Showing Protein Acyl-coenzyme A thioesterase 4 (CDBP00985)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 16 compounds
Identification
HMDB Protein ID CDBP00985
Secondary Accession Numbers Not Available
Name Acyl-coenzyme A thioesterase 4
Description Not Available
Synonyms
  1. Acyl-CoA thioesterase 4
  2. PTE-2b
  3. PTE-Ib
  4. Peroxisomal acyl coenzyme A thioester hydrolase Ib
  5. Peroxisomal long-chain acyl-CoA thioesterase Ib
Gene Name ACOT4
Protein Type Enzyme
Biological Properties
General Function Involved in thiolester hydrolase activity
Specific Function Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (By similarity). Succinyl-CoA thioesterase that also hydrolyzes long chain saturated and unsaturated monocarboxylic acyl-CoAs.
GO Classification
Biological Process
very long-chain fatty acid metabolic process
long-chain fatty acid metabolic process
dicarboxylic acid catabolic process
saturated monocarboxylic acid metabolic process
short-chain fatty acid metabolic process
succinyl-CoA metabolic process
unsaturated monocarboxylic acid metabolic process
Cellular Component
peroxisome
Function
thiolester hydrolase activity
coa hydrolase activity
hydrolase activity, acting on ester bonds
acyl-coa thioesterase activity
palmitoyl-coa hydrolase activity
catalytic activity
hydrolase activity
Molecular Function
acyl-CoA hydrolase activity
carboxylesterase activity
palmitoyl-CoA hydrolase activity
succinyl-CoA hydrolase activity
Process
acyl-coa metabolic process
metabolic process
primary metabolism
lipid metabolism
primary metabolic process
cellular metabolic process
physiological process
metabolism
lipid metabolic process
cofactor metabolic process
coenzyme metabolic process
Cellular Location
  1. Cytoplasmic
  2. Peroxisome
Pathways
Gene Properties
Chromosome Location 14
Locus 14q24.3
SNPs ACOT4
Gene Sequence 
>1266 bp
ATGTCAGCAACGCTGATCCTGGAGCCCCCAGGCCGCTGCTGCTGGAACGAGCCGGTGCGC
ATTGCCGTGCGCGGCCTGGCCCCGGAGCAGCGGGTTACGCTGCGCGCGTCCCTGCGCGAC
GAGAAGGGCGCGCTCTTCCGGGCCCACGCGCGCTACTGCGCCGACGCCCGCGGCGAGCTG
GACCTGGAGCGCGCACCCGCGCTGGGCGGCAGCTTCGCGGGACTCGAGCCCATGGGGCTG
CTCTGGGCCCTGGAACCCGAGAAGCCTTTTTGGCGCTTCCTGAAGCGGGACGTACAGATT
CCTTTTGTCGTGGAGTTGGAGGTGCTGGACGGCCACGACCCCGAGCCTGGACGGCTGCTG
TGCCAGGCGCAGCACGAGCGCCACTTCCTCCCGCCAGGGGTGCGGCGCCAGTCGGTGCGA
GCGGGCCGGGTGCGCGCCACGCTCTTCCTGCCGCCAGGACCTGGACCCTTCCCAGGGATC
ATTGACATCTTTGGTATTGGAGGGGGCCTCTTGGAATATCGAGCCAGCCTCCTTGCTGGC
CATGGCTTTGCCACGTTGGCTCTAGCTTATTATAACTTTGAAGATCTCCCCAATAACATG
GACAACATATCCCTGGAGTACTTCGAAGAAGCCGTATGCTACATGCTTCAACATCCCCAG
GTAAAAGGCCCAGGCATTGGGCTTTTGGGCATTTCTCTAGGAGCTGATATTTGTCTCTCA
ATGGCCTCATTCTTGAAGAATGTCTCAGCCACAGTTTCCATCAATGGATCTGGGATCAGT
GGGAACACAGCCATCAACTATAAGCACAGTAGCATTCCACCATTGGGCTATGACCTGAGG
AGAATCAAGGTAGCTTTCTCAGGCCTCGTGGACATTGTGGATATAAGGAATGCTCTCGTA
GGAGGGTACAAGAACCCCAGCATGATTCCAATAGAGAAGGCCCAGGGGCCCATCCTGCTC
ATTGTTGGTCAGGATGACCATAACTGGAGAAGTGAGTTGTATGCCCAAACAGTCTCTGAA
CGGTTACAGGCCCATGGAAAGGAAAAACCCCAGATCATCTGTTACCCTGGGACTGGGCAT
TACATCGAGCCTCCTTACTTCCCCCTGTGCCCAGCTTCCCTTCACAGATTACTGAACAAA
CATGTTATATGGGGTGGGGAGCCCAGGGCTCATTCTAAGGCCCAGGAAGATGCCTGGAAG
CAAATTCTAGCCTTCTTCTGCAAACACCTGGGAGGTACCCAGAAAACAGCTGTCCCTAAA
TTGTAA
Protein Properties
Number of Residues 421
Molecular Weight 46326.09
Theoretical pI 8.077
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence 
>Acyl-coenzyme A thioesterase 4
MSATLILEPPGRCCWNEPVRIAVRGLAPEQRVTLRASLRDEKGALFRAHARYCADARGEL
DLERAPALGGSFAGLEPMGLLWALEPEKPFWRFLKRDVQIPFVVELEVLDGHDPEPGRLL
CQAQHERHFLPPGVRRQSVRAGRVRATLFLPPGPGPFPGIIDIFGIGGGLLEYRASLLAG
HGFATLALAYYNFEDLPNNMDNISLEYFEEAVCYMLQHPQVKGPGIGLLGISLGADICLS
MASFLKNVSATVSINGSGISGNTAINYKHSSIPPLGYDLRRIKVAFSGLVDIVDIRNALV
GGYKNPSMIPIEKAQGPILLIVGQDDHNWRSELYAQTVSERLQAHGKEKPQIICYPGTGH
YIEPPYFPLCPASLHRLLNKHVIWGGEPRAHSKAQEDAWKQILAFFCKHLGGTQKTAVPK
L
GenBank ID Protein 187761341
UniProtKB/Swiss-Prot ID Q8N9L9
UniProtKB/Swiss-Prot Entry Name ACOT4_HUMAN
PDB IDs
GenBank Gene ID NM_152331.3
GeneCard ID ACOT4
GenAtlas ID ACOT4
HGNC ID HGNC:19748
References
General References Not Available