| Identification |
|---|
| HMDB Protein ID
| CDBP00418 |
| Secondary Accession Numbers
| Not Available |
| Name
| Histamine N-methyltransferase |
| Description
| Not Available |
| Synonyms
|
- HMT
- SubName: Histamine N-methyltransferase, isoform CRA_b
|
| Gene Name
| HNMT |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in histamine N-methyltransferase activity |
| Specific Function
| Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine.
|
| GO Classification
|
| Biological Process |
| response to interleukin-1 |
| response to cocaine |
| respiratory gaseous exchange |
| response to glucocorticoid stimulus |
| brain development |
| response to amine stimulus |
| hyperosmotic response |
| response to tumor cell |
| Cellular Component |
| cytoplasm |
| nucleus |
| Molecular Function |
| histamine N-methyltransferase activity |
|
| Cellular Location
|
- Cytoplasm
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Histidine Metabolism |    |  | | Histidinemia |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 2 |
| Locus
| 2q22.1 |
| SNPs
| HNMT |
| Gene Sequence
|
>879 bp
ATGGCATCTTCCATGAGGAGCTTGTTTTCTGACCACGGGAAATATGTTGAATCTTTCCGG
AGGTTTCTCAACCATTCCACGGAACACCAGTGCATGCAGGAATTCATGGACAAGAAGCTG
CCAGGCATAATAGGAAGGATTGGAGACACAAAATCAGAAATTAAGATTCTAAGCATAGGC
GGAGGTGCAGGTGAAATTGATCTTCAAATTCTCTCCAAAGTTCAGGCTCAATACCCAGGA
GTTTGTATCAACAATGAAGTTGTTGAGCCAAGTGCTGAACAAATTGCCAAATACAAAGAG
CTTGTAGCCAAGACATCGAACCTCGAGAACGTAAAGTTTGCTTGGCATAAGGAGACATCA
TCTGAATACCAAAGTAGAATGTTGGAGAAAAAGGAGCTTCAAAAGTGGGACTTTATTCAT
ATGATTCAAATGCTGTATTATGTAAAAGACATCCCAGCTACCCTGAAATTCTTCCATAGT
CTCTTAGGTACCAATGCTAAGATGCTCATTATTGTTGTGTCAGGAAGCAGTGGCTGGGAC
AAGCTGTGGAAAAAGTACGGATCACGCTTTCCCCAGGATGACCTCTGCCAGTATATCACA
TCAGATGACCTCACTCAGATGCTGGACAACCTAGGGCTTAAGTATGAGTGCTATGACCTT
TTGTCCACCATGGATATATCTGACTGCTTTATTGATGGTAATGAAAATGGAGACCTGCTT
TGGGATTTTTTGACTGAAACCTGCAACTTTAATGCCACAGCACCACCTGATCTCAGAGCA
GAGCTTGGGAAAGATCTACAAGAGCCTGAATTTAGTGCTAAGAAAGAGGGGAAGGTTCTT
TTTAATAATACTCTGAGTTTCATAGTGATTGAGGCATAA
|
| Protein Properties |
|---|
| Number of Residues
| 292 |
| Molecular Weight
| 6045.9 |
| Theoretical pI
| 8.349 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Histamine N-methyltransferase
MASSMRSLFSDHGKYVESFRRFLNHSTEHQCMQEFMDKKLPGIIGRIGDTKSEIKILSIG
GGAGEIDLQILSKVQAQYPGVCINNEVVEPSAEQIAKYKELVAKTSNLENVKFAWHKETS
SEYQSRMLEKKELQKWDFIHMIQMLYYVKDIPATLKFFHSLLGTNAKMLIIVVSGSSGWD
KLWKKYGSRFPQDDLCQYITSDDLTQMLDNLGLKYECYDLLSTMDISDCFIDGNENGDLL
WDFLTETCNFNATAPPDLRAELGKDLQEPEFSAKKEGKVLFNNTLSFIVIEA
|
| External Links |
|---|
| GenBank ID Protein
| 62988825 |
| UniProtKB/Swiss-Prot ID
| P50135 |
| UniProtKB/Swiss-Prot Entry Name
| HNMT_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AC093674 |
| GeneCard ID
| HNMT |
| GenAtlas ID
| HNMT |
| HGNC ID
| HGNC:5028 |
| References |
|---|
| General References
| Not Available |