Identification
HMDB Protein ID CDBP00404
Secondary Accession Numbers Not Available
Name Protein-L-isoaspartate(D-aspartate) O-methyltransferase
Description Not Available
Synonyms
  1. L-isoaspartyl protein carboxyl methyltransferase
  2. PIMT
  3. Protein L-isoaspartyl/D-aspartyl methyltransferase
  4. Protein-beta-aspartate methyltransferase
Gene Name PCMT1
Protein Type Enzyme
Biological Properties
General Function Involved in protein-L-isoaspartate (D-aspartate) O-methyltransferase activity
Specific Function Catalyzes the methyl esterification of L-isoaspartyl and D-aspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins. Acts on microtubule-associated protein 2, calreticulin, clathrin light chains a and b, Ubiquitin carboxyl-terminal hydrolase isozyme L1, phosphatidylethanolamine-binding protein 1, stathmin, beta-synuclein and alpha-synuclein (By similarity).
GO Classification
Biological Process
S-adenosylmethionine metabolic process
protein repair
S-adenosylhomocysteine metabolic process
Cellular Component
endoplasmic reticulum
Function
catalytic activity
transferase activity
s-adenosylmethionine-dependent methyltransferase activity
protein-l-isoaspartate (d-aspartate) o-methyltransferase activity
transferase activity, transferring one-carbon groups
methyltransferase activity
Molecular Function
protein-L-isoaspartate (D-aspartate) O-methyltransferase activity
Process
metabolic process
macromolecule metabolic process
macromolecule modification
protein modification process
Cellular Location
  1. Cytoplasm
Pathways
Gene Properties
Chromosome Location 6
Locus 6q24-q25
SNPs PCMT1
Gene Sequence
>684 bp
ATGGCCTGGAAATCCGGCGGCGCCAGCCACTCGGAGCTAATCCACAATCTCCGCAAAAAT
GGAATCATCAAGACAGATAAAGTATTTGAAGTGATGCTGGCTACAGACCGCTCCCACTAT
GCAAAATGTAACCCATACATGGATTCTCCACAATCAATAGGTTTCCAAGCAACAATCAGT
GCTCCACACATGCATGCATATGCGCTAGAACTTCTATTTGATCAGTTGCATGAAGGAGCT
AAAGCTCTTGATGTAGGATCTGGAAGTGGAATCCTTACTGCATGTTTTGCACGTATGGTT
GGATGTACTGGAAAAGTCATAGGAATTGATCACATTAAAGAGCTAGTAGATGACTCAGTA
AATAATGTCAGGAAGGACGATCCAACACTTCTGTCTTCAGGGAGAGTACAGCTTGTTGTG
GGGGATGGAAGAATGGGATATGCTGAAGAAGCCCCTTATGATGCCATTCATGTGGGAGCT
GCAGCCCCTGTTGTACCCCAGGCGCTAATAGATCAGTTAAAGCCCGGAGGAAGATTGATA
TTGCCTGTTGGTCCTGCAGGCGGAAACCAAATGTTGGAGCAGTATGACAAGCTACAAGAT
GGCAGCATCAAAATGAAGCCTCTGATGGGGGTGATATACGTGCCTTTAACAGATAAAGAA
AAGCAGTGGTCCAGGTGGAAGTGA
Protein Properties
Number of Residues 227
Molecular Weight 30357.695
Theoretical pI 6.725
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Protein-L-isoaspartate(D-aspartate) O-methyltransferase
MAWKSGGASHSELIHNLRKNGIIKTDKVFEVMLATDRSHYAKCNPYMDSPQSIGFQATIS
APHMHAYALELLFDQLHEGAKALDVGSGSGILTACFARMVGCTGKVIGIDHIKELVDDSI
NNVRKDDPTLLSSGRVQLVVGDGRMGYAEEAPYDAIHVGAAAPVVPQALIDQLKPGGRLI
LPVGPAGGNQMLEQYDKLQDGSIKMKPLMGVIYVPLTDKEKQWSRWK
GenBank ID Protein 158260471
UniProtKB/Swiss-Prot ID P22061
UniProtKB/Swiss-Prot Entry Name PIMT_HUMAN
PDB IDs
GenBank Gene ID AK289724
GeneCard ID PCMT1
GenAtlas ID PCMT1
HGNC ID HGNC:8728
References
General References Not Available