Showing Protein Histone-lysine N-methyltransferase SUV420H1 (CDBP04230)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 2 compounds
Identification
HMDB Protein ID CDBP04230
Secondary Accession Numbers Not Available
Name Histone-lysine N-methyltransferase SUV420H1
Description Not Available
Synonyms
  1. Lysine N-methyltransferase 5B
  2. Su(var)4-20 homolog 1
  3. Suppressor of variegation 4-20 homolog 1
  4. Suv4-20h1
Gene Name SUV420H1
Protein Type Enzyme
Biological Properties
General Function Involved in protein binding
Specific Function Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. SUV420H1 is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity).
GO Classification
Biological Process
histone H4-K20 trimethylation
regulation of transcription, DNA-dependent
transcription, DNA-dependent
Cellular Component
condensed nuclear chromosome, centromeric region
Molecular Function
histone-lysine N-methyltransferase activity
histone methyltransferase activity (H4-K20 specific)
Cellular Location
  1. Nucleus
  2. Chromosome
Pathways
Gene Properties
Chromosome Location 11
Locus 11q13.2
SNPs SUV420H1
Gene Sequence 
>2658 bp
ATGAAGTGGTTGGGAGAATCCAAGAACATGGTGGTGAATGGCAGGAGAAATGGAGGCAAG
TTGTCTAATGACCATCAGCAGAATCAATCAAAATTACAGCACACGGGGAAGGACACCCTG
AAGGCTGGCAAAAATGCAGTCGAGAGGAGGTCGAACAGATGTAATGGTAACTCGGGATTT
GAAGGACAGAGTCGCTATGTACCATCCTCTGGAATGTCCGCCAAGGAACTCTGTGAAAAT
GATGACCTAGCAACCAGTTTGGTTCTTGATCCCTATTTAGGTTTTCAAACACACAAAATG
AATACTAGCGCCTTTCCTTCGAGGAGCTCAAGGCATTTTTCAAAATCTGACAGTTTTTCT
CACAACAACCCTGTGAGATTTAGGCCTATTAAAGGAAGGCAGGAAGAACTAAAGGAAGTA
ATTGAACGTTTTAAGAAAGATGAACACTTGGAGAAAGCCTTCAAATGTTTGACTTCAGGC
GAATGGGCACGGCACTATTTTCTCAACAAGAATAAAATGCAGGAGAAATTATTCAAAGAA
CATGTATTTATTTATTTGCGAATGTTTGCAACTGACAGTGGATTTGAAATATTGCCATGT
AATAGATACTCATCAGAACAAAATGGAGCCAAAATAGTTGCAACAAAAGAGTGGAAACGA
AATGACAAAATAGAATTACTGGTGGGTTGTATTGCCGAACTTTCAGAAATTGAGGAGAAC
ATGCTACTTAGACATGGAGAAAACGACTTCAGTGTCATGTACTCCACAAGGAAAAACTGT
GCTCAACTCTGGCTGGGTCCTGCTGCGTTTATAAACCATGATTGCAGACCTAATTGTAAG
TTTGTGTCAACTGGTCGAGATACAGCATGTGTGAAGGCTCTAAGAGACATTGAACCTGGA
GAAGAAATTTCTTGTTATTATGGAGATGGGTTCTTTGGAGAAAATAATGAGTTCTGCGAG
TGTTACACTTGCGAAAGACGGGGCACTGGTGCTTTTAAATCCAGAGTGGGACTGCCTGCG
CCTGCTCCTGTTATCAATAGCAAATATGGACTCAGAGAAACAGATAAACGTTTAAATAGG
CTTAAAAAGTTAGGTGACAGCAGCAAAAATTCAGACAGTCAATCTGTCAGCTCTAACACT
GATGCAGATACCACTCAGGAAAAAAACAATGCAACTTCTAACCGAAAATCTTCAGTTGGC
GTAAAAAAGAATAGCAAGAGCAGAACGTTAACGAGGCAATCTATGTCAAGAATTCCAGCT
TCTTCCAACTCTACCTCATCTAAGCTAACTCATATAAATAATTCCAGGGTACCAAAGAAA
CTGAAGAAGCCTGCAAAGCCTTTACTTTCAAAGATAAAATTGAGAAATCATTGCAAGCGG
CTGGAGCAAAAGAATGCTTCAAGAAAACTCGAAATGGGAAACTTAGTACTGAAAGAGCCT
AAAGTAGTTCTGTATAAAAATTTGCCCATTAAAAAAGATAAGGAGCCAGAGGGACCAGCC
CAAGCCGCAGTTGCCAGCGGGTGCTTGACTAGACACGCGGCGAGAGAACACAGACAGAAT
CCTGTGAGAGGTGCTCATTCGCAGGGGGAGAGCTCGCCCTGCACCTACATAACTCGGCGG
TCAGTGAGGACAAGAACAAATCTGAAGGAGGCCTCTGACATCAAGCTTGAACCAAATACG
TTGAATGGCTATAAAAGCAGTGTGACGGAACCTTGCCCCGACAGTGGTGAACAGCTGCAG
CCAGCTCCTGTGCTGCAGGAGGAAGAACTGGCTCATGAGACTGCACAAAAAGGGGAGGCA
AAGTGTCATAAGAGTGACACAGGCATGTCCAAAAAGAAGTCACGACAAGGAAAACTTGTG
AAACAGTTTGCAAAAATAGAGGAATCTACTCCAGTGCACGATTCTCCTGGAAAAGACGAC
GCGGTACCAGATTTGATGGGTCCCCATTCTGACCAGGGTGAGCACAGTGGCACTGTGGGC
GTGCCTGTGAGCTACACAGACTGTGCTCCTTCACCCGTCGGTTGTTCAGTTGTGACATCA
GATAGCTTCAAAACAAAAGACAGCTTTAGAACTGCAAAAAGTAAAAAGAAGAGGCGAATC
ACAAGGTATGATGCACAGTTAATCCTAGAAAATAACTCTGGGATTCCCAAATTGACTCTT
CGTAGGCGTCATGATAGCAGCAGCAAAACAAATGACCAAGAGAATGATGGAATGAACTCT
TCCAAAATAAGCATCAAGTTAAGCAAAGACCATGACAACGATAACAATCTCTATGTAGCA
AAGCTTAATAATGGATTTAACTCAGGATCAGGCAGTAGTTCTACAAAATTAAAAATCCAG
CTAAAACGAGATGAGGAAAATAGGGGGTCTTATACAGAGGGGCTTCATGAAAATGGGGTG
TGCTGCAGTGATCCTCTTTCTCTCTTGGAGTCTCGAATGGAGGTGGATGACTATAGTCAG
TATGAGGAAGAAAGTACAGATGATTCCTCCTCTTCTGAGGGCGATGAAGAGGAGGATGAC
TATGATGATGACTTTGAAGACGATTTTATTCCTCTTCCTCCAGCTAAGCGCTTGAGGTTA
ATAGTTGGAAAAGACTCTATAGATATTGACATTTCTTCAAGGAGAAGAGAAGATCAGTCT
TTAAGGCTTAATGCCTAA
Protein Properties
Number of Residues 885
Molecular Weight 44617.75
Theoretical pI 8.708
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence 
>Histone-lysine N-methyltransferase SUV420H1
MKWLGESKIMVVNGRRNGGKLSNDHQQNQSKLQHTGKDTLKAGKNAVERRSNRCNGNSGF
EGQSRYVPSSGMSAKELCENDDLATSLVLDPYLGFQTHKMNTSAFPSRSSRHFSKSDSFS
HNNPVRFRPIKGRQEELKEVIERFKKDEHLEKAFKCLTSGEWARHYFLNKNKMQEKLFKE
HVFIYLRMFATDSGFEILPCNRYSSEQNGAKIVATKEWKRNDKIELLVGCIAELSEIEEN
MLLRHGENDFSVMYSTRKNCAQLWLGPAAFINHDCRPNCKFVSTGRDTACVKALRDIEPG
EEISCYYGDGFFGENNEFCECYTCERRGTGAFKSRVGLPAPAPVINSKYGLRETDKRLNR
LKKLGDSSKNSDSQSVSSNTDADTTQEKNNATSNRKSSVGVKKNSKSRTLTRQSMSRIPA
SSNSTSSKLTHINNSRVPKKLKKPAKPLLSKIKLRNHCKRLEQKNASRKLEMGNLVLKEP
KVVLYKNLPIKKDKEPEGPAQAAVASGCLTRHAAREHRQNPVRGAHSQGESSPCTYITRR
SVRTRTNLKEASDIKLEPNTLNGYKSSVTEPCPDSGEQLQPAPVLQEEELAHETAQKGEA
KCHKSDTGMSKKKSRQGKLVKQFAKIEESTPVHDSPGKDDAVPDLMGPHSDQGEHSGTVG
VPVSYTDCAPSPVGCSVVTSDSFKTKDSFRTAKSKKKRRITRYDAQLILENNSGIPKLTL
RRRHDSSSKTNDQENDGMNSSKISIKLSKDHDNDNNLYVAKLNNGFNSGSGSSSTKLKIQ
LKRDEENRGSYTEGLHENGVCCSDPLSLLESRMEVDDYSQYEEESTDDSSSSEGDEEEDD
YDDDFEDDFIPLPPAKRLRLIVGKDSIDIDISSRRREDQSLRLNA
GenBank ID Protein 50659082
UniProtKB/Swiss-Prot ID Q4FZB7
UniProtKB/Swiss-Prot Entry Name SV421_HUMAN
PDB IDs
GenBank Gene ID NM_017635.3
GeneCard ID SUV420H1
GenAtlas ID SUV420H1
HGNC ID HGNC:24283
References
General References Not Available