| Identification |
|---|
| HMDB Protein ID
| CDBP04586 |
| Secondary Accession Numbers
| Not Available |
| Name
| DNA (cytosine-5)-methyltransferase 3-like |
| Description
| Not Available |
| Synonyms
|
Not Available
|
| Gene Name
| DNMT3L |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in zinc ion binding |
| Specific Function
| Catalytically inactive regulatory factor of DNA methyltransferases. It is essential for the function of DNMT3A and DNMT3B. Activates DNMT3A and DNMT3B by binding to their catalytic domain. Accelerates the binding of DNA and AdoMet to the methyltransferases and dissociates from the complex after DNA binding to the methyltransferases. Recognizes unmethylated histone H3 lysine 4 (H3K4) and induces de novo DNA methylation by recruitment or activation of DNMT3.
|
| GO Classification
|
| Biological Process |
| spermatogenesis |
| in utero embryonic development |
| negative regulation of transcription, DNA-dependent |
| regulation of gene expression by genetic imprinting |
| DNA methylation |
| Cellular Component |
| nuclear heterochromatin |
| cytosol |
| nucleus |
| condensed nuclear chromosome |
| Function |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| transition metal ion binding |
| zinc ion binding |
| Molecular Function |
| metal ion binding |
| enzyme activator activity |
|
| Cellular Location
|
- Nucleus (Probable)
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Cysteine and methionine metabolism | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| DNMT3L |
| Gene Sequence
|
>1164 bp
ATGGCGGCCATCCCAGCCCTGGACCCAGAGGCCGAGCCCAGCATGGACGTGATTTTGGTG
GGATCCAGTGAGCTCTCAAGCTCCGTTTCACCCGGGACAGGCAGAGATCTTATTGCATAT
GAAGTCAAGGCTAACCAGCGAAATATAGAAGACATCTGCATCTGCTGCGGAAGTCTCCAG
GTTCACACACAGCACCCTCTGTTTGAGGGAGGGATCTGCGCCCCATGTAAGGACAAGTTC
CTGGATGCCCTCTTCCTGTACGACGATGACGGGTACCAATCCTACTGCTCCATCTGCTGC
TCCGGAGAGACGCTGCTCATCTGCGGAAACCCTGATTGCACCCGATGCTACTGCTTCGAG
TGTGTGGATAGCCTGGTCGGCCCCGGGACCTCGGGGAAGGTGCACGCCATGAGCAACTGG
GTGTGCTACCTGTGCCTGCCGTCCTCCCGAAGCGGGCTGCTGCAGCGTCGGAGGAAGTGG
CGCAGCCAGCTCAAGGCCTTCTACGACCGAGAGTCGGAGAATCCCCTTGAGATGTTCGAA
ACCGTGCCTGTGTGGAGGAGACAGCCAGTCCGGGTGCTGTCCCTTTTTGAAGACATCAAG
AAAGAGCTGACGAGTTTGGGCTTTTTGGAAAGTGGTTCTGACCCGGGACAACTGAAGCAT
GTGGTTGATGTCACAGACACAGTGAGGAAGGATGTGGAGGAGTGGGGACCCTTCGATCTT
GTGTACGGCGCCACAGCTCCCCTGGGCCACACCTGTGACCGTCCTCCCAGCTGGTACCTG
TTCCAGTTCCACCGGTTCCTGCAGTACGCACGGCCCAAGCCAGGCAGCCCCAGGCCCTTC
TTCTGGATGTTCGTGGACAATCTGGTGCTGAACAAGGAAGACCTGGACGTCGCATCTCGC
TTCCTGGAGATGGAGCCAGTCACCATCCCAGATGTCCACGGCGGATCCTTGCAGAATGCT
GTCCGCGTGTGGAGCAACATCCCAGCCATAAGGAGCAGCAGGCACTGGGCTCTGGTTTCG
GAAGAAGAATTGTCCCTGCTGGCCCAGAACAAGCAGAGCTCGAAGCTCGCGGCCAAGTGG
CCCACCAAGCTGGTGAAGAACTGCTTTCTCCCCCTAAGAGAATATTTCAAGTATTTTTCA
ACAGAACTCACTTCCTCTTTATAA
|
| Protein Properties |
|---|
| Number of Residues
| 387 |
| Molecular Weight
| Not Available |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
Not Available |
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>DNA (cytosine-5)-methyltransferase 3-like
MAAIPALDPEAEPSMDVILVGSSELSSSVSPGTGRDLIAYEVKANQRNIEDICICCGSLQ
VHTQHPLFEGGICAPCKDKFLDALFLYDDDGYQSYCSICCSGETLLICGNPDCTRCYCFE
CVDSLVGPGTSGKVHAMSNWVCYLCLPSSRSGLLQRRRKWRSQLKAFYDRESENPLEMFE
TVPVWRRQPVRVLSLFEDIKKELTSLGFLESGSDPGQLKHVVDVTDTVRKDVEEWGPFDL
VYGATPPLGHTCDRPPSWYLFQFHRLLQYARPKPGSPRPFFWMFVDNLVLNKEDLDVASR
FLEMEPVTIPDVHGGSLQNAVRVWSNIPAIRSSRHWALVSEEELSLLAQNKQSSKLAAKW
PTKLVKNCFLPLREYFKYFSTELTSSL
|
| External Links |
|---|
| GenBank ID Protein
| 6180116 |
| UniProtKB/Swiss-Prot ID
| Q9UJW3 |
| UniProtKB/Swiss-Prot Entry Name
| DNM3L_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AF194032 |
| GeneCard ID
| DNMT3L |
| GenAtlas ID
| DNMT3L |
| HGNC ID
| HGNC:2980 |
| References |
|---|
| General References
| Not Available |