Identification
HMDB Protein ID CDBP00398
Secondary Accession Numbers Not Available
Name Phenylethanolamine N-methyltransferase
Description Not Available
Synonyms
  1. Noradrenaline N-methyltransferase
  2. PNMTase
Gene Name PNMT
Protein Type Enzyme
Biological Properties
General Function Involved in methyltransferase activity
Specific Function Converts noradrenaline to adrenaline.
GO Classification
Biological Process
cellular nitrogen compound metabolic process
epinephrine biosynthetic process
catecholamine biosynthetic process
Cellular Component
cytosol
Function
transferase activity
transferase activity, transferring one-carbon groups
methyltransferase activity
catalytic activity
Molecular Function
phenylethanolamine N-methyltransferase activity
Cellular Location Not Available
Pathways
Gene Properties
Chromosome Location 17
Locus 17q
SNPs PNMT
Gene Sequence
>849 bp
ATGAGCGGCGCAGACCGTAGCCCCAATGCGGGCGCAGCCCCTGACTCGGCCCCGGGCCAG
GCGGCGGTGGCTTCGGCCTACCAGCGCTTCGAGCCGCGCGCCTACCTCCGCAACAACTAC
GCGCCCCCTCGCGGGGACCTGTGCAACCCGAACGGCGTCGGGCCGTGGAAGCTGCGCTGC
TTGGCGCAGACCTTCGCCACCGGTGAAGTGTCCGGACGCACCCTCATCGACATTGGTTCA
GGCCCCACCGTGTACCAGCTGCTCAGTGCCTGCAGCCACTTTGAGGACATCACCATGACA
GATTTCCTGGAGGTCAACCGCCAGGAGCTGGGGCGCTGGCTGCAGGAGGAGCCGGGGGCC
TTCAACTGGAGCATGTACAGCCAACATGCCTGCCTCATTGAGGGCAAGGGGGAATGCTGG
CAGGATAAGGAGCGCCAGCTGCGAGCCAGGGTGAAACGGGTCCTGCCCATCGACGTGCAC
CAGCCCCAGCCCCTGGGTGCTGGGAGCCCAGCTCCCCTGCCTGCTGACGCCCTGGTCTCT
GCCTTCTGCTTGGAGGCTGTGAGCCCAGATCTTGCCAGCTTTCAGCGGGCCCTGGACCAC
ATCACCACGCTGCTGAGGCCTGGGGGGCACCTCCTCCTCATCGGGGCCCTGGAGGAGTCG
TGGTACCTGGCTGGGGAGGCCAGGCTGACGGTGGTGCCAGTGTCTGAGGAGGAGGTGAGG
GAGGCCCTGGTGCGTAGTGGCTACAAGGTCCGGGACCTCCGCACCTATATCATGCCTGCC
CACCTTCAGACAGGCGTAGATGATGTCAAGGGCGTCTTCTTCGCCTGGGCTCAGAAGGTT
GGGCTGTGA
Protein Properties
Number of Residues 282
Molecular Weight 30854.745
Theoretical pI 6.072
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Phenylethanolamine N-methyltransferase
MSGADRSPNAGAAPDSAPGQAAVASAYQRFEPRAYLRNNYAPPRGDLCNPNGVGPWKLRC
LAQTFATGEVSGRTLIDIGSGPTVYQLLSACSHFEDITMTDFLEVNRQELGRWLQEEPGA
FNWSMYSQHACLIEGKGECWQDKERQLRARVKRVLPIDVHQPQPLGAGSPAPLPADALVS
AFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLTVVPVSEEEVR
EALVRSGYKVRDLRTYIMPAHLQTGVDDVKGVFFAWAQKVGL
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P11086
UniProtKB/Swiss-Prot Entry Name PNMT_HUMAN
PDB IDs
GenBank Gene ID J03727
GeneCard ID PNMT
GenAtlas ID PNMT
HGNC ID HGNC:9160
References
General References Not Available