5	MLL5	7q22.1	Q8IZD2	details
Transmembrane O-methyltransferase	LRTOMT	11q13.4	Q8WZ04	details
Protein arginine N-methyltransferase 1	PRMT1	19q13.3	Q99873	details
Protein arginine N-methyltransferase 2	PRMT2	21q22.3	P55345	details

Transcriptional Factors

Protein Name	Gene Name	Locus	Uniprot ID	Details
Histone-lysine N-methyltransferase, H3 lysine-79 specific	DOT1L	19p13.3	Q8TEK3	details
Histone-lysine N-methyltransferase SETD7	SETD7	4q28	Q8WTS6	details
Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific	NSD1	5q35	Q96L73	details
Histone-lysine N-methyltransferase SETDB1	SETDB1	1q21	Q15047	details
DNA (cytosine-5)-methyltransferase 3A	DNMT3A	2p23	Q9Y6K1	details
Histone-lysine N-methyltransferase EHMT2	EHMT2	6p21.31	Q96KQ7	details
Histone-lysine N-methyltransferase SUV39H1	SUV39H1	Xp11.23	O43463	details
Histone-lysine N-methyltransferase SUV39H2	SUV39H2	10p13	Q9H5I1	details
Histone-lysine N-methyltransferase EHMT1	EHMT1	9q34.3	Q9H9B1	details
Protein arginine N-methyltransferase 5	PRMT5	14q11.2	O14744	details
Histone-lysine N-methyltransferase SETD1A	SETD1A	16p11.2	O15047	details
PR domain zinc finger protein 2	PRDM2	1p36.21	Q13029	details
Histone-lysine N-methyltransferase MLL	MLL	11q23	Q03164	details
DNA (cytosine-5)-methyltransferase 3B	DNMT3B	20q11.2	Q9UBC3	details
N-lysine methyltransferase SETD8	SETD8	12q24.31	Q9NQR1	details
Histone-lysine N-methyltransferase MLL3	MLL3	7q36.1	Q8NEZ4	details
DNA (cytosine-5)-methyltransferase 1	DNMT1	19p13.2	P26358	details
Histone-lysine N-methyltransferase SETDB2	SETDB2	13q14	Q96T68	details
Histone-lysine N-methyltransferase ASH1L	ASH1L	1q22	Q9NR48	details
Histone-arginine methyltransferase CARM1	CARM1	19p13.2	Q86X55	details
Elongator complex protein 3	ELP3	8p21.1	Q9H9T3	details
Histone-lysine N-methyltransferase EZH2	EZH2	7q35-q36	Q15910	details
mRNA cap guanine-N7 methyltransferase	RNMT	18p11.21	O43148	details
Histone-lysine N-methyltransferase MLL2	MLL2	12q13.12	O14686	details
Histone-lysine N-methyltransferase MLL4	WBP7	19q13.1	Q9UMN6	details
Histone-lysine N-methyltransferase MLL5	MLL5	7q22.1	Q8IZD2	details
Histone-lysine N-methyltransferase NSD2	WHSC1	4p16.3	O96028	details
Histone-lysine N-methyltransferase NSD3	WHSC1L1	8p11.2	Q9BZ95	details
Histone-lysine N-methyltransferase SETD1B	SETD1B	12q24.31	Q9UPS6	details
Histone-lysine N-methyltransferase SETD2	SETD2	3p21.31	Q9BYW2	details
Histone-lysine N-methyltransferase SUV420H1	SUV420H1	11q13.2	Q4FZB7	details
Histone-lysine N-methyltransferase SUV420H2	SUV420H2	19q13.42	Q86Y97	details
Dimethyladenosine transferase 2, mitochondrial	TFB2M	1q44	Q9H5Q4	details
DNA (cytosine-5)-methyltransferase 3-like	DNMT3L		Q9UJW3	details
Histone-lysine N-methyltransferase EZH1	EZH1	17q21.1-q21.3	Q92800	details
Protein arginine N-methyltransferase 2	PRMT2	21q22.3	P55345	details
Protein arginine N-methyltransferase 6	PRMT6	1p13.3	Q96LA8	details
Protein arginine N-methyltransferase 7	PRMT7	16q22.1	Q9NVM4	details
Putative histone-lysine N-methyltransferase PRDM6	PRDM6	5q23.2	Q9NQX0	details
Probable histone-lysine N-methyltransferase PRDM7	PRDM7	16q24.3	Q9NQW5	details
Histone-lysine N-methyltransferase PRDM9	PRDM9	5p14	Q9NQV7	details
Histone-lysine N-methyltransferase setd3	SETD3	14q32.2	Q86TU7	details
N-lysine methyltransferase SMYD2	SMYD2	1q32.3	Q9NRG4	details
Trimethylguanosine synthase	TGS1	8q11	Q96RS0	details

Concentrations Data

Not Available

External Links

HMDB ID

HMDB0001185

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

KNApSAcK ID

Chemspider ID

KEGG Compound ID

BioCyc ID

BiGG ID

Wikipedia Link

S-Adenosyl_methionine

METLIN ID

6064

PubChem Compound

34756

PDB ID

Not Available

ChEBI ID

15414

References

General References

Not Available

Only showing the first 10 proteins. There are 211 proteins in total.

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Enzymes

Enzyme Details

1. Phosphatidylethanolamine N-methyltransferase

General function:: Involved in N-methyltransferase activity
Specific function:: Catalyzes three sequential methylation reactions of phosphatidylethanolamine (PE) by AdoMet, thereby producing phosphatidylcholine (PC).
Gene Name:: PEMT
Uniprot ID:: Q9UBM1
Molecular weight:: 23697.395

Enzyme Details

2. Acetylserotonin O-methyltransferase

General function:: Involved in O-methyltransferase activity
Specific function:: Isoform 1 catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine). Isoform 2 and isoform 3 lack enzyme activity.
Gene Name:: ASMT
Uniprot ID:: P46597
Molecular weight:: 41660.34

Enzyme Details

3. Methionine synthase

General function:: Involved in cobalamin binding
Specific function:: Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity).
Gene Name:: MTR
Uniprot ID:: Q99707
Molecular weight:: 140525.91

Enzyme Details

4. Catechol O-methyltransferase

General function:: Involved in magnesium ion binding
Specific function:: Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
Gene Name:: COMT
Uniprot ID:: P21964
Molecular weight:: 30036.77

Enzyme Details

5. Histone-lysine N-methyltransferase, H3 lysine-79 specific

General function:: Involved in DNA binding
Specific function:: Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA.
Gene Name:: DOT1L
Uniprot ID:: Q8TEK3
Molecular weight:: 164854.41

Enzyme Details

6. Glycine N-methyltransferase

General function:: Involved in folic acid binding
Specific function:: Catalyzes the methylation of glycine by using S-adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine.
Gene Name:: GNMT
Uniprot ID:: Q14749
Molecular weight:: 32742.0

Enzyme Details

7. Histone-lysine N-methyltransferase SETD7

General function:: Involved in histone-lysine N-methyltransferase activity
Specific function:: Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.
Gene Name:: SETD7
Uniprot ID:: Q8WTS6
Molecular weight:: 40720.595

Enzyme Details

8. S-adenosylmethionine synthase isoform type-2

General function:: Involved in methionine adenosyltransferase activity
Specific function:: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.
Gene Name:: MAT2A
Uniprot ID:: P31153
Molecular weight:: 43660.37

Enzyme Details

9. Phenylethanolamine N-methyltransferase

General function:: Involved in methyltransferase activity
Specific function:: Converts noradrenaline to adrenaline.
Gene Name:: PNMT
Uniprot ID:: P11086
Molecular weight:: 30854.745

Enzyme Details

10. Diphthine synthase

General function:: Involved in methyltransferase activity
Specific function:: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis (By similarity).
Gene Name:: DPH5
Uniprot ID:: Q9H2P9
Molecular weight:: 31651.17

Transporters

Enzyme Details

1. Putative adenosylhomocysteinase 2

General function:: Involved in adenosylhomocysteinase activity
Specific function:: Not Available
Gene Name:: AHCYL1
Uniprot ID:: O43865
Molecular weight:: 53753.0

Enzyme Details

2. Histone-lysine N-methyltransferase MLL

General function:: Involved in DNA binding
Specific function:: Histone methyltransferase that plays an essential role in early development and hematopoiesis. Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac). In the MLL1/MLL complex, it specifically mediates H3K4me, a specific tag for epigenetic transcriptional activation. Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity. Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9'. Required for transcriptional activation of HOXA9. Promotes PPP1R15A-induced apoptosis.
Gene Name:: MLL
Uniprot ID:: Q03164
Molecular weight:: 432047.735

Enzyme Details

3. S-adenosylmethionine mitochondrial carrier protein

General function:: Involved in binding
Specific function:: Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. Specifically mediates the transport of S-adenosylmethionine (SAM) into the mitochondria.
Gene Name:: SLC25A26
Uniprot ID:: Q70HW3
Molecular weight:: 20116.095

Only showing the first 10 proteins. There are 211 proteins in total.

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Showing Compound Card for S-Adenosylmethionine (CDB004888)

Structure for CDB004888 (S-Adenosylmethionine)

Enzymes

Transporters