| Identification |
|---|
| HMDB Protein ID
| CDBP04241 |
| Secondary Accession Numbers
| Not Available |
| Name
| tRNA (guanine(37)-N1)-methyltransferase |
| Description
| Not Available |
| Synonyms
|
- M1G-methyltransferase
- TRM5
- tRNA [GM37] methyltransferase
- tRNA methyltransferase 5
- tRNA methyltransferase 5 homolog
|
| Gene Name
| TRMT5 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in tRNA (guanine-N1-)-methyltransferase activity |
| Specific Function
| Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.
|
| GO Classification
|
| Cellular Component |
| nucleus |
| mitochondrial matrix |
| Molecular Function |
| tRNA (guanine(37)-N(1))-methyltransferase activity |
|
| Cellular Location
|
- Cytoplasm (Probable)
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 14 |
| Locus
| 14q23.1 |
| SNPs
| TRMT5 |
| Gene Sequence
|
>1530 bp
ATGGTGCTTTGGATCTTATGGAGGCCATTTGGATTCTCAGGAAGATTTCTGAAACTGGAA
AGCCATAGCATAACTGAATCAAAATCGTTGATTCCAGTAGCTTGGACATCCCTGACACAG
ATGCTTTTGGAAGCACCTGGTATTTTCTTATTGGGTCAAAGAAAAAGATTCTCAACCATG
CCAGAAACAGAAACACATGAGAGAGAGACTGAATTGTTTTCACCACCTTCTGATGTCCGA
GGCATGACAAAACTTGATAGAACAGCTTTTAAAAAGACAGTCAACATTCCAGTGCTTAAA
GTGAGGAAAGAAATAGTCAGTAAATTGATGCGATCCCTAAAAAGGGCAGCATTGCAGCGC
CCAGGCATAAGACGTGTGATTGAAGATCCGGAAGATAAAGAAAGTAGACTAATCATGTTG
GATCCCTATAAAATATTTACTCATGATTCCTTTGAGAAAGCAGAACTCAGTGTTTTAGAG
CAGCTTAATGTCAGTCCACAGATCTCTAAATACAATTTGGAACTAACATATGAACACTTT
AAGTCAGAAGAAATCTTGAGAGCTGTGCTTCCTGAAGGTCAAGATGTAACTTCAGGGTTT
AGCAGGATTGGACATATTGCACACCTAAACCTTCGAGATCATCAGCTGTCTTTCAAACAT
TTAATTGGCCAGGTTATGATTGACAAAAATCCAGGAATCACCTCAGCAGTAAATAAAATA
AATAATATTGACAATATGTACCGAAATTTCCAAATGGAAGTGCTATCTGGAGAGCAGAAC
ATGATGACAAAGGTTCGAGAAAACAACTACACCTATGAATTTGATTTTTCAAAAGTCTAT
TGGAATCCTCGTCTGTCTACAGAACACAGCCGTATCACAGAACTTCTCAAACCTGGGGAT
GTCCTATTTGATGTTTTTGCTGGGGTTGGGCCCTTTGCCATTCCAGTAGCAAAGAAAAAC
TGCACTGTATTTGCCAATGATCTCAATCCTGAATCTCATAAATGGCTGTTGTACAACTGT
AAATTAAATAAAGTGGACCAAAAGGTGAAAGTCTTCAACTTGGATGGGAAAGACTTCCTC
CAAGGACCAGTCAAAGAAGAGTTAATGCAGCTGCTGGGTCTGTCAAAAGAAAGAAAACCC
TCTGTGCACGTTGTCATGAACTTGCCAGCAAAAGCTATAGAGTTTCTTAGTGCTTTCAAG
TGGCTTTTAGATGGGCAGCCATGCAGCAGTGAGTTCCTTCCCATAGTGCATTGTTATAGC
TTTTCCAAAGATGCTAACCCTGCTGAGGATGTTCGGCAAAGGGCTGGAGCTGTGTTAGGC
ATTTCTCTGGAGGCATGCAGTTCAGTTCACCTGGTAAGAAATGTGGCCCCAAACAAGGAA
ATGCTGTGCATCACGTTTCAGATTCCTGCCTCTGTCCTCTACAAGAACCAGACCAGAAAT
CCAGAGAATCATGAAGATCCACCTCTTAAAAGGCAGAGGACGGCTGAAGCCTTTTCAGAC
GAAAAAACACAAATTGTTTCAAACACTTAA
|
| Protein Properties |
|---|
| Number of Residues
| 509 |
| Molecular Weight
| 58245.73 |
| Theoretical pI
| 8.61 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>tRNA (guanine-N(1)-)-methyltransferase
MVLWILWRPFGFSGRFLKLESHSITESKSLIPVAWTSLTQMLLEAPGIFLLGQRKRFSTM
PETETHERETELFSPPSDVRGMTKLDRTAFKKTVNIPVLKVRKEIVSKLMRSLKRAALQR
PGIRRVIEDPEDKESRLIMLDPYKIFTHDSFEKAELSVLEQLNVSPQISKYNLELTYEHF
KSEEILRAVLPEGQDVTSGFSRIGHIAHLNLRDHQLSFKHLIGQVMIDKNPGITSAVNKI
NNIDNMYRNFQMEVLSGEQNMMTKVRENNYTYEFDFSKVYWNPRLSTEHSRITELLKPGD
VLFDVFAGVGPFAIPVAKKNCTVFANDLNPESHKWLLYNCKLNKVDQKVKVFNLDGKDFL
QGPVKEELMQLLGLSKERKPSVHVVMNLPAKAIEFLSAFKWLLDGQPCSSEFLPIVHCYS
FSKDANPAEDVRQRAGAVLGISLEACSSVHLVRNVAPNKEMLCITFQIPASVLYKNQTRN
PENHEDPPLKRQRTAEAFSDEKTQIVSNT
|
| External Links |
|---|
| GenBank ID Protein
| 145275187 |
| UniProtKB/Swiss-Prot ID
| Q32P41 |
| UniProtKB/Swiss-Prot Entry Name
| TRMT5_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_020810.2 |
| GeneCard ID
| TRMT5 |
| GenAtlas ID
| TRMT5 |
| HGNC ID
| HGNC:23141 |
| References |
|---|
| General References
| Not Available |