Identification
HMDB Protein ID CDBP03511
Secondary Accession Numbers Not Available
Name tRNA wybutosine-synthesizing protein 1 homolog B
Description Not Available
Synonyms
  1. Radical S-adenosyl methionine and flavodoxin domain-containing protein 2
Gene Name TYW1B
Protein Type Metal Binding
Biological Properties
General Function Involved in iron ion binding
Specific Function Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA
GO Classification
Function
ion binding
cation binding
metal ion binding
binding
nucleotide binding
catalytic activity
transition metal ion binding
metal cluster binding
iron-sulfur cluster binding
iron ion binding
fmn binding
oxidoreductase activity
Process
metabolic process
oxidation reduction
Cellular Location Not Available
Pathways
Gene Properties
Chromosome Location Chromosome:7
Locus 7q11.23
SNPs TYW1B
Gene Sequence
>2007 bp
ATGGATCCTTCTGCGGATACATGGGACCTCTCCTCACCTTTAATATCATTATGGATAAAC
AGGTTTTACATTTATCTGGGCTTTGCTGTTAGCATTAGCCTTTGGATTTGTGTCCAGATT
GTCATCGAGATGCAGGGATTTGCAACAGTTCTTGCTGAAGCAGTTACGTCCCTGGATCTG
CCTGTGGCCATTATTAATCTAAAAGAATATGATCCAGATGATCATCTGATAGAAGAGGTG
ACTAGTAAAAATGTCTGTGTCTTCCTGGTTGCGACATACACTGACGGCCTACCAACCGAA
AGTGCAGAGTGGTTCTGCAAATGGTTAGAGGAAGCATCCATTGATTTTCGATTTGGCAAA
ACTTACCTGAAGGGTATGAGAGATGCGGTATTTGGCCTGGGAAATTCTGCCTATGCTAGC
CACTTCAACAAGGTTGGCAAAAATGTTGACAAGTGGCTCTGGATGCTTGGCGTGCATCGT
GTGATGAGTCGAGGGGAGGGCGACTGCGACGTGGTTAAAAGCAAGCACGGCAGCATTGAG
GCCAACTTCAGAGCATGGAAGACCAAGTTCATCTCCCAGCTGCAGGCACTTCAGAAAGGG
GAGAGAAAGAAGTCCTGTGGCGGCCACTGCAAGAAAGGCAAATGTGAATCTCACCAACAT
GGCTCAGAGGAGAGGGAGGAAGGATCTCAAGAGCAGGACGAATTGCATCACAGAGACACC
AAGGAGGAAGAACCCTTCGAGAGCTCCAGTGAAGAAGAGTTTGGTGGTGAGGACCATCAG
AGCCTAAATTCCATTGTTGATGTTGAAGATTTGGGCAAAATTATGGATCACGTGAAGAAA
GAAAAGAGAGAAAAGGAACAGCAGGAAGAGAAGTCTGGTTTGTTCAGGAACATGGGGAGG
AATGAAGATGGTGAAAGAAGAGCTATGATAACTCCTGCTCTCCGAGAAGCCCTTACTAAA
CAAGTCGATGCTCCGAGGGAGAGGAGCTTGTTACAAACACACATTCTATGGAATGAGAGC
CATCGCTGCATGGAAACCACCCCGAGCTTGGCGTGTGCTAATAAATGTGTCTTCTGTTGG
TGGCACCACAACAACCCTGTGGGCACTGAATGGTTGTGGAAGATGGACCAGCCTGAAATG
ATCTTGAAGGAAGCCATTGAAAACCATCAGAACATGATTAAGCAGTTTAAAGGAGTACCG
GGCGTCAAAGCAGAACGCTTTGAAGAAGGAATGACGGTAAAGCACTGTGCATTGTCCCTC
GTGGGAGAACCAATAATGTACCCAGAGATCAACAGGTTTTTGAAGCTACTCCACCAGTGT
AAAATCTCCAGCTTCCTGGTCACAAATGCACAATTTCCTGCGGAAATCAGGAACCTCGAG
CCAGTTACTCAGCTGTATGTCAGTGTGGATGCCAGTACCAAAGACAGCCTGAAGAAAATC
GACCGCCCACTCTTCAAGGATTTCTGGCAGCAATTCCTTGACAGTTTAAAAGCCTTGGCA
GTCAAGCAACAACGAACTGTCTACAGACTGACGCTCGTGAAAGCATGGAACGTGGACGAG
CTCCAGGCCTACGCGCAGCTCGTGTCCCTGGGGAATCCTGACTTCATCGAAGTGAAGGGC
GTTACCTACTGCAGAGAAAGTTCAGCAAGCAGTCTTACCATGGCCCATGTGCCCTGGCAT
GAGGAAGTGGTACAGTTTGTCCGCGAGCTGGTGGATCTGATCCCCGAATATGAAATTGCA
TGTGAACACGAACACTCTAATTGCCTCCTGATAGCACACAGAAAGTTTAAAATTGGTGGT
GAATGGTGGACATGGATCGATTATAACCGCTTCCAGGAGCTCATCCAGGAATATGAAGAT
AGTGGTGGATCAAAAACGTTCAGCGCAAAGGATTATATGGCCAGAACTCCTCACTGGGCA
TTATTTGGTGCCAATGAAAGAAGCTTTGATCCCAAGGACACAAGACATCAGAGAAAGAAC
AAATCAAAGGCTATTTCTGGATGTTGA
Protein Properties
Number of Residues 668
Molecular Weight 76945.9
Theoretical pI 6.22
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["None"]
Protein Sequence
>tRNA wybutosine-synthesizing protein 1 homolog B
MDPSADTWDLSSPLISLWINRFYIYLGFAVSISLWICVQIVIEMQGFATVLAEAVTSLDL
PVAIINLKEYDPDDHLIEEVTSKNVCVFLVATYTDGLPTESAEWFCKWLEEASIDFRFGK
TYLKGMRDAVFGLGNSAYASHFNKVGKNVDKWLWMLGVHRVMSRGEGDCDVVKSKHGSIE
ANFRAWKTKFISQLQALQKGERKKSCGGHCKKGKCESHQHGSEEREEGSQEQDELHHRDT
KEEEPFESSSEEEFGGEDHQSLNSIVDVEDLGKIMDHVKKEKREKEQQEEKSGLFRNMGR
NEDGERRAMITPALREALTKQVDAPRERSLLQTHILWNESHRCMETTPSLACANKCVFCW
WHHNNPVGTEWLWKMDQPEMILKEAIENHQNMIKQFKGVPGVKAERFEEGMTVKHCALSL
VGEPIMYPEINRFLKLLHQCKISSFLVTNAQFPAEIRNLEPVTQLYVSVDASTKDSLKKI
DRPLFKDFWQQFLDSLKALAVKQQRTVYRLMLVKAWNVDELQAYAQLVSLGNPDFIEVKG
VTYCRESSASSLTMAHVPWHEEVVQFVRELVDLIPEYEIACEHEHSNCLLIAHRKFKIGG
EWWTWIDYNRFQELIQEYEDSGGSKTFSAKDYMARTPHWALFGANERSFDPKDTRHQRKN
KSKAISGC
GenBank ID Protein 224282123
UniProtKB/Swiss-Prot ID Q6NUM6
UniProtKB/Swiss-Prot Entry Name TYW1B_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_001145440.1
GeneCard ID TYW1B
GenAtlas ID TYW1B
HGNC ID HGNC:33908
References
General References Not Available