Identification
HMDB Protein ID CDBP04222
Secondary Accession Numbers Not Available
Name Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase
Description Not Available
Synonyms
  1. Protein ftsJ homolog 1
  2. rRNA (uridine-2'-O-)-methyltransferase
  3. 2'-O-ribose RNA methyltransferase TRM7 homolog
Gene Name FTSJ1
Protein Type Enzyme
Biological Properties
General Function Involved in methyltransferase activity
Specific Function Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs (By similarity).
GO Classification
Biological Process
RNA methylation
rRNA processing
Function
binding
catalytic activity
transferase activity
nucleic acid binding
transferase activity, transferring one-carbon groups
methyltransferase activity
Molecular Function
methyltransferase activity
Process
one-carbon metabolic process
rrna metabolic process
rrna processing
methylation
rrna modification
rrna methylation
rna metabolic process
ncrna metabolic process
metabolic process
macromolecule metabolic process
cellular macromolecule metabolic process
cellular metabolic process
Cellular Location
  1. Cytoplasmic
Pathways
Gene Properties
Chromosome Location X
Locus Xp11.23
SNPs FTSJ1
Gene Sequence
>990 bp
ATGGGACGGACGTCAAAGGACAAGCGGGATGTCTACTACCGCCTGGCCAAGGAGAATGGC
TGGCGTGCTCGCAGCGCCTTCAAACTGCTACAACTGGATAAGGAATTCCAACTCTTCCAA
GGCGTGACACGGGCAGTTGACCTGTGTGCAGCCCCAGGCAGCTGGAGCCAGGTGCTGAGC
CAGAAGATCGGGGGCCAAGGGTCCGGCCACGTGGTGGCTGTGGACCTGCAGGCTATGGCT
CCACTACCAGGTGTGGTACAGATCCAGGGGGACATCACCCAGCTGTCCACTGCCAAGGAG
ATCATCCAGCACTTTAAGGGCTGCCCTGCGGACCTAGTGGTGTGTGACGGGGCTCCTGAT
GTAACCGGTCTCCATGATGTTGATGAGTATATGCAGGCCCAGCTCCTCCTAGCTGCTCTG
AACATTGCTACACATGTCCTGAAGCCAGGGGGCTGCTTTGTGGCCAAGATATTCCGAGGC
CGGGATGTGACGCTCCTCTACAGCCAGCTGCAGGTCTTCTTCTCCAGCGTGCTGTGTGCC
AAGCCCAGGAGCAGCCGGAACTCTAGCATCGAGGCCTTCGCTGTCTGTCAGGGCTATGAC
CCTCCCGAGGGCTTCATCCCGGACCTGAGCAAACCCCTGCTGGACCATTCTTACGACCCA
GATTTCAACCAGCTGGATGGTCCCACCCGCATCATTGTGCCTTTTGTGACCTGTGGGGAC
CTGAGCTCCTATGATTCGGACCGCAGTTACCCACTGGACCTAGAGGGCGGCTCAGAGTAC
AAGTACACTCCACCCACACAGCCCCCCATCTCGCCACCATACCAGGAGGCCTGCACGTTG
AAGAGGAAGGGGCAGCTGGCCAAGGAGATCCGCCCCCAGGACTGCCCCATCAGCAGAGTG
GACACGTTTCCCCAGCCCCTGGCCGCCCCTCAGTGCCACACCCTGCTGGCCCCTGAGATG
GAAGACAATGAAATGAGTTGTTCACCTTAA
Protein Properties
Number of Residues 329
Molecular Weight 36078.76
Theoretical pI 5.695
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Putative ribosomal RNA methyltransferase 1
MGRTSKDKRDVYYRLAKENGWRARSAFKLLQLDKEFQLFQGVTRAVDLCAAPGSWSQVLS
QKIGGQGSGHVVAVDLQAMAPLPGVVQIQGDITQLSTAKEIIQHFKGCPADLVVCDGAPD
VTGLHDVDEYMQAQLLLAALNIATHVLKPGGCFVAKIFRGRDVTLLYSQLQVFFSSVLCA
KPRSSRNSSIEAFAVCQGYDPPEGFIPDLSKPLLDHSYDPDFNQLDGPTRIIVPFVTCGD
LSSYDSDRSYPLDLEGGSEYKYTPPTQPPISPPYQEACTLKRKGQLAKEIRPQDCPISRV
DTFPQPLAAPQCHTLLAPEMEDNEMSCSP
GenBank ID Protein 7110661
UniProtKB/Swiss-Prot ID Q9UET6
UniProtKB/Swiss-Prot Entry Name RRMJ1_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_012280.2
GeneCard ID FTSJ1
GenAtlas ID FTSJ1
HGNC ID HGNC:13254
References
General References Not Available