Identification |
HMDB Protein ID
| CDBP00405 |
Secondary Accession Numbers
| Not Available |
Name
| Protein-S-isoprenylcysteine O-methyltransferase |
Description
| Not Available |
Synonyms
|
- Isoprenylcysteine carboxylmethyltransferase
- PPMT
- Prenylated protein carboxyl methyltransferase
- Prenylcysteine carboxyl methyltransferase
- pcCMT
|
Gene Name
| ICMT |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity |
Specific Function
| Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues.
|
GO Classification
|
Biological Process |
positive regulation of cell proliferation |
S-adenosylhomocysteine metabolic process |
S-adenosylmethioninamine metabolic process |
in utero embryonic development |
liver development |
protein targeting to membrane |
regulation of Ras protein signal transduction |
multicellular organism growth |
Cellular Component |
endoplasmic reticulum membrane |
endoplasmic reticulum |
membrane |
integral to membrane |
Component |
intrinsic to membrane |
integral to membrane |
cell part |
membrane part |
Function |
catalytic activity |
transferase activity |
protein methyltransferase activity |
protein carboxyl o-methyltransferase activity |
protein c-terminal carboxyl o-methyltransferase activity |
protein c-terminal s-isoprenylcysteine carboxyl o-methyltransferase activity |
transferase activity, transferring one-carbon groups |
methyltransferase activity |
Molecular Function |
cAMP response element binding protein binding |
protein C-terminal carboxyl O-methyltransferase activity |
protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity |
Process |
protein amino acid alkylation |
protein amino acid methylation |
c-terminal protein amino acid methylation |
macromolecule modification |
protein modification process |
metabolic process |
macromolecule metabolic process |
post-translational protein modification |
|
Cellular Location
|
- Endoplasmic reticulum membrane
- Multi-pass membrane protein
|
Pathways
|
Name | SMPDB/Pathwhiz | KEGG | Terpenoid backbone biosynthesis | Not Available | ![Map00900](https://www.genome.jp/kegg/misc/thumbnail/map00900.gif) |
|
Gene Properties |
Chromosome Location
| 1 |
Locus
| 1p36.21 |
SNPs
| ICMT |
Gene Sequence
|
>855 bp
ATGGCGGGCTGCGCGGCGCGGGCTCCGCCGGGCTCTGAGGCGCGTCTCAGCCTCGCCACC
TTCCTGCTGGGCGCCTCGGTGCTCGCGCTGCCGCTGCTCACGCGCGCCGGCCTGCAGGGC
CGCACCGGGCTGGCGCTCTACGTGGCCGGGCTCAACGCGCTGCTGCTGCTGCTCTATCGG
CCGCCTCGCTACCAGATAGCCATCCGAGCTTGTTTCCTGGGGTTTGTGTTCGGCTGCGGC
ACGCTGCTAAGTTTTAGCCAGTCTTCTTGGAGTCACTTTGGCTGGTACATGTGCTCCCTG
TCATTGTTCCACTATTCTGAATACTTGGTGACAGCAGTCAATAATCCCAAAAGTCTGTCC
TTGGATTCCTTTCTCCTGAATCACAGCCTGGAGTATACAGTAGCTGCTCTTTCTTCTTGG
TTAGAGTTCACACTTGAAAATATCTTTTGGCCAGAACTGAAGCAGATTACCTGGCTCAGT
GTCACAGGGCTGCTGATGGTGGTCTTCGGAGAATGTCTGAGGAAGGCGGCCATGTTTACA
GCTGGCTCCAATTTCAACCACGTGGTACAGAATGAAAAATCAGATACACATACTCTGGTG
ACCAGTGGAGTGTACGCTTGGTTTCGGCATCCTTCTTACGTCGGGTGGTTTTACTGGAGT
ATTGGAACTCAGGTGATGCTGTGTAACCCCATCTGCGGCGTCAGCTATGCCCTGACAGTG
TGGCGATTCTTCCGCGATCGAACAGAAGAAGAAGAAATCTCACTAATTCACTTTTTTGGA
GAGGAGTACCTGGAGTATAAGAAGAGGGTGCCCACGGGCCTGCCTTTCATAAAGGGGGTC
AAGGTGGACCTGTGA
|
Protein Properties |
Number of Residues
| 284 |
Molecular Weight
| 31937.775 |
Theoretical pI
| 7.961 |
Pfam Domain Function
|
|
Signals
|
Not Available
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
>Protein-S-isoprenylcysteine O-methyltransferase
MAGCAARAPPGSEARLSLATFLLGASVLALPLLTRAGLQGRTGLALYVAGLNALLLLLYR
PPRYQIAIRACFLGFVFGCGTLLSFSQSSWSHFGWYMCSLSLFHYSEYLVTAVNNPKSLS
LDSFLLNHSLEYTVAALSSWLEFTLENIFWPELKQITWLSVTGLLMVVFGECLRKAAMFT
AGSNFNHVVQNEKSDTHTLVTSGVYAWFRHPSYVGWFYWSIGTQVMLCNPICGVSYALTV
WRFFRDRTEEEEISLIHFFGEEYLEYKKRVPTGLPFIKGVKVDL
|
External Links |
GenBank ID Protein
| 3135669 |
UniProtKB/Swiss-Prot ID
| O60725 |
UniProtKB/Swiss-Prot Entry Name
| ICMT_HUMAN |
PDB IDs
|
Not Available |
GenBank Gene ID
| AF064084 |
GeneCard ID
| ICMT |
GenAtlas ID
| ICMT |
HGNC ID
| HGNC:5350 |
References |
General References
| Not Available |