Identification
HMDB Protein ID CDBP01646
Secondary Accession Numbers Not Available
Name rRNA 2'-O-methyltransferase fibrillarin
Description Not Available
Synonyms
  1. 34 kDa nucleolar scleroderma antigen
Gene Name FBL
Protein Type Enzyme
Biological Properties
General Function Involved in RNA binding
Specific Function Involved in pre-rRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'- hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA
GO Classification
Function
methyltransferase activity
rna binding
binding
catalytic activity
transferase activity
nucleic acid binding
transferase activity, transferring one-carbon groups
Process
rna metabolic process
ncrna metabolic process
trna metabolic process
trna processing
metabolic process
macromolecule metabolic process
cellular macromolecule metabolic process
rrna metabolic process
rrna processing
Cellular Location
  1. Nucleus
  2. nucleolus
Pathways
Gene Properties
Chromosome Location Chromosome:1
Locus 19q13.1
SNPs FBL
Gene Sequence
>963 bp
ATGAAGCCAGGATTCAGTCCCCGTGGGGGTGGCTTTGGCGGCCGAGGGGGCTTTGGTGAC
CGTGGTGGTCGTGGAGGCCGAGGGGGCTTTGGCGGGGGCCGAGGTCGAGGCGGAGGCTTT
AGAGGTCGTGGACGAGGAGGAGGTGGAGGCGGCGGCGGCGGTGGAGGAGGAGGAAGAGGT
GGTGGAGGCTTCCATTCTGGTGGCAACCGGGGTCGTGGTCGGGGAGGAAAAAGAGGAAAC
CAGTCGGGGAAGAATGTGATGGTGGAGCCGCATCGGCATGAGGGTGTCTTCATTTGTCGA
GGAAAGGAAGATGCACTGGTCACCAAGAACCTGGTCCCTGGGGAATCAGTTTATGGAGAG
AAGAGAGTCTCGATTTCGGAAGGAGATGACAAAATTGAGTACCGAGCCTGGAACCCCTTC
CGCTCCAAGCTAGCAGCAGCAATCCTGGGTGGTGTGGACCAGATCCACATCAAACCGGGG
GCTAAGGTTCTCTACCTCGGGGCTGCCTCGGGCACCACGGTCTCCCATGTCTCTGACATC
GTTGGTCCGGATGGTCTAGTCTATGCAGTCGAGTTCTCCCACCGCTCTGGCCGTGACCTC
ATTAACTTGGCCAAGAAGAGGACCAACATCATTCCTGTGATCGAGGATGCTCGACACCCA
CACAAATACCGCATGCTCATCGCAATGGTGGATGTGATCTTTGCTGATGTGGCCCAGCCA
GACCAGACCCGGATTGTGGCCCTGAATGCCCACACCTTCCTGCGTAATGGAGGACACTTT
GTGATTTCCATTAAGGCCAACTGCATTGACTCCACAGCCTCAGCCGAGGCCGTGTTTGCC
TCCGAAGTGAAAAAGATGCAACAGGAGAACATGAAGCCGCAGGAGCAGTTGACCCTTGAG
CCATATGAAAGAGACCATGCCGTGGTCGTGGGAGTGTACAGGCCACCCCCCAAGGTGAAG
AAC
Protein Properties
Number of Residues 321
Molecular Weight 33784.1
Theoretical pI 10.81
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["None"]
Protein Sequence
>rRNA 2'-O-methyltransferase fibrillarin
MKPGFSPRGGGFGGRGGFGDRGGRGGRGGFGGGRGRGGGFRGRGRGGGGGGGGGGGGGRG
GGGFHSGGNRGRGRGGKRGNQSGKNVMVEPHRHEGVFICRGKEDALVTKNLVPGESVYGE
KRVSISEGDDKIEYRAWNPFRSKLAAAILGGVDQIHIKPGAKVLYLGAASGTTVSHVSDI
VGPDGLVYAVEFSHRSGRDLINLAKKRTNIIPVIEDARHPHKYRMLIAMVDVIFADVAQP
DQTRIVALNAHTFLRNGGHFVISIKANCIDSTASAEAVFASEVKKMQQENMKPQEQLTLE
PYERDHAVVVGVYRPPPKVKN
GenBank ID Protein 197692469
UniProtKB/Swiss-Prot ID P22087
UniProtKB/Swiss-Prot Entry Name FBRL_HUMAN
PDB IDs Not Available
GenBank Gene ID AB451384
GeneCard ID FBL
GenAtlas ID FBL
HGNC ID HGNC:3599
References
General References Not Available