| Identification |
|---|
| HMDB Protein ID
| CDBP00415 |
| Secondary Accession Numbers
| Not Available |
| Name
| Histone-lysine N-methyltransferase SUV39H2 |
| Description
| Not Available |
| Synonyms
|
- H3-K9-HMTase 2
- Histone H3-K9 methyltransferase 2
- Lysine N-methyltransferase 1B
- Su(var)3-9 homolog 2
- Suppressor of variegation 3-9 homolog 2
|
| Gene Name
| SUV39H2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in chromatin binding |
| Specific Function
| Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher-order chromatin organization during spermatogenesis.
|
| GO Classification
|
| Biological Process |
| chromatin remodeling |
| chromatin assembly or disassembly |
| male meiosis |
| cell differentiation |
| regulation of transcription, DNA-dependent |
| transcription, DNA-dependent |
| Cellular Component |
| chromosome, centromeric region |
| chromatin |
| nuclear heterochromatin |
| Component |
| organelle |
| membrane-bounded organelle |
| intracellular membrane-bounded organelle |
| nucleus |
| organelle part |
| intracellular organelle part |
| chromosomal part |
| chromatin |
| Function |
| protein methyltransferase activity |
| protein-lysine n-methyltransferase activity |
| histone-lysine n-methyltransferase activity |
| chromatin binding |
| transferase activity, transferring one-carbon groups |
| methyltransferase activity |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| catalytic activity |
| transition metal ion binding |
| zinc ion binding |
| transferase activity |
| Molecular Function |
| histone methyltransferase activity (H3-K9 specific) |
| zinc ion binding |
| chromatin binding |
| Process |
| cellular process |
| cellular component organization at cellular level |
| organelle organization |
| chromosome organization |
| chromatin organization |
| chromatin modification |
| chromatin assembly or disassembly |
|
| Cellular Location
|
- Nucleus
- Chromosome
- centromere
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 10 |
| Locus
| 10p13 |
| SNPs
| SUV39H2 |
| Gene Sequence
|
>1233 bp
ATGGCGGCGGTCGGGGCCGAGGCGCGAGGAGCTTGGTGTGTGCCTTGCCTAGTTTCACTT
GATACTCTTCAGGAATTATGTAGAAAAGAAAAGCTCACATGTAAATCGATTGGAATCACC
AAAAGGAATCTAAACAATTATGAGGTGGAATACTTGTGTGACTACAAGGTAGTAAAGGAT
ATGGAATATTATCTTGTAAAATGGAAAGGATGGCCAGATTCTACAAATACTTGGGAACCT
TTGCAAAATCTGAAGTGCCCGTTACTGCTTCAGCAATTCTCTAATGACAAGCATAATTAT
TTATCTCAGGTAAAGAAAGGCAAAGCAATAACTCCAAAAGACAATAACAAAACTTTGAAA
CCTGCCATTGCTGAGTACATTGTGAAGAAGGCTAAACAAAGGATAGCTCTGCAGAGATGG
CAAGATGAACTCAACAGAAGAAAGAATCATAAAGGAATGATATTTGTTGAAAATACTGTT
GATTTAGAGGGCCCACCTTCAGACTTCTATTACATTAACGAATACAAACCAGCTCCTGGA
ATCAGCTTAGTCAATGAAGCTACCTTTGGTTGTTCATGCACAGATTGCTTCTTTCAAAAA
TGTTGTCCTGCTGAAGCTGGAGTTCTTTTGGCTTATAATAAAAACCAACAAATTAAAATC
CCACCTGGTACTCCCATCTATGAATGCAACTCAAGGTGTCAGTGTGGTCCTGATTGTCCC
AATAGGATTGTACAAAAAGGCACACAGTATTCGCTTTGCATCTTTCGAACTAGCAATGGA
CGTGGCTGGGGTGTAAAGACCCTTGTGAAGATTAAAAGAATGAGTTTTGTCATGGAATAT
GTTGGAGAGGTAATCACAAGTGAAGAAGCTGAAAGACGAGGACAGTTCTATGACAACAAG
GGAATCACGTATCTCTTTGATCTGGACTATGAGTCTGATGAATTCACAGTGGATGCGGCT
CGATACGGCAATGTGTCTCATTTTGTGAATCACAGCTGTGACCCAAATCTTCAGGTGTTC
AATGTTTTCATTGATAACCTCGATACTCGTCTTCCCCGAATAGCATTGTTTTCCACAAGA
ACCATAAATGCTGGAGAAGAGCTGACTTTTGATTATCAAATGAAAGGTTCTGGAGATATA
TCTTCAGATTCTATTGACCACAGCCCAGCCAAAAAGAGGGTCAGAACAGTATGTAAATGT
GGAGCTGTGACTTGCAGAGGTTACCTCAACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 410 |
| Molecular Weight
| 46682.015 |
| Theoretical pI
| 8.198 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Histone-lysine N-methyltransferase SUV39H2
MAAVGAEARGAWCVPCLVSLDTLQELCRKEKLTCKSIGITKRNLNNYEVEYLCDYKVVKD
MEYYLVKWKGWPDSTNTWEPLQNLKCPLLLQQFSNDKHNYLSQVKKGKAITPKDNNKTLK
PAIAEYIVKKAKQRIALQRWQDELNRRKNHKGMIFVENTVDLEGPPSDFYYINEYKPAPG
ISLVNEATFGCSCTDCFFQKCCPAEAGVLLAYNKNQQIKIPPGTPIYECNSRCQCGPDCP
NRIVQKGTQYSLCIFRTSNGRGWGVKTLVKIKRMSFVMEYVGEVITSEEAERRGQFYDNK
GITYLFDLDYESDEFTVDAARYGNVSHFVNHSCDPNLQVFNVFIDNLDTRLPRIALFSTR
TINAGEELTFDYQMKGSGDISSDSIDHSPAKKRVRTVCKCGAVTCRGYLN
|
| External Links |
|---|
| GenBank ID Protein
| 301171588 |
| UniProtKB/Swiss-Prot ID
| Q9H5I1 |
| UniProtKB/Swiss-Prot Entry Name
| SUV92_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| NM_001193424.1 |
| GeneCard ID
| SUV39H2 |
| GenAtlas ID
| SUV39H2 |
| HGNC ID
| HGNC:17287 |
| References |
|---|
| General References
| Not Available |