| Identification |
|---|
| HMDB Protein ID
| CDBP04359 |
| Secondary Accession Numbers
| Not Available |
| Name
| Transmembrane O-methyltransferase |
| Description
| Not Available |
| Synonyms
|
- Catechol O-methyltransferase 2
- Protein LRTOMT2
|
| Gene Name
| LRTOMT |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in O-methyltransferase activity |
| Specific Function
| Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones (By similarity). Required for auditory function.
|
| GO Classification
|
| Biological Process |
| catecholamine catabolic process |
| auditory receptor cell development |
| neurotransmitter catabolic process |
| sensory perception of sound |
| Cellular Component |
| cytoplasm |
| integral to membrane |
| Function |
| o-methyltransferase activity |
| catalytic activity |
| transferase activity |
| transferase activity, transferring one-carbon groups |
| methyltransferase activity |
| Molecular Function |
| catechol O-methyltransferase activity |
|
| Cellular Location
|
- Isoform 2:Cytoplasm
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 11 |
| Locus
| 11q13.4 |
| SNPs
| LRTOMT |
| Gene Sequence
|
>876 bp
ATGGGAACCCCATGGAGGAAGAGAAAGGGTATAGCAGGCCCTGGACTCCCCGACCTGTCC
TGTGCTCTGGTCCTCCAGCCCAGGGCCCAGGTAGGGACCATGTCCCCTGCCATTGCATTG
GCCTTCCTGCCACTGGTGGTAACATTGCTGGTGCGGTACCGGCACTACTTCCGATTGCTG
GTGCGCACGGTCTTGCTGCGAAGCCTCCGAGACTGCCTGTCAGGGCTGCGGATCGAGGAG
CGGGCCTTCAGCTACGTGCTCACCCATGCCCTGCCCGGTGACCCTGGTCACATCCTCACC
ACCCTGGACCACTGGAGCAGCCGCTGCGAGTACTTGAGCCACATGGGGCCTGTCAAAGGT
CAGATCCTGATGCGGCTGGTGGAGGAGAAGGCCCCTGCTTGTGTGCTGGAATTGGGAACC
TACTGTGGATACTCTACCCTGCTTATTGCCCGAGCCCTGCCCCCTGGGGGTCGCCTTCTT
ACTGTGGAGCGGGACCCACGCACGGCAGCAGTGGCTGAAAAACTCATCCGCCTGGCCGGC
TTTGATGAGCACATGGTGGAGCTCATCGTGGGCAGCTCAGAGGACGTGATCCCGTGCCTA
CGCACCCAGTATCAGCTGAGTCGGGCAGACCTGGTGCTCCTGGCACACCGGCCACGATGT
TACCTGAGGGACCTGCAGCTGCTGGAGGCCCATGCCCTACTGCCAGCAGGTGCCACCGTG
CTGGCTGACCATGTGCTCTTCCCTGGTGCACCCCGCTTCTTGCAGTATGCTAAGAGCTGT
GGCCGCTACCGCTGCCGCCTCCACCACACTGGCCTTCCAGACTTCCCTGCCATCAAGGAT
GGAATAGCTCAGCTCACCTATGCTGGACCAGGCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 291 |
| Molecular Weight
| 32154.43 |
| Theoretical pI
| 9.082 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Transmembrane O-methyltransferase
MGTPWRKRKGIAGPGLPDLSCALVLQPRAQVGTMSPAIALAFLPLVVTLLVRYRHYFRLL
VRTVLLRSLRDCLSGLRIEERAFSYVLTHALPGDPGHILTTLDHWSSRCEYLSHMGPVKG
QILMRLVEEKAPACVLELGTYCGYSTLLIARALPPGGRLLTVERDPRTAAVAEKLIRLAG
FDEHMVELIVGSSEDVIPCLRTQYQLSRADLVLLAHRPRCYLRDLQLLEAHALLPAGATV
LADHVLFPGAPRFLQYAKSCGRYRCRLHHTGLPDFPAIKDGIAQLTYAGPG
|
| External Links |
|---|
| GenBank ID Protein
| 223718159 |
| UniProtKB/Swiss-Prot ID
| Q8WZ04 |
| UniProtKB/Swiss-Prot Entry Name
| TOMT_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_001145308.1 |
| GeneCard ID
| LRTOMT |
| GenAtlas ID
| LRTOMT |
| HGNC ID
| HGNC:25033 |
| References |
|---|
| General References
| Not Available |