Cannabis Compound Database: Showing Protein Acyl-coenzyme A thioesterase 4 (CDBP00985)

Identification Biological properties Gene properties Protein properties External links References XML Show 16 compounds

Identification

HMDB Protein ID

CDBP00985

Secondary Accession Numbers

Not Available

Name

Acyl-coenzyme A thioesterase 4

Description

Not Available

Synonyms

Acyl-CoA thioesterase 4
PTE-2b
PTE-Ib
Peroxisomal acyl coenzyme A thioester hydrolase Ib
Peroxisomal long-chain acyl-CoA thioesterase Ib

Gene Name

ACOT4

Protein Type

Enzyme

Biological Properties

General Function

Involved in thiolester hydrolase activity

Specific Function

Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (By similarity). Succinyl-CoA thioesterase that also hydrolyzes long chain saturated and unsaturated monocarboxylic acyl-CoAs.

GO Classification

Biological Process
very long-chain fatty acid metabolic process
long-chain fatty acid metabolic process
dicarboxylic acid catabolic process
saturated monocarboxylic acid metabolic process
short-chain fatty acid metabolic process
succinyl-CoA metabolic process
unsaturated monocarboxylic acid metabolic process
Cellular Component
peroxisome
Function
thiolester hydrolase activity
coa hydrolase activity
hydrolase activity, acting on ester bonds
acyl-coa thioesterase activity
palmitoyl-coa hydrolase activity
catalytic activity
hydrolase activity
Molecular Function
acyl-CoA hydrolase activity
carboxylesterase activity
palmitoyl-CoA hydrolase activity
succinyl-CoA hydrolase activity
Process
acyl-coa metabolic process
metabolic process
primary metabolism
lipid metabolism
primary metabolic process
cellular metabolic process
physiological process
metabolism
lipid metabolic process
cofactor metabolic process
coenzyme metabolic process

Cellular Location

Cytoplasmic
Peroxisome

Pathways

Name	SMPDB/Pathwhiz	KEGG
Fatty acid elongation	Not Available
Biosynthesis of unsaturated fatty acids	Not Available

Gene Properties

Chromosome Location

Locus

14q24.3

SNPs

ACOT4

Gene Sequence

>1266 bp
ATGTCAGCAACGCTGATCCTGGAGCCCCCAGGCCGCTGCTGCTGGAACGAGCCGGTGCGC
ATTGCCGTGCGCGGCCTGGCCCCGGAGCAGCGGGTTACGCTGCGCGCGTCCCTGCGCGAC
GAGAAGGGCGCGCTCTTCCGGGCCCACGCGCGCTACTGCGCCGACGCCCGCGGCGAGCTG
GACCTGGAGCGCGCACCCGCGCTGGGCGGCAGCTTCGCGGGACTCGAGCCCATGGGGCTG
CTCTGGGCCCTGGAACCCGAGAAGCCTTTTTGGCGCTTCCTGAAGCGGGACGTACAGATT
CCTTTTGTCGTGGAGTTGGAGGTGCTGGACGGCCACGACCCCGAGCCTGGACGGCTGCTG
TGCCAGGCGCAGCACGAGCGCCACTTCCTCCCGCCAGGGGTGCGGCGCCAGTCGGTGCGA
GCGGGCCGGGTGCGCGCCACGCTCTTCCTGCCGCCAGGACCTGGACCCTTCCCAGGGATC
ATTGACATCTTTGGTATTGGAGGGGGCCTCTTGGAATATCGAGCCAGCCTCCTTGCTGGC
CATGGCTTTGCCACGTTGGCTCTAGCTTATTATAACTTTGAAGATCTCCCCAATAACATG
GACAACATATCCCTGGAGTACTTCGAAGAAGCCGTATGCTACATGCTTCAACATCCCCAG
GTAAAAGGCCCAGGCATTGGGCTTTTGGGCATTTCTCTAGGAGCTGATATTTGTCTCTCA
ATGGCCTCATTCTTGAAGAATGTCTCAGCCACAGTTTCCATCAATGGATCTGGGATCAGT
GGGAACACAGCCATCAACTATAAGCACAGTAGCATTCCACCATTGGGCTATGACCTGAGG
AGAATCAAGGTAGCTTTCTCAGGCCTCGTGGACATTGTGGATATAAGGAATGCTCTCGTA
GGAGGGTACAAGAACCCCAGCATGATTCCAATAGAGAAGGCCCAGGGGCCCATCCTGCTC
ATTGTTGGTCAGGATGACCATAACTGGAGAAGTGAGTTGTATGCCCAAACAGTCTCTGAA
CGGTTACAGGCCCATGGAAAGGAAAAACCCCAGATCATCTGTTACCCTGGGACTGGGCAT
TACATCGAGCCTCCTTACTTCCCCCTGTGCCCAGCTTCCCTTCACAGATTACTGAACAAA
CATGTTATATGGGGTGGGGAGCCCAGGGCTCATTCTAAGGCCCAGGAAGATGCCTGGAAG
CAAATTCTAGCCTTCTTCTGCAAACACCTGGGAGGTACCCAGAAAACAGCTGTCCCTAAA
TTGTAA

Protein Properties

Number of Residues

421

Molecular Weight

46326.09

Theoretical pI

8.077

Pfam Domain Function

BAAT_C (PF08840 )
Bile_Hydr_Trans (PF04775 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Acyl-coenzyme A thioesterase 4
MSATLILEPPGRCCWNEPVRIAVRGLAPEQRVTLRASLRDEKGALFRAHARYCADARGEL
DLERAPALGGSFAGLEPMGLLWALEPEKPFWRFLKRDVQIPFVVELEVLDGHDPEPGRLL
CQAQHERHFLPPGVRRQSVRAGRVRATLFLPPGPGPFPGIIDIFGIGGGLLEYRASLLAG
HGFATLALAYYNFEDLPNNMDNISLEYFEEAVCYMLQHPQVKGPGIGLLGISLGADICLS
MASFLKNVSATVSINGSGISGNTAINYKHSSIPPLGYDLRRIKVAFSGLVDIVDIRNALV
GGYKNPSMIPIEKAQGPILLIVGQDDHNWRSELYAQTVSERLQAHGKEKPQIICYPGTGH
YIEPPYFPLCPASLHRLLNKHVIWGGEPRAHSKAQEDAWKQILAFFCKHLGGTQKTAVPK
L

External Links

GenBank ID Protein

187761341

UniProtKB/Swiss-Prot ID

Q8N9L9

UniProtKB/Swiss-Prot Entry Name

ACOT4_HUMAN

PDB IDs