| Identification |
|---|
| HMDB Protein ID
| CDBP00078 |
| Secondary Accession Numbers
| Not Available |
| Name
| Phosphatidylethanolamine N-methyltransferase |
| Description
| Not Available |
| Synonyms
|
- PEAMT
- PEMT
- PEMT2
|
| Gene Name
| PEMT |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in N-methyltransferase activity |
| Specific Function
| Catalyzes three sequential methylation reactions of phosphatidylethanolamine (PE) by AdoMet, thereby producing phosphatidylcholine (PC).
|
| GO Classification
|
| Biological Process |
| response to amino acid stimulus |
| cell proliferation |
| S-adenosylhomocysteine metabolic process |
| phosphatidylcholine biosynthetic process |
| response to drug |
| response to ethanol |
| S-adenosylmethionine metabolic process |
| response to vitamin |
| negative regulation of cell proliferation |
| positive regulation of lipoprotein metabolic process |
| Cellular Component |
| brush border membrane |
| integral to membrane |
| sarcolemma |
| endoplasmic reticulum membrane |
| mitochondrial membrane |
| Function |
| catalytic activity |
| transferase activity |
| transferase activity, transferring one-carbon groups |
| methyltransferase activity |
| n-methyltransferase activity |
| Molecular Function |
| phosphatidyl-N-dimethylethanolamine N-methyltransferase activity |
| phosphatidyl-N-methylethanolamine N-methyltransferase activity |
| phosphatidylethanolamine binding |
| phosphatidylethanolamine N-methyltransferase activity |
| Process |
| metabolic process |
| organophosphate metabolic process |
| phospholipid metabolic process |
|
| Cellular Location
|
- Multi-pass membrane protein (Potential)
- Multi-pass membrane protein (Potential)
- Endoplasmic reticulum membrane
- Mitochondrion membrane
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Glycerophospholipid metabolism | Not Available |  | | Phospholipid Biosynthesis |    | | | Betaine Metabolism |    |  | | Phosphatidylcholine Biosynthesis |    | Not Available | | Phosphatidylcholine Biosynthesis PC(14:0/14:0) |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 17 |
| Locus
| 17p11.2 |
| SNPs
| PEMT |
| Gene Sequence
|
>600 bp
ATGACCCGGCTGCTGGGCTACGTGGACCCCCTGGATCCCAGCTTTGTGGCTGCCGTCATC
ACCATCACCTTCAATCCGCTCTACTGGAATGTGGTTGCACGATGGGAACACAAGACCCGC
AAGCTGAGCAGGGCCTTCGGATCCCCCTACCTGGCCTGCTACTCTCTAAGCATCACCATC
CTGCTCCTGAACTTCCTGCGCTCGCACTGCTTCACGCAGGCCATGCTGAGCCAGCCCAGG
ATGGAGAGCCTGGACACCCCCGCGGCCTACAGCCTGGGCCTCGCGCTCCTGGGACTGGGC
GTCGTGCTCGTGCTCTCCAGCTTCTTTGCACTGGGGTTCGCTGGAACTTTCCTAGGTGAT
TACTTCGGGATCCTCAAGGAGGCGAGAGTGACCGTGTTCCCCTTCAACATCCTGGACAAC
CCCATGTACTGGGGAAGCACAGCCAACTACCTGGGCTGGGCCATCATGCACGCCAGCCCC
ACGGGCCTGCTCCTGACGGTGCTGGTGGCCCTCACCTACATAATGGCTCTCCTATACGAA
GAGCCCTTCACCGCTGAGATCTACCGGCAGAAAGCCTCCGGGTCCCACAAGAGGAGCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 199 |
| Molecular Weight
| 23697.395 |
| Theoretical pI
| 8.574 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Phosphatidylethanolamine N-methyltransferase
MTRLLGYVDPLDPSFVAAVITITFNPLYWNVVARWEHKTRKLSRAFGSPYLACYSLSVTI
LLLNFLRSHCFTQAMLSQPRMESLDTPAAYSLGLALLGLGVVLVLSSFFALGFAGTFLGD
YFGILKEARVTVFPFNILDNPMYWGSTANYLGWAIMHASPTGLLLTVLVALTYIVALLYE
EPFTAEIYRQKASGSHKRS
|
| External Links |
|---|
| GenBank ID Protein
| 5459516 |
| UniProtKB/Swiss-Prot ID
| Q9UBM1 |
| UniProtKB/Swiss-Prot Entry Name
| PEMT_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AB029821 |
| GeneCard ID
| PEMT |
| GenAtlas ID
| PEMT |
| HGNC ID
| HGNC:8830 |
| References |
|---|
| General References
| Not Available |