| Identification |
|---|
| HMDB Protein ID
| CDBP04213 |
| Secondary Accession Numbers
| Not Available |
| Name
| Histone-lysine N-methyltransferase MLL5 |
| Description
| Not Available |
| Synonyms
|
- KMT2E
- Lysine N-methyltransferase 2E
- Myeloid/lymphoid or mixed-lineage leukemia protein 5
|
| Gene Name
| MLL5 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in zinc ion binding |
| Specific Function
| Histone methyltransferase that specifically mono- and dimethylates 'Lys-4' of histone H3 (H3K4me1 and H3K4me2). H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Key regulator of hematopoiesis involved in terminal myeloid differentiation and in the regulation of hematopoietic stem cell (HSCs) self-renewal by a mechanism that involves DNA methylation. Plays an essential role in retinoic-acid-induced granulopoiesis by acting as a coactivator of RAR-alpha (RARA) in target gene promoters. Also acts as an important cell cycle regulator, participating in cell cycle regulatory network machinery at multiple cell cycle stages. Required to suppress inappropriate expression of S-phase-promoting genes and maintain expression of determination genes in quiescent cells. Overexpression inhibits cell cycle progression, while knockdown induces cell cycle arrest at both the G1 and G2/M phases.
|
| GO Classification
|
| Biological Process |
| cell cycle arrest |
| positive regulation of transcription, DNA-dependent |
| erythrocyte differentiation |
| cellular response to retinoic acid |
| transcription, DNA-dependent |
| retinoic acid receptor signaling pathway |
| DNA methylation |
| neutrophil activation |
| neutrophil mediated immunity |
| positive regulation of granulocyte differentiation |
| Cellular Component |
| nuclear speck |
| MLL5-L complex |
| Function |
| binding |
| transition metal ion binding |
| zinc ion binding |
| protein binding |
| ion binding |
| cation binding |
| metal ion binding |
| Molecular Function |
| metal ion binding |
| zinc ion binding |
| transcription coactivator activity |
| histone methyltransferase activity (H3-K4 specific) |
|
| Cellular Location
|
- Nucleus speckle
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 7 |
| Locus
| 7q22.1 |
| SNPs
| MLL5 |
| Gene Sequence
|
>5577 bp
ATGAGCATAGTGATCCCATTGGGGGTTGATACAGCAGAGACGTCATACTTGGAAATGGCT
GCAGGTTCAGAACCAGAATCCGTAGAAGCTAGCCCTGTGGTAGTTGAGAAATCCAACAGT
TATCCCCACCAGTTATATACCAGCAGCTCACATCATTCACACAGTTACATTGGTTTGCCC
TATGCGGACCATAATTATGGTGCTCGTCCTCCTCCGACACCTCCGGCTTCCCCTCCTCCA
TCAGTCCTTATTAGCAAAAATGAAGTAGGCATATTTACCACTCCTAATTTTGATGAAACT
TCCAGTGCTACTACAATCAGCACATCTGAGGATGGAAGTTATGGTACTGATGTAACCAGG
TGCATATGTGGTTTTACACATGATGATGGATACATGATCTGTTGTGACAAATGCAGCGTT
TGGCAACATATTGACTGCATGGGGATTGATAGGCAGCATATTCCTGATACATATCTATGT
GAACGTTGTCAGCCTAGGAATTTGGATAAAGAGAGGGCAGTGCTACTACAACGCCGGAAA
AGGGAAAATATGTCAGATGGTGATACCAGTGCAACTGAGAGTGGTGATGAGGTTCCTGTG
GAATTATATACTGCATTTCAGCATACTCCAACATCAATTACTTTAACTGCTTCAAGAGTT
TCCAAAGTTAATGATAAAAGAAGGAAAAAAAGCGGGGAGAAAGAACAACACATTTCAAAA
TGTAAAAAGGCATTTCGTGAAGGATCTAGGAAGTCATCAAGAGTTAAGGGTTCAGCTCCA
GAGATTGATCCTTCATCTGATGGTTCAAATTTTGGATGGGAGACAAAGATCAAAGCATGG
ATGGATCGATATGAAGAAGCAAATAACAACCAGTACAGTGAGGGTGTTCAGAGGGAGGCA
CAAAGAATAGCTCTGAGATTAGGCAATGGAAATGACAAAAAAGAGATGAATAAATCCGAT
TTGAATACCAACAATTTGCTCTTCAAACCTCCTGTAGAGAGCCATATACAAAAGAATAAG
AAAATTCTTAAATCTGCAAAAGATTTGCCTCCTGATGCACTTATCATTGAATACAGAGGG
AAGTTTATGCTGAGAGAACAGTTTGAAGCAAATGGGTATTTCTTTAAAAGACCATACCCT
TTTGTGTTATTCTACTCTAAATTTCATGGGCTAGAAATGTGTGTTGATGCAAGGACTTTT
GGGAATGAGGCTCGATTCATCAGGCGGTCTTGTACACCCAATGCAGAGGTGAGGCATGAA
ATTCAAGATGGAACCATACATCTTTATATTTATTCTATACACAGTATTCCAAAGGGAACT
GAAATTACTATTGCCTTTGATTTTGACTATGGAAATTGTAAGTACAAGGTGGACTGTGCA
TGCCTCAAAGAAAACCCAGAGTGCCCTGTTCTAAAACGTAGTTCTGAATCCATGGAAAAT
ATCAATAGTGGTTATGAGACCAGACGGAAAAAAGGAAAAAAAGACAAAGATATTTCAAAA
GAAAAAGATACACAAAATCAGAATATTACTTTGGATTGTGAAGGAACGACCAACAAAATG
AAGAGCCCAGAAACTAAACAAAGAAAGCTTTCTCCACTGAGACTATCAGTATCAAATAAT
CAGGAACCAGATTTTATTGATGATATAGAAGAAAAAACTCCTATTAGTAATGAAGTAGAA
ATGGAATCAGAGGAGCAGATTGCAGAAAGGAAAAGGAAGATGACAAGAGAAGAAAGAAAA
ATGGAAGCAATTTTGCAAGCTTTTGCCAGACTTGAAAAGAGAGAGAAAAGAAGAGAACAA
GCTTTGGAAAGGATCAGCACAGCCAAAACTGAAGTTAAAACTGAATGTAAAGATACACAG
ATTGTCAGTGATGCTGAAGTTATTCAGGAACAAGCAAAAGAAGAAAATGCTAGCAAGCCA
ACCCCTGCCAAAGTAAATAGAACTAAACAGAGAAAAAGTTTTTCTCGGAGTAGGACTCAC
ATTGGACAGCAGCGTCGGAGACACAGAACTGTCAGCATGTGTTCAGATATCCAGCCATCT
TCTCCTGATATAGAAGTTACTTCACAACAAAATGATATTGAAAATACTGTACTTACAATA
GAACCAGAAACTGAAACTGCACTAGCAGAAATAATTACTGAAACTGAAGTTCCAGCACTT
AATAAATGTCCTACCAAGTACCCCAAAACAAAGAAGCACTTGGTTAATGAATGGTTAAGT
GAGAAGAATGAGAAGACAGGAAAACCTTCAGATGGCCTTTCAGAAAGGCCTCTACGCATA
ACTACAGATCCTGAAGTGTTAGCTACACAACTCAATTCTTTACCAGGTCTCACTTACAGC
CCCCATGTATACTCCACTCCTAAGCATTATATTAGATTTACTTCACCATTCCTTTCAGAA
AAAAGGAGAAGAAAAGAACCTACTGAAAACATTTCTGGTTCATGCAAGAAGCGATGGTTG
AAACAAGCTCTGGAAGAAGAAAATTCAGCAATTTTACATAGATTTAATTCACCCTGTCAA
GAAAGATCCAGAAGTCCTGCAGTCAATGGTGAAAATAAAAGTCCACTACTATTAAATGAC
AGCTGTTCCCTTCCAGATTTAACTACACCACTAAAAAAACGAAGATTTTATCAGTTGCTA
GATTCGGTTTACTCAGAAACCTCCACACCTACTCCTTCCCCGTATGCTACACCAACTCAC
ACCGATATTACTCCTATGGACCCATCTTTTGCCACGCCTCCACGGATAAAATCAGATGAT
GAAACTTGTAGAAATGGTTATAAACCCATATATTCACCAGTTACCCCAGTAACTCCTGGT
ACACCAGGAAATACCATGCACTTTGAGAATATTTCTTCCCCAGAAAGTTCTCCAGAAATA
AAGAGACGCACTTATAGTCAAGAGGGATATGACAGATCTTCAACCATGTTAACATTGGGG
CCTTTTAGAAATTCTAATTTAACTGAACTGGGTCTGCAAGAAATAAAGACTATTGGTTAT
ACGAGCCCTAGGAGTAGGACTGAAGTCAACAGGCAGTGTCCTGGAGAAAAGGAACCTGTG
TCAGACCTTCAGCTAGGACTCGATGCAGTTGAGCCAACTGCCCTACATAAAACCCTGGAA
ACGCCTGCACATGACAGGGCTGAGCCCAACAGCCAACTGGACTCGACTCACTCTGGACGG
GGCACAATGTATTCTTCCTGGGTAAAGAGCCCTGACAGAACAGGAGTTAACTTCTCAGTG
AACTCCAACTTGAGGGACCTGACACCCTCGCATCAGTTGGAGGTTGGAGGAGGCTTCCGA
ATAAGTGAGTCAAAGTGCCTGATGCAGGATGATACTAGAGGCATGTTTATGGAAACAACT
GTGTTTTGTACTTCCGAAGATGGGCTTGTATCTGGTTTCGGACGGACTGTTAATGACAAT
TTGATCGACGGGAATTGCACACCCCAGAATCCACCACAAAAGAAAAAGGTTTCTCTATTA
GAATACCGTAAGAGACAACGTGAAGCTAGGAAAAGTGGCTCTAAGACAGAGAACTTTCCA
CTCATTAGTGTATCACCCCATGCAAGTGGAAGCTTGAGCAACAATGGTGATGGCTGTGCC
AGCAGTAATGACAATGGGGAGCAGGTGGACCACACTGCTAGCCTACCTTTACCAACACCA
GCTACAGTTTATAATGCCACTTCTGAAGAAACTAGCAATAACTGCCCTGTTAAGGATGCT
ACTGCTAGTGAGAAGAATGAACCAGAAGTTCAATGGACTGCCTCAACTTCAGTGGAACAA
GTCAGAGAAAGGAGTTATCAGAGAGCTTTACTTCTCAGTGATCACCGAAAAGATAAAGAT
AGTGGGGGAGAATCACCATGTGTCTCATGTTCACCGAGTCATGTTCAGTCTTCACCTTCA
TCTCATTCAAATCACATACCCCAGTTGCAAGCTAAGGGCCCAGTCCCTTCTTTCAGTGAA
CTTATGGAAGACCCTGATCCTGAAAATCCAGAACCCACAACTACGAATGAATGTCCATCC
CCAGATACTTCTCAAAATACTTGTAAAAGTCCTCCAAAAATGAGCAAGCCTGGTTCACCT
GGATCTGTAATTCCTGCTCAAGCACACGGGAAAATATTCACAAAACCAGATCCCCAATGG
GACTCCACAGTTAGTGCATCCGAAGCTGAAAATGGTGTTCACCTAAAAACAGAGCTCCAA
CAAAAACAGCTATCAAATAACAACCAAGCACTTTCAAAGAATCATCCTCCTCAGACACAC
GTTCGTAATTCATCTGAGCAACTTTCACAAAAGCTGCCTTCTGTGCCAACAAAGTTGCAC
TGTCCTCCATCACCTCACCTAGAAAATCCTCCAAAGTCATCCACGCCTCACACACCTGTA
CAGCATGGTTATCTTTCACCAAAGCCTCCTTCACAGCAGTTAGGATCTCCCTACAGGCCT
CATCATTCACAGTCACCTCAAGTTGGAACACCTCAGCGAGAGCCTCAAAGAAACTTTTAT
CCAGCAGCACAGAACCTTCCAGCCAATACTCAGCAGGCAACTTCTGGAACATTATTTACA
CAGACACCCTCAGGACAATCTTCAGCAACATACAGTCAGTTTAACCAACAAAGTCTGAAC
AGCACGGCACCACCCCCTCCACCTCCTCCACCTCCTTCTTCGTCTTACTATCAAAACCAG
CAGCCCTCTGCAAACTTTCAGAATTATAATCAGCTCAAAGGTAGTCTTTCTCAACAAACT
GTGTTTACATCAGGACCAAATCAAGCACTTCCTGGCACCACAAGCCAGCAAACAGTTCCA
GGACACCACGTGACTCCAGGGCATTTTTTGCCCTCTCAGAACCCTACCATTCACCATCAA
ACTGCTGCTGCCGTAGTCCCCCCTCCTCCTCCACCACCACCTGCTCCAGGACCGCACCTT
GTACAACAGCCGAATTCCCATCAGCAACACTCTGTAGCACATGTAGTAGGGCCTGTTCAT
GCGGTCACCCCTGGGTCGCATATTCATTCTCAAACTGCTGGACACCACTTACCCCCACCC
CCACCCCCTCCTGGTCCTGCCCCTCATCACCATCCACCACCCCATCCATCCACAGGACTC
CAAGGTCTACAAGCACAACACCAGCATGTTGTAAATTCAGCACCCCCACCACCCCCTCCG
CCGCCACCTTCCAGTGTTTTGGCTTCTGGGCATCATACCACATCAGCTCAAGCCTTACAC
CACCCACCTCATCAAGGACCTCCACTTTTTCCTTCGAGTGCTCATCCAACTGTACCACCG
TATCCCTCACAAGCTACACATCATACCACTTTGGGACCGGGACCCCAGCACCAGCCTTCT
GGAACAGGGCCACATTGTCCATTACCTGTCACAGGTCCTCATCTCCAGCCCCAAGGACCA
AACAGTATTCCAACACCTACTGCTTCAGGGTTCTGTCCTCATCCTGGCTCTGTGGCCCTG
CCACATGGGGTTCAAGGACCTCAGCAGGCATCTCCAGTGCCTGGACAGATTCCAATTCAC
AGAGCACAGGTGCCACCAACATTTCAAAACAATTACCATGGGTCAGGGTGGCATTAA
|
| Protein Properties |
|---|
| Number of Residues
| 1858 |
| Molecular Weight
| 204963.565 |
| Theoretical pI
| 7.601 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Histone-lysine N-methyltransferase MLL5
MSIVIPLGVDTAETSYLEMAAGSEPESVEASPVVVEKSNSYPHQLYTSSSHHSHSYIGLP
YADHNYGARPPPTPPASPPPSVLISKNEVGIFTTPNFDETSSATTISTSEDGSYGTDVTR
CICGFTHDDGYMICCDKCSVWQHIDCMGIDRQHIPDTYLCERCQPRNLDKERAVLLQRRK
RENMSDGDTSATESGDEVPVELYTAFQHTPTSITLTASRVSKVNDKRRKKSGEKEQHISK
CKKAFREGSRKSSRVKGSAPEIDPSSDGSNFGWETKIKAWMDRYEEANNNQYSEGVQREA
QRIALRLGNGNDKKEMNKSDLNTNNLLFKPPVESHIQKNKKILKSAKDLPPDALIIEYRG
KFMLREQFEANGYFFKRPYPFVLFYSKFHGLEMCVDARTFGNEARFIRRSCTPNAEVRHE
IQDGTIHLYIYSIHSIPKGTEITIAFDFDYGNCKYKVDCACLKENPECPVLKRSSESMEN
INSGYETRRKKGKKDKDISKEKDTQNQNITLDCEGTTNKMKSPETKQRKLSPLRLSVSNN
QEPDFIDDIEEKTPISNEVEMESEEQIAERKRKMTREERKMEAILQAFARLEKREKRREQ
ALERISTAKTEVKTECKDTQIVSDAEVIQEQAKEENASKPTPAKVNRTKQRKSFSRSRTH
IGQQRRRHRTVSMCSDIQPSSPDIEVTSQQNDIENTVLTIEPETETALAEIITETEVPAL
NKCPTKYPKTKKHLVNEWLSEKNEKTGKPSDGLSERPLRITTDPEVLATQLNSLPGLTYS
PHVYSTPKHYIRFTSPFLSEKRRRKEPTENISGSCKKRWLKQALEEENSAILHRFNSPCQ
ERSRSPAVNGENKSPLLLNDSCSLPDLTTPLKKRRFYQLLDSVYSETSTPTPSPYATPTH
TDITPMDPSFATPPRIKSDDETCRNGYKPIYSPVTPVTPGTPGNTMHFENISSPESSPEI
KRRTYSQEGYDRSSTMLTLGPFRNSNLTELGLQEIKTIGYTSPRSRTEVNRQCPGEKEPV
SDLQLGLDAVEPTALHKTLETPAHDRAEPNSQLDSTHSGRGTMYSSWVKSPDRTGVNFSV
NSNLRDLTPSHQLEVGGGFRISESKCLMQDDTRGMFMETTVFCTSEDGLVSGFGRTVNDN
LIDGNCTPQNPPQKKKVSLLEYRKRQREARKSGSKTENFPLISVSPHASGSLSNNGDGCA
SSNDNGEQVDHTASLPLPTPATVYNATSEETSNNCPVKDATASEKNEPEVQWTASTSVEQ
VRERSYQRALLLSDHRKDKDSGGESPCVSCSPSHVQSSPSSHSNHIPQLQAKGPVPSFSE
LMEDPDPENPEPTTTNECPSPDTSQNTCKSPPKMSKPGSPGSVIPAQAHGKIFTKPDPQW
DSTVSASEAENGVHLKTELQQKQLSNNNQALSKNHPPQTHVRNSSEQLSQKLPSVPTKLH
CPPSPHLENPPKSSTPHTPVQHGYLSPKPPSQQLGSPYRPHHSQSPQVGTPQREPQRNFY
PAAQNLPANTQQATSGTLFTQTPSGQSSATYSQFNQQSLNSTAPPPPPPPPPSSSYYQNQ
QPSANFQNYNQLKGSLSQQTVFTSGPNQALPGTTSQQTVPGHHVTPGHFLPSQNPTIHHQ
TAAAVVPPPPPPPPAPGPHLVQQPNSHQQHSVAHVVGPVHAVTPGSHIHSQTAGHHLPPP
PPPPGPAPHHHPPPHPSTGLQGLQAQHQHVVNSAPPPPPPPPPSSVLASGHHTTSAQALH
HPPHQGPPLFPSSAHPTVPPYPSQATHHTTLGPGPQHQPSGTGPHCPLPVTGPHLQPQGP
NSIPTPTASGFCPHPGSVALPHGVQGPQQASPVPGQIPIHRAQVPPTFQNNYHGSGWH
|
| External Links |
|---|
| GenBank ID Protein
| 91199543 |
| UniProtKB/Swiss-Prot ID
| Q8IZD2 |
| UniProtKB/Swiss-Prot Entry Name
| MLL5_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| NM_018682.3 |
| GeneCard ID
| MLL5 |
| GenAtlas ID
| MLL5 |
| HGNC ID
| HGNC:18541 |
| References |
|---|
| General References
| Not Available |