Record Information
Version1.0
Created at2020-04-17 18:47:12 UTC
Updated at2020-12-07 19:11:12 UTC
CannabisDB IDCDB004888
Secondary Accession NumbersNot Available
Cannabis Compound Identification
Common NameS-Adenosylmethionine
DescriptionS-Adenosylmethionine, also known as SAM or adomet, belongs to the class of organic compounds known as 5'-deoxy-5'-thionucleosides. These are 5'-deoxyribonucleosides in which the ribose is thio-substituted at the 5'position by a S-alkyl group. S-Adenosylmethionine is a very strong basic compound (based on its pKa). S-Adenosylmethionine exists in all living species, ranging from bacteria to humans. Within humans, S-adenosylmethionine participates in a number of enzymatic reactions. In particular, S-adenosylmethionine and glycine can be converted into S-adenosylhomocysteine and sarcosine; which is catalyzed by the enzyme dna (cytosine-5)-methyltransferase 1. In addition, S-adenosylmethionine can be converted into S-adenosylmethioninamine; which is catalyzed by the enzyme S-adenosylmethionine decarboxylase proenzyme. In humans, S-adenosylmethionine is involved in the metabolic disorder called the glycine n-methyltransferase deficiency pathway. Outside of the human body, S-Adenosylmethionine has been detected, but not quantified in, several different foods, such as malabar plums, sunflowers, purple mangosteens, cherry tomato, and pigeon pea. This could make S-adenosylmethionine a potential biomarker for the consumption of these foods. S-Adenosylmethionine is a potentially toxic compound. A sulfonium compound that is the S-adenosyl derivative of L-methionine. S-Adenosylmethionine is expected to be in Cannabis as all living plants are known to produce and metabolize it.
Structure
Thumb
Synonyms
ValueSource
(3S)-5'-[(3-Amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine, inner saltChEBI
[1-(Adenin-9-yl)-1,5-dideoxy-beta-D-ribofuranos-5-yl][(3S)-3-amino-3-carboxypropyl](methyl)sulfoniumChEBI
AcylcarnitineChEBI
AdoMetChEBI
S-(5'-Deoxyadenosin-5'-yl)-L-methionineChEBI
SAMChEBI
SAMeChEBI
(3S)-5'-[(3-Amino-3-carboxypropyl)methylsulphonio]-5'-deoxyadenosine, inner saltGenerator
[1-(Adenin-9-yl)-1,5-dideoxy-b-D-ribofuranos-5-yl][(3S)-3-amino-3-carboxypropyl](methyl)sulfoniumGenerator
[1-(Adenin-9-yl)-1,5-dideoxy-b-D-ribofuranos-5-yl][(3S)-3-amino-3-carboxypropyl](methyl)sulphoniumGenerator
[1-(Adenin-9-yl)-1,5-dideoxy-beta-D-ribofuranos-5-yl][(3S)-3-amino-3-carboxypropyl](methyl)sulphoniumGenerator
[1-(Adenin-9-yl)-1,5-dideoxy-β-D-ribofuranos-5-yl][(3S)-3-amino-3-carboxypropyl](methyl)sulfoniumGenerator
[1-(Adenin-9-yl)-1,5-dideoxy-β-D-ribofuranos-5-yl][(3S)-3-amino-3-carboxypropyl](methyl)sulphoniumGenerator
(3S)-5'-[(3-Amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosineHMDB
2-S-Adenosyl-L-methionineHMDB
5'-Deoxyadenosine-5'-L-methionine disulfate ditosylateHMDB
5'-Deoxyadenosine-5'-L-methionine disulphate ditosylateHMDB
Active methionineHMDB
AdemetionineHMDB
AdenosylmethionineHMDB
DonametHMDB
L-S-AdenosylmethionineHMDB
S-(5'-Adenosyl)-L-methionineHMDB
S-Adenosyl methionineHMDB
S-Adenosyl-L-methionineHMDB
S-Adenosyl-L-methionine disulfate tosylateHMDB
S-Adenosyl-L-methionine disulphate tosylateHMDB
S-Adenosyl-methionineHMDB
ASTA medica brand OF ademetionine tosilate disulfateHMDB
S Adenosylmethionine sulfate tosylateHMDB
S-Adenosylmethionine sulfate tosylateHMDB
Sulfate tosylate, S-adenosylmethionineHMDB
Ademetionine europharma brandHMDB
Amet, SHMDB
Europharma brand OF ademetionineHMDB
GumbaralHMDB
Knoll brand OF brand OF ademetionine tosilate disulfateHMDB
S AdenosylmethionineHMDB
S AmetHMDB
SamyrHMDB
Tosylate, S-adenosylmethionine sulfateHMDB
S Adenosyl L methionineHMDB
SAM-eHMDB
Chemical FormulaC15H23N6O5S
Average Molecular Weight399.45
Monoisotopic Molecular Weight399.1451
IUPAC Name[(3S)-3-amino-3-carboxypropyl]({[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl})methylsulfanium
Traditional NameSAMe
CAS Registry Number485-80-3
SMILES
C[S+](CC[C@H](N)C(O)=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C1N=CN=C2N
InChI Identifier
InChI=1S/C15H22N6O5S/c1-27(3-2-7(16)15(24)25)4-8-10(22)11(23)14(26-8)21-6-20-9-12(17)18-5-19-13(9)21/h5-8,10-11,14,22-23H,2-4,16H2,1H3,(H2-,17,18,19,24,25)/p+1/t7-,8+,10+,11+,14+,27?/m0/s1
InChI KeyMEFKEPWMEQBLKI-AIRLBKTGSA-O
Chemical Taxonomy
Description Belongs to the class of organic compounds known as 5'-deoxy-5'-thionucleosides. These are 5'-deoxyribonucleosides in which the ribose is thio-substituted at the 5'position by a S-alkyl group.
KingdomOrganic compounds
Super ClassNucleosides, nucleotides, and analogues
Class5'-deoxyribonucleosides
Sub Class5'-deoxy-5'-thionucleosides
Direct Parent5'-deoxy-5'-thionucleosides
Alternative Parents
Substituents
  • 5'-deoxy-5'-thionucleoside
  • Methionine or derivatives
  • N-glycosyl compound
  • Glycosyl compound
  • Pentose monosaccharide
  • 6-aminopurine
  • Alpha-amino acid
  • L-alpha-amino acid
  • Alpha-amino acid or derivatives
  • Imidazopyrimidine
  • Purine
  • Aminopyrimidine
  • Hydroxy fatty acid
  • Thia fatty acid
  • N-substituted imidazole
  • Fatty acyl
  • Monosaccharide
  • Imidolactam
  • Pyrimidine
  • Azole
  • Imidazole
  • Heteroaromatic compound
  • Tetrahydrofuran
  • Amino acid or derivatives
  • 1,2-diol
  • Amino acid
  • Secondary alcohol
  • Oxacycle
  • Azacycle
  • Carboxylic acid derivative
  • Carboxylic acid
  • Organoheterocyclic compound
  • Monocarboxylic acid or derivatives
  • Organic oxide
  • Organopnictogen compound
  • Alcohol
  • Carbonyl group
  • Organic oxygen compound
  • Organic nitrogen compound
  • Hydrocarbon derivative
  • Primary amine
  • Organosulfur compound
  • Organooxygen compound
  • Primary aliphatic amine
  • Amine
  • Organonitrogen compound
  • Organic cation
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Ontology
Physiological effect

Health effect:

Disposition

Route of exposure:

Source:

Biological location:

Role

Industrial application:

Biological role:

Physical Properties
StateSolid
Experimental Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling Point78 °CNot Available
Water Solubility1.19 g/lALOGPS
logP-5.3ChemAxon
Predicted Properties
PropertyValueSource
logP-2ALOGPS
logP-5.3ChemAxon
logS-2.6ALOGPS
pKa (Strongest Acidic)1.7ChemAxon
pKa (Strongest Basic)9.41ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count10ChemAxon
Hydrogen Donor Count5ChemAxon
Polar Surface Area182.63 ŲChemAxon
Rotatable Bond Count7ChemAxon
Refractivity96.23 m³·mol⁻¹ChemAxon
Polarizability40.37 ųChemAxon
Number of Rings3ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Spectra
EI-MS/GC-MS
TypeDescriptionSplash KeyView
Predicted GC-MSS-Adenosylmethionine, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positivesplash10-0a5c-5965000000-324e4a3cbf936132bcf1Spectrum
Predicted GC-MSS-Adenosylmethionine, 3 TMS, Predicted GC-MS Spectrum - 70eV, Positivesplash10-00ea-7958582000-3dd40cf273f182ee53ddSpectrum
MS/MS
TypeDescriptionSplash KeyView
MS/MSLC-MS/MS Spectrum - LC-ESI-QQ , positivesplash10-0002-0019000000-6dfa0dc65a9863755c2aSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QQ , positivesplash10-0udj-0293000000-57cc9d4430592060d41dSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QQ , positivesplash10-0udr-1940000000-ed4985bea80649d27efeSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QQ , positivesplash10-000b-8920000000-8f05e9898f0d26ddf3f8Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QQ , positivesplash10-000e-9400000000-e5c5617045d9915e8e46Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-IT , positivesplash10-0udi-0090000000-93017671648813ece8a5Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-000i-0914000000-95030ceaf1c187dcf656Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-000i-0900000000-c3fae8b7a68475b614a4Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-000i-2900000000-44078fd7eaeafcc5bba8Spectrum
NMRNot Available
Pathways
Pathways
Protein Targets
Enzymes
Protein NameGene NameLocusUniprot IDDetails
Phosphatidylethanolamine N-methyltransferasePEMT17p11.2Q9UBM1 details
Acetylserotonin O-methyltransferaseASMTXp22.3 or Yp11.3P46597 details
Methionine synthaseMTR1q43Q99707 details
Catechol O-methyltransferaseCOMT22q11.21P21964 details
Histone-lysine N-methyltransferase, H3 lysine-79 specificDOT1L19p13.3Q8TEK3 details
Glycine N-methyltransferaseGNMT6p12Q14749 details
Histone-lysine N-methyltransferase SETD7SETD74q28Q8WTS6 details
S-adenosylmethionine synthase isoform type-2MAT2A2p11.2P31153 details
Phenylethanolamine N-methyltransferasePNMT17qP11086 details
Diphthine synthaseDPH51p21.2Q9H2P9 details
Arsenite methyltransferaseAS3MT10q24.32Q9HBK9 details
Mitochondrial tRNA-specific 2-thiouridylase 1TRMU22q13O75648 details
Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specificNSD15q35Q96L73 details
Histone-lysine N-methyltransferase SETDB1SETDB11q21Q15047 details
Protein-L-isoaspartate(D-aspartate) O-methyltransferasePCMT16q24-q25P22061 details
Protein-S-isoprenylcysteine O-methyltransferaseICMT1p36.21O60725 details
Indolethylamine N-methyltransferaseINMT7p14.3O95050 details
DNA (cytosine-5)-methyltransferase 3ADNMT3A2p23Q9Y6K1 details
Hexaprenyldihydroxybenzoate methyltransferase, mitochondrialCOQ36q16.2Q9NZJ6 details
S-adenosylmethionine synthase isoform type-1MAT1A10q22Q00266 details
Histone-lysine N-methyltransferase EHMT2EHMT26p21.31Q96KQ7 details
S-adenosylmethionine decarboxylase proenzymeAMD16q21P17707 details
Methionine synthase reductaseMTRR5p15.31Q9UBK8 details
Histone-lysine N-methyltransferase SUV39H1SUV39H1Xp11.23O43463 details
Nicotinamide N-methyltransferaseNNMT11q23.1P40261 details
Histone-lysine N-methyltransferase SUV39H2SUV39H210p13Q9H5I1 details
Histone-lysine N-methyltransferase EHMT1EHMT19q34.3Q9H9B1 details
Guanidinoacetate N-methyltransferaseGAMT19p13.3Q14353 details
Histamine N-methyltransferaseHNMT2q22.1P50135 details
Thiopurine S-methyltransferaseTPMT6p22.3P51580 details
N6-adenosine-methyltransferase 70 kDa subunitMETTL314q11.1Q86U44 details
Putative adenosylhomocysteinase 3AHCYL27q32.1Q96HN2 details
AdenosylhomocysteinaseAHCY20q11.22P23526 details
Putative adenosylhomocysteinase 2AHCYL11p13.2O43865 details
Cystathionine beta-synthaseCBS21q22.3P35520 details
Lipoyl synthase, mitochondrialLIAS4p14O43766 details
Protein arginine N-methyltransferase 5PRMT514q11.2O14744 details
Histone-lysine N-methyltransferase SETD1ASETD1A16p11.2O15047 details
rRNA 2'-O-methyltransferase fibrillarinFBL19q13.1P22087 details
Histone-lysine N-methyltransferase MLLMLL11q23Q03164 details
DNA (cytosine-5)-methyltransferase 3BDNMT3B20q11.2Q9UBC3 details
tRNA (cytosine(38)-C(5))-methyltransferaseTRDMT110p15.1O14717 details
N-lysine methyltransferase SETD8SETD812q24.31Q9NQR1 details
Histone-lysine N-methyltransferase MLL3MLL37q36.1Q8NEZ4 details
Methionine adenosyltransferase 2 subunit betaMAT2BQ9NZL9 details
DNA (cytosine-5)-methyltransferase 1DNMT119p13.2P26358 details
Histone-lysine N-methyltransferase SETDB2SETDB213q14Q96T68 details
S-adenosylmethionine mitochondrial carrier proteinSLC25A263p14.1Q70HW3 details
tRNA (cytosine(34)-C(5))-methyltransferaseNSUN25p15.31Q08J23 details
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrialCOQ512q24.31Q5HYK3 details
Histone-lysine N-methyltransferase ASH1LASH1L1q22Q9NR48 details
N-acetylserotonin O-methyltransferase-like proteinASMTLO95671 details
Histone-arginine methyltransferase CARM1CARM119p13.2Q86X55 details
Histone-lysine N-methyltransferase EZH2EZH27q35-q36Q15910 details
rRNA/tRNA 2'-O-methyltransferase fibrillarin-like protein 1FBLL15q34A6NHQ2 details
Leucine carboxyl methyltransferase 2LCMT215q15.3O60294 details
mRNA cap guanine-N7 methyltransferaseRNMT18p11.21O43148 details
Probable S-adenosyl-L-methionine-dependent methyltransferase METT5D1METT5D111p14.1A6NJ78 details
Histone-lysine N-methyltransferase MLL2MLL212q13.12O14686 details
Histone-lysine N-methyltransferase MLL4WBP719q13.1Q9UMN6 details
Histone-lysine N-methyltransferase MLL5MLL57q22.1Q8IZD2 details
Histone-lysine N-methyltransferase NSD2WHSC14p16.3O96028 details
Histone-lysine N-methyltransferase NSD3WHSC1L18p11.2Q9BZ95 details
Putative methyltransferase NSUN5CNSUN5P27q11.23Q63ZY6 details
Putative methyltransferase NSUN3NSUN33q11.1Q9H649 details
Putative methyltransferase NSUN4NSUN41p34Q96CB9 details
Putative methyltransferase NSUN5NSUN57q11.23Q96P11 details
Putative methyltransferase NSUN6NSUN610p12.31Q8TEA1 details
Putative methyltransferase NSUN7NSUN74p14Q8NE18 details
Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferaseFTSJ1Xp11.23Q9UET6 details
Putative ribosomal RNA methyltransferase 2FTSJ27p22Q9UI43 details
Histone-lysine N-methyltransferase SETD1BSETD1B12q24.31Q9UPS6 details
Histone-lysine N-methyltransferase SETD2SETD23p21.31Q9BYW2 details
Histone-lysine N-methyltransferase SETMARSETMAR3p26.1Q53H47 details
Histone-lysine N-methyltransferase SMYD3SMYD31q44Q9H7B4 details
Histone-lysine N-methyltransferase SUV420H1SUV420H111q13.2Q4FZB7 details
Histone-lysine N-methyltransferase SUV420H2SUV420H219q13.42Q86Y97 details
Probable methyltransferase TARBP1TARBP11q42.3Q13395 details
Dimethyladenosine transferase 1, mitochondrialTFB1M6q25.1-q25.3Q8WVM0 details
Dimethyladenosine transferase 2, mitochondrialTFB2M1q44Q9H5Q4 details
tRNA guanosine-2'-O-methyltransferase TRM11 homologTRMT116q11.1-q22.33Q7Z4G4 details
tRNA (guanine(26)-N(2))-dimethyltransferaseTRMT119p13.2Q9NXH9 details
tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61ATRMT61A14q32Q96FX7 details
tRNA (guanine-N(7)-)-methyltransferaseMETTL112q13Q9UBP6 details
tRNA (adenine(58)-N(1))-methyltransferase, mitochondrialTRMT61B2p23.2Q9BVS5 details
tRNA (guanine(37)-N1)-methyltransferaseTRMT514q23.1Q32P41 details
Probable S-adenosyl-L-methionine-dependent methyltransferase METT5D2METT5D23q25.31P0C7V9 details
Transmembrane O-methyltransferaseLRTOMT11q13.4Q8WZ04 details
DNA (cytosine-5)-methyltransferase 3-likeDNMT3LQ9UJW3 details
Histone-lysine N-methyltransferase EZH1EZH117q21.1-q21.3Q92800 details
Leucine carboxyl methyltransferase 1LCMT116p12.1Q9UIC8 details
tRNA (uracil(54)-C(5))-methyltransferase homologTRMT2BXq22.1Q96GJ1 details
Protein arginine N-methyltransferase 1PRMT119q13.3Q99873 details
Protein arginine N-methyltransferase 2PRMT221q22.3P55345 details
Protein arginine N-methyltransferase 6PRMT61p13.3Q96LA8 details
Protein arginine N-methyltransferase 7PRMT716q22.1Q9NVM4 details
Calmodulin-lysine N-methyltransferaseCAMKMT2p21Q7Z624 details
Probable dimethyladenosine transferaseDIMT15q12.1Q9UNQ2 details
HemK methyltransferase family member 1HEMK1Q9Y5R4 details
Small RNA 2'-O-methyltransferaseHENMT11p13.3Q5T8I9 details
Methyltransferase-like protein 2BMETTL2BQ6P1Q9 details
Methyltransferase-like protein 6METTL6Q8TCB7 details
Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1FTSJD26p21.2Q8N1G2 details
Ribosomal RNA small subunit methyltransferase NEP1EMG112p13.3Q92979 details
N-terminal Xaa-Pro-Lys N-methyltransferase 1NTMT19q34.11Q9BV86 details
Alpha N-terminal protein methyltransferase 1BMETTL11B1q24.2Q5VVY1 details
Putative histone-lysine N-methyltransferase PRDM6PRDM65q23.2Q9NQX0 details
Probable histone-lysine N-methyltransferase PRDM7PRDM716q24.3Q9NQW5 details
Histone-lysine N-methyltransferase PRDM9PRDM95p14Q9NQV7 details
Histone-lysine N-methyltransferase setd3SETD314q32.2Q86TU7 details
N-lysine methyltransferase SMYD2SMYD21q32.3Q9NRG4 details
Trimethylguanosine synthaseTGS18q11Q96RS0 details
Probable tRNA (uracil-O(2)-)-methyltransferaseTRMT444p16.1Q8IYL2 details
Uncharacterized methyltransferase WBSCR22WBSCR22O43709 details
Transporters
Protein NameGene NameLocusUniprot IDDetails
Putative adenosylhomocysteinase 2AHCYL11p13.2O43865 details
Histone-lysine N-methyltransferase MLLMLL11q23Q03164 details
S-adenosylmethionine mitochondrial carrier proteinSLC25A263p14.1Q70HW3 details
Metal Bindings
Protein NameGene NameLocusUniprot IDDetails
Methionine synthaseMTR1q43Q99707 details
Catechol O-methyltransferaseCOMT22q11.21P21964 details
S-adenosylmethionine synthase isoform type-2MAT2A2p11.2P31153 details
Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specificNSD15q35Q96L73 details
Histone-lysine N-methyltransferase SETDB1SETDB11q21Q15047 details
DNA (cytosine-5)-methyltransferase 3ADNMT3A2p23Q9Y6K1 details
S-adenosylmethionine synthase isoform type-1MAT1A10q22Q00266 details
Histone-lysine N-methyltransferase EHMT2EHMT26p21.31Q96KQ7 details
Methionine synthase reductaseMTRR5p15.31Q9UBK8 details
Histone-lysine N-methyltransferase SUV39H1SUV39H1Xp11.23O43463 details
Histone-lysine N-methyltransferase SUV39H2SUV39H210p13Q9H5I1 details
Histone-lysine N-methyltransferase EHMT1EHMT19q34.3Q9H9B1 details
Cystathionine beta-synthaseCBS21q22.3P35520 details
Lipoyl synthase, mitochondrialLIAS4p14O43766 details
PR domain zinc finger protein 2PRDM21p36.21Q13029 details
Histone-lysine N-methyltransferase MLLMLL11q23Q03164 details
Molybdenum cofactor biosynthesis protein 1MOCS16p21.3Q9NZB8 details
DNA (cytosine-5)-methyltransferase 3BDNMT3B20q11.2Q9UBC3 details
Histone-lysine N-methyltransferase MLL3MLL37q36.1Q8NEZ4 details
DNA (cytosine-5)-methyltransferase 1DNMT119p13.2P26358 details
Histone-lysine N-methyltransferase SETDB2SETDB213q14Q96T68 details
tRNA wybutosine-synthesizing protein 1 homologTYW17q11.21Q9NV66 details
tRNA wybutosine-synthesizing protein 1 homolog BTYW1B7q11.23Q6NUM6 details
Histone-lysine N-methyltransferase ASH1LASH1L1q22Q9NR48 details
Elongator complex protein 3ELP38p21.1Q9H9T3 details
Histone-lysine N-methyltransferase MLL2MLL212q13.12O14686 details
Histone-lysine N-methyltransferase MLL4WBP719q13.1Q9UMN6 details
Histone-lysine N-methyltransferase MLL5MLL57q22.1Q8IZD2 details
Histone-lysine N-methyltransferase NSD2WHSC14p16.3O96028 details
Histone-lysine N-methyltransferase NSD3WHSC1L18p11.2Q9BZ95 details
Histone-lysine N-methyltransferase SETD2SETD23p21.31Q9BYW2 details
Histone-lysine N-methyltransferase SETMARSETMAR3p26.1Q53H47 details
Histone-lysine N-methyltransferase SMYD3SMYD31q44Q9H7B4 details
tRNA:m(4)X modification enzyme TRM13 homologTRMT131p21.2Q9NUP7 details
tRNA (guanine(26)-N(2))-dimethyltransferaseTRMT119p13.2Q9NXH9 details
DNA (cytosine-5)-methyltransferase 3-likeDNMT3LQ9UJW3 details
Alkylated DNA repair protein alkB homolog 8ALKBH811q22.3Q96BT7 details
Small RNA 2'-O-methyltransferaseHENMT11p13.3Q5T8I9 details
Putative histone-lysine N-methyltransferase PRDM6PRDM65q23.2Q9NQX0 details
Histone-lysine N-methyltransferase PRDM9PRDM95p14Q9NQV7 details
N-lysine methyltransferase SMYD2SMYD21q32.3Q9NRG4 details
Probable tRNA (uracil-O(2)-)-methyltransferaseTRMT444p16.1Q8IYL2 details
Receptors
Protein NameGene NameLocusUniprot IDDetails
Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specificNSD15q35Q96L73 details
Histone-arginine methyltransferase CARM1CARM119p13.2Q86X55 details
Histone-lysine N-methyltransferase EZH2EZH27q35-q36Q15910 details
Histone-lysine N-methyltransferase MLL2MLL212q13.12O14686 details
Histone-lysine N-methyltransferase MLL5MLL57q22.1Q8IZD2 details
Transmembrane O-methyltransferaseLRTOMT11q13.4Q8WZ04 details
Protein arginine N-methyltransferase 1PRMT119q13.3Q99873 details
Protein arginine N-methyltransferase 2PRMT221q22.3P55345 details
Transcriptional Factors
Protein NameGene NameLocusUniprot IDDetails
Histone-lysine N-methyltransferase, H3 lysine-79 specificDOT1L19p13.3Q8TEK3 details
Histone-lysine N-methyltransferase SETD7SETD74q28Q8WTS6 details
Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specificNSD15q35Q96L73 details
Histone-lysine N-methyltransferase SETDB1SETDB11q21Q15047 details
DNA (cytosine-5)-methyltransferase 3ADNMT3A2p23Q9Y6K1 details
Histone-lysine N-methyltransferase EHMT2EHMT26p21.31Q96KQ7 details
Histone-lysine N-methyltransferase SUV39H1SUV39H1Xp11.23O43463 details
Histone-lysine N-methyltransferase SUV39H2SUV39H210p13Q9H5I1 details
Histone-lysine N-methyltransferase EHMT1EHMT19q34.3Q9H9B1 details
Protein arginine N-methyltransferase 5PRMT514q11.2O14744 details
Histone-lysine N-methyltransferase SETD1ASETD1A16p11.2O15047 details
PR domain zinc finger protein 2PRDM21p36.21Q13029 details
Histone-lysine N-methyltransferase MLLMLL11q23Q03164 details
DNA (cytosine-5)-methyltransferase 3BDNMT3B20q11.2Q9UBC3 details
N-lysine methyltransferase SETD8SETD812q24.31Q9NQR1 details
Histone-lysine N-methyltransferase MLL3MLL37q36.1Q8NEZ4 details
DNA (cytosine-5)-methyltransferase 1DNMT119p13.2P26358 details
Histone-lysine N-methyltransferase SETDB2SETDB213q14Q96T68 details
Histone-lysine N-methyltransferase ASH1LASH1L1q22Q9NR48 details
Histone-arginine methyltransferase CARM1CARM119p13.2Q86X55 details
Elongator complex protein 3ELP38p21.1Q9H9T3 details
Histone-lysine N-methyltransferase EZH2EZH27q35-q36Q15910 details
mRNA cap guanine-N7 methyltransferaseRNMT18p11.21O43148 details
Histone-lysine N-methyltransferase MLL2MLL212q13.12O14686 details
Histone-lysine N-methyltransferase MLL4WBP719q13.1Q9UMN6 details
Histone-lysine N-methyltransferase MLL5MLL57q22.1Q8IZD2 details
Histone-lysine N-methyltransferase NSD2WHSC14p16.3O96028 details
Histone-lysine N-methyltransferase NSD3WHSC1L18p11.2Q9BZ95 details
Histone-lysine N-methyltransferase SETD1BSETD1B12q24.31Q9UPS6 details
Histone-lysine N-methyltransferase SETD2SETD23p21.31Q9BYW2 details
Histone-lysine N-methyltransferase SUV420H1SUV420H111q13.2Q4FZB7 details
Histone-lysine N-methyltransferase SUV420H2SUV420H219q13.42Q86Y97 details
Dimethyladenosine transferase 2, mitochondrialTFB2M1q44Q9H5Q4 details
DNA (cytosine-5)-methyltransferase 3-likeDNMT3LQ9UJW3 details
Histone-lysine N-methyltransferase EZH1EZH117q21.1-q21.3Q92800 details
Protein arginine N-methyltransferase 2PRMT221q22.3P55345 details
Protein arginine N-methyltransferase 6PRMT61p13.3Q96LA8 details
Protein arginine N-methyltransferase 7PRMT716q22.1Q9NVM4 details
Putative histone-lysine N-methyltransferase PRDM6PRDM65q23.2Q9NQX0 details
Probable histone-lysine N-methyltransferase PRDM7PRDM716q24.3Q9NQW5 details
Histone-lysine N-methyltransferase PRDM9PRDM95p14Q9NQV7 details
Histone-lysine N-methyltransferase setd3SETD314q32.2Q86TU7 details
N-lysine methyltransferase SMYD2SMYD21q32.3Q9NRG4 details
Trimethylguanosine synthaseTGS18q11Q96RS0 details
Concentrations Data
Not Available
HMDB IDHMDB0001185
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FoodDB IDFDB031152
KNApSAcK IDC00007347
Chemspider ID21169292
KEGG Compound IDC00019
BioCyc IDS-ADENOSYLMETHIONINE
BiGG ID33530
Wikipedia LinkS-Adenosyl_methionine
METLIN ID6064
PubChem Compound34756
PDB IDNot Available
ChEBI ID15414
References
General ReferencesNot Available

Only showing the first 10 proteins. There are 211 proteins in total.

Enzymes

General function:
Involved in N-methyltransferase activity
Specific function:
Catalyzes three sequential methylation reactions of phosphatidylethanolamine (PE) by AdoMet, thereby producing phosphatidylcholine (PC).
Gene Name:
PEMT
Uniprot ID:
Q9UBM1
Molecular weight:
23697.395
General function:
Involved in O-methyltransferase activity
Specific function:
Isoform 1 catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine). Isoform 2 and isoform 3 lack enzyme activity.
Gene Name:
ASMT
Uniprot ID:
P46597
Molecular weight:
41660.34
General function:
Involved in cobalamin binding
Specific function:
Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity).
Gene Name:
MTR
Uniprot ID:
Q99707
Molecular weight:
140525.91
General function:
Involved in magnesium ion binding
Specific function:
Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
Gene Name:
COMT
Uniprot ID:
P21964
Molecular weight:
30036.77
General function:
Involved in DNA binding
Specific function:
Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA.
Gene Name:
DOT1L
Uniprot ID:
Q8TEK3
Molecular weight:
164854.41
General function:
Involved in folic acid binding
Specific function:
Catalyzes the methylation of glycine by using S-adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine.
Gene Name:
GNMT
Uniprot ID:
Q14749
Molecular weight:
32742.0
General function:
Involved in histone-lysine N-methyltransferase activity
Specific function:
Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.
Gene Name:
SETD7
Uniprot ID:
Q8WTS6
Molecular weight:
40720.595
General function:
Involved in methionine adenosyltransferase activity
Specific function:
Catalyzes the formation of S-adenosylmethionine from methionine and ATP.
Gene Name:
MAT2A
Uniprot ID:
P31153
Molecular weight:
43660.37
General function:
Involved in methyltransferase activity
Specific function:
Converts noradrenaline to adrenaline.
Gene Name:
PNMT
Uniprot ID:
P11086
Molecular weight:
30854.745
General function:
Involved in methyltransferase activity
Specific function:
S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis (By similarity).
Gene Name:
DPH5
Uniprot ID:
Q9H2P9
Molecular weight:
31651.17

Transporters

General function:
Involved in adenosylhomocysteinase activity
Specific function:
Not Available
Gene Name:
AHCYL1
Uniprot ID:
O43865
Molecular weight:
53753.0
General function:
Involved in DNA binding
Specific function:
Histone methyltransferase that plays an essential role in early development and hematopoiesis. Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac). In the MLL1/MLL complex, it specifically mediates H3K4me, a specific tag for epigenetic transcriptional activation. Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity. Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9'. Required for transcriptional activation of HOXA9. Promotes PPP1R15A-induced apoptosis.
Gene Name:
MLL
Uniprot ID:
Q03164
Molecular weight:
432047.735
General function:
Involved in binding
Specific function:
Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. Specifically mediates the transport of S-adenosylmethionine (SAM) into the mitochondria.
Gene Name:
SLC25A26
Uniprot ID:
Q70HW3
Molecular weight:
20116.095

Only showing the first 10 proteins. There are 211 proteins in total.