| Identification |
|---|
| HMDB Protein ID
| CDBP02209 |
| Secondary Accession Numbers
| Not Available |
| Name
| tRNA (cytosine(38)-C(5))-methyltransferase |
| Description
| Not Available |
| Synonyms
|
- DNA (cytosine-5)-methyltransferase-like protein 2
- DNA MTase homolog HsaIIP
- DNA methyltransferase homolog HsaIIP
- Dnmt2
- M.HsaIIP
- PuMet
|
| Gene Name
| TRDMT1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in DNA binding |
| Specific Function
| Specifically methylates cytosine 38 in the anticodon loop of tRNA(Asp).
|
| GO Classification
|
| Biological Process |
| response to amphetamine |
| tRNA processing |
| Cellular Component |
| nucleus |
| Function |
| binding |
| nucleic acid binding |
| dna binding |
| Molecular Function |
| DNA (cytosine-5-)-methyltransferase activity |
| RNA binding |
| DNA binding |
| Process |
| cellular macromolecule metabolic process |
| dna metabolic process |
| dna modification |
| dna alkylation |
| dna methylation |
| metabolic process |
| macromolecule metabolic process |
|
| Cellular Location
|
- Nucleus (Probable)
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 10 |
| Locus
| 10p15.1 |
| SNPs
| TRDMT1 |
| Gene Sequence
|
>1176 bp
ATGGAGCCCCTGCGGGTGCTGGAGCTATACAGCGGCGTGGGCGGCATGCACCACGCGCTG
AGAGAAAGCTGTATACCTGCACAAGTGGTGGCTGCCATTGATGTCAACACTGTCGCTAAT
GAAGTATACAAGTATAATTTTCCTCACACACAGTTACTTGCCAAGACGATTGAAGGCATT
ACACTCGAAGAGTTTGACAGATTATCTTTTGATATGATTTTAATGAGCCCTCCCTGCCAG
CCATTCACAAGGATTGGCCGGCAGGGTGATATGACTGATTCAAGGACGAATAGCTTCTTA
CATATTCTAGATATTCTCCCAAGATTACAAAAATTACCAAAGTATATTCTTTTGGAAAAT
GTTAAAGGTTTTGAAGTATCTTCTACAAGAGACCTCTTGATACAAACAATAGAAAATTGT
GGCTTTCAGTACCAAGAATTTCTATTATCTCCAACCTCTCTTGGCATTCCAAATTCAAGG
CTACGATATTTTCTTATTGCAAAGCTTCAGTCAGAGCCATTACCCTTTCAAGCCCCTGGT
CAGGTACTGATGGAGTTCCCCAAAATTGAATCTGTACATCCACAAAAATATGCAATGGAT
GTAGAAAATAAAATTCAAGAAAAGAACGTTGAACCAAATATTAGCTTTGATGGCAGCATA
CAGTGTTCTGGAAAAGATGCCATTCTTTTTAAGCTTGAAACTGCAGAAGAAATTCACAGG
AAAAATCAACAAGATAGTGATCTCTCTGTGAAAATGCTAAAAGATTTTCTTGAAGATGAC
ACTGACGTGAACCAGTATCTTTTACCACCAAAGTCATTGCTGCGATATGCTCTTCTGTTA
GACATTGTTCAGCCCACTTGTAGAAGGTCCGTGTGCTTTACCAAAGGATATGGAAGCTAC
ATAGAAGGGACAGGGTCTGTGTTACAGACTGCAGAGGATGTGCAGGTTGAGAATATCTAC
AAATCCCTTACCAATTTGTCACAAGAAGAACAGATAACAAAGCTGTTAATACTTAAACTG
CGATATTTCACTCCTAAAGAAATAGCAAATCTCCTTGGATTTCCTCCAGAGTTCGGATTT
CCTGAGAAGATAACAGTGAAACAGCGTTATCGCCTACTTGGAAATAGTCTCAACGTGCAT
GTAGTAGCTAAACTAATCAAAATCTTATATGAATAA
|
| Protein Properties |
|---|
| Number of Residues
| 391 |
| Molecular Weight
| 44596.17 |
| Theoretical pI
| 6.083 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>tRNA (cytosine-5-)-methyltransferase
MEPLRVLELYSGVGGMHHALRESCIPAQVVAAIDVNTVANEVYKYNFPHTQLLAKTIEGI
TLEEFDRLSFDMILMSPPCQPFTRIGRQGDMTDSRTNSFLHILDILPRLQKLPKYILLEN
VKGFEVSSTRDLLIQTIENCGFQYQEFLLSPTSLGIPNSRLRYFLIAKLQSEPLPFQAPG
QVLMEFPKIESVHPQKYAMDVENKIQEKNVEPNISFDGSIQCSGKDAILFKLETAEEIHR
KNQQDSDLSVKMLKDFLEDDTDVNQYLLPPKSLLRYALLLDIVQPTCRRSVCFTKGYGSY
IEGTGSVLQTAEDVQVENIYKSLTNLSQEEQITKLLILKLRYFTPKEIANLLGFPPEFGF
PEKITVKQRYRLLGNSLNVHVVAKLIKILYE
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| O14717 |
| UniProtKB/Swiss-Prot Entry Name
| TRDMT_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AF012128 |
| GeneCard ID
| TRDMT1 |
| GenAtlas ID
| TRDMT1 |
| HGNC ID
| HGNC:2977 |
| References |
|---|
| General References
| Not Available |