| Identification |
|---|
| HMDB Protein ID
| CDBP02429 |
| Secondary Accession Numbers
| Not Available |
| Name
| 3-hydroxymethyl-3-methylglutaryl-CoA lyase, cytoplasmic |
| Description
| Not Available |
| Synonyms
|
- 3-hydroxymethyl-3-methylglutaryl-CoA lyase-like protein 1
- Endoplasmic reticulum 3-hydroxymethyl-3-methylglutaryl-CoA lyase
- er-cHL
|
| Gene Name
| HMGCLL1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in catalytic activity |
| Specific Function
| Non-mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis, the products of which support energy production in nonhepatic animal tissues.
|
| GO Classification
|
| Biological Process |
| ketone body biosynthetic process |
| Cellular Component |
| endoplasmic reticulum membrane |
| cytosol |
| endoplasmic reticulum |
| perinuclear region of cytoplasm |
| membrane |
| Function |
| catalytic activity |
| Molecular Function |
| metal ion binding |
| hydroxymethylglutaryl-CoA lyase activity |
| Process |
| metabolic process |
|
| Cellular Location
|
Not Available
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | (S)-3-hydroxy-3-methylglutaryl-CoA degradation | Not Available | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 6 |
| Locus
| 6p12.1 |
| SNPs
| HMGCLL1 |
| Gene Sequence
|
>1113 bp
ATGGGGAATGTGCCATCCGCGGTGAAGCACTGCCTCAGCTACCAGCAGCTTCTCCGGGAG
CATCTCTGGATCGGGGATTCAGTGGCAGGGGCGCTCGACCCCGCGCAGACTTCTCTTCTA
ACAAACCTTCACTGCTTTCAGCCCGATGTCTCTGGCTTCTCAGTCTCCTTGGCAGGCACG
GTGGCTTGTATCCACTGGGAAACATCCCAGTTATCTGGACTCCCTGAGTTTGTTAAAATA
GTAGAAGTTGGGCCTAGGGATGGATTGCAGAATGAAAAGGTTATAGTTCCTACAGATATA
AAAATTGAATTTATCAATCGACTTTCCCAAACTGGCTTGTCTGTAATAGAAGTGACTAGC
TTTGTGTCTTCCAGATGGGTACCACAGATGGCTGATCACACTGAAGTAATGAAAGGCATT
CATCAATATCCAGGAGTTCGCTATCCTGTCCTTACTCCTAATCTTCAGGGTTTTCACCAT
GCTGTTGCTGCTGGAGCTACTGAGATATCAGTTTTTGGAGCTGCATCTGAATCCTTTAGC
AAGAAGAATATTAACTGTTCCATTGAAGAAAGTATGGGAAAATTTGAGGAGGTTGTTAAG
TCTGCAAGACACATGAATATTCCAGCACGAGGGTATGTGTCTTGTGCTCTGGGCTGTCCA
TATGAAGGAAGTATTACACCGCAAAAAGTGACAGAAGTGTCTAAGAGATTGTACGGCATG
GGTTGTTATGAGATCTCTCTAGGAGACACAATTGGAGTGGGAACTCCAGGAAGTATGAAA
AGAATGTTGGAAAGTGTGATGAAAGAAATCCCACCAGGTGCTCTTGCTGTTCACTGTCAT
GACACATACGGACAAGCCTTAGCAAATATCCTTACGGCCCTTCAGATGGGAATTAATGTG
GTGGACTCCGCAGTATCCGGATTAGGTGGCTGCCCTTATGCAAAAGGTGCTTCTGGGAAT
GTAGCCACTGAGGATTTGATATATATGCTTAATGGCCTGGGGCTCAATACAGGTGTGAAT
CTATACAAAGTGATGGAAGCTGGTGACTTTATTTGCAAAGCTGTGAATAAAACCACAAAC
TCTAAAGTAGCACAAGCCTCCTTCAATGCTTGA
|
| Protein Properties |
|---|
| Number of Residues
| 370 |
| Molecular Weight
| 36327.465 |
| Theoretical pI
| 6.605 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Probable 3-hydroxymethyl-3-methylglutaryl-CoA lyase 2
MGNVPSAVKHCLSYQQLLREHLWIGDSVAGALDPAQTSLLTNLHCFQPDVSGFSVSLAGT
VACIHWETSQLSGLPEFVKIVEVGPRDGLQNEKVIVPTDIKIEFINRLSQTGLSVIEVTS
FVSSRWVPQMADHTEVMKGIHQYPGVRYPVLTPNLQGFHHAVAAGATEISVFGAASESFS
KKNINCSIEESMGKFEEVVKSARHMNIPARGYVSCALGCPYEGSITPQKVTEVSKRLYGM
GCYEISLGDTIGVGTPGSMKRMLESVMKEIPPGALAVHCHDTYGQALANILTALQMGINV
VDSAVSGLGGCPYAKGASGNVATEDLIYMLNGLGLNTGVNLYKVMEAGDFICKAVNKTTN
SKVAQASFNA
|
| External Links |
|---|
| GenBank ID Protein
| 109150427 |
| UniProtKB/Swiss-Prot ID
| Q8TB92 |
| UniProtKB/Swiss-Prot Entry Name
| HMGC2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_019036.2 |
| GeneCard ID
| HMGCLL1 |
| GenAtlas ID
| HMGCLL1 |
| HGNC ID
| HGNC:21359 |
| References |
|---|
| General References
| Not Available |