Showing Protein N-lysine methyltransferase SETD8 (CDBP02246)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 2 compounds
Identification
HMDB Protein ID CDBP02246
Secondary Accession Numbers Not Available
Name N-lysine methyltransferase SETD8
Description Not Available
Synonyms
  1. H4-K20-HMTase SETD8
  2. Lysine N-methyltransferase 5A
  3. PR-Set7
  4. PR/SET domain-containing protein 07
  5. PR/SET07
  6. SET domain-containing protein 8
  7. Histone-lysine N-methyltransferase SETD8
Gene Name SETD8
Protein Type Enzyme
Biological Properties
General Function Involved in histone-lysine N-methyltransferase activity
Specific Function Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes.
GO Classification
Biological Process
mitosis
cell division
peptidyl-lysine monomethylation
negative regulation of transcription from RNA polymerase II promoter
regulation of DNA damage response, signal transduction by p53 class mediator
transcription, DNA-dependent
Cellular Component
chromosome
nucleus
Molecular Function
histone-lysine N-methyltransferase activity
transcription corepressor activity
Cellular Location
  1. Nucleus
  2. Chromosome
Pathways
Gene Properties
Chromosome Location 12
Locus 12q24.31
SNPs SETD8
Gene Sequence 
>1182 bp
ATGGGGGAAGGGGGCGCCGCGGCGGCGCTGGTGGCGGCGGCAGCAGCAGCAGCAGCGGCA
GCGGCAGCGGTGGTGGCCGGGCAGCGGCGGCGGCGGCTAGGGCGCAGGGCGCGCTGCCAT
GGGCCTGGCCGGGCTGCAGGCGGGAAGATGTCCAAGCCCTGCGCGGTGGAGGCGGCGGCG
GCGGCGGTGGCAGCGACGGCCCCGGGCCCGGAGATGGTGGAGCGGAGGGGCCCGGGGAGG
CCCCGCACCGACGGGGAGAACGTATTTACCGGGCAGTCAAAGATCTATTCCTACATGAGC
CCGAACAAATGCTCTGGAATGCGTTTCCCCCTTCAGGAAGAGAACTCAGTTACACATCAC
GAAGTCAAATGCCAGGGGAAACCATTAGCTGGAATCTACAGGAAACGAGAAGAGAAAAGA
AATGCTGGGAACGCAGTACGGAGCGCCATGAAGTCCGAGGAACAGAAGATCAAAGACGCC
AGGAGACGTCCCCTGGTACCTTTTCCAAACCAAAAATCTGAAGCAGCAGAACCTCCAAAA
ACTCCACCCTCATCTTGTGATTCCACCAATGCAGCCATCGCCAAGCAAGCCCTGAAAAAG
CCCATCAAGGGCAAACAGGCCCCCCGAAAAAAAGCTCAAGGAAAAACGCAACAGAATCGC
AAACTTACGGATTTCTACCCTGTCCGAAGGAGCTCCAGGAAGAGCAAAGCCGAGCTGCAG
TCTGAAGAAAGGAAAAGAATAGATGAATTGATTGAAAGTGGGAAGGAAGAAGGAATGAAG
ATCGACCTCATCGATGGCAAAGGCAGGGGTGTGATTGCCACCAAGCAGTTCTCCCGGGGT
GCCTTTGTGGTGGAATACCACGGGGACCTCATCGAGATCACCGACGCCAAGAAACGGGAG
GCTCTGTACGCACAGGACCCTTCCACGGGCTGCTACATGTACTATTTTCAGTATCTGAGC
AAAACCTACTGCGTGGATGCAACTAGAGAGACAAATCGCCTAGGAAGACTGATCAATCAC
AGCAAACGTGGGAACTGCCAAACCAAACTGCACGACATCGACGGCGTACCTCACCTCATC
CTCATCGCCTCCCGAGACATCGCGGCTGGGGAGGAGCCCCTGTATGACTATGGGGACCGC
AGCAAGGCTTCCATTGAAGCCCACCCATGGCTGAAGCATTAA
Protein Properties
Number of Residues 393
Molecular Weight 39222.325
Theoretical pI 9.567
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence 
>Histone-lysine N-methyltransferase SETD8
MGEGGAAAALVAAAAAAAAAAAAVVAGQRRRRLGRRARCHGPGRAAGGKMSKPCAVEAAA
AAVAATAPGPEMVERRGPGRPRTDGENVFTGQSKIYSYMSPNKCSGMRFPLQEENSVTHH
EVKCQGKPLAGIYRKREEKRNAGNAVRSAMKSEEQKIKDARKGPLVPFPNQKSEAAEPPK
TPPSSCDSTNAAIAKQALKKPIKGKQAPRKKAQGKTQQNRKLTDFYPVRRSSRKSKAELQ
SEERKRIDELIESGKEEGMKIDLIDGKGRGVIATKQFSRGDFVVEYHGDLIEITDAKKRE
ALYAQDPSTGCYMYYFQYLSKTYCVDATRETNRLGRLINHSKCGNCQTKLHDIDGVPHLI
LIASRDIAAGEELLYDYGDRSKASIEAHPWLKH
GenBank ID Protein 15029567
UniProtKB/Swiss-Prot ID Q9NQR1
UniProtKB/Swiss-Prot Entry Name SETD8_HUMAN
PDB IDs
GenBank Gene ID AF287261
GeneCard ID SETD8
GenAtlas ID SETD8
HGNC ID HGNC:29489
References
General References Not Available