Showing Protein Bile acid-CoA:amino acid N-acyltransferase (CDBP00521)
| Identification | |||||||||||||||||||||||||||||||||||||
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| HMDB Protein ID | CDBP00521 | ||||||||||||||||||||||||||||||||||||
| Secondary Accession Numbers | Not Available | ||||||||||||||||||||||||||||||||||||
| Name | Bile acid-CoA:amino acid N-acyltransferase | ||||||||||||||||||||||||||||||||||||
| Description | Not Available | ||||||||||||||||||||||||||||||||||||
| Synonyms |
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| Gene Name | BAAT | ||||||||||||||||||||||||||||||||||||
| Protein Type | Enzyme | ||||||||||||||||||||||||||||||||||||
| Biological Properties | |||||||||||||||||||||||||||||||||||||
| General Function | Involved in thiolester hydrolase activity | ||||||||||||||||||||||||||||||||||||
| Specific Function | Involved in bile acid metabolism. In liver hepatocytes catalyzes the second step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi. The major components of bile are cholic acid and chenodeoxycholic acid. In a first step the bile acids are converted to an acyl-CoA thioester, either in peroxisomes (primary bile acids deriving from the cholesterol pathway), or cytoplasmic at the endoplasmic reticulum (secondary bile acids). May catalyze the conjugation of primary or secondary bile acids, or both. The conjugation increases the detergent properties of bile acids in the intestine, which facilitates lipid and fat-soluble vitamin absorption. In turn, bile acids are deconjugated by bacteria in the intestine and are recycled back to the liver for reconjugation (secondary bile acids). May also act as an acyl-CoA thioesterase that regulates intracellular levels of free fatty acids. In vitro, catalyzes the hydrolysis of long- and very long-chain saturated acyl-CoAs to the free fatty acid and coenzyme A (CoASH), and conjugates glycine to these acyl-CoAs. | ||||||||||||||||||||||||||||||||||||
| GO Classification |
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| Cellular Location |
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| Pathways |
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| Gene Properties | |||||||||||||||||||||||||||||||||||||
| Chromosome Location | 9 | ||||||||||||||||||||||||||||||||||||
| Locus | 9q22.3 | ||||||||||||||||||||||||||||||||||||
| SNPs | BAAT | ||||||||||||||||||||||||||||||||||||
| Gene Sequence |
>1257 bp ATGATCCAGTTGACAGCTACCCCTGTGAGTGCACTTGTTGATGAGCCAGTGCATATCCGA GCTACAGGCCTGATTCCCTTTCAGATGGTGAGTTTTCAGGCATCACTGGAAGATGAAAAC GGAGACATGTTTTATTCTCAAGCCCACTATAGGGCCAATGAATTCGGTGAGGTGGACCTG AATCATGCTTCTTCACTTGGAGGGGATTATATGGGAGTCCACCCCATGGGTCTCTTCTGG TCTCTGAAACCTGAAAAGCTATTAACAAGACTGTTGAAAAGAGATGTGATGAATAGGCCT TTCCAGGTCCAAGTAAAACTTTATGACTTAGAGTTAATAGTGAACAATAAAGTTGCCAGT GCTCCAAAGGCCAGCCTGACTTTGGAGAGGTGGTATGTGGCACCTGGTGTCACACGAATT AAGGTTCGAGAAGGCCGCCTTCGAGGAGCTCTCTTTCTCCCTCCAGGAGAGGGTCTCTTC CCAGGGGTAATTGATTTGTTTGGTGGTTTGGGTGGGCTGCTTGAATTTCGGGCCAGCCTC CTAGCCAGTCGTGGCTTCGCCTCCTTGGCCTTGGCTTACCATAACTATGAAGACCTGCCC CGCAAACCAGAAGTAACAGATTTGGAATATTTTGAGGAGGCTGCCAACTTTCTCCTGAGA CATCCAAAGGTCTTTGGCTCAGGCGTTGGGGTAGTCTCTGTATGTCAAGGAGTACAGATT GGACTATCTATGGCTATTTACCTAAAGCAAGTCACAGCCACGGTACTTATTAATGGGACC AACTTTCCTTTTGGCATTCCACAGGTATATCATGGTCAGATCCATCAGCCCCTTCCCCAT TCTGCACAATTAATATCCACCAATGCCTTGGGGTTACTAGAGCTCTATCGCACTTTTGAG ACAACTCAAGTTGGGGCCAGTCAATATTTGTTTCCTATTGAAGAGGCCCAGGGGCAATTC CTCTTCATTGTAGGAGAAGGTGATAAGACTATCAACAGCAAAGCACACGCTGAACAAGCC ATAGGACAGCTGAAGAGACATGGGAAGAACAACTGGACCCTGCTATCTTACCCTGGGGCA GGCCACCTGATAGAACCTCCCTATTCTCCTCTGTGCTGTGCCTCAACGACCCACGATTTG AGGTTACACTGGGGAGGAGAGGTGATCCCACACGCAGCTGCACAGGAACATGCTTGGAAG GAGATCCAGAGATTTCTCAGGAAGCACCTCATTCCAGATGTGACCAGTCAACTCTAA |
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| Protein Properties | |||||||||||||||||||||||||||||||||||||
| Number of Residues | 418 | ||||||||||||||||||||||||||||||||||||
| Molecular Weight | 46298.865 | ||||||||||||||||||||||||||||||||||||
| Theoretical pI | 6.996 | ||||||||||||||||||||||||||||||||||||
| Pfam Domain Function | |||||||||||||||||||||||||||||||||||||
| Signals | Not Available | ||||||||||||||||||||||||||||||||||||
| Transmembrane Regions | Not Available | ||||||||||||||||||||||||||||||||||||
| Protein Sequence |
>Bile acid-CoA:amino acid N-acyltransferase MIQLTATPVSALVDEPVHIRATGLIPFQMVSFQASLEDENGDMFYSQAHYRANEFGEVDL NHASSLGGDYMGVHPMGLFWSLKPEKLLTRLLKRDVMNRPFQVQVKLYDLELIVNNKVAS APKASLTLERWYVAPGVTRIKVREGRLRGALFLPPGEGLFPGVIDLFGGLGGLLEFRASL LASRGFASLALAYHNYEDLPRKPEVTDLEYFEEAANFLLRHPKVFGSGVGVVSVCQGVQI GLSMAIYLKQVTATVLINGTNFPFGIPQVYHGQIHQPLPHSAQLISTNALGLLELYRTFE TTQVGASQYLFPIEEAQGQFLFIVGEGDKTINSKAHAEQAIGQLKRHGKNNWTLLSYPGA GHLIEPPYSPLCCASTTHDLRLHWGGEVIPHAAAQEHAWKEIQRFLRKHLIPDVTSQL |
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| External Links | |||||||||||||||||||||||||||||||||||||
| GenBank ID Protein | Not Available | ||||||||||||||||||||||||||||||||||||
| UniProtKB/Swiss-Prot ID | Q14032 | ||||||||||||||||||||||||||||||||||||
| UniProtKB/Swiss-Prot Entry Name | BAAT_HUMAN | ||||||||||||||||||||||||||||||||||||
| PDB IDs | Not Available | ||||||||||||||||||||||||||||||||||||
| GenBank Gene ID | L34081 | ||||||||||||||||||||||||||||||||||||
| GeneCard ID | BAAT | ||||||||||||||||||||||||||||||||||||
| GenAtlas ID | BAAT | ||||||||||||||||||||||||||||||||||||
| HGNC ID | HGNC:932 | ||||||||||||||||||||||||||||||||||||
| References | |||||||||||||||||||||||||||||||||||||
| General References | Not Available | ||||||||||||||||||||||||||||||||||||
