Record Information
Version1.0
Created at2020-04-17 19:08:31 UTC
Updated at2020-12-07 19:11:33 UTC
CannabisDB IDCDB005092
Secondary Accession NumbersNot Available
Cannabis Compound Identification
Common NameAcetyl-CoA
DescriptionAcetyl-CoA, also known as acetyl coenzyme A or accoa, belongs to the class of organic compounds known as o-glucuronides. These are glucuronides in which the aglycone is linked to the carbohydrate unit through an O-glycosidic bond. Thus, acetyl-CoA is considered to be a fatty ester lipid molecule. Acetyl-CoA is a very hydrophobic molecule, practically insoluble (in water), and relatively neutral. Acetyl-CoA exists in all living species, ranging from bacteria to humans. In humans, acetyl-CoA is involved in the metabolic disorder called the long chain acyl-coa dehydrogenase deficiency (lcad) pathway. An acyl-CoA having acetyl as its S-acetyl component. Outside of the human body, Acetyl-CoA has been detected, but not quantified in, several different foods, such as amaranths, lemon verbena, strawberries, lingonberries, and carobs. This could make acetyl-CoA a potential biomarker for the consumption of these foods. Acetyl-CoA is expected to be in Cannabis as all living plants are known to produce and metabolize it.
Structure
Thumb
Synonyms
ValueSource
AcCoAChEBI
Acetyl coenzyme AChEBI
S-Acetyl-CoAChEBI
S-Acetyl-coenzyme AChEBI
Ac-CoAHMDB
Ac-coenzyme AHMDB
Ac-S-CoAHMDB
Ac-S-coenzyme AHMDB
Acetyl-coenzyme AHMDB
Acetyl-S-CoAHMDB
Acetyl-S-coenzyme AHMDB
Acetylcoenzyme AHMDB
S-Acetate CoAHMDB
S-Acetate coenzyme AHMDB
S-Acetyl coenzyme AHMDB
coenzyme A, AcetylHMDB
Acetyl CoAHMDB
CoA, AcetylHMDB
Chemical FormulaC23H38N7O17P3S
Average Molecular Weight809.57
Monoisotopic Molecular Weight809.1258
IUPAC Name{[(2R,3S,4R,5R)-2-({[({[(3R)-3-[(2-{[2-(acetylsulfanyl)ethyl]carbamoyl}ethyl)carbamoyl]-3-hydroxy-2,2-dimethylpropoxy](hydroxy)phosphoryl}oxy)(hydroxy)phosphoryl]oxy}methyl)-5-(6-amino-9H-purin-9-yl)-4-hydroxyoxolan-3-yl]oxy}phosphonic acid
Traditional Nameacetyl-CoA
CAS Registry Number72-89-9
SMILES
CC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N
InChI Identifier
InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/t13-,16-,17-,18+,22-/m1/s1
InChI KeyZSLZBFCDCINBPY-ZSJPKINUSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as o-glucuronides. These are glucuronides in which the aglycone is linked to the carbohydrate unit through an O-glycosidic bond.
KingdomOrganic compounds
Super ClassOrganic oxygen compounds
ClassOrganooxygen compounds
Sub ClassCarbohydrates and carbohydrate conjugates
Direct ParentO-glucuronides
Alternative Parents
Substituents
  • 1-o-glucuronide
  • O-glucuronide
  • Glycosyl compound
  • O-glycosyl compound
  • Pyrrolidinylpyridine
  • Alkaloid or derivatives
  • Beta-hydroxy acid
  • Hydroxy acid
  • Monosaccharide
  • Oxane
  • Pyran
  • Pyridine
  • Pyrrolidone
  • 2-pyrrolidone
  • N-alkylpyrrolidine
  • Pyrrolidine
  • Tertiary carboxylic acid amide
  • Heteroaromatic compound
  • Secondary alcohol
  • Carboxamide group
  • Lactam
  • Azacycle
  • Organoheterocyclic compound
  • Carboxylic acid
  • Oxacycle
  • Carboxylic acid derivative
  • Polyol
  • Acetal
  • Monocarboxylic acid or derivatives
  • Organopnictogen compound
  • Organic nitrogen compound
  • Carbonyl group
  • Alcohol
  • Organic oxide
  • Hydrocarbon derivative
  • Organonitrogen compound
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External DescriptorsNot Available
Ontology
Disposition

Route of exposure:

Source:

Biological location:

Role

Industrial application:

Biological role:

Physical Properties
StateSolid
Experimental Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
logPNot AvailableNot Available
Predicted Properties
PropertyValueSource
logP-0.58ALOGPS
logP-5.9ChemAxon
logS-2.3ALOGPS
pKa (Strongest Acidic)0.82ChemAxon
pKa (Strongest Basic)4.01ChemAxon
Physiological Charge-4ChemAxon
Hydrogen Acceptor Count17ChemAxon
Hydrogen Donor Count9ChemAxon
Polar Surface Area363.63 ŲChemAxon
Rotatable Bond Count20ChemAxon
Refractivity172.21 m³·mol⁻¹ChemAxon
Polarizability70.62 ųChemAxon
Number of Rings3ChemAxon
BioavailabilityNoChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Spectra
EI-MS/GC-MSNot Available
MS/MS
TypeDescriptionSplash KeyView
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT 35V, positivesplash10-0fb9-0035910000-cecfaf54528fc3ef9f00Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT 35V, positivesplash10-0ufr-0005900000-491971eb7a5c2b327554Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT 35V, negativesplash10-0a4i-0900000000-1b259612c3897ed851f0Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT 35V, negativesplash10-08i0-0001901200-8d4f5232c27f2875cf8bSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT 35V, negativesplash10-08i0-0000901200-33f8d3ced8c83336df0cSpectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-000i-1901000300-57c996f08055dba75dd7Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-000i-0902000000-dffb00601bfc54014ae4Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-000i-2901000000-155f0890adf4c76dca85Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-0arr-6820231930-984ae0f98e0d17e4a7fcSpectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-003r-3910100000-87da6b6d742efbc6e74aSpectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-057i-5900000000-8701decc3b2311880b97Spectrum
NMRNot Available
Pathways
Pathways
Protein Targets
Enzymes
Protein NameGene NameLocusUniprot IDDetails
Hydroxymethylglutaryl-CoA lyase, mitochondrialHMGCL1p36.1-p35P35914 details
ATP-citrate synthaseACLY17q21.2P53396 details
Histone acetyltransferase p300EP30022q13.2Q09472 details
Pyruvate dehydrogenase E1 component subunit beta, mitochondrialPDHB3p21.1-p14.2P11177 details
Acetyl-CoA acetyltransferase, cytosolicACAT26q25.3Q9BWD1 details
Diamine acetyltransferase 2SAT217p13.1Q96F10 details
Malonyl-CoA decarboxylase, mitochondrialMLYCD16q24O95822 details
Acetyl-CoA carboxylase 2ACACB12q24.11O00763 details
Pyruvate carboxylase, mitochondrialPC11q13.4-q13.5P11498 details
Arylamine N-acetyltransferase 1NAT18p22P18440 details
Arylamine N-acetyltransferase 2NAT28p22P11245 details
5-aminolevulinate synthase, nonspecific, mitochondrialALAS13p21.1P13196 details
General transcription factor 3C polypeptide 4GTF3C49q34.13Q9UKN8 details
Acyl-coenzyme A thioesterase 12ACOT125q14.1Q8WYK0 details
Choline O-acetyltransferaseCHAT10q11.2P28329 details
Nuclear receptor coactivator 3NCOA320q12Q9Y6Q9 details
Histone acetyltransferase KAT2BKAT2B3p24Q92831 details
Carnitine O-acetyltransferaseCRAT9q34.1P43155 details
Diamine acetyltransferase 1SAT1Xp22.1P21673 details
Serotonin N-acetyltransferaseAANAT17q25Q16613 details
3-ketoacyl-CoA thiolase, mitochondrialACAA218q21.1P42765 details
Testis-specific chromodomain protein Y 1CDY1Yq11.23Q9Y6F8 details
Fatty acid synthaseFASN17q25P49327 details
Histone acetyltransferase KAT5KAT511q13Q92993 details
Acetyl-coenzyme A synthetase, cytoplasmicACSS220q11.22Q9NR19 details
Acetyl-CoA acetyltransferase, mitochondrialACAT111q22.3P24752 details
Nuclear receptor coactivator 1NCOA12p23Q15788 details
Hydroxymethylglutaryl-CoA synthase, mitochondrialHMGCS21p13-p12P54868 details
Acetyl-coenzyme A synthetase 2-like, mitochondrialACSS120p11.23-p11.21Q9NUB1 details
Citrate synthase, mitochondrialCS12q13.2O75390 details
Testis-specific chromodomain protein Y 2CDY2AYq11.221Q9Y6F7 details
3-ketoacyl-CoA thiolase, peroxisomalACAA13p22.2P09110 details
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrialPDHA1Xp22.1P08559 details
Acetyl-CoA carboxylase 1ACACA17q21Q13085 details
Trifunctional enzyme subunit beta, mitochondrialHADHB2p23P55084 details
2-amino-3-ketobutyrate coenzyme A ligase, mitochondrialGCAT22q13.1O75600 details
Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrialPDHA24q22-q23P29803 details
Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrialALDH6A114q24.3Q02252 details
Glucosamine 6-phosphate N-acetyltransferaseGNPNAT114q22.1Q96EK6 details
Hydroxymethylglutaryl-CoA synthase, cytoplasmicHMGCS15p14-p13Q01581 details
Dihydrolipoyl dehydrogenase, mitochondrialDLD7q31-q32P09622 details
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrialDLAT11q23.1P10515 details
Long-chain specific acyl-CoA dehydrogenase, mitochondrialACADL2q34P28330 details
Short-chain specific acyl-CoA dehydrogenase, mitochondrialACADS12q24.31P16219 details
Medium-chain specific acyl-CoA dehydrogenase, mitochondrialACADM1p31P11310 details
Peroxisomal acyl-coenzyme A oxidase 1ACOX117q25.1Q15067 details
Peroxisomal acyl-coenzyme A oxidase 2ACOX23p14.3Q99424 details
Isovaleryl-CoA dehydrogenase, mitochondrialIVD15q14-q15P26440 details
Peroxisomal acyl-coenzyme A oxidase 3ACOX34p15.3O15254 details
Glutaryl-CoA dehydrogenase, mitochondrialGCDH19p13.2Q92947 details
Hepatic triacylglycerol lipaseLIPC15q21-q23P11150 details
Diacylglycerol O-acyltransferase 1DGAT18q24.3O75907 details
2-oxoisovalerate dehydrogenase subunit beta, mitochondrialBCKDHB6q14.1P21953 details
2-oxoisovalerate dehydrogenase subunit alpha, mitochondrialBCKDHA19q13.1-q13.2P12694 details
Acyl-CoA desaturaseSCD10q24.31O00767 details
Sterol O-acyltransferase 2SOAT212q13.13O75908 details
Sterol O-acyltransferase 1SOAT11q25P35610 details
N-acetylglutamate synthase, mitochondrialNAGS17q21.31Q8N159 details
Bile acid-CoA:amino acid N-acyltransferaseBAAT9q22.3Q14032 details
Long-chain-fatty-acid--CoA ligase 4ACSL4Xq22.3-q23O60488 details
Long-chain-fatty-acid--CoA ligase 1ACSL14q35P33121 details
Long-chain-fatty-acid--CoA ligase 6ACSL65q31Q9UKU0 details
Long-chain-fatty-acid--CoA ligase 5ACSL510q25.1-q25.2Q9ULC5 details
Long-chain-fatty-acid--CoA ligase 3ACSL32q34-q35O95573 details
Glycerol-3-phosphate acyltransferase 1, mitochondrialGPAM10q25.2Q9HCL2 details
Trans-2-enoyl-CoA reductase, mitochondrialMECR1p35.3Q9BV79 details
Peroxisomal trans-2-enoyl-CoA reductasePECR2q35Q9BY49 details
Cytosolic acyl coenzyme A thioester hydrolaseACOT71p36O00154 details
Acyl-coenzyme A thioesterase 2, mitochondrialACOT214q24.3P49753 details
Acyl-coenzyme A thioesterase 4ACOT414q24.3Q8N9L9 details
Acyl-coenzyme A thioesterase 8ACOT820q13.12O14734 details
Dihydroxyacetone phosphate acyltransferaseGNPAT1q42O15228 details
1-acyl-sn-glycerol-3-phosphate acyltransferase gammaAGPAT321q22.3Q9NRZ7 details
1-acyl-sn-glycerol-3-phosphate acyltransferase betaAGPAT29q34.3O15120 details
1-acyl-sn-glycerol-3-phosphate acyltransferase alphaAGPAT16p21.3Q99943 details
Short/branched chain specific acyl-CoA dehydrogenase, mitochondrialACADSB10q26.13P45954 details
Very long-chain acyl-CoA synthetaseSLC27A215q21.2O14975 details
Peroxisome proliferator-activated receptor gammaPPARG3p25P37231 details
Peroxisome proliferator-activated receptor alphaPPARA22q12-q13.1|22q13.31Q07869 details
Peroxisome proliferator-activated receptor deltaPPARD6p21.2Q03181 details
Acyl-CoA-binding proteinDBI2q12-q21P07108 details
Histone acetyltransferase KAT2AKAT2A17q21Q92830 details
Fatty acid-binding protein, heartFABP31p33-p32P05413 details
1-acyl-sn-glycerol-3-phosphate acyltransferase epsilonAGPAT58p23.1Q9NUQ2 details
Acetyl-coenzyme A transporter 1SLC33A13q25.31O00400 details
Bile acyl-CoA synthetaseSLC27A519q13.43Q9Y2P5 details
Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrialDBT1p31P11182 details
2-acylglycerol O-acyltransferase 2MOGAT211q13.5Q3SYC2 details
Long-chain fatty acid transport protein 3SLC27A31q21.3Q5K4L6 details
Acyl-CoA dehydrogenase family member 10ACAD1012q24.12Q6JQN1 details
Acyl-CoA dehydrogenase family member 11ACAD113q22.1Q709F0 details
Glycerol-3-phosphate acyltransferase 4AGPAT68p11.21Q86UL3 details
Acyl-coenzyme A synthetase ACSM1, mitochondrialACSM116p12.3Q08AH1 details
Diacylglycerol O-acyltransferase 2DGAT211q13.5Q96PD7 details
1-acyl-sn-glycerol-3-phosphate acyltransferase deltaAGPAT46q26Q9NRZ5 details
2-acylglycerol O-acyltransferase 1MOGAT12q36.1Q96PD6 details
3-hydroxymethyl-3-methylglutaryl-CoA lyase, cytoplasmicHMGCLL16p12.1Q8TB92 details
Isobutyryl-CoA dehydrogenase, mitochondrialACAD811q25Q9UKU7 details
Acyl-CoA dehydrogenase family member 9, mitochondrialACAD93q21.3Q9H845 details
Long-chain fatty acid transport protein 4SLC27A49q34.11Q6P1M0 details
Fatty acyl-CoA reductase 1FAR111p15.2Q8WVX9 details
Fatty acyl-CoA reductase 2FAR212p11.22Q96K12 details
Acyl-CoA wax alcohol acyltransferase 1AWAT1Xq13.1Q58HT5 details
Acyl-CoA wax alcohol acyltransferase 2AWAT2Xq13.1Q6E213 details
Diacylglycerol O-acyltransferase 2-like protein 6DGAT2L6Q6ZPD8 details
Putative diacylglycerol O-acyltransferase 2-like protein 7DGAT2L77q22.1Q6IED9 details
2-acylglycerol O-acyltransferase 3MOGAT37q22.1Q86VF5 details
Lysophospholipid acyltransferase 5LPCAT312p13Q6P1A2 details
Lysophosphatidylcholine acyltransferase 1LPCAT15p15.33Q8NF37 details
Lysophosphatidylcholine acyltransferase 2LPCAT216q12.2Q7L5N7 details
Lysocardiolipin acyltransferase 1LCLAT12p23.1Q6UWP7 details
Lysophospholipid acyltransferase LPCAT4LPCAT415q14Q643R3 details
Glycerol-3-phosphate acyltransferase 3AGPAT94q21.23Q53EU6 details
Glycine N-acyltransferaseGLYAT11q12.1Q6IB77 details
Glycine N-acyltransferase-like protein 1GLYATL111q12.1Q969I3 details
Glycine N-acyltransferase-like protein 2GLYATL211q12.1Q8WU03 details
Dihydrolipoamide S-acetyltransferaseDLAT11q23.1Q86YI5 details
Enoyl-CoA delta isomerase 2, mitochondrialECI26p24.3O75521 details
Acyl-CoA synthetase family member 4AASDH4q12Q4L235 details
ACSS2 proteinACSS220q11.22Q96FY7 details
Very long-chain specific acyl-CoA dehydrogenase, mitochondrialACADVL17p13.1P49748 details
Acyl-coenzyme A oxidase-like proteinACOXL2q13Q9NUZ1 details
Acyl-coenzyme A synthetase ACSM6, mitochondrialACSM610q23.33Q6P461 details
Acyl-coenzyme A synthetase ACSM2A, mitochondrialACSM2A16p12.3Q08AH3 details
Acyl-coenzyme A synthetase ACSM2B, mitochondrialACSM2B16p12.3Q68CK6 details
Acyl-coenzyme A synthetase ACSM3, mitochondrialACSM316p13.11Q53FZ2 details
Acyl-coenzyme A synthetase ACSM5, mitochondrialACSM516p12.3Q6NUN0 details
Peroxisomal coenzyme A diphosphatase NUDT7NUDT716q23.1P0C024 details
Acyl-coenzyme A synthetase ACSM4, mitochondrialACSM412p13.31P0C7M7 details
3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrialOXSM3p24.2Q9NWU1 details
Histone acetyltransferase KAT6BKAT6B10q22.2Q8WYB5 details
MYST3 proteinMYST38p11A5PKX7 details
Histone acetyltransferase KAT8KAT816p11.2Q9H7Z6 details
Histone acetyltransferase type B catalytic subunitHAT12q31.2-q33.1O14929 details
Glycerol-3-phosphate acyltransferase 2, mitochondrialGPAT22q11.1Q6NUI2 details
Chromodomain Y-like proteinCDYL6p25.1Q9Y232 details
Peroxisomal D3,D2-enoyl-CoA isomerase isoform 1 variantQ53GC8 details
Nef-associated protein 1C9orf1569q22.33Q9BU70 details
Acyl-coenzyme A thioesterase 9, mitochondrialACOT9Q9Y305 details
Acyl-CoA synthetase family member 3, mitochondrialACSF316q24.3Q4G176 details
Acyl-coenzyme A thioesterase 1ACOT114q24.3Q86TX2 details
Cytosolic acyl coenzyme A thioester hydrolase-likeACOT7LQ6ZUV0 details
Acyl-CoA synthetase family member 2, mitochondrialACSF217q21.33Q96CM8 details
Acyl-coenzyme A thioesterase 11ACOT111p32.3Q8WXI4 details
Long-chain-fatty-acid--CoA ligase ACSBG2ACSBG219p13.3Q5FVE4 details
Long-chain-fatty-acid--CoA ligase ACSBG1ACSBG115q23-q24Q96GR2 details
Circadian locomoter output cycles protein kaputCLOCK4q12O15516 details
Histone acetyltransferase KAT7KAT717q21.32O95251 details
Acyl-CoA synthetase short-chain family member 3, mitochondrialACSS312q21.31Q9H6R3 details
Alpha-tubulin N-acetyltransferaseATAT16p21.33Q5SQI0 details
Heparan-alpha-glucosaminide N-acetyltransferaseHGSNAT8p11.1Q68CP4 details
Histone acetyltransferase KAT6AKAT6A8p11Q92794 details
N-alpha-acetyltransferase 10NAA10Xq28P41227 details
N-alpha-acetyltransferase 11NAA114q21.21Q9BSU3 details
N-alpha-acetyltransferase 20NAA2020p11.23P61599 details
N-alpha-acetyltransferase 30NAA3014q22.3Q147X3 details
N-alpha-acetyltransferase 60NAA6016p13.3Q9H7X0 details
N-acetylaspartate synthetaseNAT8L4p16.3Q8N9F0 details
Transporters
Protein NameGene NameLocusUniprot IDDetails
Fatty acid synthaseFASN17q25P49327 details
Very long-chain acyl-CoA synthetaseSLC27A215q21.2O14975 details
Fatty acid-binding protein, heartFABP31p33-p32P05413 details
Acetyl-coenzyme A transporter 1SLC33A13q25.31O00400 details
Bile acyl-CoA synthetaseSLC27A519q13.43Q9Y2P5 details
Long-chain fatty acid transport protein 1SLC27A119p13.11Q6PCB7 details
Acyl-CoA synthetase family member 4AASDH4q12Q4L235 details
Fatty acid-binding protein, intestinalFABP24q28-q31P12104 details
Metal Bindings
Protein NameGene NameLocusUniprot IDDetails
ATP-citrate synthaseACLY17q21.2P53396 details
Histone acetyltransferase p300EP30022q13.2Q09472 details
CREB-binding proteinCREBBP16p13.3Q92793 details
Acetyl-CoA carboxylase 2ACACB12q24.11O00763 details
Pyruvate carboxylase, mitochondrialPC11q13.4-q13.5P11498 details
Fatty acid synthaseFASN17q25P49327 details
Histone acetyltransferase KAT5KAT511q13Q92993 details
Acetyl-CoA acetyltransferase, mitochondrialACAT111q22.3P24752 details
Acetyl-CoA carboxylase 1ACACA17q21Q13085 details
2-oxoisovalerate dehydrogenase subunit alpha, mitochondrialBCKDHA19q13.1-q13.2P12694 details
Acyl-CoA desaturaseSCD10q24.31O00767 details
Trans-2-enoyl-CoA reductase, mitochondrialMECR1p35.3Q9BV79 details
Peroxisome proliferator-activated receptor gammaPPARG3p25P37231 details
Peroxisome proliferator-activated receptor alphaPPARA22q12-q13.1|22q13.31Q07869 details
Peroxisome proliferator-activated receptor deltaPPARD6p21.2Q03181 details
Acyl-coenzyme A synthetase ACSM1, mitochondrialACSM116p12.3Q08AH1 details
3-hydroxymethyl-3-methylglutaryl-CoA lyase, cytoplasmicHMGCLL16p12.1Q8TB92 details
Lysophosphatidylcholine acyltransferase 1LPCAT15p15.33Q8NF37 details
Lysophosphatidylcholine acyltransferase 2LPCAT216q12.2Q7L5N7 details
Acyl-coenzyme A synthetase ACSM6, mitochondrialACSM610q23.33Q6P461 details
Acyl-coenzyme A synthetase ACSM2A, mitochondrialACSM2A16p12.3Q08AH3 details
Acyl-coenzyme A synthetase ACSM2B, mitochondrialACSM2B16p12.3Q68CK6 details
Acyl-coenzyme A synthetase ACSM3, mitochondrialACSM316p13.11Q53FZ2 details
Acyl-coenzyme A synthetase ACSM5, mitochondrialACSM516p12.3Q6NUN0 details
Peroxisomal coenzyme A diphosphatase NUDT7NUDT716q23.1P0C024 details
Elongator complex protein 3ELP38p21.1Q9H9T3 details
Acyl-coenzyme A synthetase ACSM4, mitochondrialACSM412p13.31P0C7M7 details
Histone acetyltransferase KAT6BKAT6B10q22.2Q8WYB5 details
MYST3 proteinMYST38p11A5PKX7 details
Histone acetyltransferase KAT8KAT816p11.2Q9H7Z6 details
Histone acetyltransferase KAT7KAT717q21.32O95251 details
Histone acetyltransferase KAT6AKAT6A8p11Q92794 details
Receptors
Protein NameGene NameLocusUniprot IDDetails
Histone acetyltransferase p300EP30022q13.2Q09472 details
Nuclear receptor coactivator 3NCOA320q12Q9Y6Q9 details
Histone acetyltransferase KAT5KAT511q13Q92993 details
Nuclear receptor coactivator 1NCOA12p23Q15788 details
Peroxisome proliferator-activated receptor gammaPPARG3p25P37231 details
Peroxisome proliferator-activated receptor alphaPPARA22q12-q13.1|22q13.31Q07869 details
Peroxisome proliferator-activated receptor deltaPPARD6p21.2Q03181 details
Benzodiazepine receptor ligandBRLQ71U42 details
Transcriptional Factors
Protein NameGene NameLocusUniprot IDDetails
Histone acetyltransferase p300EP30022q13.2Q09472 details
CREB-binding proteinCREBBP16p13.3Q92793 details
General transcription factor 3C polypeptide 4GTF3C49q34.13Q9UKN8 details
Nuclear receptor coactivator 3NCOA320q12Q9Y6Q9 details
Histone acetyltransferase KAT2BKAT2B3p24Q92831 details
Histone acetyltransferase KAT5KAT511q13Q92993 details
Nuclear receptor coactivator 1NCOA12p23Q15788 details
Peroxisome proliferator-activated receptor gammaPPARG3p25P37231 details
Peroxisome proliferator-activated receptor alphaPPARA22q12-q13.1|22q13.31Q07869 details
Peroxisome proliferator-activated receptor deltaPPARD6p21.2Q03181 details
Histone acetyltransferase KAT2AKAT2A17q21Q92830 details
Isobutyryl-CoA dehydrogenase, mitochondrialACAD811q25Q9UKU7 details
Elongator complex protein 3ELP38p21.1Q9H9T3 details
Histone acetyltransferase KAT6BKAT6B10q22.2Q8WYB5 details
MYST3 proteinMYST38p11A5PKX7 details
Histone acetyltransferase KAT8KAT816p11.2Q9H7Z6 details
Chromodomain Y-like proteinCDYL6p25.1Q9Y232 details
Circadian locomoter output cycles protein kaputCLOCK4q12O15516 details
Histone acetyltransferase KAT7KAT717q21.32O95251 details
Histone acetyltransferase KAT6AKAT6A8p11Q92794 details
Concentrations Data
Not Available
HMDB IDHMDB0001206
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FoodDB IDFDB022491
KNApSAcK IDC00007259
Chemspider ID392413
KEGG Compound IDC00024
BioCyc IDACETYL-COA
BiGG ID33558
Wikipedia LinkAcetyl-CoA
METLIN ID6082
PubChem Compound444493
PDB IDNot Available
ChEBI ID15351
References
General ReferencesNot Available

Only showing the first 10 proteins. There are 226 proteins in total.

Enzymes

General function:
Involved in catalytic activity
Specific function:
Key enzyme in ketogenesis (ketone body formation). Terminal step in leucine catabolism.
Gene Name:
HMGCL
Uniprot ID:
P35914
Molecular weight:
34359.84
General function:
Involved in ATP citrate synthase activity
Specific function:
ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine.
Gene Name:
ACLY
Uniprot ID:
P53396
Molecular weight:
120838.27
General function:
Involved in transcription cofactor activity
Specific function:
Functions as histone acetyltransferase and regulates transcription via chromatin remodeling. Acetylates all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional activation. Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Also functions as acetyltransferase for nonhistone targets. Acetylates 'Lys-131' of ALX1 and acts as its coactivator in the presence of CREBBP. Acetylates SIRT2 and is proposed to indirectly increase the transcriptional activity of TP53 through acetylation and subsequent attenuation of SIRT2 deacetylase function. Acetylates HDAC1 leading to its inactivation and modulation of transcription. Acts as a TFAP2A-mediated transcriptional coactivator in presence of CITED2. Plays a role as a coactivator of NEUROD1-dependent transcription of the secretin and p21 genes and controls terminal differentiation of cells in the intestinal epithelium. Promotes cardiac myocyte enlargement. Can also mediate transcriptional repression. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Acetylates FOXO1 and enhances its transcriptional activity.
Gene Name:
EP300
Uniprot ID:
Q09472
Molecular weight:
264159.725
General function:
Involved in catalytic activity
Specific function:
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.
Gene Name:
PDHB
Uniprot ID:
P11177
Molecular weight:
39233.1
General function:
Involved in transferase activity, transferring acyl groups other than amino-acyl groups
Specific function:
Not Available
Gene Name:
ACAT2
Uniprot ID:
Q9BWD1
Molecular weight:
41350.5
General function:
Involved in N-acetyltransferase activity
Specific function:
Enzyme which catalyzes the acetylation of polyamines. Substrate specificity: norspermidine > spermidine = spermine >> N(1)acetylspermine = putrescine.
Gene Name:
SAT2
Uniprot ID:
Q96F10
Molecular weight:
19154.905
General function:
Involved in malonyl-CoA decarboxylase activity
Specific function:
Catalyzes the conversion of malonyl-CoA to acetyl-CoA. In the fatty acid biosynthesis MCD selectively removes malonyl-CoA and thus assures that methyl-malonyl-CoA is the only chain elongating substrate for fatty acid synthase and that fatty acids with multiple methyl side chains are produced. In peroxisomes it may be involved in degrading intraperoxisomal malonyl-CoA, which is generated by the peroxisomal beta-oxidation of odd chain-length dicarboxylic fatty acids.
Gene Name:
MLYCD
Uniprot ID:
O95822
Molecular weight:
55002.94
General function:
Involved in acetyl-CoA carboxylase activity
Specific function:
ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.
Gene Name:
ACACB
Uniprot ID:
O00763
Molecular weight:
276538.575
General function:
Involved in catalytic activity
Specific function:
Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate.
Gene Name:
PC
Uniprot ID:
P11498
Molecular weight:
129632.565
General function:
Involved in acetyltransferase activity
Specific function:
Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens.
Gene Name:
NAT1
Uniprot ID:
P18440
Molecular weight:
33898.445

Transporters

General function:
Involved in transferase activity
Specific function:
Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities and an acyl carrier protein.
Gene Name:
FASN
Uniprot ID:
P49327
Molecular weight:
273424.06
General function:
Involved in catalytic activity
Specific function:
Acyl-CoA synthetase probably involved in bile acid metabolism. Proposed to activate C27 precurors of bile acids to their CoA thioesters derivatives before side chain cleavage via peroxisomal beta-oxidation occurs. In vitro, activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol. Does not utilize C24 bile acids as substrates. In vitro, also activates long- and branched-chain fatty acids and may have additional roles in fatty acid metabolism. May be involved in translocation of long-chain fatty acids (LFCA) across membranes (By similarity).
Gene Name:
SLC27A2
Uniprot ID:
O14975
Molecular weight:
64614.99
General function:
Involved in negative regulation of cell proliferation
Specific function:
FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters
Gene Name:
FABP3
Uniprot ID:
P05413
Molecular weight:
14857.9
General function:
Carbohydrate transport and metabolism
Specific function:
Probable acetyl-CoA transporter necessary for O-acetylation of gangliosides.
Gene Name:
SLC33A1
Uniprot ID:
O00400
Molecular weight:
60908.39
General function:
Involved in catalytic activity
Specific function:
Acyl-CoA synthetase involved in bile acid metabolism. Proposed to catalyze the first step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi by activating them to their CoA thioesters. Seems to activate secondary bile acids entering the liver from the enterohepatic circulation. In vitro, also activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol.
Gene Name:
SLC27A5
Uniprot ID:
Q9Y2P5
Molecular weight:
75384.375
General function:
Lipid transport and metabolism
Specific function:
Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. The LFCA import appears to be hormone-regulated in a tissue-specific manner. In adipocytes, but not myocytes, insulin induces a rapid translocation of FATP1 from intracellular compartments to the plasma membrane, paralleled by increased LFCA uptake. May act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane- associated multimeric protein complex to trap and draw fatty acids towards accumulation. Plays a pivotal role in regulating available LFCA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. May be involved in regulation of cholesterol metabolism. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids
Gene Name:
SLC27A1
Uniprot ID:
Q6PCB7
Molecular weight:
71107.5
General function:
Involved in acyl carrier activity
Specific function:
Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA
Gene Name:
AASDH
Uniprot ID:
Q4L235
Molecular weight:
122596.1
General function:
Involved in binding
Specific function:
FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long- chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor
Gene Name:
FABP2
Uniprot ID:
P12104
Molecular weight:
15207.2

Only showing the first 10 proteins. There are 226 proteins in total.