| Identification |
|---|
| HMDB Protein ID
| CDBP04590 |
| Secondary Accession Numbers
| Not Available |
| Name
| Histone acetyltransferase KAT8 |
| Description
| Not Available |
| Synonyms
|
- MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1
- MYST-1
- hMOF
- Lysine acetyltransferase 8
|
| Gene Name
| KAT8 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in chromatin binding |
| Specific Function
| Histone acetyltransferase which may be involved in transcriptional activation. May influence the function of ATM. As part of the MSL complex it is involved in acetylation of nucleosomal histone H4 producing specifically H4K16ac. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. That activity is less specific than the one of the MSL complex.
|
| GO Classification
|
| Biological Process |
| negative regulation of transcription, DNA-dependent |
| positive regulation of transcription, DNA-dependent |
| transcription, DNA-dependent |
| myeloid cell differentiation |
| histone H4-K5 acetylation |
| histone H4-K8 acetylation |
| histone H4-K16 acetylation |
| Cellular Component |
| MLL1 complex |
| kinetochore |
| MSL complex |
| Component |
| organelle part |
| intracellular organelle part |
| chromosomal part |
| chromatin |
| organelle |
| membrane-bounded organelle |
| intracellular membrane-bounded organelle |
| nucleus |
| Function |
| binding |
| catalytic activity |
| transferase activity |
| transferase activity, transferring acyl groups |
| transferase activity, transferring acyl groups other than amino-acyl groups |
| chromatin binding |
| Molecular Function |
| metal ion binding |
| transcription factor binding |
| methylated histone residue binding |
| histone acetyltransferase activity |
| Process |
| organelle organization |
| chromosome organization |
| chromatin organization |
| biological regulation |
| regulation of biological process |
| regulation of metabolic process |
| regulation of macromolecule metabolic process |
| regulation of gene expression |
| regulation of transcription |
| chromatin assembly or disassembly |
| cellular process |
| cellular component organization at cellular level |
|
| Cellular Location
|
- Nucleus
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 16 |
| Locus
| 16p11.2 |
| SNPs
| MYST1 |
| Gene Sequence
|
>1377 bp
ATGGCGGCACAGGGAGCTGCTGCGGCGGTTGCGGCGGGGACTTCAGGGGTCGCGGGGGAG
GGCGAGCCCGGGCCCGGGGAGAATGCGGCCGCTGAGGGGACCGCCCCATCCCCGGGCCGC
GTCTCTCCGCCGACCCCGGCGCGCGGCGAGCCGGAAGTCACGGTGGAGATCGGAGAAACG
TACCTGTGCCGGCGACCGGATAGCACCTGGCATTCTGCTGAAGTGATCCAGTCTCGAGTG
AACGACCAGGAGGGCCGAGAGGAATTCTATGTACACTACGTGGGCTTTAACCGGCGGCTG
GACGAGTGGGTAGACAAGAACCGGCTGGCGCTGACCAAGACAGTGAAGGATGCTGTACAG
AAGAACTCAGAGAAGTACCTGAGCGAGCTCGCAGAGCAGCCTGAGCGCAAGATCACTCGC
AACCAAAAGCGCAAGCATGATGAGATCAACCATGTGCAGAAGACTTATGCAGAGATGGAC
CCCACCACAGCAGCCTTGGAGAAGGAGCATGAGGCGATCACCAAGGTGAAGTATGTGGAC
AAGATCCACATCGGGAACTACGAAATTGATGCCTGGTATTTCTCACCATTCCCCGAAGAC
TATGGGAAACAGCCCAAGCTCTGGCTCTGCGAGTACTGCCTCAAGTACATGAAATATGAG
AAGAGCTACCGCTTCCACTTGGGTCAGTGCCAGTGGCGGCAGCCCCCCGGGAAAGAGATC
TACCGCAAGAGCAACATCTCCGTGTACGAAGTTGATGGCAAAGACCATAAGATTTACTGT
CAGAACCTGTGTCTGCTGGCCAAGCTTTTCCTGGACCATAAGACACTGTACTTTGACGTG
GAGCCGTTCGTCTTTTACATCCTGACTGAGGTGGACCGGCAGGGGGCCCACATTGTTGGC
TACTTCTCCAAGGAGAAGGAGTCCCCGGATGGAAACAATGTGGCCTGCATCCTGACCTTG
CCCCCCTACCAACGCCGCGGCTACGGGAAGTTCCTCATCGCTTTCAGTTATGAGCTCTCC
AAGCTGGAGAGCACAGTCGGCTCCCCGGAGAAGCCACTGTCTGACCTGGGCAAGCTCAGC
TACCGCAGCTACTGGTCCTGGGTGCTGCTAGAGATCCTGCGGGACTTCCGGGGCACACTG
TCCATCAAGGACCTCAGCCAGATGACCAGTATCACCCAAAATGACATCATCAGTACCCTG
CAATCCCTCAATATGGTCAAGTACTGGAAGGGCCAGCACGTGATCTGTGTCACACCCAAG
CTGGTGGAGGAGCACCTCAAAAGTGCCCAGTATAAGAAACCACCCATCACAGTGGACTCC
GTCTGCCTCAAGTGGGCACCCCCCAAGCACAAGCAAGTCAAGCTCTCCAAGAAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 458 |
| Molecular Weight
| 52402.345 |
| Theoretical pI
| 8.267 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Probable histone acetyltransferase MYST1
MAAQGAAAAVAAGTSGVAGEGEPGPGENAAAEGTAPSPGRVSPPTPARGEPEVTVEIGET
YLCRRPDSTWHSAEVIQSRVNDQEGREEFYVHYVGFNRRLDEWVDKNRLALTKTVKDAVQ
KNSEKYLSELAEQPERKITRNQKRKHDEINHVQKTYAEMDPTTAALEKEHEAITKVKYVD
KIHIGNYEIDAWYFSPFPEDYGKQPKLWLCEYCLKYMKYEKSYRFHLGQCQWRQPPGKEI
YRKSNISVYEVDGKDHKIYCQNLCLLAKLFLDHKTLYFDVEPFVFYILTEVDRQGAHIVG
YFSKEKESPDGNNVACILTLPPYQRRGYGKFLIAFSYELSKLESTVGSPEKPLSDLGKLS
YRSYWSWVLLEILRDFRGTLSIKDLSQMTSITQNDIISTLQSLNMVKYWKGQHVICVTPK
LVEEHLKSAQYKKPPITVDSVCLKWAPPKHKQVKLSKK
|
| External Links |
|---|
| GenBank ID Protein
| 226371636 |
| UniProtKB/Swiss-Prot ID
| Q9H7Z6 |
| UniProtKB/Swiss-Prot Entry Name
| MYST1_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| NM_032188.2 |
| GeneCard ID
| MYST1 |
| GenAtlas ID
| MYST1 |
| HGNC ID
| HGNC:17933 |
| References |
|---|
| General References
| Not Available |