Identification
HMDB Protein ID CDBP05167
Secondary Accession Numbers Not Available
Name Protein arginine N-methyltransferase 2
Description Not Available
Synonyms
  1. Histone-arginine N-methyltransferase PRMT2
Gene Name PRMT2
Protein Type Enzyme
Biological Properties
General Function Not Available
Specific Function Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, histone H4. Acts as a coactivator (with NCOA2) of the androgen receptor (AR)-mediated transactivation. Acts as a coactivator (with estrogen) of estrogen receptor (ER)-mediated transactivation. Enhances PGR, PPARG, RARA-mediated transactivation. May inhibit NF-kappa-B transcription and promote apoptosis. Represses E2F1 transcriptional activity (in a RB1-dependent manner). May be involved in growth regulation.
GO Classification
Biological Process
negative regulation of G1/S transition of mitotic cell cycle
negative regulation of NF-kappaB transcription factor activity
negative regulation of transcription, DNA-dependent
positive regulation of transcription, DNA-dependent
regulation of androgen receptor signaling pathway
developmental cell growth
induction of apoptosis
Cellular Component
cytosol
nucleus
Molecular Function
estrogen receptor binding
histone-arginine N-methyltransferase activity
signal transducer activity
transcription coactivator activity
Cellular Location Not Available
Pathways
Gene Properties
Chromosome Location 21
Locus 21q22.3
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues Not Available
Molecular Weight 37166.79
Theoretical pI 5.235
Pfam Domain Function Not Available
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>gi|338968840|ref|NP_001229793.1| protein arginine N-methyltransferase 2 isoform 2 [Homo sapiens]
MATSGDCPRSESQGEEPAECSEAGLLQEGVQPEEFVAIADYAATDETQLSFLRGEKILIL
RQTTADWWWG
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P55345
UniProtKB/Swiss-Prot Entry Name Not Available
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID HGNC:5186
References
General References Not Available