Cannabis Compound Database: Showing Protein Lipoyl synthase, mitochondrial (CDBP01536)

Identification Biological properties Gene properties Protein properties External links References XML Show 4 compounds

Identification

HMDB Protein ID

CDBP01536

Secondary Accession Numbers

Not Available

Name

Lipoyl synthase, mitochondrial

Description

Not Available

Synonyms

LS
Lip-syn
Lipoate synthase
Lipoic acid synthase

Gene Name

LIAS

Protein Type

Enzyme

Biological Properties

General Function

Involved in catalytic activity

Specific Function

Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity).

GO Classification

Biological Process
response to lipopolysaccharide
response to oxidative stress
inflammatory response
neural tube closure
Cellular Component
mitochondrion
Function
binding
catalytic activity
lipoate synthase activity
transferase activity
transferase activity, transferring sulfur-containing groups
metal cluster binding
iron-sulfur cluster binding
4 iron, 4 sulfur cluster binding
sulfurtransferase activity
Molecular Function
metal ion binding
lipoate synthase activity
4 iron, 4 sulfur cluster binding
Process
metabolic process
lipoic acid metabolic process
lipoic acid biosynthetic process
lipoate biosynthetic process
cellular metabolic process
cofactor metabolic process
coenzyme metabolic process

Cellular Location

Mitochondrion

Pathways

Name	SMPDB/Pathwhiz	KEGG
protein lipoylation via endogenous pathway	Not Available	Not Available
Lipoic acid metabolism	Not Available

Gene Properties

Chromosome Location

Locus

4p14

SNPs

LIAS

Gene Sequence

>1119 bp
ATGTCTCTACGCTGCGGGGATGCAGCCCGCACCCTGGGGCCCCGGGTATTTGGGAGATAT
TTTTGCAGCCCAGTCAGACCGTTAAGCTCCTTGCCAGATAAAAAAAAGGAACTCCTACAG
AATGGACCAGACCTTCAAGATTTTGTATCTGGTGATCTTGCAGACAGGAGCACCTGGGAT
GAATATAAAGGAAACCTAAAACGCCAGAAAGGAGAAAGGTTAAGACTACCTCCATGGCTA
AAGACAGAGATTCCCATGGGGAAAAATTACAATAAACTGAAAAATACTTTGCGGAATTTA
AATCTCCATACAGTATGTGAGGAAGCTCGATGTCCCAATATTGGAGAGTGTTGGGGAGGT
GGAGAATATGCCACCGCCACAGCCACGATCATGTTGATGGGTGACACATGTACAAGAGGT
TGCAGATTTTGTTCTGTTAAGACTGCAAGAAATCCTCCTCCACTGGATGCCAGTGAGCCC
TACAATACTGCAAAGGCAATTGCAGAATGGGGTCTGGATTATGTTGTCCTGACGTCTGTG
GATCGAGATGATATGCCTGATGGGGGAGCTGAACACATTGCAAAGACCGTATCATATTTA
AAGGAAAGGAATCCAAAAATCCTTGTGGAGTGTCTTACTCCTGATTTTCGAGGTGATCTC
AAAGCAATAGAAAAAGTTGCTCTGTCAGGATTAGATGTGTATGCACATAATGTAGAAACA
GTCCCGGAATTACAGAGTAAGGTTCGTGATCCTCGGGCCAATTTTGATCAGTCCCTACGT
GTACTGAAACATGCCAAGAAGGTTCAGCCTGATGTTATTTCTAAAACATCTATAATGTTG
GGTTTAGGCGAGAATGATGAGCAAGTATATGCAACAATGAAAGCACTTCGTGAGGCAGAT
GTAGACTGCTTGACTTTAGGACAATATATGCAGCCAACAAGGCGTCACCTTAAGGTTGAA
GAATATATTACTCCTGAAAAATTCAAATACTGGGAAAAAGTAGGAAATGAACTTGGATTT
CATTATACTGCAAGTGGCCCTTTGGTGCGTTCTTCATATAAAGCAGGTGAATTTTTCCTG
AAAAATCTAGTGGCTAAAAGAAAAACAAAAGACCTCTAA

Protein Properties

Number of Residues

372

Molecular Weight

41910.695

Theoretical pI

8.591

Pfam Domain Function

Radical_SAM (PF04055 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Lipoyl synthase, mitochondrial
MSLRCGDAARTLGPRVFGRYFCSPVRPLSSLPDKKKELLQNGPDLQDFVSGDLADRSTWD
EYKGNLKRQKGERLRLPPWLKTEIPMGKNYNKLKNTLRNLNLHTVCEEARCPNIGECWGG
GEYATATATIMLMGDTCTRGCRFCSVKTARNPPPLDASEPYNTAKAIAEWGLDYVVLTSV
DRDDMPDGGAEHIAKTVSYLKERNPKILVECLTPDFRGDLKAIEKVALSGLDVYAHNVET
VPELQSKVRDPRANFDQSLRVLKHAKKVQPDVISKTSIMLGLGENDEQVYATMKALREAD
VDCLTLGQYMQPTRRHLKVEEYITPEKFKYWEKVGNELGFHYTASGPLVRSSYKAGEFFL
KNLVAKRKTKDL

External Links

GenBank ID Protein

Not Available

UniProtKB/Swiss-Prot ID

O43766

UniProtKB/Swiss-Prot Entry Name

LIAS_HUMAN

PDB IDs

Not Available

GenBank Gene ID

AK292238

GeneCard ID