Identification |
HMDB Protein ID
| CDBP05401 |
Secondary Accession Numbers
| Not Available |
Name
| N-acetylaspartate synthetase |
Description
| Not Available |
Synonyms
|
- NAA synthetase
- Camello-like protein 3
- N-acetyltransferase 8-like protein
|
Gene Name
| NAT8L |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Not Available |
Specific Function
| Plays a role in the regulation of lipogenesis by producing N-acetylaspartate acid (NAA), a brain-specific metabolite. NAA occurs in high concentration in brain and its hydrolysis plays a significant part in the maintenance of intact white matter. Promotes dopamine uptake by regulating TNF-alpha expression. Attenuates methamphetamine-induced inhibition of dopamine uptake.
|
GO Classification
|
Biological Process |
positive regulation of dopamine uptake involved in synaptic transmission |
Cellular Component |
mitochondrial membrane |
rough endoplasmic reticulum membrane |
integral to membrane |
Molecular Function |
aspartate N-acetyltransferase activity |
|
Cellular Location
|
Not Available
|
Pathways
|
Not Available
|
Gene Properties |
Chromosome Location
| 4 |
Locus
| 4p16.3 |
SNPs
| Not Available |
Gene Sequence
|
Not Available
|
Protein Properties |
Number of Residues
| Not Available |
Molecular Weight
| 32836.875 |
Theoretical pI
| 8.821 |
Pfam Domain Function
|
Not Available |
Signals
|
Not Available
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
>gi|263192221|ref|NP_848652.2| N-acetylaspartate synthetase [Homo sapiens]
MHCGPPDMVCETKIVAAEDHEALPGAKKDALLAAAGAMWPPLPAAPGPAAAPPAPPPAPV
AQPHGGAGGA
|
External Links |
GenBank ID Protein
| Not Available |
UniProtKB/Swiss-Prot ID
| Q8N9F0 |
UniProtKB/Swiss-Prot Entry Name
| Not Available |
PDB IDs
|
Not Available |
GenBank Gene ID
| Not Available |
GeneCard ID
| Not Available |
GenAtlas ID
| Not Available |
HGNC ID
| HGNC:26742 |
References |
General References
| Not Available |