| Identification |
|---|
| HMDB Protein ID
| CDBP00521 |
| Secondary Accession Numbers
| Not Available |
| Name
| Bile acid-CoA:amino acid N-acyltransferase |
| Description
| Not Available |
| Synonyms
|
- BACAT
- BAT
- Glycine N-choloyltransferase
- Long-chain fatty-acyl-CoA hydrolase
|
| Gene Name
| BAAT |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in thiolester hydrolase activity |
| Specific Function
| Involved in bile acid metabolism. In liver hepatocytes catalyzes the second step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi. The major components of bile are cholic acid and chenodeoxycholic acid. In a first step the bile acids are converted to an acyl-CoA thioester, either in peroxisomes (primary bile acids deriving from the cholesterol pathway), or cytoplasmic at the endoplasmic reticulum (secondary bile acids). May catalyze the conjugation of primary or secondary bile acids, or both. The conjugation increases the detergent properties of bile acids in the intestine, which facilitates lipid and fat-soluble vitamin absorption. In turn, bile acids are deconjugated by bacteria in the intestine and are recycled back to the liver for reconjugation (secondary bile acids). May also act as an acyl-CoA thioesterase that regulates intracellular levels of free fatty acids. In vitro, catalyzes the hydrolysis of long- and very long-chain saturated acyl-CoAs to the free fatty acid and coenzyme A (CoASH), and conjugates glycine to these acyl-CoAs.
|
| GO Classification
|
| Biological Process |
| acyl-CoA metabolic process |
| organ regeneration |
| bile acid conjugation |
| glycine metabolic process |
| taurine metabolic process |
| fatty acid metabolic process |
| liver development |
| bile acid and bile salt transport |
| bile acid biosynthetic process |
| Cellular Component |
| cytosol |
| peroxisomal matrix |
| Function |
| thiolester hydrolase activity |
| coa hydrolase activity |
| hydrolase activity, acting on ester bonds |
| acyl-coa thioesterase activity |
| palmitoyl-coa hydrolase activity |
| catalytic activity |
| hydrolase activity |
| Molecular Function |
| glycine N-choloyltransferase activity |
| N-acyltransferase activity |
| very long chain acyl-CoA hydrolase activity |
| carboxylesterase activity |
| palmitoyl-CoA hydrolase activity |
| medium-chain acyl-CoA hydrolase activity |
| Process |
| acyl-coa metabolic process |
| metabolic process |
| primary metabolic process |
| cellular metabolic process |
| lipid metabolic process |
| cofactor metabolic process |
| coenzyme metabolic process |
|
| Cellular Location
|
- Cytoplasm
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Primary bile acid biosynthesis | Not Available |  | | Biosynthesis of unsaturated fatty acids | Not Available |  | | Peroxisome | Not Available |  | | Bile secretion | Not Available |  | | Bile Acid Biosynthesis |    | |
|
| Gene Properties |
|---|
| Chromosome Location
| 9 |
| Locus
| 9q22.3 |
| SNPs
| BAAT |
| Gene Sequence
|
>1257 bp
ATGATCCAGTTGACAGCTACCCCTGTGAGTGCACTTGTTGATGAGCCAGTGCATATCCGA
GCTACAGGCCTGATTCCCTTTCAGATGGTGAGTTTTCAGGCATCACTGGAAGATGAAAAC
GGAGACATGTTTTATTCTCAAGCCCACTATAGGGCCAATGAATTCGGTGAGGTGGACCTG
AATCATGCTTCTTCACTTGGAGGGGATTATATGGGAGTCCACCCCATGGGTCTCTTCTGG
TCTCTGAAACCTGAAAAGCTATTAACAAGACTGTTGAAAAGAGATGTGATGAATAGGCCT
TTCCAGGTCCAAGTAAAACTTTATGACTTAGAGTTAATAGTGAACAATAAAGTTGCCAGT
GCTCCAAAGGCCAGCCTGACTTTGGAGAGGTGGTATGTGGCACCTGGTGTCACACGAATT
AAGGTTCGAGAAGGCCGCCTTCGAGGAGCTCTCTTTCTCCCTCCAGGAGAGGGTCTCTTC
CCAGGGGTAATTGATTTGTTTGGTGGTTTGGGTGGGCTGCTTGAATTTCGGGCCAGCCTC
CTAGCCAGTCGTGGCTTCGCCTCCTTGGCCTTGGCTTACCATAACTATGAAGACCTGCCC
CGCAAACCAGAAGTAACAGATTTGGAATATTTTGAGGAGGCTGCCAACTTTCTCCTGAGA
CATCCAAAGGTCTTTGGCTCAGGCGTTGGGGTAGTCTCTGTATGTCAAGGAGTACAGATT
GGACTATCTATGGCTATTTACCTAAAGCAAGTCACAGCCACGGTACTTATTAATGGGACC
AACTTTCCTTTTGGCATTCCACAGGTATATCATGGTCAGATCCATCAGCCCCTTCCCCAT
TCTGCACAATTAATATCCACCAATGCCTTGGGGTTACTAGAGCTCTATCGCACTTTTGAG
ACAACTCAAGTTGGGGCCAGTCAATATTTGTTTCCTATTGAAGAGGCCCAGGGGCAATTC
CTCTTCATTGTAGGAGAAGGTGATAAGACTATCAACAGCAAAGCACACGCTGAACAAGCC
ATAGGACAGCTGAAGAGACATGGGAAGAACAACTGGACCCTGCTATCTTACCCTGGGGCA
GGCCACCTGATAGAACCTCCCTATTCTCCTCTGTGCTGTGCCTCAACGACCCACGATTTG
AGGTTACACTGGGGAGGAGAGGTGATCCCACACGCAGCTGCACAGGAACATGCTTGGAAG
GAGATCCAGAGATTTCTCAGGAAGCACCTCATTCCAGATGTGACCAGTCAACTCTAA
|
| Protein Properties |
|---|
| Number of Residues
| 418 |
| Molecular Weight
| 46298.865 |
| Theoretical pI
| 6.996 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Bile acid-CoA:amino acid N-acyltransferase
MIQLTATPVSALVDEPVHIRATGLIPFQMVSFQASLEDENGDMFYSQAHYRANEFGEVDL
NHASSLGGDYMGVHPMGLFWSLKPEKLLTRLLKRDVMNRPFQVQVKLYDLELIVNNKVAS
APKASLTLERWYVAPGVTRIKVREGRLRGALFLPPGEGLFPGVIDLFGGLGGLLEFRASL
LASRGFASLALAYHNYEDLPRKPEVTDLEYFEEAANFLLRHPKVFGSGVGVVSVCQGVQI
GLSMAIYLKQVTATVLINGTNFPFGIPQVYHGQIHQPLPHSAQLISTNALGLLELYRTFE
TTQVGASQYLFPIEEAQGQFLFIVGEGDKTINSKAHAEQAIGQLKRHGKNNWTLLSYPGA
GHLIEPPYSPLCCASTTHDLRLHWGGEVIPHAAAQEHAWKEIQRFLRKHLIPDVTSQL
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q14032 |
| UniProtKB/Swiss-Prot Entry Name
| BAAT_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| L34081 |
| GeneCard ID
| BAAT |
| GenAtlas ID
| BAAT |
| HGNC ID
| HGNC:932 |
| References |
|---|
| General References
| Not Available |