| Identification |
|---|
| HMDB Protein ID
| CDBP04226 |
| Secondary Accession Numbers
| Not Available |
| Name
| Histone-lysine N-methyltransferase SETD1B |
| Description
| Not Available |
| Synonyms
|
- Lysine N-methyltransferase 2G
- SET domain-containing protein 1B
- hSET1B
|
| Gene Name
| SETD1B |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in nucleotide binding |
| Specific Function
| Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. The non-overalpping localization with SETD1A suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression. Specifically tri-methylates 'Lys-4' of histone H3 in vitro.
|
| GO Classification
|
| Biological Process |
| transcription, DNA-dependent |
| histone H3-K4 methylation |
| regulation of transcription, DNA-dependent |
| Cellular Component |
| chromosome |
| nuclear speck |
| Set1C/COMPASS complex |
| Function |
| binding |
| nucleotide binding |
| nucleic acid binding |
| Molecular Function |
| histone-lysine N-methyltransferase activity |
| RNA binding |
| nucleotide binding |
|
| Cellular Location
|
- Nucleus speckle
- Chromosome
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 12 |
| Locus
| 12q24.31 |
| SNPs
| SETD1B |
| Gene Sequence
|
>5772 bp
ATGGAGAACAGTCACCCCCCCCACCACCACCACCAGCAGCCCCCGCCGCAGCCCGGCCCT
TCGGGCGAGAGGAGGAACCACCATTGGAGAAGTTACAAGTTGATGATTGACCCGGCTCTG
AAAAAGGGGCATCATAAACTGTACCGCTACGATGGGCAGCATTTCAGCCTGGCGATGTCC
AGCAACCGCCCGGTGGAAATTGTCGAAGATCCCCGGGTCGTCGGGATCTGGACCAAAAAC
AAGGAGCTGGAGCTGTCGGTGCCCAAATTCAAGATCGATGAGTTCTACGTGGGCCCGGTG
CCTCCGAAGCAGGTGACATTTGCCAAGCTGAATGATAACATCCGTGAAAACTTCCTGAGG
GACATGTGCAAGAAGTATGGGGAGGTGGAGGAGGTGGAGATTTTGTACAACCCCAAGACC
AAGAAGCACCTGGGCATCGCCAAGGTGGTCTTTGCCACGGTCCGGGGAGCCAAGGATGCC
GTTCAGCACTTGCACAGCACTTCCGTCATGGGCAACATTATCCACGTGGAGCTGGACACC
AAAGGGGAAACCCGAATGCGGTTCTATGAACTGTTGGTCACTGGCCGATACACCCCCCAG
ACCCTCCCAGTGGGCGAGCTGGACGCTGTCTCTCCAATCGTGAATGAGACCCTGCAGCTG
TCAGATGCCCTGAAGCGCCTCAAGGATGGAGGCCTGTCTGCAGGCTGTGGCTCCGGCTCC
TCCTCTGTCACCCCCAATAGCGGTGGGACACCCTTCTCCCAGGACACAGCTTATTCCAGC
TGCCGCCTGGACACACCCAACTCCTATGGACAGGGCACCCCGCTCACACCGCGCCTGGGC
ACCCCTTTCTCACAGGACTCCAGCTACTCCAGCCGCCAGCCCACACCCTCATACCTCTTC
AGCCAGGACCCTGCAGTGACCTTCAAGGCCCGGCGCCACGAGAGCAAGTTCACGGACGCC
TACAACCGCCGCCACGAACATCATTATGTACACAATTCTCCCGCGGTCACTGCGGTGGCC
GGGGCCACAGCCGCTTTCCGGGGTTCCTCGGACCTCCCGTTCGGAGCAGTCGGCGGCACT
GGGGGCAGCAGCGGTCCCCCGTTCAAGGCTCAACCACAGGATTCAGCCACATTTGCCCAC
ACTCCACCACCCGCCCAAGCAACCCCTGCTCCTGGATTCAAGTCTGCTTTCTCTCCGTAT
CAGACCCCAGTGGCCCACTTCCCTCCACCCCCGGAAGAGCCCACCGCCACAGCCGCTTTT
GGGGCCCGCGACAGTGGGGAGTTCCGGAGGGCACCGGCGCCCCCACCCCTGCCACCTGCT
GAGCCTCTGGCCAAGGAGAAGCCAGGCACGCCACCCGGCCCGCCGCCCCCCGACACCAAC
AGCATGGAGCTGGGCGGCCGGCCCACCTTCGGCTGGAGTCCTGAGCCCTGTGACAGCCCT
GGCACGCCCACGCTGGAGTCGTCCCCTGCAGGGCCAGAGAAACCCCACGACAGCCTGGAC
TCGCGCATCGAGATGCTGCTGAAGGAGCAGCGCACCAAGCTGCTCTTCCTGAGGGAGCCG
GACTCGGACACCGAGCTGCAGATGGAGGGCAGCCCCATCTCCTCCTCCTCCTCCCAGCTC
TCCCCACTGGCCCCCTTTGGCACCAACTCCCAGCCAGGCTTCCGGGGCCCCACGCCCCCC
TCGTCACGCCCCTCCAGCACCGGCCTGGAGGATATCAGCCCAACACCCCTCCCAGACTCC
GACGAGGACGAGGAGCTCGACCTGGGCCTTGGGCCTCGGCCTCCACCTGAGCCAGGCCCC
CCGGACCCTGCTGGGCTTCTGAGCCAGACAGCTGAGGTGGCCTTGGACCTGGTTGGAGAC
AGAACCCCGACCTCAGAGAAGATGGATGAGGGCCAGCAGTCCTCAGGCGAGGACATGGAG
ATCTCGGATGACGAGATGCCCTCGGCCCCCATCACCAGCGCTGACTGCCCCAAGCCCATG
GTGGTGACCCCAGGAGCGGCAGCCGTGGCAGCCCCTTCTGTGCTAGCCCCAACCCTGCCG
CTGCCCCCGCCACCTGGCTTCCCCCCGCTGCCCCCCCCACCACCACCACCCCCACCGCAG
CCTGGCTTCCCCATGCCCCCACCGCTGCCCCCACCGCCGCCCCCACCCCCTCCAGCCCAC
CCTGCTGTGACAGTGCCCCCACCACCCTTGCCAGCGCCGCCTGGAGTCCCGCCCCCACCC
ATCCTGCCACCACTGCCCCCCTTTCCGCCGGGCCTGTTCCCTGTGATGCAGGTGGACATG
AGCCACGTGCTGGGTGGCCAGTGGGGCGGCATGCCCATGTCCTTCCAGATGCAAACGCAG
GTGCTCAGCCGGCTGATGACGGGCCAGGGCGCCTGCCCCTACCCGCCCTTCATGGCCGCT
GCGGCCGCCGCTGCCTCAGCTGGGCTCCAGTTTGTCAACCTGCCGCCCTACCGGGGCCCC
TTCTCCCTGAGCAACTCCGGCCCAGGCCGCGGGCAGCACTGGCCACCACTGCCCAAGTTT
GACCCGTCAGTGCCTCCACCAGGCTACATGCCACGCCAGGAGGACCCACACAAAGCCACG
GTGGATGGCGTCCTGCTGGTGGTCCTCAAAGAACTCAAGGCCATCATGAAGCGTGACCTG
AACCGCAAGATGGTGGAAGTGGTGGCTTTCCGGGCCTTTGACGAGTGGTGGGACAAGAAG
GAGCGGATGGCCAAGGCCTCGCTGACCCCGGTGAAGTCGGGCGAGCACAAGGACGAGGAC
AGGCCGAAGCCCAAGGACCGCATCGCCTCGTGCCTGCTGGAGTCATGGGGCAAGGGCGAG
GGCCTGGGCTACGAGGGCCTGGGCCTGGGCATTGGGCTGCGTGGGGCCATTCGCCTGCCC
TCCTTCAAGGTCAAGAGGAAGGAGCCACCAGACACCACCTCATCTGGCGACCAGAAGCGG
CTGCGGCCCTCGACCTCTGTGGATGAGGAAGATGAAGAGTCCGAGCGAGAGCGAGACCGG
GATATGGCAGACACCCCCTGTGAGCTCGCCAAGCGGGACCCCAAGGGCGTGGGTGTGCGG
CGGCGGCCGGCGCGGCCTCTGGAGCTGGACAGTGGTGGGGAGGAGGACGAGAAGGAGTCA
TTGTCGGAGGAACAGGAGAGCACCGAGGAGGAAGAGGAGGCGGAGGAGGAGGAGGAGGAG
GAAGATGACGACGATGACGACAGTGATGACCGGGACGAGTCTGAGAACGATGACGAGGAC
ACAGCCCTGTCAGAGGCGAGTGAGAAGGACGAAGGGGACTCGGATGAAGAGGAGACAGTG
AGCATTGTAACCTCCAAGGCCGAAGCCACGTCGTCCAGTGAGAGTTCCGAGTCTTCTGAG
TTTGAGTCAAGCTCCGAGTCCTCGCCCTCATCCTCGGAGGATGAGGAGGAGGTAGTGGCC
AGGGAAGAGGAGGAAGAAGAGGAGGAGGAGGAGATGGTGGCCGAGGAAAGCATGGCTTCT
GCAGGCCCTGAGGACTTTGAGCAGGACGGGGAGGAAGCGGCTCTGGCCCCGGGGGCACCT
GCAGTGGACTCGTTGGGCATGGAAGAGGAGGTGGACATCGAGACTGAGGCTGTGGCCCCT
GAGGAGCGGCCCTCCATGCTGGACGAGCCCCCCTTGCCTGTGGGTGTTGAAGAGCCAGCG
GACTCCAGGGAGCCGCCTGAGGAACCAGGCCTGAGCCAGGAAGGGGCCATGTTGCTGTCT
CCAGAGCCCCCTGCCAAGGAGGTGGAGGCTCGACCCCCATTGTCCCCTGAGCGAGCTCCA
GAACATGACCTGGAAGTGGAGCCGGAGCCCCCTATGATGCTCCCCTTGCCGCTGCAACCA
CCATTGCCGCCCCCACGACCACCCCGGCCACCCAGCCCACCGCCGGAGCCTGAGACCACA
GATGCCTCACACCCATCTGTCCCTCCGGAGCCCCTTGCCGAGGACCACCCCCCGCATACT
CCAGGCCTCTGTGGCAGCCTGGCCAAGTCGCAGAGCACAGAGACGGTGCCAGCCACACCA
GGCGGGGAGCCCCCGCTATCAGGGGGCAGCAGTGGCCTGTCCCTGAGCTCTCCGCAAGTG
CCCGGCAGCCCCTTCTCCTACCCAGCCCCGTCCCCTAGCTTGAGCAGTGGGGGCCTCCCT
CGGACACCTGGCCGGGACTTCAGCTTCACACCCACCTTCTCCGAGCCCAGCGGGCCCTTG
CTCCTGCCCGTCTGCCCACTCCCCACTGGCCGACGCGATGAACGCTCCGGGCCCCTGGCC
TCCCCGGTGCTCCTGGAGACGGGCCTGCCCCTCCCTCTGCCCCTTCCCCTGCCCTTGCCC
TTGGCATTGCCCGCCGTCTTGCGGGCCCAGGCTCGTGCGCCCACCCCGCTGCCACCCCTG
CTGCCCGCCCCCCTGGCCTCTTGCCCTCCCCCAATGAAGAGGAAGCCGGGCCGGCCCCGG
CGATCCCCACCATCTATGCTCTCCTTGGATGGGCCCTTGGTCCGACCACCAGCAGGGGCC
GCCCTTGGAAGGGAACTCCTGCTCCTGCCGGGCCAGCCACAGACCCCCGTCTTCCCCAGC
ACCCATGACCCCCGGACGGTGACCCTGGACTTCCGGAACGCGGGGATCCCAGCCCCTCCA
CCACCCCTTCCCCCCCAGCCACCCCCACCCCCACCTCCCCCACCTGTAGAGCCCACCAAG
CTGCCCTTTAAGGAGCTAGACAACCAGTGGCCCTCCGAGGCCATTCCTCCGGGCCCCCGT
GGGCGCGATGAGGTCACTGAGGAATACATGGAGTTGGCCAAGAGCCGGGGGCCGTGGCGC
CGGCCACCTAAGAAGCGCCATGAGGACCTGGTGCCACCTGCGGGCTCGCCCGAACTCTCG
CCACCCCAGCCCCTCTTCCGGCCCCGCTCGGAGTTTGAGGAGATGACCATCCTGTATGAC
ATCTGGAACGGTGGCATCGATGAGGAGGACATCCGCTTCCTGTGTGTCACCTACGAGCGA
CTGCTACAGCAGGACAATGGCATGGACTGGCTTAACGACACGCTCTGGGTCTACCATCCC
TCCACCAGCCTCTCTTCAGCTAAGAAGAAGAAACGGGACGATGGCATCCGCGAGCACGTG
ACGGGCTGTGCCCGCAGTGAGGGCTTCTACACCATCGACAAGAAGGACAAGCTCAGATAC
CTCAACAGCAGCCGTGCCAGCACCGATGAGCCCCCCGCAGACACCCAGGGCATGAGCATC
CCAGCACAGCCCCACGCCTCCACCCGGGCAGGCTCGGAGCGGCGTTCGGAGCAGCGCCGC
CTGCTGTCCTCCTTCACTGGCAGCTGTGACAGTGACCTGCTCAAGTTCAACCAGCTCAAG
TTCCGGAAGAAAAAGCTCAAGTTCTGCAAGAGCCACATTCACGACTGGGGCTTGTTCGCC
ATGGAGCCCATCGCGGCTGACGAGATGGTCATCGAGTACGTGGGCCAGAATATCCGTCAG
GTGATCGCAGACATGCGGGAGAAGCGTTATGAGGACGAGGGCATCGGGAGCAGCTACATG
TTCCGGGTGGACCATGACACCATCATCGACGCCACCAAGTGCGGCAACTTCGCGCGCTTC
ATCAACCACAGCTGCAACCCCAACTGCTATGCCAAGGTGATCACGGTGGAGTCACAGAAG
AAGATAGTCATCTACTCGAAGCAGCACATTAACGTCAATGAGGAGATTACCTATGACTAT
AAGTTCCCCATCGAGGACGTCAAGATCCCCTGCCTCTGTGGCTCCGAGAACTGCCGGGGG
ACCCTCAACTAG
|
| Protein Properties |
|---|
| Number of Residues
| 1923 |
| Molecular Weight
| 208729.73 |
| Theoretical pI
| 4.954 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Histone-lysine N-methyltransferase SETD1B
MENSHPPHHHHQQPPPQPGPSGERRNHHWRSYKLMIDPALKKGHHKLYRYDGQHFSLAMS
SNRPVEIVEDPRVVGIWTKNKELELSVPKFKIDEFYVGPVPPKQVTFAKLNDNIRENFLR
DMCKKYGEVEEVEILYNPKTKKHLGIAKVVFATVRGAKDAVQHLHSTSVMGNIIHVELDT
KGETRMRFYELLVTGRYTPQTLPVGELDAVSPIVNETLQLSDALKRLKDGGLSAGCGSGS
SSVTPNSGGTPFSQDTAYSSCRLDTPNSYGQGTPLTPRLGTPFSQDSSYSSRQPTPSYLF
SQDPAVTFKARRHESKFTDAYNRRHEHHYVHNSPAVTAVAGATAAFRGSSDLPFGAVGGT
GGSSGPPFKAQPQDSATFAHTPPPAQATPAPGFKSAFSPYQTPVAHFPPPPEEPTATAAF
GARDSGEFRRAPAPPPLPPAEPLAKEKPGTPPGPPPPDTNSMELGGRPTFGWSPEPCDSP
GTPTLESSPAGPEKPHDSLDSRIEMLLKEQRTKLLFLREPDSDTELQMEGSPISSSSSQL
SPLAPFGTNSQPGFRGPTPPSSRPSSTGLEDISPTPLPDSDEDEELDLGLGPRPPPEPGP
PDPAGLLSQTAEVALDLVGDRTPTSEKMDEGQQSSGEDMEISDDEMPSAPITSADCPKPM
VVTPGAAAVAAPSVLAPTLPLPPPPGFPPLPPPPPPPPPQPGFPMPPPLPPPPPPPPPAH
PAVTVPPPPLPAPPGVPPPPILPPLPPFPPGLFPVMQVDMSHVLGGQWGGMPMSFQMQTQ
VLSRLMTGQGACPYPPFMAAAAAAASAGLQFVNLPPYRGPFSLSNSGPGRGQHWPPLPKF
DPSVPPPGYMPRQEDPHKATVDGVLLVVLKELKAIMKRDLNRKMVEVVAFRAFDEWWDKK
ERMAKASLTPVKSGEHKDEDRPKPKDRIASCLLESWGKGEGLGYEGLGLGIGLRGAIRLP
SFKVKRKEPPDTTSSGDQKRLRPSTSVDEEDEESERERDRDMADTPCELAKRDPKGVGVR
RRPARPLELDSGGEEDEKESLSEEQESTEEEEEAEEEEEEEDDDDDDSDDRDESENDDED
TALSEASEKDEGDSDEEETVSIVTSKAEATSSSESSESSEFESSSESSPSSSEDEEEVVA
REEEEEEEEEEMVAEESMASAGPEDFEQDGEEAALAPGAPAVDSLGMEEEVDIETEAVAP
EERPSMLDEPPLPVGVEEPADSREPPEEPGLSQEGAMLLSPEPPAKEVEARPPLSPERAP
EHDLEVEPEPPMMLPLPLQPPLPPPRPPRPPSPPPEPETTDASHPSVPPEPLAEDHPPHT
PGLCGSLAKSQSTETVPATPGGEPPLSGGSSGLSLSSPQVPGSPFSYPAPSPSLSSGGLP
RTPGRDFSFTPTFSEPSGPLLLPVCPLPTGRRDERSGPLASPVLLETGLPLPLPLPLPLP
LALPAVLRAQARAPTPLPPLLPAPLASCPPPMKRKPGRPRRSPPSMLSLDGPLVRPPAGA
ALGRELLLLPGQPQTPVFPSTHDPRTVTLDFRNAGIPAPPPPLPPQPPPPPPPPPVEPTK
LPFKELDNQWPSEAIPPGPRGRDEVTEEYMELAKSRGPWRRPPKKRHEDLVPPAGSPELS
PPQPLFRPRSEFEEMTILYDIWNGGIDEEDIRFLCVTYERLLQQDNGMDWLNDTLWVYHP
STSLSSAKKKKRDDGIREHVTGCARSEGFYTIDKKDKLRYLNSSRASTDEPPADTQGMSI
PAQPHASTRAGSERRSEQRRLLSSFTGSCDSDLLKFNQLKFRKKKLKFCKSHIHDWGLFA
MEPIAADEMVIEYVGQNIRQVIADMREKRYEDEGIGSSYMFRVDHDTIIDATKCGNFARF
INHSCNPNCYAKVITVESQKKIVIYSKQHINVNEEITYDYKFPIEDVKIPCLCGSENCRG
TLN
|
| External Links |
|---|
| GenBank ID Protein
| 210032580 |
| UniProtKB/Swiss-Prot ID
| Q9UPS6 |
| UniProtKB/Swiss-Prot Entry Name
| SET1B_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| NM_015048.1 |
| GeneCard ID
| SETD1B |
| GenAtlas ID
| SETD1B |
| HGNC ID
| HGNC:29187 |
| References |
|---|
| General References
| Not Available |