Identification |
HMDB Protein ID
| CDBP00031 |
Secondary Accession Numbers
| Not Available |
Name
| 3-ketoacyl-CoA thiolase, mitochondrial |
Description
| Not Available |
Synonyms
|
- Acetyl-CoA acyltransferase
- Beta-ketothiolase
- Mitochondrial 3-oxoacyl-CoA thiolase
- T1
|
Gene Name
| ACAA2 |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in transferase activity, transferring acyl groups other than amino-acyl groups |
Specific Function
| Abolishes BNIP3-mediated apoptosis and mitochondrial damage.
|
GO Classification
|
Biological Process |
negative regulation of apoptotic process |
cholesterol biosynthetic process |
acetyl-CoA metabolic process |
fatty acid beta-oxidation |
Cellular Component |
mitochondrial inner membrane |
mitochondrion |
Function |
catalytic activity |
transferase activity |
transferase activity, transferring acyl groups |
transferase activity, transferring acyl groups other than amino-acyl groups |
Molecular Function |
acetyl-CoA C-acyltransferase activity |
Process |
metabolic process |
|
Cellular Location
|
- Mitochondrion
|
Pathways
|
Name | SMPDB/Pathwhiz | KEGG |
---|
Fatty acid elongation | Not Available |  | Fatty Acid Elongation In Mitochondria |    |  | Long-chain-3-hydroxyacyl-coa dehydrogenase deficiency (LCHAD) |    | Not Available | Fatty acid Metabolism |    |  | Ethylmalonic Encephalopathy |    | Not Available |
|
Gene Properties |
Chromosome Location
| 18 |
Locus
| 18q21.1 |
SNPs
| ACAA2 |
Gene Sequence
|
>1194 bp
ATGGCTCTGCTCCGAGGTGTGTTTGTAGTTGCTGCTAAGCGAACGCCCTTTGGAGCTTAC
GGAGGCCTTCTGAAAGACTTCACTGCTACTGACTTGTCTGAATTTGCTGCCAAGGCTGCC
TTGTCTGCTGGCAAAGTCTCACCTGAAACAGTTGACAGTGTGATTATGGGCAATGTCCTG
CAGAGTTCTTCAGATGCTATATATTTGGCAAGGCATGTTGGTTTGCGTGTGGGAATCCCA
AAGGAGACCCCAGCTCTCACGATTAATAGGCTCTGTGGTTCTGGTTTTCAGTCCATTGTG
AATGGATGTCAGGAAATTTGTGTTAAAGAAGCTGAAGTTGTTTTATGTGGAGGAACCGAA
AGCATGAGCCAAGCTCCCTACTGTGTCAGAAATGTGCGTTTTGGAACCAAGCTTGGATCA
GATATCAAGCTGGAAGATTCTTTATGGGTATCATTAACAGATCAGCATGTCCAGCTCCCC
ATGGCAATGACTGCAGAGAATCTTGCTGTAAAACACAAAATAAGCAGAGAAGAATGTGAC
AAATATGCCCTGCAGTCACAGCAGAGATGGAAAGCTGCTAATGATGCTGGCTACTTTAAT
GATGAAATGGCACCAATTGAAGTGAAGACAAAGAAAGGAAAACAGACAATGCAGGTAGAC
GAGCATGCTCGGCCCCAAACCACCCTGGAACAGTTACAGAAACTTCCTCCAGTATTCAAG
AAAGATGGAACTGTTACTGCAGGGAATGCATCGGGTGTAGCTGATGGTGCTGGAGCTGTT
ATCATAGCTAGTGAAGATGCTGTTAAGAAACATAACTTCACACCACTGGCAAGAATTGTG
GGCTACTTTGTATCTGGATGTGATCCCTCTATCATGGGTATTGGTCCTGTCCCTGCTATC
AGTGGGGCACTGAAGAAAGCAGGACTGAGTCTTAAGGACATGGATTTGGTAGAGGTGAAT
GAAGCTTTTGCTCCCCAGTACTTGGCTGTTGAGAGGAGTTTGGATCTTGACATAAGTAAA
ACCAATGTGAATGGAGGAGCCATTGCTTTGGGTCACCCACTGGGAGGATCTGGATCAAGA
ATTACTGCACACCTGGTTCACGAATTAAGGCGTCGAGGTGGAAAATATGCCGTTGGATCA
GCTTGCATTGGAGGTGGCCAAGGTATTGCTGTCATCATTCAGAGCACAGCCTGA
|
Protein Properties |
Number of Residues
| 397 |
Molecular Weight
| 41923.82 |
Theoretical pI
| 8.09 |
Pfam Domain Function
|
|
Signals
|
Not Available
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
>3-ketoacyl-CoA thiolase, mitochondrial
MALLRGVFVVAAKRTPFGAYGGLLKDFTATDLSEFAAKAALSAGKVSPETVDSVIMGNVL
QSSSDAIYLARHVGLRVGIPKETPALTINRLCGSGFQSIVNGCQEICVKEAEVVLCGGTE
SMSQAPYCVRNVRFGTKLGSDIKLEDSLWVSLTDQHVQLPMAMTAENLAVKHKISREECD
KYALQSQQRWKAANDAGYFNDEMAPIEVKTKKGKQTMQVDEHARPQTTLEQLQKLPPVFK
KDGTVTAGNASGVADGAGAVIIASEDAVKKHNFTPLARIVGYFVSGCDPSIMGIGPVPAI
SGALKKAGLSLKDMDLVEVNEAFAPQYLAVERSLDLDISKTNVNGGAIALGHPLGGSGSR
ITAHLVHELRRRGGKYAVGSACIGGGQGIAVIIQSTA
|
External Links |
GenBank ID Protein
| 12804931 |
UniProtKB/Swiss-Prot ID
| P42765 |
UniProtKB/Swiss-Prot Entry Name
| THIM_HUMAN |
PDB IDs
|
Not Available |
GenBank Gene ID
| BC001918 |
GeneCard ID
| ACAA2 |
GenAtlas ID
| ACAA2 |
HGNC ID
| HGNC:83 |
References |
General References
| Not Available |