| Identification |
|---|
| HMDB Protein ID
| CDBP04234 |
| Secondary Accession Numbers
| Not Available |
| Name
| Dimethyladenosine transferase 2, mitochondrial |
| Description
| Not Available |
| Synonyms
|
- HCV NS5A-transactivated protein 5
- Hepatitis C virus NS5A-transactivated protein 5
- Mitochondrial 12S rRNA dimethylase 2
- Mitochondrial transcription factor B2
- S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 2
- h-mtTFB
- h-mtTFB2
- hTFB2M
- mtTFB2
|
| Gene Name
| TFB2M |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in rRNA (adenine-N6,N6-)-dimethyltransferase activity |
| Specific Function
| S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity. Compared to TFB1M, it activates transcription of mitochondrial DNA more efficiently, while it has less methyltransferase activity |
| GO Classification
|
| Component |
| mitochondrion |
| organelle |
| membrane-bounded organelle |
| intracellular membrane-bounded organelle |
| Function |
| catalytic activity |
| transferase activity |
| protein binding |
| transcription factor binding |
| transcription cofactor activity |
| rna methyltransferase activity |
| rrna (adenine-n6,n6-)-dimethyltransferase activity |
| rrna methyltransferase activity |
| transferase activity, transferring one-carbon groups |
| methyltransferase activity |
| n-methyltransferase activity |
| binding |
| Process |
| biological regulation |
| regulation of biological process |
| regulation of metabolic process |
| regulation of macromolecule metabolic process |
| regulation of gene expression |
| regulation of transcription |
| regulation of transcription, dna-dependent |
| rrna metabolic process |
| rrna processing |
| rrna modification |
| rrna methylation |
| rna metabolic process |
| ncrna metabolic process |
| metabolic process |
| macromolecule metabolic process |
| cellular macromolecule metabolic process |
|
| Cellular Location
|
- Mitochondrion
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 1q44 |
| SNPs
| TFB2M |
| Gene Sequence
|
>1191 bp
ATGTGGATCCCAGTGGTCGGGCTTCCTCGGCGGCTGAGGCTCTCCGCCTTGGCGGGCGCT
GGTCGCTTTTGCATTTTAGGGTCTGAAGCGGCGACGCGAAAGCATTTGCCGGCGAGGAAC
CACTGTGGGCTCTCTGACTCCTCTCCGCAGCTGTGGCCCGAACCGGATTTCAGGAATCCG
CCAAGGAAGGCGTCTAAGGCCAGCTTAGACTTTAAGCGTTACGTAACCGATCGGAGATTG
GCTGAGACCCTGGCGCAAATCTATTTGGGAAAACCAAGTAGACCTCCACACCTACTGCTG
GAGTGCAATCCAGGTCCTGGAATCCTGACTCAGGCATTACTTGAAGCTGGTGCCAAAGTG
GTTGCGCTCGAAAGTGACAAAACTTTTATTCCACATTTGGAGTCCTTAGGAAAAAATCTG
GATGGAAAACTACGAGTGATTCACTGTGACTTCTTTAAACTAGATCCTAGAAGTGGTGGA
GTAATAAAACCACCTGCTATGTCTTCTCGAGGGCTCTTTAAGAATTTGGGAATAGAAGCA
GTTCCTTGGACAGCAGACATCCCTTTAAAAGTAGTTGGAATGTTCCCAAGTAGAGGTGAG
AAAAGGGCACTTTGGAAACTCGCATATGACTTGTATTCCTGTACTTCTATATATAAATTT
GGACGAATAGAAGTAAATATGTTTATTGGTGAAAAAGAATTCCAGAAACTAATGGCAGAT
CCTGGAAATCCAGACTTGTATCATGTATTAAGTGTTATCTGGCAATTAGCTTGTGAGATT
AAGGTTCTGCACATGGAGCCTTGGTCATCATTTGATATATACACCCGGAAAGGGCCGCTG
GAAAACCCAAAGCGTAGGGAATTATTAGACCAATTACAACAAAAGCTGTATCTTATTCAA
ATGATTCCTCGTCAAAATTTATTTACCAAGAACTTAACACCTATGAACTATAATATATTT
TTTCACTTGTTAAAGCACTGTTTTGGGAGGCGCAGCGCCACTGTAATAGACCACTTACGT
TCATTGACTCCACTTGATGCGAGAGATATATTGATGCAAATAGGAAAACAGGAGGATGAG
AAAGTAGTTAACATGCACCCTCAAGACTTCAAAACACTTTTTGAAACTATAGAGCGTTCC
AAAGATTGTGCTTATAAATGGCTGTATGATGAAACCCTGGAAGATAGGTAG
|
| Protein Properties |
|---|
| Number of Residues
| 396 |
| Molecular Weight
| 45348.4 |
| Theoretical pI
| 9.63 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Dimethyladenosine transferase 2, mitochondrial
MWIPVVGLPRRLRLSALAGAGRFCILGSEAATRKHLPARNHCGLSDSSPQLWPEPDFRNP
PRKASKASLDFKRYVTDRRLAETLAQIYLGKPSRPPHLLLECNPGPGILTQALLEAGAKV
VALESDKTFIPHLESLGKNLDGKLRVIHCDFFKLDPRSGGVIKPPAMSSRGLFKNLGIEA
VPWTADIPLKVVGMFPSRGEKRALWKLAYDLYSCTSIYKFGRIEVNMFIGEKEFQKLMAD
PGNPDLYHVLSVIWQLACEIKVLHMEPWSSFDIYTRKGPLENPKRRELLDQLQQKLYLIQ
MIPRQNLFTKNLTPMNYNIFFHLLKHCFGRRSATVIDHLRSLTPLDARDILMQIGKQEDE
KVVNMHPQDFKTLFETIERSKDCAYKWLYDETLEDR
|
| External Links |
|---|
| GenBank ID Protein
| 33328300 |
| UniProtKB/Swiss-Prot ID
| Q9H5Q4 |
| UniProtKB/Swiss-Prot Entry Name
| TFB2M_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF529366 |
| GeneCard ID
| TFB2M |
| GenAtlas ID
| TFB2M |
| HGNC ID
| HGNC:18559 |
| References |
|---|
| General References
| Not Available |