| Identification |
|---|
| HMDB Protein ID
| CDBP01536 |
| Secondary Accession Numbers
| Not Available |
| Name
| Lipoyl synthase, mitochondrial |
| Description
| Not Available |
| Synonyms
|
- LS
- Lip-syn
- Lipoate synthase
- Lipoic acid synthase
|
| Gene Name
| LIAS |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in catalytic activity |
| Specific Function
| Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity).
|
| GO Classification
|
| Biological Process |
| response to lipopolysaccharide |
| response to oxidative stress |
| inflammatory response |
| neural tube closure |
| Cellular Component |
| mitochondrion |
| Function |
| binding |
| catalytic activity |
| lipoate synthase activity |
| transferase activity |
| transferase activity, transferring sulfur-containing groups |
| metal cluster binding |
| iron-sulfur cluster binding |
| 4 iron, 4 sulfur cluster binding |
| sulfurtransferase activity |
| Molecular Function |
| metal ion binding |
| lipoate synthase activity |
| 4 iron, 4 sulfur cluster binding |
| Process |
| metabolic process |
| lipoic acid metabolic process |
| lipoic acid biosynthetic process |
| lipoate biosynthetic process |
| cellular metabolic process |
| cofactor metabolic process |
| coenzyme metabolic process |
|
| Cellular Location
|
- Mitochondrion
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | protein lipoylation via endogenous pathway | Not Available | Not Available | | Lipoic acid metabolism | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 4 |
| Locus
| 4p14 |
| SNPs
| LIAS |
| Gene Sequence
|
>1119 bp
ATGTCTCTACGCTGCGGGGATGCAGCCCGCACCCTGGGGCCCCGGGTATTTGGGAGATAT
TTTTGCAGCCCAGTCAGACCGTTAAGCTCCTTGCCAGATAAAAAAAAGGAACTCCTACAG
AATGGACCAGACCTTCAAGATTTTGTATCTGGTGATCTTGCAGACAGGAGCACCTGGGAT
GAATATAAAGGAAACCTAAAACGCCAGAAAGGAGAAAGGTTAAGACTACCTCCATGGCTA
AAGACAGAGATTCCCATGGGGAAAAATTACAATAAACTGAAAAATACTTTGCGGAATTTA
AATCTCCATACAGTATGTGAGGAAGCTCGATGTCCCAATATTGGAGAGTGTTGGGGAGGT
GGAGAATATGCCACCGCCACAGCCACGATCATGTTGATGGGTGACACATGTACAAGAGGT
TGCAGATTTTGTTCTGTTAAGACTGCAAGAAATCCTCCTCCACTGGATGCCAGTGAGCCC
TACAATACTGCAAAGGCAATTGCAGAATGGGGTCTGGATTATGTTGTCCTGACGTCTGTG
GATCGAGATGATATGCCTGATGGGGGAGCTGAACACATTGCAAAGACCGTATCATATTTA
AAGGAAAGGAATCCAAAAATCCTTGTGGAGTGTCTTACTCCTGATTTTCGAGGTGATCTC
AAAGCAATAGAAAAAGTTGCTCTGTCAGGATTAGATGTGTATGCACATAATGTAGAAACA
GTCCCGGAATTACAGAGTAAGGTTCGTGATCCTCGGGCCAATTTTGATCAGTCCCTACGT
GTACTGAAACATGCCAAGAAGGTTCAGCCTGATGTTATTTCTAAAACATCTATAATGTTG
GGTTTAGGCGAGAATGATGAGCAAGTATATGCAACAATGAAAGCACTTCGTGAGGCAGAT
GTAGACTGCTTGACTTTAGGACAATATATGCAGCCAACAAGGCGTCACCTTAAGGTTGAA
GAATATATTACTCCTGAAAAATTCAAATACTGGGAAAAAGTAGGAAATGAACTTGGATTT
CATTATACTGCAAGTGGCCCTTTGGTGCGTTCTTCATATAAAGCAGGTGAATTTTTCCTG
AAAAATCTAGTGGCTAAAAGAAAAACAAAAGACCTCTAA
|
| Protein Properties |
|---|
| Number of Residues
| 372 |
| Molecular Weight
| 41910.695 |
| Theoretical pI
| 8.591 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Lipoyl synthase, mitochondrial
MSLRCGDAARTLGPRVFGRYFCSPVRPLSSLPDKKKELLQNGPDLQDFVSGDLADRSTWD
EYKGNLKRQKGERLRLPPWLKTEIPMGKNYNKLKNTLRNLNLHTVCEEARCPNIGECWGG
GEYATATATIMLMGDTCTRGCRFCSVKTARNPPPLDASEPYNTAKAIAEWGLDYVVLTSV
DRDDMPDGGAEHIAKTVSYLKERNPKILVECLTPDFRGDLKAIEKVALSGLDVYAHNVET
VPELQSKVRDPRANFDQSLRVLKHAKKVQPDVISKTSIMLGLGENDEQVYATMKALREAD
VDCLTLGQYMQPTRRHLKVEEYITPEKFKYWEKVGNELGFHYTASGPLVRSSYKAGEFFL
KNLVAKRKTKDL
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| O43766 |
| UniProtKB/Swiss-Prot Entry Name
| LIAS_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AK292238 |
| GeneCard ID
| LIAS |
| GenAtlas ID
| LIAS |
| HGNC ID
| HGNC:16429 |
| References |
|---|
| General References
| Not Available |