Showing Protein Dimethyladenosine transferase 1, mitochondrial (CDBP04233)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 compounds
Identification
HMDB Protein ID CDBP04233
Secondary Accession Numbers Not Available
Name Dimethyladenosine transferase 1, mitochondrial
Description Not Available
Synonyms
  1. Mitochondrial 12S rRNA dimethylase 1
  2. Mitochondrial transcription factor B1
  3. S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 1
  4. h-mtTFB
  5. h-mtTFB1
  6. hTFB1M
  7. mtTFB1
Gene Name TFB1M
Protein Type Enzyme
Biological Properties
General Function Involved in rRNA (adenine-N6,N6-)-dimethyltransferase activity
Specific Function S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity
GO Classification
Function
catalytic activity
transferase activity
rna methyltransferase activity
rrna (adenine) methyltransferase activity
rrna (adenine-n6,n6-)-dimethyltransferase activity
rrna methyltransferase activity
transferase activity, transferring one-carbon groups
methyltransferase activity
n-methyltransferase activity
Process
metabolic process
macromolecule metabolic process
cellular macromolecule metabolic process
rrna metabolic process
rrna processing
rrna modification
rna metabolic process
ncrna metabolic process
Cellular Location
  1. Mitochondrion
Pathways
Gene Properties
Chromosome Location Chromosome:6
Locus 6q25.1-q25.3
SNPs TFB1M
Gene Sequence 
>1041 bp
ATGGCTGCCTCCGGAAAACTCAGCACTTGCCGTCTCCCTCCGTTGCCCACGATTCGAGAA
ATCATTAAGTTGTTAAGACTGCAAGCAGCGAACGAGCTATCACAGAATTTCCTCCTGGAC
TTGAGGCTGACAGATAAGATTGTAAGGAAAGCTGGCAATCTGACAAATGCTTATGTTTAC
GAAGTGGGCCCTGGGCCAGGGGGAATCACAAGATCTATTCTTAATGCCGACGTCGCTGAA
CTTCTGGTGGTTGAAAAGGACACTCGATTTATTCCTGGATTACAGATGCTTTCTGATGCA
GCACCTGGGAAACTGAGAATTGTTCATGGAGATGTCTTGACATTTAAGGTAGAAAAGGCT
TTTTCAGAAAGTCTTAAAAGACCCTGGGAAGATGATCCTCCAAATGTACATATTATTGGA
AATCTGCCTTTTAGTGTTTCAACTCCACTGATTATCAAGTGGCTTGAAAATATTTCCTGT
AGAGATGGACCTTTTGTTTATGGCAGAACTCAGATGACTTTGACTTTTCAAAAGGAAGTG
GCAGAGAGACTTGCAGCCAATACAGGAAGCAAACAGCGTAGTCGCCTCTCTGTTATGGCT
CAGTACCTCTGCAATGTTCGACACATCTTTACAATTCCAGGACAAGCTTTTGTCCCCAAA
CCAGAGGTGGACGTGGGCGTGGTGCACTTCACTCCCTTGATACAGCCCAAGATAGAGCAG
CCATTCAAGCTGGTGGAAAAAGTGGTTCAGAATGTATTTCAGTTCCGAAGGAAATACTGC
CATCGAGGGCTCAGAATGTTATTCCCTGAAGCGCAGCGCTTGGAAAGCACGGGCAGGCTG
TTAGAGTTGGCAGACATAGACCCTACTCTTCGGCCCCGCCAGCTCTCCATCTCACACTTT
AAGAGCCTCTGTGATGTATACAGAAAAATGTGTGATGAAGACCCACAACTCTTTGCATAT
AATTTCAGAGAAGAACTCAAGCGAAGAAAAAGCAAAAATGAAGAAAAAGAAGAGGATGAC
GCAGAGAATTACAGACTCTAG
Protein Properties
Number of Residues 346
Molecular Weight 39542.6
Theoretical pI 9.74
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["None"]
Protein Sequence 
>Dimethyladenosine transferase 1, mitochondrial
MAASGKLSTCRLPPLPTIREIIKLLRLQAAKQLSQNFLLDLRLTDKIVRKAGNLTNAYVY
EVGPGPGGITRSILNADVAELLVVEKDTRFIPGLQMLSDAAPGKLRIVHGDVLTFKVEKA
FSESLKRPWEDDPPNVHIIGNLPFSVSTPLIIKWLENISCRDGPFVYGRTQMTLTFQKEV
AERLAANTGSKQRSRLSVMAQYLCNVRHIFTIPGQAFVPKPEVDVGVVHFTPLIQPKIEQ
PFKLVEKVVQNVFQFRRKYCHRGLRMLFPEAQRLESTGRLLELADIDPTLRPRQLSISHF
KSLCDVYRKMCDEDPQLFAYNFREELKRRKSKNEEKEEDDAENYRL
GenBank ID Protein 4929619
UniProtKB/Swiss-Prot ID Q8WVM0
UniProtKB/Swiss-Prot Entry Name TFB1M_HUMAN
PDB IDs Not Available
GenBank Gene ID AF151833
GeneCard ID TFB1M
GenAtlas ID TFB1M
HGNC ID HGNC:17037
References
General References Not Available