| Identification |
|---|
| HMDB Protein ID
| CDBP04717 |
| Secondary Accession Numbers
| Not Available |
| Name
| tRNA (uracil(54)-C(5))-methyltransferase homolog |
| Description
| Not Available |
| Synonyms
|
- TRM2 homolog
|
| Gene Name
| TRMT2B |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in RNA methyltransferase activity |
| Specific Function
| Probable S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNA. May also have a role in tRNA stabilization or maturation (By similarity).
|
| GO Classification
|
| Cellular Component |
| mitochondrion |
| Function |
| transferase activity |
| rna methyltransferase activity |
| transferase activity, transferring one-carbon groups |
| methyltransferase activity |
| catalytic activity |
| Molecular Function |
| S-adenosylmethionine-dependent tRNA (m5U54) methyltransferase activity |
| Process |
| rna metabolic process |
| metabolic process |
| macromolecule metabolic process |
| cellular macromolecule metabolic process |
| rna processing |
|
| Cellular Location
|
Not Available
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| X |
| Locus
| Xq22.1 |
| SNPs
| TRMT2B |
| Gene Sequence
|
>1515 bp
ATGGCAGGCCTTAAGAGAAGAGTCCCACTGCACAGCCTCAGATACTTCATCTCCATGGTG
GGTCTCTTCTCCAAACCAGGACTGCTTCCCTGGTATGCCAGAAATCCACCAGGATGGTCA
CAGCTCTTTCTGGGCACAGTATGTAAGGGAGATTTCACCCGTGTGATAGCCACGAAATGT
CAGAAAGGACAAAAAAGTCAGAAGAAACCAAGCCATCTTGGACCACTAGATGGTTCCTGG
CAGGAAAGGCTGGCTGATGTTGTGACACCACTCTGGAGGTTGAGCTATGAAGAACAGCTC
AAGGTGAAATTTGCAGCTCAGAAGAAAATTTTACAAAGACTAGAGTCTTACATCCAAATG
CTCAATGGAGTCAGTGTGACAACGGCTGTACCCAAATCTGAGAGGCTCTCTTGTCTTCTC
CATCCTATTATACCCTCTCCTGTCATCAATGGTTACCGAAATAAGTCCACCTTCTCTGTG
AACCGAGGTCCAGATGGCAATCCAAAGACTGTGGGGTTCTACCTGGGAACTTGGAGAGAT
GGGAACGTTGTCTGTGTGCAGTCTAATCATCTGAAAAACATCCCTGAGAAACACAGTCAA
GTGGCGCAGTACTATGAAGTATTCCTTCGACAGTCTCCATTGGAGCCCTGCCTTGTATTT
CATGAAGGTGGATACTGGCGTGAGCTCACAGTCCGCACCAATAGCCAAGGGCGCACAATG
GCTATCATCACTTTCCATCCCCAGAAATTAAGTCAGGAGGAGCTCCATGTTCAGAAGGAG
ATTGTAAAGGAATTTTTCATCAGAGGTCCTGGAGCAGCCTGTGGCTTGACCTCACTTTAC
TTCCAGGAAAGTACCATGACCCGTTGCAGCCATCAGCAGTCTCCCTATCAGCTTCTGTTT
GGGGAACCCTACATCTTTGAAGAACTTCTGAGCTTGAAGATCCGCATCTCTCCAGATGCC
TTTTTCCAGATTAACACAGCTGGTGCAGAGATGCTGTATCGGACTGTGGGGGAGCTGACT
GGAGTGAACTCTGACACCATCCTTCTTGACATCTGCTGTGGAACTGGTGTGATTGGCCTC
TCTCTGGCTCAGCATACATCTCGGGTCCTTGGGATTGAATTGTTGGAGCAGGCAGTGGAG
GATGCAAGATGGACTGCAGCCTTCAATGGCATCACCAACTCTGAATTTCATACTGGTCAA
GCAGAGAAGATTTTGCCAGGGCTGCTAAAGTCAAAGGAAGATGGACAGTCAATTGTTGCT
GTGGTGAACCCAGCCCGTGCCGGACTGCATTACAAGGTGATTCAAGCCATTCGAAACTTC
AGGGCCATCCACACGCTAGTTTTTGTTTCCTGCAAGCTCCATGGTGAATCCACTAGGAAT
GTCATTGAGCTGTGCTGTCCTCCAGACCCTGCTAAGAAGCTCTTAGGCGAGCCCTTTGTC
CTGCAGCAAGCTGTACCTGTGGATTTGTTCCCTCACACCCCACATTGTGAGCTGGTGCTC
CTCTTTACTCGATAA
|
| Protein Properties |
|---|
| Number of Residues
| 504 |
| Molecular Weight
| 56475.965 |
| Theoretical pI
| 8.804 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>tRNA (uracil-5-)-methyltransferase homolog
MAGLKRRVPLHSLRYFISMVGLFSKPGLLPWYARNPPGWSQLFLGTVCKGDFTRVIATKC
QKGQKSQKKPSHLGPLDGSWQERLADVVTPLWRLSYEEQLKVKFAAQKKILQRLESYIQM
LNGVSVTTAVPKSERLSCLLHPIIPSPVINGYRNKSTFSVNRGPDGNPKTVGFYLGTWRD
GNVVCVQSNHLKNIPEKHSQVAQYYEVFLRQSPLEPCLVFHEGGYWRELTVRTNSQGHTM
AIITFHPQKLSQEELHVQKEIVKEFFIRGPGAACGLTSLYFQESTMTRCSHQQSPYQLLF
GEPYIFEELLSLKIRISPDAFFQINTAGAEMLYRTVGELTGVNSDTILLDICCGTGVIGL
SLAQHTSRVLGIELLEQAVEDARWTAAFNGITNSEFHTGQAEKILPGLLKSKEDGQSIVA
VVNPARAGLHYKVIQAIRNFRAIHTLVFVSCKLHGESTRNVIELCCPPDPAKKLLGEPFV
LQQAVPVDLFPHTPHCELVLLFTR
|
| External Links |
|---|
| GenBank ID Protein
| 10434333 |
| UniProtKB/Swiss-Prot ID
| Q96GJ1 |
| UniProtKB/Swiss-Prot Entry Name
| TRM2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AK022749 |
| GeneCard ID
| TRMT2B |
| GenAtlas ID
| TRMT2B |
| HGNC ID
| HGNC:25748 |
| References |
|---|
| General References
| Not Available |