| Identification |
|---|
| HMDB Protein ID
| CDBP00408 |
| Secondary Accession Numbers
| Not Available |
| Name
| Hexaprenyldihydroxybenzoate methyltransferase, mitochondrial |
| Description
| Not Available |
| Synonyms
|
- 3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase
- DHHB methyltransferase
- DHHB-MT
- DHHB-MTase
- Dihydroxyhexaprenylbenzoate methyltransferase
- 2-polyprenyl-6-hydroxyphenyl methylase
- 3-demethylubiquinone-10 3-methyltransferase
|
| Gene Name
| COQ3 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in methyltransferase activity |
| Specific Function
| Not Available |
| GO Classification
|
| Biological Process |
| glycerol metabolic process |
| ubiquinone biosynthetic process |
| Cellular Component |
| mitochondrial matrix |
| Function |
| catalytic activity |
| transferase activity |
| c-methyltransferase activity |
| quinone cofactor methyltransferase activity |
| 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity |
| transferase activity, transferring one-carbon groups |
| methyltransferase activity |
| Molecular Function |
| 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity |
| 3-demethylubiquinone-9 3-O-methyltransferase activity |
| hexaprenyldihydroxybenzoate methyltransferase activity |
| O-methyltransferase activity |
| Process |
| cofactor metabolic process |
| coenzyme metabolic process |
| metabolic process |
| cellular metabolic process |
| oxidoreduction coenzyme metabolic process |
| ubiquinone metabolic process |
| ubiquinone biosynthetic process |
|
| Cellular Location
|
- Mitochondrion matrix (Probable)
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Ubiquinone and other terpenoid-quinone biosynthesis | Not Available |  | | Ubiquinone Biosynthesis |    | |
|
| Gene Properties |
|---|
| Chromosome Location
| 6 |
| Locus
| 6q16.2 |
| SNPs
| COQ3 |
| Gene Sequence
|
>1110 bp
ATGTGGAGTGGCCGTAAGCTGGGCTCCTCCGGGGGTTGGTTTTTAAGAGTGCTGGGGCCT
GGAGGCTGTAATACAAAAGCTGCGCGTCCCTTAATTTCCTCGGCGGTTTATGTGAAGAAC
CAGCTCAGTGGGACTCTACAGATTAAACCAGGGGTTTTCAATGAATACAGAACCATATGG
TTCAAATCCTACAGGACGATCTTTTCCTGTTTGAACAGAATAAAGAGTTTCAGGTACCCT
TGGGCGAGACTGTACAGTACTTCCCAAACCACTGTCGACAGCGGTGAGGTAAAAACCTTC
TTGGCCCTGGCTCACAAATGGTGGGATGAACAAGGAGTATATGCACCTCTTCATTCCATG
AATGACCTGAGGGTGCCATTTATTAGGGACAATCTTCTGAAAACAATTCCTAATCACCAG
CCAGGAAAACCTTTGTTGGGGATGAAGATTCTTGACGTTGGCTGTGGTGGTGGGCTGTTA
ACTGAACCTCTAGGGCGGCTTGGGGCTTCAGTTATTGGAATCGACCCTGTGGATGAGAAC
ATTAAAACAGCACAATGCCATAAATCATTTGATCCAGTCCTGGATAAGAGAATAGAGTAC
AGAGTGTGTTCCCTGGAAGAGATTGTGGAAGAGACTGCAGAAACATTTGATGCTGTTGTA
GCTTCTGAAGTTGTAGAACATGTGATTGATCTAGAAACATTTTTACAGTGCTGCTGTCAA
GTGTTAAAACCCGGTGGTTCTTTATTCATTACTACAATCAACAAAACACAACTTTCCTAT
GCCTTGGGAATTGTTTTTTCAGAGCAAATTGCAAGTATTGTACCAAAAGGTACTCATACA
TGGGAGAAGTTTGTTTCACCTGAAACACTAGAGAGCATTCTGGAATCAAATGGTCTGTCA
GTTCAAACAGTGGTAGGAATGCTCTATAACCCCTTCTCAGGTTACTGGCATTGGAGTGAA
AATACCAGCCTTAACTATGCAGCTTATGCTGTGAAATCCAGGGTCCAGGAACACCCAGCC
TCTGCTGAGTTTGTTTTAAAGGGAGAAACAGAAGAGCTCCAAGCTAATGCCTGCACCAAT
CCAGCTGTGCATGAAAAGCTGAAGAAATGA
|
| Protein Properties |
|---|
| Number of Residues
| 369 |
| Molecular Weight
| 41053.76 |
| Theoretical pI
| 7.422 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Hexaprenyldihydroxybenzoate methyltransferase, mitochondrial
MWSGRKLGSSGGWFLRVLGPGGCNTKAARPLISSAVYVKNQLSGTLQIKPGVFNEYRTIW
FKSYRTIFSCLNRIKSFRYPWARLYSTSQTTVDSGEVKTFLALAHKWWDEQGVYAPLHSM
NDLRVPFIRDNLLKTIPNHQPGKPLLGMKILDVGCGGGLLTEPLGRLGASVIGIDPVDEN
IKTAQCHKSFDPVLDKRIEYRVCSLEEIVEETAETFDAVVASEVVEHVIDLETFLQCCCQ
VLKPGGSLFITTINKTQLSYALGIVFSEQIAGIVPKGTHTWEKFVSPETLESILESNGLS
VQTVVGMLYNPFSGYWHWSENTSLNYAAHAVKSRVQEHPASAEFVLKGETEELQANACTN
PAVHEKLKK
|
| External Links |
|---|
| GenBank ID Protein
| 118600965 |
| UniProtKB/Swiss-Prot ID
| Q9NZJ6 |
| UniProtKB/Swiss-Prot Entry Name
| COQ3_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_017421.3 |
| GeneCard ID
| COQ3 |
| GenAtlas ID
| COQ3 |
| HGNC ID
| HGNC:18175 |
| References |
|---|
| General References
| Not Available |